Review
Physiology
Charlene Hanlon, Clara J. Ziezold, Gregoy Y. Bedecarrats
Summary: Estradiol-17 beta (E-2) plays a crucial role in the sexual maturation and egg production of hens. It can be synthesized not only by the gonads, but also by various non-gonadal tissues. This review highlights the sources, activity, and impact of E-2 in these tissues, as well as its importance in embryonic development, hen maturation, yolk formation, and skeletal development.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Garrett B. Scarpa, Joseph R. Starrett, Geng-Lin Li, Colin Brooks, Yuichi Morohashi, Yoko Yazaki-Sugiyama, Luke Remage-Healey
Summary: Neuroestrogens modulate the temporal precision of sensory neurons by altering their intrinsic and synaptic properties.
Article
Behavioral Sciences
William B. Foster, Katherine F. Beach, Paige F. Carson, Kagan C. Harris, Brandon L. Alonso, Leo T. Costa, Roy C. Simamora, Jaclyn E. Corbin, Keegan F. Hoag, Sophia I. Mercado, Anya G. Bernhard, Cary H. Leung, Eric J. Nestler, Laura E. Been
Summary: In placental mammals, elevated levels of estradiol during pregnancy decrease rapidly after birth, potentially leading to an estrogen withdrawal state that affects affective states in the postpartum period. The neural mechanisms underlying these affective changes are not well studied.
HORMONES AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Lu Xia, Lu Liu, Yiying Cai, Yiying Zhang, Fangchao Tong, Qiang Wang, Jing Ding, Xin Wang
Summary: The study revealed that GSDMD-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures. Following SE, GSDMD expression increased and GSDMD-N expression was significantly elevated. DMF treatment resulted in decreased SRS, reduced damaged astrocytes, and attenuated expression of inflammatory factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Aimun A. B. Jamjoom, Jonathan Rhodes, Peter J. D. Andrews, Seth G. N. Grant
Summary: Traumatic brain injury (TBI) is a major cause of death and disability worldwide, with potential long-term consequences such as dementia. Recent research has shown that TBI has a significant impact on synapse structure and function, leading to synapse loss. This review highlights the role of synapses in TBI pathophysiology, including the impact of secondary injury processes such as excitotoxicity, inflammation, and oxidative stress. Astrocytes are proposed to play a crucial role in mediating synapse loss and recovery after TBI.
Review
Cell Biology
A. Denise R. Garcia
Summary: The Sonic hedgehog (Shh) molecular signaling pathway is a key regulator of neurodevelopment, with diverse functions in various cell types and developmental stages. In addition to its roles in development, Shh signaling continues into adulthood and is now recognized as an important regulator of astrocyte function. Astrocytes play essential roles in nervous system functions, including synapse formation, coordination of CNS inflammatory responses, and Shh signaling mediates communication between neurons and astrocytes, influencing astrocyte identity, synaptic organization, and inflammation regulation.
Review
Endocrinology & Metabolism
Colin J. Saldanha
Summary: Steroid hormones, such as 17 beta-estradiol, can be synthesized in multiple tissues and affect various physiological endpoints. The mechanisms underlying the temporal and spatial specificity of their modulation remain unclear. This review highlights the role of aromatase in astrocytes and synapses in providing localized delivery of estradiol. The understanding of neuroestradiol provision and its potential involvement in species-specific behaviors is discussed.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Daiane F. Engel, Licio A. Velloso
Summary: In experimental models, hypothalamic dysfunction is a crucial component in the pathophysiology of diet-induced obesity. Structural and functional changes in neurons, microglia, astrocytes, and tanycytes of the mediobasal hypothalamus, shortly after the introduction of a high-fat diet, impact caloric intake, energy expenditure, and systemic glucose tolerance. Inflammation plays a central role in this response, and there is a temporal sequence of events determining the fate of different cells involved in the central regulation of whole-body energy homeostasis.
Review
Geriatrics & Gerontology
Mingsheng Sun, Jing Rong, Mengdi Zhou, Yi Liu, Shiqi Sun, Lu Liu, Dingjun Cai, Fanrong Liang, Ling Zhao
Summary: Migraine, a prevalent neurological disease, is closely associated with neurogenic inflammation. The interaction between microglia and astrocytes, crucial in the pathology of Alzheimer's disease and other inflammation-related central nervous system diseases, has recently emerged as a novel focus in neuroimmune research. However, the role of this interaction in the pathogenesis and treatment of migraine remains to be explored. By reviewing relevant evidence, we aim to provide new insights for future research and treatment.
Review
Cell Biology
Xiying Fu, Yicun Wang, Fangyi Zhao, Ranji Cui, Wei Xie, Qianqian Liu, Wei Yang
Summary: Depression and obesity frequently co-occur and have a bidirectional relationship. The mechanisms underlying the mutual control of these disorders are largely unknown. This review focuses on potential mechanisms and treatments for the co-morbidity of obesity and depression.
Review
Neurosciences
Fang Yu, Tingting Huang, Yuanyuan Ran, Da Li, Lin Ye, Guiqin Tian, Jianing Xi, Zongjian Liu
Summary: This passage discusses the interaction between microglial activation and endogenous neuroplasticity, focusing on plastic alterations in the overall brain network and their implications for structural and functional restoration after stroke. It also summarizes recent advances in the impacts of microglial phenotype polarization on brain plasticity, aiming to discuss the potential efficacy of microglia-based extrinsic restorative interventions in promoting post-stroke recovery.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biology
Jing Wang, Uday P. Pratap, Yujiao Lu, Gangadhara R. Sareddy, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Darrell W. Brann
Summary: Recent research has found that the steroid hormone 17 beta-estradiol (E-2) is produced in the brain by both neurons and astrocytes. A new inducible knockout mouse model was created to specifically deplete the E-2 in astrocytes of adult mice, providing a better research model for studying brain-derived E-2 and its functions. The characterization of this mouse model confirmed the specific depletion of aromatase and E-2 in astrocytes, and revealed the neuroprotective role of astrocyte-derived E-2 in cerebral ischemia.
Article
Cell Biology
Ines Leleu, Delphine Genete, Sophie Salome Desnoulez, Nasreddine Saidi, Priscille Brodin, Frank Lafont, Stanislas Tomavo, Sylviane Pied
Summary: Cerebral malaria is a neuroinflammatory disease induced by P. falciparum infection. This study demonstrates a non-canonical autophagy-lysosomal pathway in astrocytes plays a key role in the transfer and degradation of parasite microvesicles. Inhibition of autophagy process affects the transfer of microvesicles and impacts the development of cerebral malaria.
Article
Neurosciences
Courtney Clyburn, Kaitlin E. Carson, Caleb R. Smith, R. Alberto Travagli, Kirsteen N. Browning
Summary: Prolonged exposure to a high-fat diet leads to hyperphagia and weight gain, but within a short period of time, caloric intake is regulated and energy balance is restored. Acute high-fat diet exposure activates brainstem astrocytes, increasing glutamatergic transmission to gastric-projecting neurons and restoring caloric balance. Inhibiting brainstem astrocytes reduces glutamatergic signaling, disrupts gastric tone and motility, delays gastric emptying, and prevents the decrease in food intake during energy regulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Pharmacology & Pharmacy
Wen Wang, Qiaoyun Li, Zhongqiu Zhao, Yutong Liu, Yi Wang, Hui Xiong, Zhinan Mei
Summary: Paeonol, a bioactive phenol, has potential effects in treating dry skin disease. This study found that paeonol can reduce scratching behavior and skin inflammation, while inhibiting the expression of astrocyte activity-dependent genes in the spinal cord. These effects are mediated by CXCR3.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Alyssa L. Pedersen, Jenna L. Brownrout, Colin J. Saldanha
Article
Endocrinology & Metabolism
David J. Bailey, Yekaterina V. Makeyeva, Elizabeth R. Paitel, Alyssa L. Pedersen, Angel T. Hon, Jordan A. Gunderson, Colin J. Saldanha
Article
Immunology
Alyssa L. Pedersen, Colin J. Saldanha
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Biochemistry & Molecular Biology
Michelle K. Biederman, Megan M. Nelson, Kathryn C. Asalone, Alyssa L. Pedersen, Colin J. Saldanha, John R. Bracht
Editorial Material
Psychology, Biological
Colin J. Saldanha, Terry L. Davidson
PHYSIOLOGY & BEHAVIOR
(2018)
Article
Psychology, Biological
Alyssa L. Pedersen, Jenna L. Brownrout, Colin J. Saldanha
PHYSIOLOGY & BEHAVIOR
(2018)
Article
Multidisciplinary Sciences
Alyssa L. Pedersen, Cassie J. Gould, Colin J. Saldanha
SCIENTIFIC REPORTS
(2017)
Article
Environmental Sciences
Cassie J. Gould, Colin J. Saldanha, Victoria P. Connaughton
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2019)
Review
Endocrinology & Metabolism
Kelli A. Duncan, Colin J. Saldanha
FRONTIERS IN NEUROENDOCRINOLOGY
(2020)
Article
Evolutionary Biology
Kathryn C. Asalone, Ajuni K. Takkar, Colin J. Saldanha, John R. Bracht
Summary: The study introduces a new transcriptomic method for identifying GRC sequences in songbirds, successfully identifying 733 contigs as high confidence GRC sequences. By using comparative coverage analysis, two new GRC genes and 16 previously unplaced genes were identified.
GENOME BIOLOGY AND EVOLUTION
(2021)
Review
Endocrinology & Metabolism
Barney A. Schlinger, Luke Remage-Healey, Colin J. Saldanha
Summary: Songbirds have been key research subjects in understanding estrogen synthesis and function in the brain. Studies in songbirds have provided insights into the evolution of neural estrogen signaling, potentially contributing to their success as one of the most resilient vertebrate groups on the planet.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Colin J. Saldanha
Summary: Steroid hormones, such as 17 beta-estradiol, can be synthesized in multiple tissues and affect various physiological endpoints. The mechanisms underlying the temporal and spatial specificity of their modulation remain unclear. This review highlights the role of aromatase in astrocytes and synapses in providing localized delivery of estradiol. The understanding of neuroestradiol provision and its potential involvement in species-specific behaviors is discussed.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Meredith J. J. Goyette, Sidney L. L. Murray, Colin J. J. Saldanha, Kathleen F. Holton
Summary: This paper reviews the mechanism of interaction between sex hormones and glutamatergic neurotransmission and explores these interactions in various neurological and psychiatric conditions. The research suggests that sex hormones can directly modulate glutamatergic neurotransmission, particularly with the protective effects of estrogens against excitotoxicity. Overall, there is a significant role for sex hormones, especially estrogens, in the modulation of glutamatergic neurotransmission.
NEUROENDOCRINOLOGY
(2023)
Meeting Abstract
Ophthalmology
Cassie Janell Gould, Colin J. Saldanha, Victoria P. Connaughton
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)