Role of Kupffer Cells in Driving Hepatic Inflammation and Fibrosis in HIV Infection

HIV infection modulates IL‐1β response to LPS stimulation through a TLR4‐NLRP3 pathway in human liver macrophages

(2019) Lumin Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Natural Impact: NK Cells at the Intersection of Cancer and HIV Disease

(2019) Olivier Lucar et al.   Frontiers in Immunology

Alcohol Metabolism Potentiates HIV-Induced Hepatotoxicity: Contribution to End-Stage Liver Disease

(2019) Murali Ganesan et al.   Biomolecules

Exposure to previous cART is associated with significant liver fibrosis and cirrhosis in human immunodeficiency virus-infected patients

(2018) Evrim Anadol et al.   PLoS One

Mechanisms for Cell-to-Cell Transmission of HIV-1

(2018) Lucie Bracq et al.   Frontiers in Immunology

No recovery of replication-competent HIV-1 from human liver macrophages

(2018) Abraham J. Kandathil et al.   JOURNAL OF CLINICAL INVESTIGATION

The innate immune receptor TREM-1 promotes liver injury and fibrosis

(2018) Anh Thu Nguyen-Lefebvre et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Asiatic acid protects against hepatic ischemia/reperfusion injury by inactivation of Kupffer cells via PPARγ/NLRP3 inflammasome signaling pathway

(2017) Ying Xu et al.   Oncotarget

Liver fibrosis in HIV-infected individuals on long-term antiretroviral therapy

(2016) Katherine W. Kooij et al.   AIDS

Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types

(2016) Shadi Salloum et al.   HEPATOLOGY

HIV-1 gp120 signaling through TLR4 modulates innate immune activation in human macrophages and the biology of hepatic stellate cells

(2016) Manuela Del Cornò et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Frontline Science: HIV infection of Kupffer cells results in an amplified proinflammatory response to LPS

(2016) Arevik Mosoian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads

(2016) Susanna L. Lamers et al.   JOURNAL OF VIROLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage

(2015) Tristan I. Evans et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 Infected Peripheral Blood Mononuclear Cells Modulate the Fibrogenic Activity of Hepatic Stellate Cells through Secreted TGF-β and JNK Signaling

(2014) Deepti Gupta et al.   PLoS One

Liver fibrosis in HIV

(2014) Jürgen K. Rockstroh et al.   Current Opinion in HIV and AIDS

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

(2014) Céline Vaure et al.   Frontiers in Immunology

Cell-to-cell vs. cell-free HIV-1 transmission from macrophages to CD4+ T lymphocytes

(2013) Guido Poli   AIDS

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Decreasing mortality and changing patterns of causes of death in the Swiss HIV Cohort Study

(2013) R Weber et al.   HIV MEDICINE

Impaired CD4+ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients

(2013) Andreas Glässner et al.   JOURNAL OF HEPATOLOGY

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

(2013) H. Huang et al.   JOURNAL OF IMMUNOLOGY

Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan®) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment

(2013) Sang Hoon Han et al.   PLoS One

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

X4 Human Immunodeficiency Virus Type 1 gp120 Promotes Human Hepatic Stellate Cell Activation and Collagen I Expression through Interactions with CXCR4

(2012) Feng Hong et al.   PLoS One

Nonalcoholic Fatty Liver Disease and HIV Infection

(2012) Anaïs Vallet-Pichard et al.   SEMINARS IN LIVER DISEASE

The Burden of Liver Disease in Human Immunodeficiency Virus-Infected Patients

(2012) Massimo Puoti et al.   SEMINARS IN LIVER DISEASE

Toll-Like Receptors in Liver Fibrosis: Cellular Crosstalk and Mechanisms

(2012) Ling Yang et al.   Frontiers in Physiology

High prevalence of liver fibrosis associated with HIV infection: a study in rural Rakai, Uganda

(2011) Lara Stabinski et al.   ANTIVIRAL THERAPY

Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury

(2011) Karim C. El Kasmi et al.   HEPATOLOGY

Causes of death and risk factors among HIV-infected persons in the HAART era: analysis of a large urban cohort

(2011) S. Leone et al.   INFECTION

Increasing burden of liver disease in patients with HIV infection

(2011) Deepak Joshi et al.   LANCET

Prevalence and risk factors for abnormal liver stiffness in HIV-infected patients without viral hepatitis coinfection: role of didanosine

(2010) Nicolás Merchante et al.   ANTIVIRAL THERAPY

Prevalence and risk factors for significant liver fibrosis among HIV-monoinfected patients

(2010) Michelle DallaPiazza et al.   BMC INFECTIOUS DISEASES

Liver Disease in the HIV–Infected Individual

(2010) Jennifer C. Price et al.   Clinical Gastroenterology and Hepatology

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: Implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis

(2010) Ana C. Tuyama et al.   HEPATOLOGY

T-Cell Dysfunction in HIV-1-Infected Patients With Impaired Recovery of CD4 Cells Despite Suppression of Viral Replication

(2010) Christian Erikstrup et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

gp120 modulates the biology of human hepatic stellate cells: a link between HIV infection and liver fibrogenesis

(2009) R. Bruno et al.   GUT

Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus

(2009) Juan Macías et al.   HEPATOLOGY

Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: The French national Mortalité 2005 study

(2009) Dominique Salmon-Ceron et al.   JOURNAL OF HEPATOLOGY

Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats

(2008) Koji Tomiyama et al.   HEPATOLOGY

Determination of the Underlying Cause of Death in Three Multicenter International HIV Clinical Trials

(2008) Alan R. Lifson et al.   HIV CLINICAL TRIALS

Hazardous drinking is associated with an elevated aspartate aminotransferase to platelet ratio index in an urban HIV-infected clinical cohort

(2008) AA Chaudhry et al.   HIV MEDICINE

Kupffer cell products and interleukin 1? directly promote VLDL secretion and apoB mRNA up-regulation in rodent hepatocytes

(2008) Nerea Bartolomé et al.   Innate Immunity