Longitudinal biomarkers in amyotrophic lateral sclerosis

Diagnostic and Prognostic Performance of Neurofilaments in ALS

(2019) Koen Poesen et al.   Frontiers in Neurology

Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS

(2019) Rangariroyashe Hannah Chipika et al.   Frontiers in Neurology

Genetic Convergence Brings Clarity to the Enigmatic Red Line in ALS

(2019) Casey Cook et al.   NEURON

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

(2019) David R Beers et al.   LANCET NEUROLOGY

Genetics of amyotrophic lateral sclerosis: A review

(2019) Stéphane Mathis et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neurofilament as a potential biomarker for spinal muscular atrophy

(2019) Basil T. Darras et al.   Annals of Clinical and Translational Neurology

Blood neurofilament light as a potential endpoint in Phase 2 studies in MS

(2019) Maria Pia Sormani et al.   Annals of Clinical and Translational Neurology

Are Circulating Cytokines Reliable Biomarkers for Amyotrophic Lateral Sclerosis?

(2019) Laura Moreno-Martinez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurofilaments in pre-symptomatic ALS and the impact of genotype

(2019) Michael Benatar et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

(2019) Javier H. Jara et al.   Journal of Neuroinflammation

C9ORF72 protein function and immune dysregulation in amyotrophic lateral sclerosis

(2019) Jesse D. Lai et al.   NEUROSCIENCE LETTERS

Mechanisms of Immune Activation by c9orf72-Expansions in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

(2019) Kyle J. Trageser et al.   Frontiers in Neuroscience

Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models

(2018) Alex McCampbell et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease

(2018) L.M. Bekris et al.   JOURNAL OF NEUROIMMUNOLOGY

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis

(2018) Christina N. Fournier et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

(2018) Juan Fortea et al.   LANCET NEUROLOGY

Comparison of elevated phosphorylated neurofilament heavy chains in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis

(2017) Maxim De Schaepdryver et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease

(2017) Koen Poesen et al.   NEUROLOGY

Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis

(2017) Christian Lunetta et al.   JAMA Neurology

Assessment of a multiple biomarker panel for diagnosis of amyotrophic lateral sclerosis

(2016) Xueping Chen et al.   BMC Neurology

Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis

(2016) Lucas T. Vu et al.   Neurotherapeutics

ALS biomarkers for therapy development: State of the field and future directions

(2015) Michael Benatar et al.   MUSCLE & NERVE

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis

(2015) C.-H. Lu et al.   NEUROLOGY

Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis

(2015) J. Kuhle et al.   NEUROLOGY

Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis

(2014) Paola Italiani et al.   Journal of Neuroinflammation

Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?

(2014) Hiroshi Mitsumoto et al.   LANCET NEUROLOGY

The phenotypic variability of amyotrophic lateral sclerosis

(2014) Bart Swinnen et al.   Nature Reviews Neurology

Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients

(2014) Koji Abe et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

MCP-1/CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS

(2013) Motoko Kawaguchi-Niida et al.   Acta Neuropathologica Communications

A multiplex immunoassay gives different results than singleplex immunoassays which may bias epidemiologic associations

(2012) Lawrence de Koning et al.   CLINICAL BIOCHEMISTRY

Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: a possible marker of disease severity and progression

(2012) R. Tortelli et al.   EUROPEAN JOURNAL OF NEUROLOGY

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

Biomarkers in amyotrophic lateral sclerosis: opportunities and limitations

(2011) Robert Bowser et al.   Nature Reviews Neurology

Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process

(2009) Stefania Mantovani et al.   JOURNAL OF NEUROIMMUNOLOGY