Review
Immunology
Dennis McGonagle, Abdulla Watad, Kassem Sharif, Charlie Bridgewood
Summary: IL-23 plays a crucial role in spondyloarthritis, with implications in the genetic basis, disease progression and treatment efficacy. However, further studies are necessary to determine the specific effects and mechanisms of IL-23 in different disease sites.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Dominique Baeten, Iannis E. Adamopoulos
Summary: This article discusses the pathobiology of axial spondyloarthritis, particularly the role of IL-23/IL-17 axis, and shares relevant lessons learned for translating emerging biological insights into clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sara Di Carlo, Georg Haecker, Ian E. Gentle
Summary: GM-CSF promotes the ubiquitination and enhanced processing of IL-1 beta through suppression of antioxidant responses, leading to its pro-inflammatory effect.
Review
Immunology
Hua Zhang, Han-Lei Jiang, Sheng-Ming Dai
Summary: IL-23 is not a principal proinflammatory cytokine in the pathogenesis of axSpA, and IL-23 blockers are not effective in the treatment of AS.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Rheumatology
Juergen Braun, Robert B. M. Landewe
Summary: Three monoclonal antibodies targeting interleukin-23 have been approved for psoriasis treatment, with two also approved for psoriatic arthritis. However, they have shown to be ineffective in axial spondyloarthritis and may be due to generic effects rather than specific inflammation.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Haiting Zhang, Yu Wei, Huanhuan Jia, Diling Chen, Xiaocui Tang, Jian Wang, Meili Chen, Yinrui Guo
Summary: Understanding the communication and interaction mechanisms between the host and its resident microorganisms is crucial for precise diagnosis and treatment. This study investigated the gut mycobiota and microbiota in ankylosing spondylitis (AS) monkeys and healthy controls. The results showed a clear difference in gut fungi and bacteria composition between the two groups, suggesting a close link between fungal and bacterial dysbiosis and AS. K. pintolopesii was identified as a potential marker microorganism for AS, although further research is needed to fully understand its specific mechanism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Mai M. Abdelmoaty, Jatin Machhi, Pravin Yeapuri, Farah Shahjin, Vikas Kumar, Katherine E. Olson, R. Lee Mosley, Howard E. Gendelman
Summary: This study investigates the gene and protein expression changes in monocytes before and during treatment in Parkinson's disease (PD) patients. The results show that monocytes may serve as early biomarkers for tracking immune-based interventions in PD, providing new insights for treatment and research.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Rheumatology
Kalliopi Klavdianou, Styliani Tsiami, Xenofon Baraliakos
Summary: Axial SpA is a rheumatic disease characterized by inflammation leading to bone formation and functional impairment. While TNF-alpha and IL-17 have shown efficacy as therapeutic targets in axSpA, clinical trials of anti-IL-23 monoclonal antibodies have yielded negative results, suggesting the existence of an IL-23 independent pathway. The Janus kinase (JAK) pathway is also a potential therapeutic target for further research in improving understanding and management of SpA pathogenesis.
Article
Immunology
Zena Chen, Xuqi Zheng, Xinyu Wu, Jialing Wu, Xiaomin Li, Qiujing Wei, Xi Zhang, Linkai Fang, Ou Jin, Jieruo Gu
Summary: The study found that the gut microbiome was significantly restored in AS patients after adalimumab therapy, with a higher abundance of Comamonas in non-responders compared to responders, although no statistical difference was observed. These results suggest the potential of gut microbiome as biomarkers for therapeutic evaluation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Alireza Rezaiemanesh, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mahdi Vojdanian, Farhad Babaie, Jila Mahdavi, Misagh Rajabinejad, Ahmad Reza Jamshidi, Mohammad Hossein Nicknam
Summary: ER stress in macrophages from AS patients plays a role in the increased production of IL-23. The autophagy pathway is not involved in the modulation of IL-23 production by AS macrophages.
Article
Immunology
Milena Iwaszko, Joanna Wielinska, Jerzy Swierkot, Katarzyna Kolossa, Renata Sokolik, Bartosz Bugaj, Monika Chaszczewska-Markowska, Slawomir Jeka, Katarzyna Bogunia-Kubik
Summary: The IL-33 gene polymorphisms are closely associated with clinical parameters, disease activity, and response to TNF inhibitor treatment in patients with RA and AS, with the rs16924159 AA genotype potentially linked to higher disease activity and poor treatment response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Joanna Witoszynska-Sobkowiak, Dorota Sikorska, Rafal Rutkowski, Karolina Niklas, Iwona Zychowska, Wlodzimierz Samborski
Summary: The study assessed the impact of anti-TNF-a treatment on tryptophan metabolism in patients with ankylosing spondylitis. The results showed a predominance of the kynurenine pathway in AS patients, with no significant changes after treatment, and no significant correlation between tryptophan metabolism components and clinical activity, depression, or inflammatory markers.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Kelly L. Monaghan, Wen Zheng, Halima Akhter, Lei Wang, Amanda G. Ammer, Peng Li, Jian-Xin Lin, Gangqing Hu, Warren J. Leonard, Edwin C. K. Wan
Summary: In immune responses, monocytes have diverse functions such as pathogen clearance and tissue repair. However, abnormal control of monocyte activation can lead to chronic inflammation and tissue damage. This study reveals that GM-CSF-induced STAT5 tetramerization plays a critical role in determining monocyte fate and function. Monocytes require STAT5 tetramers to differentiate into moDCs, while the absence of STAT5 tetramers results in the differentiation into a distinct monocyte-derived macrophage population. In a colitis model, STAT5 tetramer-deficient monocytes worsen disease severity, and this is associated with overexpression of arginase I and reduced nitric oxide synthesis. Inhibition of arginase I and sustained supplementation of nitric oxide ameliorate the worsened colitis in STAT5 tetramer-deficient mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Eon Jeong Nam, Won Kee Lee
Summary: This study examined the likelihood of achieving clinical remission in patients with ankylosing spondylitis receiving tumor necrosis factor-alpha inhibitors. Age and improvement in disease activity markers within three months were identified as independent predictors of achieving clinical remission.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Angela Ceribelli, Francesca Motta, Matteo Vecellio, Natasa Isailovic, Francesco Ciccia, Carlo Selmi
Summary: Spondyloarthritis (SpA) is a group of inflammatory musculoskeletal diseases with common genetic backgrounds, and IL-17 and IL-23 have been identified as key cytokines in its pathogenesis. Treatment options for axial SpA differ significantly from peripheral arthritis, with new therapies targeting these cytokines showing promising results for both axial psoriatic arthritis and ankylosing spondylitis.
FRONTIERS IN IMMUNOLOGY
(2021)