Article
Medical Laboratory Technology
Surong Zhang, Xueni Zeng, Shaona Lin, Minchao Liang, Huaxing Huang
Summary: This study identified prognostic-related genes, genomic variants, copy deletions, and significant mutations in LUAD using multi-omics data analysis. A 7-gene signature was constructed as an independent prognostic factor for LUAD patients, which showed consistent results in various datasets. The findings provided new prognostic and diagnostic biomarkers and therapeutic targets for LUAD.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Genetics & Heredity
Yongchun Song, Kui Yang, Tuanhe Sun, Ruixiang Tang
Summary: The comprehensive analysis of genomic and epigenomic regulation in sarcomas provides new insights into multilayered pathobiology. The four molecular subtypes and three prognostic markers developed in this study improve the current understanding of the molecular mechanisms underlying sarcomas.
BMC MEDICAL GENOMICS
(2021)
Article
Genetics & Heredity
Qian Liang, Lele Zhang, Wenjun Wang, Jingyu Zhao, Qiaoli Li, Hong Pan, Zhen Gao, Liwei Fang, Jun Shi
Summary: High expression of DC-STAMP is associated with adverse prognosis in AML patients and is also correlated with immune cell infiltration and high levels of immune checkpoint genes.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Tao Zhou, Kai Qian, Yun-Yun Li, Wen-Ke Cai, Sun-Jun Yin, Ping Wang, Gong-Hao He
Summary: This study systematically investigated the functions and clinical prognostic value of pyroptosis-related genes (PRGs) in acute myeloid leukemia (AML). The results showed that these genes were associated with AML prognosis and could serve as independent predictors. Furthermore, these genes were also associated with the tumor immune microenvironment and drug sensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Yanhui Wei, Zhaoxu Miao, Xuejun Guo, Songwei Feng
Summary: This study found that cuprotosis is associated with the prognosis of AML patients, and the subtypes A and B of cuprotosis have lower risk scores and longer survival times compared to other subtypes. Cuprotosis is also related to the prognosis and immunological characteristics of AML patients.
Article
Oncology
Huaxin Zhu, Hengyang Ouyang, Xinyi Pan, Zhixiong Zhang, Jiacong Tan, Nianzu Yu, Meihua Li, Yeyu Zhao
Summary: High expression of ASF1B in gliomas is associated with poor prognosis and may serve as a reliable prognostic biomarker. Functional enrichment analysis revealed its association with nuclear division and cell cycle. Immune infiltration analysis showed positive or negative correlation between ASF1B and certain immune cell types.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xueying Zhao, Jin Chen, Shangqi Yin, Jingren Shi, Mei Zheng, Chaonan He, Huan Meng, Ying Han, Jinyu Han, Jingjing Guo, Zhengrong Yuan, Yajie Wang
Summary: This study evaluated the prognostic value of cuproptosis-related gene expression in hepatocellular carcinoma (HCC) and identified 20 genes that may serve as new prognostic biomarkers for HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Wei Han, Yi-Zhu Wu, Xiao-Yu Zhao, Zhen-Hua Gong, Guo-Liang Shen
Summary: Elevated expressions of MCM2-6 and MCM10 were significantly associated with melanoma and worse prognosis; GSEA revealed involvement of hallmark pathways like mTORC1 signaling, G2M checkpoint, E2F targets, and mitotic spindle; Potential correlations were found between MCM expression and immune cell infiltration in melanoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhibo Guo, Dan Guo, Desheng Kong, Sicheng Bian, Linlin Zhao, Qi Li, Leilei Lin, Jiali Hao, Lili Sun, Yinghua Li
Summary: This study discovered the aberrant expression of PLXNB2 in AML patients and explored its potential role as a prognostic biomarker and potential target in AML. High expression of PLXNB2 is associated with poor prognosis in AML patients and may exert oncogenic effects by modulating immune functions, endothelial cell functions, and cell interactions. AML patients with high PLXNB2 expression could benefit more from HSCT treatment.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Zhibo Guo, Dan Guo, Desheng Kong, Sicheng Bian, Linlin Zhao, Qi Li, Leilei Lin, Jiali Hao, Lili Sun, Yinghua Li
Summary: In adult patients with AML, overexpression of PLXNB2 is associated with poor prognosis and may exert an oncogenic role by modulating immune functions, endothelial cell functions and cell interactions. Patients with high PLXNB2 expression may benefit more from HSCT.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Genetics & Heredity
Jianhua Mu, Jianan Gong, Miao Shi, Yinian Zhang
Summary: This study aimed to establish a prognostic model for glioblastoma (GBM) patients based on aging-related genes (ARGs) to determine patient prognosis. Thirteen genes were selected to establish the prognostic model, which showed good prediction ability. Additionally, significant differences in immune infiltration and mutation characteristics were observed between high and low-risk score groups.
BMC MEDICAL GENOMICS
(2023)
Article
Genetics & Heredity
Yalun Li, Gang Chen, Kun Zhang, Jianqiao Cao, Huishan Zhao, Yizi Cong, Guangdong Qiao
Summary: This study used bioinformatic methods to predict breast cancer by selecting therapy genes and possible biomarkers. It identified differentially expressed genes associated with survival and confirmed three hub genes (EZH2, CCNB1, and PPARG) as potential prognostic biomarkers and therapeutic targets for breast cancer.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Cong Zhang, Tiantian Xu, Kun Ji, Shoujin Cao, Yunbo Cao, Jing Ai, Li Jing, Jun-Hui Sun
Summary: The high expression of PSMD11 in HCC tissues is associated with poor prognosis and tumor metabolism-related pathways. Low PSMD11 expression is correlated with increased immune effector cell infiltration, enhanced responsiveness to molecular targeted drugs, and reduced somatic mutation rate. PSMD11 may modulate HCC development through interactions with cuproptosis-related genes ATP7A, DLAT, and PDHA1.
MOLECULAR CARCINOGENESIS
(2023)
Article
Genetics & Heredity
Dinglong Yang, Hetong Li, Yujing Chen, Chunjiang Li, Weiping Ren, Yongbo Huang
Summary: This study investigates the prognostic and immunoregulatory value of BCL7B gene in pan-cancer, revealing its close association with various cancer types in terms of development and prognosis, as well as its interactions with immune cell infiltration and regulation.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Yaodong He, Yunshan Li, Junwei Xiang, Xu Huang, Mingyu Zhao, Yuanyin Wang, Ran Chen
Summary: Tyrosine kinase 2 (TYK2) is overexpressed in head and neck squamous cell carcinoma (HNSCC) and is associated with tumor growth, prognosis, and immune infiltration. TYK2 can serve as a novel biomarker for assessing the prognosis of HNSCC patients and aiding in immunotherapy against HNSCC.
FRONTIERS IN GENETICS
(2022)