Article
Endocrinology & Metabolism
Yang Liu, Yue Qu, Chloe Cheng, Pei-Yin Tsai, Kaydine Edwards, Siwen Xue, Supriya Pandit, Sakura Eguchi, Navneet Sanghera, Joeva J. Barrow
Summary: This study investigates the role of Nipsnap1 in the maintenance of non-shivering thermogenesis (NST). The results show that Nipsnap1 is a critical regulator of long-term thermogenic maintenance in brown adipose tissue (BAT). Mice lacking Nipsnap1 are unable to sustain activated energy expenditure and exhibit lower body temperature when exposed to extended cold challenge.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Amanda J. Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: Obesity is associated with various metabolic disorders and cardiovascular diseases, causing increased hospitalizations, morbidity, and mortality. Dysfunction of adipose tissue due to chronic nutrient stress can lead to oxidative stress, mitochondrial dysfunction, inflammation, hypoxia, and insulin resistance. This study aimed to reduce adipose tissue oxidative stress by overexpressing the antioxidant mitochondrial catalase (mCAT) in adipose tissue to improve systemic metabolic function. The results showed that the AdipoQ-mCAT mice were protected from further metabolic impairment under obesogenic dietary conditions compared to obese wild-type mice, highlighting the critical role of physiological H2O2 signaling in metabolism and adipose tissue function.
Article
Multidisciplinary Sciences
Jilong Han, Tingting Guo, Yaojing Yue, Zengkui Lu, Jianbin Liu, Chao Yuan, Chune Niu, Min Yang, Bohui Yang
Summary: Tail adipose tissue plays a crucial role in enhancing environmental tolerance for sheep, and this study aimed to explore the development mechanisms of this trait. Proteomic analysis revealed differentially expressed proteins in the tail adipose tissues between fat-tailed and thin-tailed sheep, mainly related to metabolism pathways and the peroxisome proliferator activated receptor signaling pathway. Up-regulated proteins like ACS L1, HSD17 beta 4, FABP4 may contribute to tail fat deposition by promoting adipocyte proliferation and fat accumulation.
Article
Multidisciplinary Sciences
Ji Seul Han, Yong Geun Jeon, Minsik Oh, Gung Lee, Hahn Nahmgoong, Sang Mun Han, Jeehye Choi, Ye Young Kim, Kyung Cheul Shin, Jiwon Kim, Kyuri Jo, Sung Sik Choe, Eun Jung Park, Sun Kim, Jae Bum Kim
Summary: “The study demonstrates that HIF alpha plays a key role in regulating thermogenic function in response to cold and re-warming. Specifically, HIF2 alpha suppresses PKA activity by inducing miR-3085-3p expression, leading to downregulation of PKA C alpha. Ablation of adipocyte HIF2 alpha stimulates retention of beige adipocytes during re-warming after cold stimuli. Moreover, administration of miR-3085-3p promotes beige-to-white transition via downregulation of PKA C alpha and mitochondrial abundance in adipocyte HIF2 alpha deficient mice. These findings highlight the importance of HIF2 alpha-dependent PKA regulation in dynamic remodeling of beige adipocytes as thermostats.”
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Chad C. Doucette, Davide Barteselli, Daniel C. Nguyen, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, Aaron C. Brown
Summary: In this study, an optogenetic approach was used to activate UCP1-dependent thermogenesis in brown adipocytes. This system allows for precise, chemical free, temporal control of UCP1-dependent thermogenesis, which can contribute to our understanding of brown adipocyte biology and the development of therapies for obesity-related disorders.
Article
Biochemistry & Molecular Biology
Zhuanzhuan Liu, Shihong Xu, Zhiwei Zhang, Hanying Wang, Qiyue Jing, Shenghan Zhang, Mengnan Liu, Jinzhi Han, Yanbo Kou, Yanxia Wei, Lu Wang, Yugang Wang
Summary: FAM96A plays a crucial role in regulating Fe metabolism and obesity development, maintaining intracellular and systemic Fe homeostasis. Loss of FAM96A leads to adipocyte hypertrophy and reduction in organismal energy expenditure.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Guan Huang, Cuishan Yang, Sheng Guo, Miaoling Huang, Liping Deng, Ying Huang, Puxin Chen, Feng Chen, Xiaohong Huang
Summary: This study reveals the crucial role of PIP5K1c in regulating obesity, hyperlipidaemia, hepatic steatosis, and insulin resistance induced by a high fat diet. PIP5K1c deficiency reduces adipocyte volume and enhances energy expenditure, protecting against weight gain. These findings suggest that targeting PIP5K1c could be a potential strategy for treating obesity.
LIPIDS IN HEALTH AND DISEASE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Raghav Jain, Judith Simcox
Summary: Localized hyperthermia has been found to activate thermogenic mechanisms, leading to increased energy expenditure and reduced body weight in both mice and humans.
Article
Biochemistry & Molecular Biology
Alexandre Pinel, Jean-Paul Rigaudiere, Beatrice Morio, Frederic Capel
Summary: The study showed that continuous intake of EPA-rich fish oil for three generations could reduce activation of inflammatory processes, maintain metabolic homeostasis, and decrease dysregulation of cholesterol metabolism and mitochondrial functions in response to an obesogenic diet. Continuous intake of long chain n-3 PUFA may be beneficial in preventing the effects of energy-dense, nutrient-poor foods.
Article
Pharmacology & Pharmacy
Honglin Si, Tianlin Gao, Jing Yang, Jing Zhu, Ying Han, Chengwei Li, Jianxin Wang, Jianyu Li, Yanjie Zhao, Lei Chen, Yuxin Zheng, Menghui Jiang
Summary: Air pollution, especially due to industrialization in developing countries, has become a serious health risk, with a focus on the relationship between obesity/overweight and PM2.5. This study exposed young mice to PM2.5 using a real-ambient exposure system and found that it led to increased weight and adipocyte size in adipose tissue, altered lipid metabolism, and disrupted mitochondrial function. These findings provide new insights into the hazardous effects of air pollution and the underlying mechanism.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaoyu Ding, Xiaona Chang, Jiaxuan Wang, Nannan Bian, Yu An, Guang Wang, Jia Liu
Summary: The study found that serum Metrnl levels were reduced in individuals with overweight or obesity and were independently associated with adverse lipid profile. This finding suggests that modifying circulating Metrnl levels may serve as a potential therapeutic target for atherogenic dyslipidemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ruiyi Zhu, Shuchun Chen
Summary: This study investigated the effect of semaglutide on lipid metabolism in obese mice. The results showed that semaglutide can effectively reduce visceral fat and blood lipids and improve glucose metabolism in obese mice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Qian-Wen Sun, Chun-Fang Lian, Yan-Min Chen, Jun Ye, Wei Chen, Yue Gao, Hong-Liang Wang, Li-Li Gao, Yu-Ling Liu, Yan-Fang Yang
Summary: The study found that Ramulus Mori alkaloids can regulate lipid metabolism and alleviate obesity-induced adipose inflammation, showing potential in the treatment of obesity.
Article
Plant Sciences
Eun A. Kim, Ju-Hwan Yang, Eun-Hye Byeon, Woong Kim, Dawon Kang, Jaehee Han, Seong-Geun Hong, Deok-Ryong Kim, Sang-Je Park, Jae-Won Huh, Hyeonsook Cheong, Seung-Pil Yun, Dong-Kun Lee
Summary: The study demonstrates that pine needle extract inhibits obesity by increasing hypothalamic POMC neuronal activity and improving physiological conditions after high-fat diet-induced obesity. Additionally, PNE also suppresses lipogenesis in white adipose tissue.
Article
Endocrinology & Metabolism
Youn Ju Kim, Hye Jin Kim, Sang Gyu Lee, Do Hyun Kim, Su In Jang, Hye Sun Go, Won Jun Lee, Je Kyung Seong
Summary: Exercise training has positive effects on metabolic health, helping to counteract weight gain, fatty liver, and insulin resistance. This may be attributed to its ability to enhance the browning of white fat, whole-body oxygen uptake, and heat generation.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Engineering, Multidisciplinary
Yafei Wu, Guijun Qin, Guixia Wang, Libin Liu, Bing Chen, Qingbo Guan, Zhongshang Yuan, Xu Hou, Ling Gao, Chao Xu, Haiqing Zhang, Xu Zhang, Qiu Li, Yongfeng Song, Fei Jing, Shizhan Ma, Shanshan Shao, Meng Zhao, Qingling Guo, Nanwei Tong, Hongyan Zhao, Xiaomin Xie, Chao Liu, Zhongyan Shan, Zhifeng Cheng, Xuefeng Yu, Shulin Chen, Tao Yang, Yangang Wang, Dongmei Li, Zhaoli Yan, Lixin Guo, Qiuhe Ji, Wenjuan Wang, Jiajun Zhao
Summary: The aim of this study was to explore the associations of moderate-to-vigorous-intensity physical activity (MVPA) time and sedentary (SED) time with a history of cardiovascular disease (CVD) and multifactorial control status among type 2 diabetes mellitus (T2DM) patients in China. The study found that higher MVPA time was associated with lower odds of CVD risk, regardless of SED time, among patients with T2DM. Rating: 8/10.
Article
Cardiac & Cardiovascular Systems
Tae Kyung Yoo, Mi Yeon Lee, Seong Hwan Kim, Ming-Hua Zheng, Giovanni Targher, Christopher D. Byrne, Ki-Chul Sung
Summary: A cohort study suggests that metabolic dysfunction-associated fatty liver disease (MAFLD) predicts cardiovascular disease (CVD) mortality better than non-alcoholic fatty liver disease (NAFLD).
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Editorial Material
Multidisciplinary Sciences
Lei Miao, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng
Article
Medicine, General & Internal
Xiaoshan Feng, Ruirui Xuan, Yingchun Dong, Xiaoqin Wu, Yiping Cheng, Zinuo Yuan, Hang Dong, Junming Han, Fang Zhong, Jiajun Zhao, Xiude Fan
Summary: As the diagnostic criteria for metabolic dysfunction-associated fatty liver disease (MAFLD) do not exclude alcohol consumption, some patients initially diagnosed with alcoholic fatty liver disease (AFLD) may be diagnosed with dual-etiology fatty liver disease (AFLD&MAFLD). It is important to explore the impact of this classification change on clinical manifestations.
Article
Health Care Sciences & Services
Jing Du, Shizhan Ma, Li Fang, Meng Zhao, Zhongshang Yuan, Yiping Cheng, Jiajun Zhao, Xiude Fan, Qingling Guo, Zhongming Wu
Summary: This study found a correlation between muscle distribution and nonalcoholic fatty liver disease (NAFLD). Higher muscle mass in the lower limbs, extremities, and trunk was associated with a lower risk of NAFLD. Furthermore, a decrease in muscle mass in the lower limbs and trunk was linked to increased severity of NAFLD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Letter
Endocrinology & Metabolism
Giovanni Targher, Alessandro Mantovani, Christopher D. Byrne
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Andrew Collier, Christopher Curran, Lyall Cameron, Sarah H. Wild, Christopher D. Byrne
Summary: This retrospective cohort study investigated the distribution of fibrosis risk scores (FIB4, NFS, and APRI) and their association with all-cause mortality in individuals with type 2 diabetes. The results showed that all three fibrosis risk scores were positively associated with all-cause mortality, with higher relative risks in younger individuals. Effective interventions are needed to reduce excess mortality in individuals at high risk of liver fibrosis.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hae Suk Cheong, Yoosoo Chang, Yejin Kim, Eun-Jeong Joo, Min-Jung Kwon, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
Summary: This study found that non-diabetic hyperglycaemia and insulin resistance are associated with the risk of infection-related mortality. Both low and high levels of glucose and insulin resistance are independently related to an increased risk of infection-related mortality.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Yoosun Cho, Yoosoo Chang, Seungho Ryu, Sarah H. Wild, Christopher D. Byrne
Summary: The combination of non-alcoholic fatty liver disease (NAFLD) and prior gestational diabetes mellitus (pGDM) increases the risk of subsequent type 2 diabetes mellitus (T2DM) in women. NAFLD and pGDM improve the prediction of T2DM compared to conventional risk factors. NAFLD and pGDM have a synergistic effect on the development of T2DM in women.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Xiao-Dong Zhou, Giovanni Targher, Christopher D. Byrne, Virend Somers, Seung Up Kim, C. Anwar A. Chahal, Vincent Wai-Sun Wong, Jingjing Cai, Michael D. Shapiro, Mohammed Eslam, Philippe Gabriel Steg, Ki-Chul Sung, Anoop Misra, Jian-Jun Li, Carlos Brotons, Yuli Huang, George V. Papatheodoridis, Aijun Sun, Yusuf Yilmaz, Wah Kheong Chan, Hui Huang, Nahum Mendez-Sanchez, Saleh A. Alqahtani, Helena Cortez-Pinto, Gregory Y. H. Lip, Robert J. de Knegt, Ponsiano Ocama, Manuel Romero-Gomez, Marat Fudim, Giada Sebastiani, Jang Won Son, John D. Ryan, Ignatios Ikonomidis, Sombat Treeprasertsuk, Daniele Pastori, Monica Lupsor-Platon, Herbert Tilg, Hasmik Ghazinyan, Jerome Boursier, Masahide Hamaguchi, Mindie H. Nguyen, Jian-Gao Fan, George Boon-Bee Goh, Mamun Al Mahtab, Saeed Hamid, Nilanka Perera, Jacob George, Ming-Hua Zheng
Summary: Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is closely linked to cardiovascular disease (CVD), but the CVD risk is often underestimated. An international panel of experts conducted a Delphi survey to establish the association between MAFLD and CVD risk, and identified potential areas for future research.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Dan-Qin Sun, Giovanni Targher, Christopher D. Byrne, David C. Wheeler, Vincent Wai-Sun Wong, Jian-Gao Fan, Herbert Tilg, Wei-Jie Yuan, Christoph Wanner, Xin Gao, Michelle T. Long, Mehmet Kanbay, Mindie H. Nguyen, Sankar D. Navaneethan, Yusuf Yilmaz, Yuli Huang, Rino A. Gani, Pierluigi Marzuillo, Jerome Boursier, Huijie Zhang, Chan-Young Jung, Jin Chai, Luca Valenti, George Papatheodoridis, Giovanni Musso, Yu-Jun Wong, Mohamed El-Kassas, Nahum Mendez-Sanchez, Silvia Sookoian, Michael Pavlides, Ajay Duseja, Adriaan G. Holleboom, Junping Shi, Wah-Kheong Chan, Yasser Fouad, Junwei Yang, Sombat Treeprasertsuk, Helena Cortez-Pinto, Masahide Hamaguchi, Manuel Romero-Gomez, Mamun Al Mahtab, Ponsiano Ocama, Atsushi Nakajima, Chunsun Dai, Mohammed Eslam, Lai Wei, Jacob George, Ming-Hua Zheng
Summary: A multidisciplinary panel of 50 international experts reached a consensus on the link between MAFLD and CKD using a Delphi-based approach. This consensus statement provides guidance on the epidemiology, mechanisms, management, and treatment of MAFLD and CKD, as well as the relationship between the severity of MAFLD and the risk of CKD, establishing a framework for early prevention and management of these two common and interconnected diseases.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Tina Reinson, Janisha Patel, Mead Mathews, Derek Fountain, Ryan M. Buchanan, Christopher D. Byrne
Summary: Liver fibrosis is a major risk factor for severe liver diseases. The use of enhanced liver fibrosis (ELF) test and vibration-controlled transient elastography (VCTE) is recommended for assessing advanced liver fibrosis in nonalcoholic fatty liver disease patients. However, the accuracy of ELF in predicting significant fibrosis in real-world practice is uncertain. This study aims to evaluate the accuracy of ELF using VCTE, determine the optimal ELF cutoff value for identifying different stages of fibrosis, and develop a simple algorithm for detecting significant fibrosis.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Oncology
Declan Mcdonnell, Adrian W. E. Cheang, Sam Wilding, Sarah H. Wild, Adam E. Frampton, Christopher D. Byrne, Zaed Z. Hamady
Summary: This study found a positive association between dysglycaemia detected by high HbA1c and the risk of PDAC. The risk is higher in individuals with diabetes and those with higher HbA1c values.
Article
Gastroenterology & Hepatology
Mengzhu Li, Xiude Fan, Jiajun Zhao, Dawei Wang
Summary: In this study, a predictive signature based on stress granule-related genes was established as an independent prognostic tool for hepatocellular carcinoma (HCC). The signature demonstrated strong predictive power, with the identified genes affecting HCC cell proliferation and metastasis by regulating stress granule formation.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Giovanni Targher, Alessandro Mantovani, Christopher Byrne
Summary: Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins that stimulate insulin secretion. Tirzepatide, a dual GLP-1 and GIP receptor agonist, is effective in promoting weight loss. Incretin signalling not only decreases the risk of developing NAFLD, but also has beneficial effects in treating NAFLD and its complications.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)