Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 6, Issue 7, Pages 4077-4086Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c00591
Keywords
salmon calcitonin; thermosensitive hydrogel; long-term release; osteogenic response
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Funding
- National Natural Science Foundation of China [51925304, 21534008, 51703138, 51773128]
- Department of Science and Technology of Sichuan Province [2019JDRC0090]
- China Postdoctoral Science Foundation [2018M633368]
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The common pathological characteristic of osteoporosis and hypercalcemia is the disorder of calcium homeostasis. Currently, salmon calcitonin (sCT), a clinical regenerative medicine, is an attractive chioice to regulate calcium metabolism for alleviation of osteoporosis and hypercalcemia. Unfortunately, serum sCT is quickly cleared in vivo, leading to its short half-life. Here, we designed a versatile hydrogel, based on salmon calcitonin-oxidized calcium alginate (sCT-OCA) conjugate and hydroxypropyl chitin (HPCH). The release profile showed that sCT could be released from HPCH hydrogels loaded with sCT-OCA conjugate (sCT-OCA-HPCH) for at least 28 days with conformation stability. The cellular test demonstrated that the biocompatible sCT-OCA-HPCH, compared with sCT formulation, had capacity in up-regulating alkaline phosphatase activity (similar to 63% increase) and promoting calcium to deposit into extracellular matrix (similar to 42% increase). These results indicated that thermosensitive sCT-OCA-HPCH hydrogel herein is a versatile platform for many applications such as calcium metabolism regulation, osteoporosis treatment, and hypercalcemia therapy.
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