Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 6, Issue 9, Pages 5001-5011Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c00581
Keywords
peptide hydrogel; microfibers; microfluidics; dual-drug delivery; wound healing
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Funding
- National Natural Science Foundation of China [21605160]
- Jiangsu Natural Science Foundation [BK20171387]
- Jiangsu Innovation and Enterpreneurship Project
- Open Research Fund of State Key Laboratory of Bioelectronics Southeast University
- Double First-Class University project [CPU2018GY25]
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Infected wounds caused by persistent inflammation exhibit poor vascularization and cellular infiltration. In order to rapidly control the inflammatory effect and accelerate wound healing, it is necessary to develop a novel drug vehicle addressing the need for infected wounds. Herein, we developed a novel dual-drug delivery system with micrometer-scale alginate fibers encapsulated in instant self-assembly peptide hydrogel. Short peptides with the sequence of Nap-Gly-Phe-Phe-Lys-His (Nap-GFFKH) could self-assemble outside the microfluidic-based alginate microfibers in weak acidic solution (pH approximate to 6.0) within 5 s. The gelation condition is close to the pH environment of the human skin. We further constructed recombinant bovine basic fibroblast growth factor (FGF-2) in fibrous alginate, which was encapsulated in antibiotic-loaded peptide hydrogel. The dual-drug delivery system exhibited good mechanical property and sustained release profiles, where antibiotic could be rapidly released from the peptide hydrogel, while the growth factor could be gradually released within 7 days. Both in vitro antibacterial experiments and in vivo animal experiments confirmed that such a dual-drug delivery system has good antibacterial activity and enhances wound healing property. We suggested that the dual-drug delivery system could be potentially applied for controlled drug release in infected wound healing, drug combination for melanoma therapy, and tissue engineering.
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