Journal
FRONTIERS IN CHEMISTRY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2020.00519
Keywords
anoplin; structural modification; structure-activity relationship; antimicrobial activity; antitumor activity
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Funding
- National Natural Science Foundation of China [81903654]
- Program for Professor of Special Appointment (Young Eastern Scholar) at Shanghai Institutions of Higher Learning [QD2018035]
- Shanghai Chenguang Program of Education Commission of Shanghai Municipality [18CG46]
- Shanghai Sailing Program of Science and Technology Commission of Shanghai Municipality [19YF1449400]
- National Key Subject of Drug Innovation [2019ZX09201005-007]
- National Key R&D program for key research project of modernization of traditional Chinese medicine [2019YFC1711602]
- Graduate Innovation Training research project of Shanghai University of Traditional Chinese Medicine [Y2019064]
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Anoplin is an amphipathic, alpha-helical bioactive peptide from wasp venom. In recent years, pharmaceutical and organic chemists discovered that anoplin and its derivatives showed multiple pharmacological activities in antibacterial, antitumor, antifungal, and antimalarial activities. Owing to the simple and unique structure and diverse biological activities, anoplin has attracted considerable research interests. This review highlights the advances in structural modification, biological activities, and the outlook of anoplin in order to provide a basis for new drug design and delivery.
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