Article
Biochemistry & Molecular Biology
Akiko Suzuki, Chihiro Iwaya, Kenichi Ogata, Hiroki Yoshioka, Junbo Shim, Isei Tanida, Masaaki Komatsu, Norihiro Tada, Junichi Iwata
Summary: Sjogren's syndrome is a chronic autoimmune disease characterized by immune cell infiltration of the exocrine glands. Deficiency in enzymes involved in the ubiquitin modification pathway leads to a Sjogren's syndrome-like phenotype, and activation of GATE16 is crucial for exocytosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Min Song, Jide Tian, Blake Middleton, Cuong Q. Nguyen, Daniel L. Kaufman
Summary: Oral administration of GABA may have potential for ameliorating Sjogren's syndrome (SS) by increasing salivary and tear production and reducing symptoms. This treatment does not significantly affect lymphocytic infiltration and could provide a new approach for improving SS symptoms.
Review
Immunology
Qi An, Jingwen Zhao, Xueqing Zhu, Baoqi Yang, Zewen Wu, Yazhen Su, Liyun Zhang, Ke Xu, Dan Ma
Summary: This article explores the pathogenesis of Sjogrens syndrome caused by autoantibodies attacking salivary and lacrimal gland tissues, focusing on the role of T cells and therapeutic targeting of T cells for treatment of patients with SS.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Developmental Biology
Sameed Khan, Sarah Fitch, Sarah Knox, Ripla Arora
Summary: Fluid secretion is crucial for the survival of mammals, and each glandular unit has its own unique structure and function. This article reviews the structural characteristics of glandular organs, discusses the impact of developmental defects on secretory function, and explores how knowledge of structure-function relationships can be applied to diagnostics, regenerative approaches, and tissue regeneration.
Article
Immunology
Yung-Hsiang Chao, Chin-Hsiu Liu, Yu-An Pan, Fu-Shun Yen, Jeng-Yuan Chiou, James Cheng-Chung Wei
Summary: This population-based cohort study found that patients with a history of endometriosis have an increased risk of developing Sjogren's syndrome, especially within the first five years after diagnosis, and in the age group of 20-39.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Petros Moustardas, Naomi Yamada-Fowler, Eirini Apostolou, Athanasios G. Tzioufas, Maria Turkina, Giannis Spyrou
Summary: Through proteomics analysis, we found 88 deregulated proteins in females and 55 in males in wildtype vs knockout comparisons. Additionally, we identified 416 proteins significantly different in the salivary gland proteome of wildtype female vs male mice, highlighting pathways that could drive the strong female bias of the pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Juliana Ramalho Guimaraes, Marina de Castro Coelho, Naila Francis Paulo de Oliveira
Summary: Sjogren's syndrome (SS) is a chronic disease characterized by dysfunction of salivary and lacrimal glands. Genetic, environmental, and epigenetic factors are important contributors to its pathogenesis. DNA methylation has been found to play a role in SS, and these findings may lead to the development of new diagnostic and therapeutic approaches.
Article
Immunology
Yu Cao, Hao Lu, Wangzi Xu, Ming Zhong
Summary: The study reveals a causal relationship between gut microbiota composition and Sjogren's Syndrome risk, with some microbial species positively correlated and others negatively correlated. Additionally, four genes related to gut microbiota were found to have a causal effect on Sjogren's Syndrome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kimberly J. Jasmer, Lucas T. Woods, Kevin Munoz Forti, Adam L. Martin, Jean M. Camden, Marco Colonna, Gary A. Weisman
Summary: The P2Y(2)R antagonist AR-C118925 significantly enhances salivation and reduces lymphocytic foci and immune cell markers in SMGs of NOD.H-2(h4) DKO mice with SS. B cells are the primary immune cell population in inflamed SMGs expressing elevated levels of P2Y(2)R.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Immunology
Donghyun Kim, Ye Jin Jeong, Yerin Lee, Jihoon Choi, Young Min Park, Oh Chan Kwon, Yong Woo Ji, Sung Jun Ahn, Hyung Keun Lee, Min-Chan Park, Jae-Yol Lim
Summary: Recent studies have shown that the oral microbiome in patients with Sjogren's syndrome (SS) differs significantly from that in healthy individuals. The composition and diversity of the oral microbiome are correlated with clinical features of SS, especially ductal structures and salivary flow, suggesting that the oral microbiome may serve as a potential diagnostic biomarker for SS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Erich Horeth, Akinsola Oyelakin, Eun-Ah Christine Song, Monika Che, Jonathan Bard, Sangwon Min, Jeremy Kiripolsky, Jill M. Kramer, Satrajit Sinha, Rose-Anne Romano
Summary: Sjogren's Syndrome is a chronic autoimmune disease affecting salivary and lacrimal glands. RNA sequencing and single-cell RNA sequencing have revealed important pathways and regulatory networks in the pathobiology of SS, as well as the diversity in activated state of salivary gland epithelial cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jing Zhou, Xiaofeng Zhang, Qing Yu
Summary: This study demonstrates the critical role of plasmacytoid dendritic cells (pDCs) in the pathogenesis of autoimmune Sjogren's syndrome (SS) by using a pDC-depleting antibody in the NOD mouse model. Depletion of pDCs significantly alleviates inflammation and secretory dysfunction in the salivary glands, highlighting the important contribution of pDCs in the development of SS-like salivary gland exocrinopathy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Rheumatology
Viktoria Fana, U. M. Dohn, Simon Krabbe, L. Terslev
Summary: This study demonstrated the effectiveness of the OMERACT Ultrasound Scoring System in evaluating salivary gland involvement in patients suspected of Sjogren's syndrome, with good sensitivity and excellent specificity for diagnosing primary SS and fulfilling the 2016 ACR/EULAR criteria. The findings support the use of ultrasound in diagnosing pSS and endorse the incorporation of ultrasound in the classification criteria.
Review
Medicine, General & Internal
Margherita Sisto, Domenico Ribatti, Sabrina Lisi
Summary: Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by lymphoplasmacytic infiltration of salivary and lacrimal glands, causing glandular damage. Recent research suggests a link between chronic inflammation and fibrosis of the salivary glands, potentially related to the epithelial to mesenchymal transition (EMT). The involvement of fibrosis in the pathogenesis of SS is still under debate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Alexander Carvajal-Gonzalez, Suma Sri Chennapragada, Ekin Ozluk, Phani Morisetti
Summary: The evaluation of bilateral lung nodules on imaging is challenging due to the wide range of possible causes. This case study presents a woman with multiple lung nodules, which were ultimately found to be related to an underlying autoimmune condition (Sjogren's syndrome). Management with intravenous steroids resulted in significant improvement.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)