Article
Oncology
Michelle C. M. Lee, Jacob J. Kachura, Paraskevi A. Vlachou, Raissa Dzulynsky, Amy Di Tomaso, Haider Samawi, Nancy Baxter, Christine Brezden-Masley
Summary: Chemotherapy-associated steatosis in colorectal cancer patients was retrospectively analyzed in this study, with findings suggesting a higher risk of steatosis development in patients receiving adjuvant chemotherapy compared to those not receiving chemotherapy. However, patients using statins for pre-existing hyperlipidemia during chemotherapy may have a lower risk of developing chemotherapy-associated steatosis. Further prospective trials are needed to explore the potential protective effects of statins in this patient population.
Article
Oncology
Wenjie Ni, Shufei Yu, Zefen Xiao, Zongmei Zhou, Dongfu Chen, Qinfu Feng, Jun Liang, Jima Lv, Shugeng Gao, Yousheng Mao, Qi Xue, Kelin Sun, Xiangyang Liu, Dekang Fang, Jian Li, Dali Wang, Jun Zhao, Yushun Gao
Summary: The study demonstrated that postoperative radiotherapy/postoperative concurrent chemoradiotherapy (PORT/POCRT) could significantly improve disease-free survival and overall survival in patients with stage IIB-III esophageal squamous cell carcinoma.
Article
Oncology
Mizuki Tamai, Jun Kiuchi, Yoshiaki Kuriu, Tomohiro Arita, Hiroki Shimizu, Takuma Ohashi, Hirotaka Konishi, Yusuke Yamamoto, Ryo Morimura, Atsushi Shiozaki, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
Summary: Preoperative Prognostic Nutritional Index (PNI) is crucial for the prognosis of colorectal cancer (CRC). Postoperative PNI value can serve as a prognostic biomarker for CRC patients undergoing adjuvant chemotherapy (AC). Patients with low PNI value can improve prognosis by recovering PNI value through the introduction of AC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Tina Fransgaard, Lau Caspar Thygesen, Ismail Gogenur
Summary: This study found no association between postoperative complications and long-term prognosis when adjusting for time to adjuvant chemotherapy.
COLORECTAL DISEASE
(2021)
Article
Medicine, Research & Experimental
Cecilia Villegas, Rebeca Perez, Olov Sterner, Ivan Gonzalez-Chavarria, Cristian Paz
Summary: Colorectal cancer is the second leading cause of cancer death worldwide, mainly affecting men, with about 20% of cases due to hereditary syndromes. Curcumin, the main polyphenol pigment in turmeric, has antioxidant properties and synergistic effects with both anticancer and anti-inflammatory drugs in inhibiting the progression of CRC through multiple signaling pathways.
Article
Medicine, General & Internal
Di Zhang, Lixi Li, Tingyu Wen, Yun Wu, Fei Ma
Summary: This study aimed to investigate the impact of lymph node parameters on postoperative hypopharyngeal squamous cell carcinoma (HSCC) and develop a nomogram to predict prognosis and aid in chemotherapy decisions. The findings suggest that the lymph node parameter-based nomogram can effectively stratify prognosis and identify patients who would benefit from chemotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Hordur M. Kolbeinsson, Allison Hoppe, Jessica Walker, Sreenivasa Chandana, M. Mura Assifi, Mathew Chung, Gerald Paul Wright
Summary: This study identified that high tumor grade, perineural invasion, and N0 node status of the primary tumor are associated with an increased risk of liver recurrence after curative-intent treatment of colorectal liver metastases. These factors represent a target population that may benefit the most from adjuvant liver-directed regional chemotherapy.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Alem Gebremariam, Mathewos Assefa, Adamu Addissie, Alemayehu Worku, Nebiyu Dereje, Aynalem Abreha, Wondemagegnehu Tigeneh, Lydia E. Pace, Eva Johanna Kantelhardt, Ahmedin Jemal
Summary: A significant number of breast cancer patients in Addis Ababa, Ethiopia experience delays in initiation of adjuvant chemotherapy, particularly among low-income women, despite a high level of treatment completion. This highlights the importance of public policy interventions to improve access to healthcare for low-income populations and enhance breast cancer care.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Medicine, General & Internal
Sapna P. Patel, Megan Othus, Yuanbin Chen, G. Paul Wright, Kathleen J. Yost, John R. Hyngstrom, Siwen Hu-Lieskovan, Christopher D. Lao, Leslie A. Fecher, Thach-Giao Truong, Jennifer L. Eisenstein, Sunandana Chandra, Jeffrey A. Sosman, Kari L. Kendra, Richard C. Wu, Craig E. Devoe, Gary B. Deutsch, Aparna Hegde, Maya Khalil, Ankit Mangla, Amy M. Reese, Merrick I. Ross, Andrew S. Poklepovic, Giao Q. Phan, Adedayo A. Onitilo, Demet G. Yasar, Benjamin C. Powers, Gary C. Doolittle, Gino K. In, Niels Kokot, Geoffrey T. Gibney, Michael B. Atkins, Montaser Shaheen, James A. Warneke, Alexandra Ikeguchi, Jose E. Najera, Bartosz Chmielowski, Joseph G. Crompton, Justin D. Floyd, Eddy Hsueh, Kim A. Margolin, Warren A. Chow, Kenneth F. Grossmann, Eliana Dietrich, Victor G. Prieto, Michael C. Lowe, Elizabeth I. Buchbinder, John M. Kirkwood, Larissa Korde, James Moon, Elad Sharon, Vernon K. Sondak, Antoni Ribas
Summary: This study aimed to investigate whether giving pembrolizumab both before and after surgery would improve event-free survival in patients with resectable stage III or IV melanoma. Results showed that patients who received pembrolizumab both before and after surgery had significantly longer event-free survival. Overall rating: 9 out of 10.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Oncology
Yiwei Zhang, Yuqiao Chen, Jia Huang, Xiaofeng Wu, Rong Tang, Qiulin Huang, Yunhua Xu, Xiuda Peng, Kai Fu, Shuai Xiao
Summary: Mucinous adenocarcinoma (MAC) is a histological subtype of colorectal carcinoma (CRC) and its prognosis is controversial. This study assessed the impact of MAC on the survival of patients treated with surgery and first-line adjuvant chemotherapy, and found that MAC patients had poorer disease-free survival. Therefore, further research is needed to study the role of first-line adjuvant chemotherapy regimens in these patients.
Article
Oncology
Yuchong Yang, Yao Lu, Hui Tan, Ming Bai, Xia Wang, Shaohua Ge, Tao Ning, Le Zhang, Jingjing Duan, Yansha Sun, Rui Liu, Hongli Li, Yi Ba, Ting Deng
Summary: The timing of postoperative adjuvant chemotherapy has significant effects on the survival rate of colorectal cancer patients. Starting chemotherapy within 8 weeks after surgery leads to better outcomes. There is no noticeable difference in survival benefits between starting chemotherapy within 5-8 weeks and within <= 4 weeks. Delaying chemotherapy for approximately 5-6 months after surgery is still beneficial in improving prognosis compared to patients not receiving chemotherapy.
Article
Multidisciplinary Sciences
Bin Wang, Yang Song, Zhuo Chen, Xiaona Su, Xin Yang, Zhi Wei, Junxia Chen, Chuan Chen, Mengxia Li
Summary: This study aimed to investigate the therapeutic effect and safety of ALK inhibitor in ALK-positive lung cancer patients. A total of 59 patients were recruited and divided into two groups: conventional adjuvant chemotherapy and targeted therapy with crizotinib. The results showed that targeted therapy significantly improved disease-free survival (DFS) and overall survival (OS) compared to adjuvant chemotherapy (P < 0.05). Elevated aspartate transaminase/alanine aminotransferase, nausea, and vomiting were the most common adverse events observed.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Difei Yao, Lingyan Yu, Wei He, Yangmin Hu, Huimin Xu, Ying Yuan, Haibin Dai
Summary: This study aimed to estimate trends in drug use, prescribing patterns and spending for antineoplastic drug therapies for colorectal cancer (CRC) in major cities of China. The results showed an increase in both the number of prescriptions and the annual cost of antineoplastic drugs for CRC, with a shift towards more combination therapies over monotherapy. The study provides valuable information for informing treatment decisions and evaluating the financial burden of CRC drug treatment.
Review
Medicine, General & Internal
Emmanouil Georgilis, Maria Gavriatopoulou, Diamantis I. Tsilimigras, Panagiotis Malandrakis, Theodosios Theodosopoulos, Ioannis Ntanasis-Stathopoulos
Summary: Although surgical resection is the gold standard for resectable colorectal cancer liver metastases (CRLMs), the management after surgery remains controversial. This systematic review aimed to evaluate the efficacy, tolerability, and safety profile of different chemotherapeutic agents used as adjuvant treatment after surgical resection of CRLMs. The results showed that adjuvant therapy improved regression-free survival (RFS) and disease-free survival (DFS), but did not significantly prolong overall survival (OS), and the choice of therapeutic strategy did not have a differential impact on patient outcomes. More high-quality clinical trials are needed to determine which patients would benefit the most from adjuvant therapy after surgery for CRLMs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Arnos Pantelis, Almog Ben-Yaacov, Mohammad Adileh, Gal Schtrechman, Einat Shacham-Shmueli, Ben Boursi, Ofer Margalit, Naama Halpern, Eyal Mor, Dan Assaf, Klug Maximiliano, Aviram Nissan, Shachar Laks
Summary: This study reviewed the outcomes of patients with CRPM who had stable lung metastases undergoing CRS/HIPEC, showing that the presence of stable lung metastases does not seem to affect the outcomes of CRS/HIPEC. Patients with stable lung disease should still be considered for CRS/HIPEC after multidisciplinary discussion.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Geriatrics & Gerontology
Sergio Salmeron Rios, Marta Mas Romero, Elisa Belen Cortes Zamora, Maria Teresa Tabernero Sahuquillo, Luis Romero Rizos, Pedro Manuel Sanchez-Jurado, Gines Sanchez-Nievas, Jose Joaquin Blas Senalada, Inmaculada Garcia Nogueras, Juan de Dios Estrella Cazalla, Fernando Andres-Pretel, Antonio Murillo Romero, Volker Martin Lauschke, Justin Stebbing, Pedro Abizanda, Almudena Avendano Cespedes
Summary: This study found that older adults in LTCFs experience a rapid decline in antibody titers over the first 6 months after receiving the second dose of the BNT162b2 vaccine. Only individuals with pre-vaccination COVID-19 infection showed a slower rate of antibody decrease.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Respiratory System
Xianghua Ye, Jinsong Yang, Justin Stebbing, Ling Peng
Summary: Background radiation recall pneumonitis (RRP) is a rare but severe complication associated with previous irradiated fields, which can be triggered by chemotherapy, targeted drugs, and immune checkpoint inhibitors. This case report highlights the increased risk of RRP in patients receiving immunotherapy after prior radiation therapy.
BMC PULMONARY MEDICINE
(2022)
Article
Oncology
Ling Peng, Bao-Dong Qin, Song Xu, Yang Xia, Jin-Song Yang, Kui Xiao, Justin Stebbing
Summary: This study conducted a meta-analysis to explore the association between the use of bevacizumab and the risk of infections in non-small-cell lung cancer (NSCLC) patients. The results indicate that bevacizumab treatment is not significantly associated with a higher risk of infections in NSCLC patients, providing reassurance regarding the safety of bevacizumab in this population.
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Meeting Abstract
Oncology
J. Stebbing, Y. Baranau, V. Baryash, V. Moiseyenko, D. Boliukh, N. Z. Antone, A. Manikhas, A. Chornobai, S. H. Kim, K. Ahn, T. Park, E. H. Baek, S. Park, S. J. Lee, I. S. Chang, S. H. Kim, J. Y. Lee, J. I. Choi
ANNALS OF ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhiqiang Wang, Liping Zhu, Kesang Li, Yilan Sun, Georgios Giamas, Justin Stebbing, Ling Peng, Zhentao Yu
Summary: The study developed a prognostic signature based on AS for ccRCC, which was significantly correlated with TIME diversity and ICI-related genes. C4orf19 was identified as a promising prognostic factor in ccRCC. Splicing regulatory networks provide insight into potential functions of AS events related to TIME, contributing to prognosis monitoring of ccRCC.
CANCER GENE THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Zhiqiang Wang, Liping Zhu, Li Li, Justin Stebbing, Zibing Wang, Ling Peng
Summary: A prognostic signature for bladder cancer was constructed by analyzing molecular characteristics and tumor-immune interactions. Two immunophenotypes and immunological characteristics were identified, and a 17-immune gene signature was developed as an independent prognostic tool for bladder cancer. Additionally, a nomogram was generated to predict the clinical outcome based on the immune signature and clinical characteristics.
CANCER GENE THERAPY
(2022)
Article
Surgery
Anirban Ghosh, Adam Hussein, Alan Askari, Vigyan Jain, Md Tanveer Adil
Summary: This study found that two-stage DS can lead to sustained weight loss, resolution of comorbidities, and improvement in quality of life in patients with BMI over 60 kg/m(2).
Article
Endocrinology & Metabolism
Andrew Currie, Roel Bolckmans, Alan Askari, James Byrne, Ahmed R. Ahmed, Rachel L. Batterham, Kamal Mahawar, Alexander Dimitri Miras, Chris M. Pring, Peter K. Small, Richard Welbourn
Summary: This study analyzed the baseline characteristics, disease severity, and operations performed on people with obesity and T2DM undergoing bariatric-metabolic surgery in the NHS. The study found that bariatric-metabolic surgery is used for people with T2DM much later in the disease process when it is less effective. National guidance and data from RCTs have had little impact on clinical practice.
Article
Biochemistry & Molecular Biology
Alessandro Agnarelli, Andrea Lauer Betran, Athanasios Papakyriakou, Viviana Vella, Mark Samuels, Panagiotis Papanastasopoulos, Christina Giamas, Erika J. Mancini, Justin Stebbing, John Spencer, Chiara Cilibrasi, Angeliki Ditsiou, Georgios Giamas
Summary: Recently, the oncogenic role of LMTK3 has been established in different tumors, making it a potential target for cancer therapy. In this study, a highly specific small molecule inhibitor for LMTK3, called C36, was identified and shown to have significant therapeutic effects in cancer cell lines. The binding affinity between LMTK3 and C36 was demonstrated through microscale thermophoresis, and C36 was found to inhibit the activity of LMTK3 by binding to both the ATP- and substrate-binding sites. Treatment with C36 led to decreased proliferation and increased apoptosis in breast cancer cells, highlighting the potential of LMTK3 inhibitors for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Fei Liang, Ling Peng, Zhengyu Wu, Georgios Giamas, Justin Stebbing
Summary: Although the use of prospective biomarker validation in phase III trials has increased in the past decade, issues such as undisclosed changes in trial design after commencement, inadequate reporting of results in biomarker-negative groups, and recommending treatment in biomarker-negative groups despite modest effects require significant improvement.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Review
Surgery
David Nocca, Andrew C. C. Currie, Saadeddine Joumaa, Pierre Brinas, Marius Nedelcu, Thomas Gautier
Summary: This article discusses a new technical amendment of incorporating Nissen fundoplication into sleeve gastrectomy to optimize outcomes and reduce complications.
Article
Surgery
Emma Rose Mcglone, Iain M. Carey, Andrew Currie, Kamal Mahawar, Richard Welbourn, Ahmed R. Ahmed, Chris Pring, Peter K. Small, Omar A. Khan
Summary: During the COVID-19 pandemic, there was a significant decrease in total number of elective bariatric surgeries in the UK, with 32% of hospitals experiencing a 75%-100% reduction in surgery volume. The proportion of cases performed in the National Health Service dropped from 74% to 53%, with no changes in baseline body mass index and prevalence of type 2 diabetes. Length of stay and surgical complication rate remained unchanged as well.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Review
Gastroenterology & Hepatology
Mohammed Al-Rashedy, Tanmoy Mukherjee, Alan Askari, Shashank Gurjar
Summary: This systematic review aimed to assess the short- and long-term outcomes after ileorectal anastomosis (IRA) for ulcerative colitis (UC). The results showed a relatively low leak rate and a low risk of colorectal cancer in the rectal remnant after IRA. However, IRA had a significant failure rate. Most patients reported a high quality of life post-IRA surgery.
ARAB JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Primary Health Care
James Lewis, Alan Askari, Arihant Mehta, Yasmin Razak, Prash Patel, Ravi Misra, Henry Tilney, Tanveer Ahmed, Mooyad Ahmed, Adnan Syeed, John Camilleri-Brennan, Ralph John Nicholls, James Macalister Kinross
Summary: This study evaluated the feasibility, acceptability, and safety of digital rectoscopy in primary care. The results showed that it is a feasible and acceptable method, with no serious adverse events reported. It also demonstrated the potential to reduce referrals and save costs.
Article
Surgery
T. S. Hettiarachchi, A. Askari, E. Rudge, L. T. Hao, S. Sarwar, D. Dowsett, A. El Hadi, Irshad Shaikh
Summary: This study compares the surgical outcomes of robotic assisted surgery and laparoscopic surgery for left sided colorectal resections. The results show that robotic surgery has shorter length of stay, lower rate of conversion to open surgery, and lower complication rates compared to laparoscopic surgery. There is no significant difference between the two groups in terms of anastomotic leak rates and complete resection.
JOURNAL OF ROBOTIC SURGERY
(2023)