Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 7, Issue 7, Pages 1245-1251Publisher
WILEY
DOI: 10.1002/acn3.51094
Keywords
neutrophil-related chemokines; CXCL1; CXCL5; CXCL7; neuromyelitis optica
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Funding
- National Natural Science Foundation of China [81901239, 81673950]
- Guangdong Provincial Science and Technology plan projects [2017A020215182]
- Guangzhou Science and Technology Project [201704020111]
- Natural Science Foundation of Guangdong Province [2019A1515011434, 2019A1515011611]
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Pathologic findings showed that neutrophils played an important role in the pathogenesis of NMO. This study aims to investigate the CSF levels of neutrophil-related chemokines in NMO. CXCL1, CXCL5, and CXCL7 were measured in 95 patients with NMO, 15 patients with MS, 18 patients with GFAP astrocytopathy, and 16 controls. The CSF level of CXCL1, CXCL5, and CXCL7 was significantly elevated in the NMO group but not correlated with the patient clinical severity. Besides, the CSF CXCL1, CXCL5, and CXCL7 could act as biomarkers to distinguish NMO from MS with good reliability, especially the CXCL7.
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