Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Review
Chemistry, Multidisciplinary
Dong Liu, Mengmeng Long, Leilei Gao, Yanjun Chen, Fang Li, Yang Shi, Ning Gu
Summary: The respiratory system is crucial in vertebrate biology, but viral infections can cause severe damage. Currently, there are no effective treatments, but nanomedicine shows potential. This review provides a summary of the pathology and clinical treatments of respiratory injuries, focusing on nanomedicine formulations tested in preclinical models.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Corina N. D'Alessandro-Gabazza, Taro Yasuma, Tetsu Kobayashi, Masaaki Toda, Ahmed M. Abdel-Hamid, Hajime Fujimoto, Osamu Hataji, Hiroki Nakahara, Atsuro Takeshita, Kota Nishihama, Tomohito Okano, Haruko Saiki, Yuko Okano, Atsushi Tomaru, Valeria Fridman D'Alessandro, Miyako Shiraishi, Akira Mizoguchi, Ryoichi Ono, Junpei Ohtsuka, Masayuki Fukumura, Tetsuya Nosaka, Xuenan Mi, Diwakar Shukla, Kensuke Kataoka, Yasuhiro Kondoh, Masaki Hirose, Toru Arai, Yoshikazu Inoue, Yutaka Yano, Roderick Mackie, Isaac Cann, Esteban C. Gabazza
Summary: The authors demonstrate that a monoclonal neutralizing antibody against the proapoptotic peptide corisin, derived from the lung microbiota, can improve acute exacerbation of pulmonary fibrosis and the severity of endotoxin-induced acute lung injury in mice. The study provides insights into the processing and release of corisin and shows that an anticorisin monoclonal antibody can ameliorate lung fibrosis and acute lung injury. These findings highlight the role of corisin in the pathogenesis of the diseases and offer a novel approach to treating the incurable disease.
NATURE COMMUNICATIONS
(2022)
Article
Veterinary Sciences
Mathieu V. V. Paulin, Elisabeth C. C. Snead
Summary: This case report describes a 6-year-old castrated male Labradoodle with non-cardiogenic pulmonary edema due to primary adrenocortical insufficiency. Oxygen supplementation and hormone replacement therapy were effective in managing the pulmonary edema.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Luigi Pisani, Anna De Nicolo, Marcella Schiavone, Adetunji O. Adeniji, Angela De Palma, Francesco di Gennaro, Edward Ejiro Emuveyan, Salvatore Grasso, Patricia C. Henwood, Alimamy P. Koroma, Stije Leopold, Claudia Marotta, Giuseppe Marulli, Giovanni Putoto, Enzo Pisani, James Russel, Ary Serpa Neto, Arjen M. Dondorp, Eva Hanciles, Michael M. Koroma, Marcus J. Schultz
Summary: This study aimed to determine the frequency, timing, and types of pulmonary complications in critically ill parturients, and found that pulmonary complications were associated with poor outcomes.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Review
Critical Care Medicine
Mairi Ziaka, Aristomenis Exadaktylos
Summary: Experimental and clinical studies have shown that isolated acute brain injury can cause severe dysfunction of peripheral organs, especially the lung. The complex pathophysiology of brain-lung interactions involve factors like neurogenic pulmonary edema and inflammation. Prior research suggests that in an inflammatory environment, interventions like mechanical ventilation may contribute to lung injury development.
Article
Medicine, Research & Experimental
Qiaoyi Xu, Shuya Mei, Fang Nie, Zhiyun Zhang, Junqi Feng, Jinyuan Zhang, Xiaoqing Qian, Yuan Gao, Zhengyu He, Shunpeng Xing
Summary: The study demonstrates that lipopolysaccharide induces activation of the JNK signaling pathway and TNF-alpha secretion in pulmonary macrophages, leading to interaction between inflammation and metabolism that promotes lung fibroblast glycolysis. This interaction plays a crucial role in lipopolysaccharide-induced pulmonary fibrosis.
LABORATORY INVESTIGATION
(2022)
Review
Clinical Neurology
Mairi Ziaka, Aristomenis Exadaktylos
Summary: In recent years, there have been significant findings on the complex pathophysiology of acute brain injury-induced cardiac complications, particularly neurogenic stress cardiomyopathy (NSC). These complications involve sympathetic hyperactivity, activation of the hypothalamic-pituitary-adrenal axis, immune and inflammatory pathways. However, the understanding of secondary and delayed cerebral complications in patients with NSC, especially those with stroke, remains limited. This review aims to discuss the stroke-heart-brain axis and highlight the main pathophysiological mechanisms leading to secondary cerebral injury, emphasizing the need for further research to improve outcomes in this specific patient population.
Review
Biochemistry & Molecular Biology
Marcia V. de Carvalho, Cassiano F. Goncalves-de-Albuquerque, Adriana R. Silva
Summary: PPARs, as members of the nuclear receptor superfamily, regulate genes related to lipid, glucose metabolism, and inflammation. Among them, PPARγ functions as a receptor with certain ligands to inhibit the expression of inflammatory mediators, therefore playing a crucial role in controlling excessive inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Mairi Ziaka, Aristomenis Exadaktylos
Summary: There is a complex interrelation between lung and brain in patients with acute lung injury (ALI), especially in those with acute respiratory distress syndrome (ARDS). The pathophysiology of this interrelation involves various factors such as hypoxemia, lung protective ventilation, hypotension, disruption of the blood-brain barrier, and neuroinflammation, making the brain vulnerable to secondary lung-mediated acute brain injury. While a protective ventilator strategy can maintain brain homeostasis, mechanical ventilation with low tidal volumes may have negative effects.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ri Tang, Shuya Mei, Qiaoyi Xu, Jinhua Feng, Yang Zhou, Shunpeng Xing, Zhengyu He, Yuan Gao
Summary: Recent clinical research has found that mechanical ventilation (MV) can lead to pulmonary fibrosis, known as mechanical ventilation-induced pulmonary fibrosis (MVPF). This study investigates the potential mechanism of MVPF using a mouse model and an alveolar epithelial cell cyclic strain model, revealing that the ASK1-ER stress pathway plays a crucial role in the release of fibrotic extracellular vesicles (EVs) from alveolar epithelial cells, which contribute to fibroblast activation and the initiation of pulmonary fibrosis during MV.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Nanoscience & Nanotechnology
Shuai Bian, Hongfei Cai, Youbin Cui, Wanguo Liu, Chunsheng Xiao
Summary: ALI and ARDS can cause life-threatening respiratory failure with a high mortality rate. Despite some clinical interventions, there is still no completely effective treatment for ALI. Recent advances in nanotechnology may provide new possibilities for the pharmacotherapy of ALI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Critical Care Medicine
Richard K. Albert
Summary: This Perspective summarizes the mechanisms by which continuous volume-targeted ventilation (CVTV) causes ventilator-induced lung injury (VILI) by affecting surfactant function.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Qianying Lu, Sifan Yu, Xiangyan Meng, Mingyu Shi, Siyu Huang, Junfeng Li, Jianfeng Zhang, Yangfan Liang, Mengjun Ji, Yanmei Zhao, Haojun Fan
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response that destroys lung parenchymal cells and reduces lung function. MicroRNAs play a crucial role in regulating inflammatory and immune responses in ALI/ARDS and may serve as diagnostic indicators and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
S. T. Tsikis, S. C. Fligor, T. I. Hirsch, A. Pan, L. J. Yu, H. Kishikawa, M. M. Joiner, P. D. Mitchell, M. Puder
Summary: This study using an LPS-induced disease model reveals the long-term pulmonary functional outcomes of acute lung injury (ALI) and identifies angiogenic proteins as potential therapeutic targets following lung injury.
SCIENTIFIC REPORTS
(2022)
Article
Anesthesiology
Maria C. Borrelli, Andrew J. Sprowell, Anna Moldysz, Mohammed Idris, Samantha L. Armstrong, John J. Kowalczyk, Yunping Li, Philip E. Hess
Summary: This study investigates the relationship between intrathecal morphine and enhanced recovery pathways after cesarean delivery. The results indicate that lower doses provide shorter duration of analgesia and higher pain scores. In contrast, a dose of 250 mcg offers longer-lasting pain relief with similar side effects. Both 150 mcg and 250 mcg doses allow a majority of patients to avoid additional opioid use within 72 hours.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2024)
Article
Anesthesiology
Jose Sanchez, Rohan Prabhu, Jean Guglielminotti, Ruth Landau
Summary: This study evaluates the incidence of self-reported pain and the administration of intravenous medication (IVM) during cesarean delivery. The results show that 11.5% of women reported pain during the procedure, and a proportion of them received analgesic IVM. Risk factors for pain included substance use disorder and intrapartum epidural extension.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2024)
Letter
Anesthesiology
Kei Ugata, Katsushi Doi, Noritaka Imamachi, Keita Matsumoto, Hiroyuki Kushizaki
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2024)
