Article
Chemistry, Multidisciplinary
Juan Carlos Garcia-Mayorga, Haret-Codratian Rosu, Alma Berenice Jasso-Salcedo, Vladimir Alonso Escobar-Barrios
Summary: This study investigates the synthesis and characterization of polydopamine (PDA) using dopamine (DA) as the monomer and (hydroxymethyl)aminomethane (TRIS) as the oxidant. The effect of temperature and TRIS concentration on the kinetics of dopamine polymerization is evaluated, and the correlation between the synthesis parameters and morphological, structural, and thermal properties of polydopamine is established. Scanning Electron Microscopy (SEM) and Differential Scanning Calorimetry (DSC) are utilized to evaluate the morphology and thermal behavior of PDA, respectively. Structural studies using infrared and Raman spectroscopy, as well as X-ray Diffraction (XRD), confirm the graphitic-like structure of PDA.
Article
Chemistry, Physical
Adrian Olejnik, Karol Olbrysi, Jakub Karczewski, Jacek Ryl, Robert Bogdanowicz, Katarzyna Siuzdak
Summary: In this work, the electropolymerization of quinone-rich polydopamine (PDA) on hydrogenated TiO2 nanotubes is described, resulting in improved photoactivity in the visible spectrum. The deposition of PDA is uniform on the nanotube walls and its chemical structure depends on the pH of the supporting electrolyte. The modification of the nanotubes leads to a 20-fold increase in photocurrent response and improvement in quantum efficiency at specific wavelengths.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Mitchell D. Nothling, Christopher G. Bailey, Lucy L. Fillbrook, Guannan Wang, Yijie Gao, Dane R. McCamey, Marzieh Monfared, Sandy Wong, Jonathon E. Beves, Martina H. Stenzel
Summary: Modifying surfaces using free radical polymerization allows the incorporation of diverse physicochemical properties of vinyl polymers onto new materials. By utilizing the surface attachment of polydopamine (PDA), a range of different surfaces were primed for free radical polymer attachment. The strategy resulted in covalent polymer attachment on both porous and nonporous substrates, imparting new properties to the functionalized materials.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biophysics
Yucai Zhang, Chengbo Qian, Daochang Li, Li Zhao
Summary: In this study, B-10-enriched GdBO3 nanoparticles were coated with mesoporous silica and hydrophilic polyglycerol to achieve excellent colloidal stability in physiological media. In vitro and in vivo experiments demonstrated low cytotoxicity, concentration-dependent uptake by cancer cells, and long circulation time in mice without acute toxicity. Additionally, the nanoparticles showed promise as a T-1-weighted MRI contrast agent with a proton longitudinal relaxivity of 0.67 mM(-1) s(-1), indicating their potential for cancer theranostics.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Saranshu Singla, Zepeng Yang, Anvay Patil, Hao Guo, Bram Vanthournout, K. Zin Htut, Matthew D. Shawkey, Mesfin Tsige, Ali Dhinojwala
Summary: The study examines the importance of hollow melanosomes in generating structural colors, highlighting the higher saturation of hollow particles with thin shells. These results have potential applications in various fields such as paints, coatings, and cosmetics.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Fabio Mollica, Rosa Lucernati, Riccardo Amorati
Summary: Polydopamine (PDA) nanoparticles have been studied for their antioxidant activity, with purified PDA unable to quench alkylperoxyls while copolymerized PDA nanoparticles show good antioxidant activity. Theoretical calculations suggest that PDA has an onion-like structure, with a catechol-rich core and a quinone-represented surface.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Engineering, Environmental
Yanlong Kong, Lei Zhou, Shiyang Liao, Changping Wang, Jing Chen, Xiaopan Cai, Shichang Zhao, Dianwen Song, Yadong Zhang
Summary: A bone-targeted nanotheranostic was designed to treat osteosarcoma, showing high photothermal efficiency and bone targeting affinity after optimization. This nanotherapy successfully inhibited bone destruction and tumor growth in an experimental animal model, providing a potential new treatment for osteosarcoma.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biophysics
Jan Svoboda, Martin Kral, Marcela Dendisova, Pavel Matejka, Ognen Pop-Georgievski
Summary: This study investigated the growth of polydopamine on different substrates and found that the chemical nature of the substrate influences the structure of the resulting polydopamine in the early stages of layer formation. However, a unified chemical structure was observed at later stages of layer formation regardless of the substrate type. Various surface-sensitive techniques were utilized in this research to analyze the effects of polymerization time and substrate on polydopamine structure.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Floriane Bahuon, Vincent Darcos, Sulabh Patel, Zana Marin, Jean Coudane, Gregoire Schwach, Benjamin Nottelet
Summary: This study reports on a novel polyester copolymer containing synthetic analogue of natural melanin, evaluated in a sustained-release drug delivery system for ocular intravitreal administration of drugs. The biomaterial combines the drug-binding properties of melanin naturally present in the eye, with the ocular tolerability and biodegradation of polyester implants, making it suitable for ocular applications.
Article
Polymer Science
Matthew J. Herman, Michael R. Bull, Erik B. Watkins, Daniel E. Hooks, Nathan A. Miller, Cheng Liu, John D. Yeager
Summary: This study reports neutron reflectometry (NR) studies of bio-mimetic polymer polydopamine (PDA) deposited from differing initial concentrations of precursor material dopamine hydrochloride. Confocal laser scanning microscopy (CLSM) and atomic force microscopy (AFM) were performed to understand the surface structure and mechanical differences of PDA. The results show that film structure and quality are heavily impacted by the initial concentration of dopamine hydrochloride and the polymerization time, indicating the highly customizable nature of PDA.
Review
Chemistry, Multidisciplinary
Peng Yang, Fang Zhu, Zhengbiao Zhang, Yiyun Cheng, Zhao Wang, Yiwen Li
Summary: PDA is a promising candidate for stimuli-responsive smart materials, with excellent photo-responsive properties and active surface functionality for loading various responsive motifs. This review summarizes recent advances in design strategies, responsive mechanisms, and diverse applications of stimuli-responsive PDA-based materials, covering stimuli such as light, pH, chemicals, temperature, etc.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Electrochemistry
Neha Bisht, Neeraj Dwivedi, Ajit Khosla, D. P. Mondal, Avanish Kumar Srivastava, Chetna Dhand
Summary: The biosensor is a rapidly expanding field with wide applications in healthcare, pharmacology, environmental control, food quality assessment, security and defense, and diagnostics. Among them, electrochemical biosensors are popular due to their high sensitivity, low detection limit, automation capabilities, low testing cost, and the emergence of disposable devices. Polydopamine (PDA) has been introduced as a coating material rich in catechol, imine, and amine groups, providing a perfect environment for biomolecule immobilization and offering possibilities for designing unique diagnostic tools. This review summarizes the research progress on PDA-based electrochemical biosensors, including enzymatic biosensors, genosensors, immunosensors, and aptasensors. The future potential of PDA-based biosensors for smart sensor systems leveraging artificial intelligence and Internet of things technologies is also discussed.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Qingqing Zhou, Wen Wu, Tieling Xing
Summary: Research on the polymerization of dopamine and its modification on the surface of materials has been extensively studied. The study investigated the process of laccase catalyzing the rapid polymerization of dopamine and in situ dyeing of silk fabric. The results showed that laccase catalyzed dyeing under acidic conditions achieved the same effect as 24 hours of dyeing under alkaline conditions, and the enzyme-catalyzed polydopamine had better uniformity on the substrate surface. Molecular simulation analysis revealed the interaction between dopamine oligomers and silk fibroin, including hydrogen bonding and pi-pi stacking interactions. The modified silk fabrics exhibited good hydrophobicity after reacting with different metal salt solutions.
Article
Chemistry, Physical
Krzysztof Moraczewski, Rafal Malinowski, Daniel Laczny, Marek Macko
Summary: The research focused on modifying maize stems by depositing polydopamine or tannic acid coatings on the surface. The use of an oxidant, potassium permanganate, was effective in increasing the deposition rate of polydopamine coatings. The modified maize stems showed potential as fillers for biodegradable polymers to improve mechanical properties.
SURFACES AND INTERFACES
(2021)
Review
Biotechnology & Applied Microbiology
Luyao Tian, Xia Li, Haixia Ji, Qing Yu, Mingjuan Yang, Lanping Guo, Luqi Huang, Wenyuan Gao
Summary: This paper provides a comprehensive review of the application of multifunctional nanotechnology in tumor therapy, focusing on synthetic melanin nanoparticles for bioimaging, photothermal therapy, and drug delivery. It also discusses the current challenges and future directions for clinical translation of MNPs.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Polymer Science
Ahmad Telfah, M-Ali Al-Akhras, Kholoud A. Al-Izzy, Ahmad A. Ahmad, Riad Ababneh, Mais Jamil A. Ahmad, Carlos J. Tavares, Roland Hergenroder
Summary: The study investigates PEO/I-2 complex composites stand-free films using various techniques and finds that the electrical conductivity of the system increases significantly by doping PEO with 5 wt% of iodine.
Article
Materials Science, Ceramics
Imen Dhahri, Mohammad Ellouze, Salima Labidi, Qais M. Al-Bataineh, Johannes Etzkorn, Hajer Guermazi, Ahmad Telfah, Carlos J. Tavares, Roland Hergenroder, Tamara Appel
Summary: By synthesizing nanocomposites and conducting various analyses, the impact of Bi2O3 on the optical and structural properties of ZnO was investigated. Bi2O3 doping significantly alters the bandgap and Urbach energies of ZnO, leading to nanoparticle aggregation. Density-functional theory calculations were in agreement with experimental results, providing valuable insights into the studied system.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Physical
Wallace T. Figueiredo, Ravi Prakash, Clovis G. Vieira, Dirlleia S. Lima, Vagner E. Carvalho, Edmar A. Soares, Silvio Buchner, Hannes Raschke, Oscar W. Perez-Lopez, Daniel L. Baptista, Roland Hergenroder, Maximiliano Segala, Fabiano Bernardi
Summary: This study utilized NAP-XPS, UPS, and DFT calculations to investigate the electronic factor of the SMSI effect in Pd/TiO2 nanoparticles, revealing charge transfer from Pd nanoparticles to TiO2 support through Pd-O-Ti entities at the Pd-TiO2 interface during reduction treatment at 300 degrees C.
APPLIED SURFACE SCIENCE
(2022)
Article
Immunology
Duaa Abuarqoub, Nouf N. Mahmoud, Rand Zaza, Rana Abu-Dahab, Enam A. Khalil, Dima A. Sabbah
Summary: This study investigated the immunological response after treating THP-1 cells with gold nanorods conjugated with a PI3K alpha inhibitor. The results showed that the nanocomplex and free drug had similar effects on the expression of inflammatory cytokines at the gene and protein levels, downregulating IL-1 beta, IL-6, and TNF-alpha, while upregulating IL-8, IL-10, and TGF-beta. The GNR treatment group also had significant effects on the expression of certain cytokines.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Suhair Sunoqrot, Mohammad Niazi, Mohammad A. Al-Natour, Malak Jaber, Luay Abu-Qatouseh
Summary: This study developed a nanoparticle formulation of coal tar (CT) based on biocompatible poly(lactide-co-glycolide) (PLGA) for the treatment of psoriasis. The CT-loaded PLGA nanoparticles showed high loading efficiency, small particle size, and colloidal stability. Compared to crude CT, the CT nanoparticles significantly reduced cytotoxicity, staining ability, and improved washability.
Article
Polymer Science
Qais M. Al-Bataineh, Ahmad Telfah, Norman Ahlmann, Elen Tolstik, Carlos J. Tavares, Roland Hergenroeder
Summary: This study proposes a novel dopant material for improving the energy storage in azo molecules. The addition of organometallic material with a platinum base atom (sodium hexachloroplatinate (IV)) to polyethylene oxide-methyl red films enhances energy storage. The photoisomerization kinetics, electrical conductivity distribution, and chemical and crystal structure are also investigated.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Ahmad Telfah, Qais M. Al-Bataineh, Elen Tolstik, Ahmad A. Ahmad, Ahmad M. Alsaad, Riad Ababneh, Carlos J. Tavares, Roland Hergenroeder
Summary: This study synthesized PEO:I-2 complex composite films with different I-2 concentrations and investigated their optical and optoelectronic properties. It was found that the addition of I-2 increased the electrical conductivity of the composite and decreased the transmittance of PEO. Furthermore, the study revealed the reaction mechanism between PEO and I-2 through NMR spectroscopy analysis.
Article
Pharmacology & Pharmacy
Suhair Sunoqrot, Malak Alkurdi, Abdel Qader Al Bawab, Alaa M. Hammad, Rabab Tayyem, Ali Abu Obeed, Mohammed Abufara
Summary: This study developed a nanoparticle formulation to improve the bioactivity and oral bioavailability of MR, a bioactive plant polyphenol. The optimal nanoparticles were about 200nm in size with an almost neutral surface charge and a loading efficiency of 82%. The nanoparticles exhibited sustained release of MR, showed enhanced anti-inflammatory activity, and achieved a 5.6-fold increase in bioavailability and prolonged plasma half-life when orally administered to mice.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Instruments & Instrumentation
Alaa M. Hammad, Lujain F. Alzaghari, Malek Alfaraj, Laith Al-Shawaf, Suhair Sunoqrot
Summary: This study investigated the behavioral and molecular correlates of cigarette smoking withdrawal-induced anxiety-like behavior in rats, and found that the administration of antioxidant nanoassemblies prepared from coffee extracts can mitigate these effects.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Suhair Sunoqrot, Samah Abusulieh, Osama H. Abusara
Summary: Combining chemotherapeutic agents with bioactive natural products can reduce dose and side effects, while nanoparticle-mediated drug delivery can improve therapeutic effects. Polyquercetin-based nanoparticles co-assembled with doxorubicin showed sustained drug release. In vitro evaluation against breast cancer cells revealed that the combination of nanoparticles with bioactive natural products had a positive effect on promoting apoptosis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yara Salem, Hiba N. Rajha, Suhair Sunoqrot, Alaa M. Hammad, Ines Castangia, Maria Manconi, Maria Letizia Manca, Dana Al Lababidi, Joe A. Touma, Richard G. Maroun, Nicolas Louka
Summary: Exhausted grape seed residues can be transformed into promising cosmetic scrubs capable of releasing antioxidant molecules during exfoliation process, showing good physical stability and no irritation phenomena. This highlights the importance of effectively utilizing agro-industrial by-products for the development of sustainable and zero-waste cosmeceutics.
Article
Nanoscience & Nanotechnology
Suhair Sunoqrot, Amal G. Al-Bakri, Lina Hasan Ibrahim, Neda'a Aldaken
Summary: A nanomedicine loaded with Amphotericin B (AmB) was successfully synthesized using plant-inspired oxidative self-polymerization of quercetin (QCT). The AmB-loaded nanoparticles showed high drug loading efficiency, sustained release of AmB, and improved biocompatibility compared to free AmB. These results demonstrate the potential of these polymerized QCT nanoparticles as a viable delivery platform for AmB in the treatment of fungal infections and other AmB-susceptible pathogens.
ACS APPLIED BIO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Ali I. M. Ibrahim, Hassan Abul-Futouh, Laurance M. S. Bourghli, Mohammad Abu-Sini, Suhair Sunoqrot, Balqis Ikhmais, Vibhu Jha, Qusai Sarayrah, Dina H. Abulebdah, Worood H. Ismail
Summary: This study investigated the antibacterial activity, biocompatibility, cytotoxicity, and spectroscopic properties of a thionated form of levofloxacin. The results showed that the thionated compound exhibited lower minimum inhibitory concentrations against certain bacteria, increased biocompatibility with normal cells, and higher cytotoxicity against cancer cells compared to levofloxacin.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Materials Science, Biomaterials
Eveen Al-Shalabi, Samah Abusulieh, Alaa M. Hammad, Suhair Sunoqrot
Summary: This study developed a nanocarrier platform for delivering ROF, a bioactive flavonoid, to treat inflammatory diseases. The ROF-loaded nanoparticles demonstrated excellent stability, sustained drug release, and superior efficacy in relieving oxidative stress and inhibiting inflammation.
BIOMATERIALS SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Shahriar Sharifi, Amir Ata Saei, Hassan Gharibi, Nouf N. Mahmoud, Shannon Harkins, Naruphorn Dararatana, Erika M. Lisabeth, Vahid Serpooshan, Akos Vegvari, Anna Moore, Morteza Mahmoudi
Summary: Albumin-based hydrogels, especially the non-immunogenic photocurable version described in the study, demonstrate excellent biocompatibility and anti-inflammatory properties, making them promising materials for biomedical applications. The modifications and cross-linking of methacrylated HSA were found to reduce macrophage adhesion and inflammatory pathways, with potential for use in passivation coatings and other biomedical applications. In vitro and Ex-Ovo assay results confirmed the biocompatibility and slight angiogenesis-modulating effects of the photocurable albumin hydrogels.
ACS APPLIED BIO MATERIALS
(2022)
