Review
Pharmacology & Pharmacy
Ekaterina Mostovenko, Christopher G. Canal, MiJin Cho, Kirti Sharma, Aaron Erdely, Matthew J. Campen, Andrew K. Ottens
Summary: The field of nanoscience has revealed the wide diversity of nano-scale particulates from natural and anthropogenic sources, raising concerns about their impacts on human health. Inhalation is the primary route of entry, depositing nanoparticles deep into the lungs and potentially affecting organs like the cardiovascular system and brain. Research has shown that the translocation of nanoparticles from the lungs to the circulation, as well as the release of molecules from the lungs into the bloodstream, can lead to various systemic outcomes.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Environmental Sciences
Ayush Jha, Diksha Pathania, Bhavna Sonu, Bhavna Damathia, Pankaj Raizada, Sarvesh Rustagi, Pardeep Singh, Gokana Mohana Rani, Vishal Chaudhary
Summary: The increasing demand for food due to population growth has led to higher consumption of fertilizers in global agriculture. However, excessive use of inefficient chemical fertilizers is negatively impacting ecosystem health, soil fertility, environmental contamination, and human health. To address these challenges, nanotechnological and biotechnological approaches have been integrated to develop nano-enabled biogenic fertilizers (NBF), revolutionizing the agriculture sector and food production.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Laura-Jayne. A. Ellis, Stephen Kissane, Iseult Lynch
Summary: This study highlights the importance of environmental nano-biological interactions on model species and their progeny for nanomaterial risk assessment. It shows how maternal exposure to silver and titanium dioxide NMs affects the biological traits of offspring across multiple generations, with different levels of exposure leading to varying outcomes in terms of growth, reproduction, and survival. The research also reveals transgenerational responses to NM exposure concentrations, providing valuable insights for environmental risk assessments and predicting impacts on ecological systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Fernanda Neves Estrela, Abraao Tiago Batista Guimaraes, Fabiano Guimaraes Silva, Thiarlen Marinho da Luz, Abner Marcelino Silva, Paulo Sergio Pereira, Guilherme Malafaia
Summary: The study found that short-term exposure to PS NPs affected fish's response to mirror tests, as well as induced inactivity towards alarm substances and DNA damage. Increased oxidative stress was observed, and while antioxidant levels were elevated, they were not sufficient to counteract the effects of free radicals produced by the treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Civil
Tommaso Lazzarin, Daniele P. Viero, Daniela Molinari, Francesco Ballio, Andrea Defina
Summary: Commonly adopted procedures for flood damage assessment have limitations in describing the time evolution of hazard and exposure during the flood event. This study proposes a new framework that considers how flood damage evolves in time, showing potential for flood risk assessment and management.
JOURNAL OF HYDROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Raisibe Florence Lehutso, Yolanda Tancu, Arjun Maity, Melusi Thwala
Summary: Analytical limitations have hindered the determination of nanopollution characteristics from nano-enabled products (NEPs), which are actual sources of nanopollution. This study examined the properties of engineered nanomaterials (ENMs) in 18 commercial products, revealing their diverse morphologies and negative charges. Despite identifying key ENM characteristics for environmental risk assessment, challenges persist in accurately determining concentrations in NEPs.
Article
Toxicology
Elizabeth C. Bowdridge, Evan DeVallance, Krista L. Garner, Julie A. Griffith, Kallie Schafner, Madison Seaman, Kevin J. Engels, Kimberley Wix, Thomas P. Batchelor, William T. Goldsmith, Salik Hussain, Timothy R. Nurkiewicz
Summary: The study found increased H2O2 production capacity and phosphorylation of NF-κB in F0 dams following maternal nano-TiO2 inhalation exposure. Additionally, F1 nano-TiO2 exposed females exhibited estrogen disruption and vascular dysfunction, resulting in smaller F1 and F2 offspring. The findings suggest that maternal exposure to engineered nanomaterials has long-lasting biological impacts across generations.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Xiaohong Huang, Chaoxian Gao, Wenzhi Cai, Yanling Tao, Xiao Zhong, Haiying Liu, Xiaodan Hong, Xiaorong Ding, Hong Lu, Wenjuan Lai, Xiaoqing Yi, Yeqing Gu
Summary: The study found that the risk of DNA damage in nurses exposed to antineoplastic drugs is higher, indicating that occupational exposure to antineoplastic agents is an important global public health problem that requires urgent attention.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Hussein H. Mwanga, Roslynn Baatjies, Mohamed Fareed Jeebhay
Summary: This study investigated the occupational risk factors and exposure-response relationships for airway disease among health workers exposed to cleaning agents. The results showed that certain medical instrument cleaning agents, tasks, and patient care activities were positively associated with asthma-related outcomes. There was also a strong association between the use of sprays for fixed surface cleaning and asthma symptoms.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Matteo Scopetti, Donato Morena, Federico Manetti, Alessandro Santurro, Nicola Di Fazio, Stefano D'Errico, Martina Padovano, Paola Frati, Vittorio Fineschi
Summary: The systematic review aims to summarize the available evidence regarding the mechanism of cannabinoids-induced brain damage as a substrate of neurological, psychiatric, and behavioral effects, and to provide support for future investigations and legislative choices. The consumption of cannabinoids is associated with the development of psychiatric, neurocognitive, neurological disorders and, in some cases of acute consumption, even death.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Construction & Building Technology
Jia Luo, Sheliang Wang, Xiaoyi Quan, Jin Xu, Juntao Li, Kangning Liu, Fan Xu, Zhilong Hong
Summary: The synergistic effects of Nano-SiO2 (NS) and recycled concrete aggregate (RCA) on the performance of recycled aggregate concrete (RAC) were investigated under dry-wet cycles of sulfuric acid. It was found that adding 4% NS significantly improved the mass loss, compressive strength, ultrasonic sound velocity, and microstructure of RAC. The addition of NS not only reduced porosity and inhibited crack generation, but also improved the interfacial transition zone (ITZ), leading to enhanced durability.
Review
Chemistry, Multidisciplinary
Mbuyiselwa Shadrack Moloi, Raisibe Florence Lehutso, Mariana Erasmus, Paul Johan Oberholster, Melusi Thwala
Summary: The rapid commercialization of nano-enabled products has increased the potential environmental release of engineered nanomaterials along the product life cycle. Studies show that the engineered nanomaterials released from products are mainly associated with the matrix of the respective nano-enabled products, which can hinder the proper isolation of nano-driven toxicity effects. Despite current limitations in ecotoxicology data, risk estimation suggests elevated risks to fish from fabrics' PR-nAg, and potential effects on algae, echinoderms, and crustaceans from sunscreens' PR-nZnO and PR-nTiO(2), with no significant risk to echinoderms from PR-nTiO(2).
Review
Chemistry, Multidisciplinary
Samantha Llewellyn, Marye Niemeyer, Penny Nymark, Martijn J. Mone, Bob van de Water, Gillian E. Conway, Gareth J. S. Jenkins, Shareen H. Doak
Summary: This review discusses the chronic liver damage caused by exposure to engineered nanomaterials and the challenges in using in vitro models to assess genotoxicity. It identifies the need for advancements in assessing DNA damage in the liver and highlights the importance of supporting various biochemical endpoints in nano(gen)toxicology research.
Article
Environmental Sciences
Nadeem Ullah Khan, Asrar Ali, Umerdad Khudadad, Uzma Rahim Khan, Noman Ali, Salman Muhammad Soomar, Shehryar Abid, Mahmood Jilani, Seemin Jamali, Junaid A. Razzak
Summary: This study reviewed the health outcomes and challenges of cases of soybean dust exposure in Kemari district of Karachi, Pakistan, finding that the main symptoms included shortness of breath and neurological symptoms.
JOURNAL OF HEALTH POPULATION AND NUTRITION
(2023)
Article
Chemistry, Analytical
Premkumari Kumarathasan, Nazila Nazemof, Dalibor Breznan, Erica Blais, Hiroyuki Aoki, James Gomes, Renaud Vincent, Sadhna Phanse, Mohan Babu
Summary: This study evaluated the internalization and mitochondrial effects of silica nanoparticles (SiNPs) with different sizes and surface modifications. The findings suggest that physicochemical properties are determinants of SiNP exposure-related mitochondrial effects. Mitochondrial exposures combined with proteomic analysis can serve as a new approach in risk assessment, providing insights into related toxicity mechanisms.
Article
Chemistry, Multidisciplinary
Michael J. Burgum, Martin J. D. Clift, Stephen J. Evans, Nicole Hondow, Mark Miller, Sandra Bustamante Lopez, Adam Williams, Afshin Tarat, Gareth J. Jenkins, Shareen H. Doak
Summary: This study assessed the inhalation hazard of industrially relevant FLG with different surface functionalization and found that neutral-FLG and amine-FLG can induce genotoxicity in human lung epithelial cells, while carboxyl-FLG does not cause significant genotoxicity. This suggests a possible role for carboxyl groups in scavenging radicals produced via oxidative stress.
Article
Toxicology
Katherine E. Chapman, Eleanor C. Wilde, Fiona M. Chapman, Jatin R. Verma, Ume-Kulsoom Shah, Leanne M. Stannard, Anna L. Seager, James A. Tonkin, M. Rowan Brown, Ann T. Doherty, George E. Johnson, Shareen H. Doak, Gareth J. S. Jenkins
Summary: The study employed a holistic, multiple-endpoint approach using low doses of selected carcinogens and non-carcinogens to assess perturbations in molecular and cellular endpoints, successfully distinguishing carcinogens from non-carcinogens. Avoidance of misleading in vitro outcomes could lead to the reduction and replacement of animals in carcinogenicity testing.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Natalie Burden, Martin J. D. Clift, Gareth J. S. Jenkins, Briony Labram, Fiona Sewell
Summary: The unique properties of nanomaterials require additional considerations for safety assessment compared to traditional materials. Developing new testing methods is essential to effectively evaluate the hazards and risks associated with nanomaterials.
Review
Chemistry, Multidisciplinary
Samantha Llewellyn, Marye Niemeyer, Penny Nymark, Martijn J. Mone, Bob van de Water, Gillian E. Conway, Gareth J. S. Jenkins, Shareen H. Doak
Summary: This review discusses the chronic liver damage caused by exposure to engineered nanomaterials and the challenges in using in vitro models to assess genotoxicity. It identifies the need for advancements in assessing DNA damage in the liver and highlights the importance of supporting various biochemical endpoints in nano(gen)toxicology research.
Article
Biotechnology & Applied Microbiology
Michael J. Burgum, Martin J. D. Clift, Stephen J. Evans, Nicole Hondow, Afshin Tarat, Gareth J. Jenkins, Shareen H. Doak
Summary: The study found that FLG induced cytotoxicity in TT1 cells in monoculture experiments, while in co-culture experiments, FLG induced genotoxicity without cytotoxic effects. Pre-exposure of co-cultures to N-acetylcysteine (NAC) showed that genotoxicity observed in the co-culture experiment was driven by oxidative stress and revealed secondary mechanisms of DNA damage.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Nicholas G. Mowbray, Rowena Griffiths, Ashley Akbari, Hayley Hutchings, Gareth Jenkins, Bilal Al-Sarireh
Summary: The study found that centralisation of pancreatic cancer services in South Wales led to a small increase in overall survival for patients, but did not significantly improve survival for patients undergoing surgical resection or chemotherapy. Despite increased rates of surgical resection and chemotherapy utilization, many patients still did not receive any treatment.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Nanoscience & Nanotechnology
Samantha Llewellyn, Wolfgang J. Parak, Jonas Huhn, Michael J. Burgum, Stephen J. Evans, Katherine E. Chapman, Gareth J. S. Jenkins, Shareen H. Doak, Martin J. D. Clift
Summary: This study investigates the potential (geno)toxicity and impact on telomere integrity of gold (Au) and silver (Ag) nanoparticles (ENPs) in lung epithelial cell lines. Gold ENPs showed a significant genotoxic response and induced DNA damage and cell cycle stall, while silver ENPs did not show significant genotoxicity. Both ENPs may have the potential to cause telomere attrition. Additionally, the study confirms that both lung cell cultures used are suitable and reliable for assessing ENP hazards.
Article
Toxicology
Stephen J. Evans, Rachel L. Lawrence, Martha Ilett, Michael J. Burgum, Kirsty Meldrum, Nicole Hondow, Gareth J. Jenkins, Martin J. D. Clift, Shareen H. Doak
Summary: This study assessed the cellular interaction and cytotoxicity of five types of TiO2 particles in human lymphoblast and type-II alveolar epithelial cells. The results showed that these industrially relevant TiO2 particles did not induce cytotoxicity within the applied dose range.
TOXICOLOGY IN VITRO
(2022)
Article
Toxicology
Samantha Llewellyn, Ali Kermanizadeh, Victor Ude, Nicklas Raun Jacobsen, Gillian E. Conway, Ume-Kulsoom Shah, Marije Niemeijer, Martijn J. Mone, Bob van de Water, Shambhu Roy, Wolfgang Moritz, Vicki Stone, Gareth J. S. Jenkins, Shareen H. Doak
Summary: To reduce animal testing, the development of physiologically relevant in vitro test systems is emphasized. This study evaluated the transferability and reproducibility of two liver models for nanomaterial and chemical hazard assessment, showing good consistency and reproducibility.
TOXICOLOGY IN VITRO
(2022)
Editorial Material
Ecology
Gareth B. Jenkins, Andrew P. Beckerman, Celine Bellard, Ana Benitez-Lopez, Aaron M. Ellison, Christopher G. Foote, Andrew L. Hufton, Marcus A. Lashley, Christopher J. Lortie, Zhaoxue Ma, Allen J. Moore, Shawn R. Narum, Johan Nilsson, Bridget O'Boyle, Diogo B. Provete, Orly Razgour, Loren Rieseberg, Cynthia Riginos, Luca Santini, Benjamin Sibbett, Pedro R. Peres-Neto
Summary: We urge journals to mandate archiving open data in a user-friendly format for readers. Consistent implementation will allow contributors to receive recognition through open data citation and promote scientific advancements.
ECOLOGY AND EVOLUTION
(2023)
Article
Genetics & Heredity
Leanne M. Stannard, Ann Doherty, Katherine E. Chapman, Shareen H. Doak, Gareth J. Jenkins
Summary: Cadmium chloride (CdCl2) has multiple effects on cells, including DNA damage, cell cycle abnormalities, and changes in cell shape. The main mechanisms behind these effects involve the generation of reactive oxygen species (ROS), oxidative DNA damage, and activation of p53.