Journal
TOPICS IN CURRENT CHEMISTRY
Volume 378, Issue 4, Pages -Publisher
SPRINGER INT PUBL AG
DOI: 10.1007/s41061-020-00303-9
Keywords
Remote C-H functionalization; 8-Aminoquinoline; Single electron transfer mechanism; Site-selective
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Funding
- Natural Science Foundation of China [21676076, 21878081, 21971060, 2018RS3042]
- Recruitment program for Foreign Experts of China [WQ20164300353]
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8-Aminoquinoline is a common nitrogen-containing heterocyclic framework in many natural products, functional materials and useful drugs. It has been developed as a powerful bidentate directing group or ligand auxiliary in the field of C-H bond activation/functionalization in recent years. In this context, the synthesis of substituted 8-aminoquinoline is of great importance. In this review we focus on the functionalization of positions C2-C7 on the 8-aminoquinoline ring, which involves the formation of C-C and C-Z (Z = heteroatom) bonds by transition metal catalysts, photocatalysts or metal-free conditions. Mechanistically, a single electron transfer (SET) pathway is suggested in most cases.
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