Article
Cardiac & Cardiovascular Systems
Lusi Xu, Gaizun Hu, Jiahe Qiu, Yuxuan Fan, Yixuan Ma, Takahiro Miura, Masahiro Kohzuki, Osamu Ito
Summary: High-fructose diet induces hypertension and renal damage, which are exaggerated in salt-sensitive Dahl salt-sensitive rats through renal renin-angiotensin system activation. The effects can be controlled by renin-angiotensin system inhibitors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Chin-Chou Huang, Chia-Min Chung, Chih-Yu Yang, Hsin-Bang Leu, Po-Hsun Huang, Liang-Yu Lin, Tao-Cheng Wu, Shing-Jong Lin, Wen-Harn Pan, Jaw-Wen Chen
Summary: This study found an association between SLC12A3 gene polymorphisms and renal function in patients with hypertension.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Sonja Brennan, David L. Watson, Donna M. Rudd, Yogavijayan Kandasamy
Summary: This study compares the renal parenchymal growth of preterm infants to intrauterine fetal growth, providing insights into the effects of prematurity on nephrogenesis. Measuring renal parenchyma thickness using ultrasound is a novel non-invasive method for evaluating nephron endowment. The differences in renal parenchymal thickness of preterm infants may be attributed to a deficit in nephron number and compensatory hyperfiltration.
PEDIATRIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Raymond R. Townsend, David E. Kandzari, Kazuomi Kario, Roland E. Schmieder, Konstantinos Tsiou, Stuart Pocock, Shukri David, Kiritkumar Patel, Anjani Rao, Antony Walton, Jason E. Bloom, Thomas Weber, Markus Suppan, Lucas Lauder, Sidney A. Cohen, Pamela McKenna, Martin Fahy, Michael Boehm, Michael A. Weber
Summary: The study aimed to evaluate the impact of renal denervation (RDN) on the renin-angiotensin-aldosterone system in blood pressure regulation. Results showed that plasma renin activity and aldosterone levels significantly decreased compared to baseline in RDN patients at 3 months, with higher baseline PRA levels associated with a more significant reduction in blood pressure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nadin Hoffmann, Joerg Peters
Summary: The (pro)renin receptor (P)RR has important roles in the kidney and brain, independently of prorenin, in activating inflammatory and fibrotic responses in renal dysfunction and being linked to hypertension in the brain. By regulating pH and function of v-ATPase, (P) RR plays crucial roles in cellular homeostasis and autophagy in kidney, brain, and heart.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Nirupama Ramkumar, Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, William Wheatley, Jae Min Cho, J. David Symons, Donald E. Kohan
Summary: Loss of sPRR reduces baseline blood pressure, decreases Ang II-induced hypertension and renal injury, and is associated with greater endothelium-dependent vasorelaxation of resistance-sized arteries.
CIRCULATION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Naomi D. L. Fisher, Ajay J. Kirtane, Joost Daemen, Florian Rader, Melvin D. Lobo, Manish Saxena, Josephine Abraham, Roland E. Schmieder, Andrew S. P. Sharp, Philippe Gosse, Lisa Claude, Yang Song, Michel Azizi
Summary: This study investigated the association between plasma renin and aldosterone concentrations and the blood pressure response to renal denervation. The results showed that renal denervation reduced daytime ambulatory systolic blood pressure, but renin and aldosterone concentrations did not predict the blood pressure response to renal denervation.
JOURNAL OF HYPERTENSION
(2022)
Article
Endocrinology & Metabolism
Antero Ylaenen, Ilkka Poersti, Riikka Nevalainen, Tero Hinkka, Heini Huhtala, Niina Matikainen, Esa Haemaelaeinen, Onni Niemelae, Pasi Nevalainen
Summary: This study investigated the association between renal cysts and non-suppressed plasma renin in patients with primary aldosteronism. It found that renal cysts are common in these patients and may interfere with diagnostics, especially in patients aged 50 years or less.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Yujia Zhai, Bizhong Che, Yang Liu, Hao Peng, Aili Wang, Yanbo Peng, Jing Chen, Yonghong Zhang, Tan Xu, Chongke Zhong, Jiang He
Summary: This study investigated whether different blood pressure management strategies should be used for acute stroke patients with or without impaired renal function. The results showed that early antihypertensive treatment had no effect on clinical outcomes in ischemic stroke patients with different renal function status.
Article
Peripheral Vascular Disease
Hiroko Ogata, Yuto Yamazaki, Yuta Tezuka, Xin Gao, Kei Omata, Yoshikiyo Ono, Yoshihide Kawasaki, Tomoaki Tanaka, Hidekazu Nagano, Norio Wada, Yutaka Oki, Akira Ikeya, Kenji Oki, Yoshiyu Takeda, Mitsuhiro Kometani, Kazunori Kageyama, Ken Terui, Celso E. Gomez-Sanchez, Shujun Liu, Ryo Morimoto, Kensuke Joh, Hiroshi Sato, Mariko Miyazaki, Akihiro Ito, Yoichi Arai, Yasuhiro Nakamura, Sadayoshi Ito, Fumitoshi Satoh, Hironobu Sasano
Summary: Research found that patients with hyperaldosteronism have more pronounced renal damage, characterized by global and segmental glomerulosclerosis, interstitial fibrosis, arteriosclerosis, and arteriolar hyalinization. These results suggest the potential clinical significance of early intervention using mineralocorticoid receptor antagonists or blockers.
Article
Cardiac & Cardiovascular Systems
Lin Zhao, Jinhong Xue, Yi Zhou, Xueqi Dong, Fang Luo, Xiongjing Jiang, Xinping Du, Xianliang Zhou, Xu Meng
Summary: A study found that the prevalence of coexisting primary aldosteronism (PA) and renal artery stenosis (RAS) among PA patients was 6.9%, with a higher prevalence of resistant hypertension in the severe RAS group. Treatment with standard methods significantly decreased the prevalence of resistant hypertension when both PA and RAS were treated.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Urology & Nephrology
Hassan N. Ibrahim, Dina N. Murad, Sean A. Hebert, Horacio E. Adrogue, Hana Nguyen, Duc T. Nguyen, Arthur J. Matas, Edward A. Graviss
Summary: The study found that obese kidney donors were more likely to develop diabetes, hypertension, and proteinuria compared to nonobese donors. Obese donors had a higher increase in eGFR in the first 10 years post-donation, but this trend became comparable to nonobese donors thereafter. The absolute risk of developing ESKD was small for obese donors, and their risk of death was similar to that of nonobese donors.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Benedikt Marahrens, Arndt Schulze, Jan Wysocki, Meei-Hua Lin, Minghao Ye, Yashpal S. Kanwar, Michael Bader, Juan Carlos Q. Velez, Jeffrey H. Miner, Daniel Batlle
Summary: The study found that aminopeptidase A deficiency results in increased blood pressure and altered glomerular structure in mice, but without significant proteinuria. Additionally, the activity, protein, and mRNA levels of certain enzymes in the renin-angiotensin system in the kidney may be regulated compensatory in knockout mice.
KIDNEY INTERNATIONAL
(2021)
Article
Peripheral Vascular Disease
Sho Katsuragawa, Atsushi Goto, Satoru Shinoda, Kosuke Inoue, Kazuki Nakai, Jun Saito, Tetsuo Nishikawa, Yuya Tsurutani
Summary: The study suggests that reversing renin suppression with optimal mineralocorticoid receptor antagonist titration may help mitigate adverse renal outcomes in medically treated primary aldosteronism patients.
Article
Medicine, Research & Experimental
Nisita Chaihongsa, Putcharawipa Maneesai, Weerapon Sangartit, Siwayu Rattanakanokchai, Prapassorn Potue, Juthamas Khamseekaew, Sarawoot Bunbupha, Poungrat Pakdeechote
Summary: This study found that galangin can reduce blood pressure, cardiac dysfunction, and hypertrophy in hypertensive rats. It can also decrease the activity of angiotensin converting enzyme and the concentration of angiotensin II, and reduce the overexpression of certain proteins in cardiac tissue. Furthermore, galangin can attenuate kidney damage and oxidative stress, while increasing antioxidant enzyme activity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Obstetrics & Gynecology
Meegan Kilcullen, Yogavijayan Kandasamy, David Watson, Yvonne Cadet-James
Summary: The study aimed to identify stillbirth rates, risk factors, and causes among Aboriginal and Torres Strait Islander populations in North Queensland. The results showed that Indigenous infants had a slightly higher stillbirth rate compared to non-Indigenous infants, with maternal risk factors including poorer physical health and fertility issues, and fetal risk factors including congenital anomalies and preterm birth.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Cell Biology
Sonia Tamanna, Saije K. Morosin, Sarah J. Delforce, Dirk F. van Helden, Eugenie R. Lumbers, Kirsty G. Pringle
Summary: This study found that the mRNA levels of ACE, ACE2 and NEP are altered during syncytialisation in primary trophoblasts, but not in BeWo cells. The protein levels and activity of ACE, ACE2 and NEP remained unchanged. Further studies are needed to investigate the placental levels of these enzymes in pregnancies complicated by placental insufficiency.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Bevyn Jarrott, Richard Head, Kirsty G. Pringle, Eugenie R. Lumbers, Jennifer H. Martin
Summary: Infection with SARS-CoV-2 can lead to COVID-19, with a range of symptoms from asymptomatic to severe. Some patients, diagnosed with LONG COVID, experience various symptoms even after 12 weeks. Longitudinal clinical studies suggest that a battery of cytokine markers can identify infected patients with persistent inflammation and troubling symptoms. There is a hypothesis that drugs activating NRF2 or the hormone melatonin may help alleviate symptoms in LONG COVID patients.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Review
Pharmacology & Pharmacy
Richard J. Head, Eugenie R. Lumbers, Bevyn Jarrott, Felix Tretter, Gary Smith, Kirsty G. Pringle, Saiful Islam, Jennifer H. Martin
Summary: This article discusses the importance of viewing the COVID-19 pandemic from a systems analysis perspective and highlights the thermodynamic basis of SARS-CoV-2 infection. By combining pharmacology and human physiology, the study reveals the key mechanisms of SARS-CoV-2 infection and emphasizes the impact of viral surface structure variations on immune evasion and infectivity.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Review
Pharmacology & Pharmacy
Eugenie R. Lumbers, Richard Head, Gary R. Smith, Sarah J. Delforce, Bevyn Jarrott, Jennifer H. Martin, Kirsty G. Pringle
Summary: Interaction between SARS-CoV-2 and its receptor ACE2 leads to an uncontrolled inflammatory response, resulting in the pathogenesis of COVID-19. The renin-angiotensin system plays a crucial role in the host response to infection and injury, and disruption of ACE2 by SARS-CoV-2 leads to tissue damage.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Article
Public, Environmental & Occupational Health
B. L. Mah, A. Brown, S. Eades, K. G. Pringle, K. M. Rae
Summary: The study found that pregnant Australian Indigenous women experience high levels of psychological distress during pregnancy, which is associated with various stressful life events and social disadvantages. Immediate attention and interventions are needed to address the high levels of psychological distress and provide appropriate support services for this group.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2022)
Article
Pediatrics
Ravi Tankala, Lee Huang, Matthew Hiskens, Venkat Vangaveti, Yoga Kandasamy, Gopakumar Hariharan
Summary: This study aimed to review the outcomes of neonatal retrievals over 32 weeks gestation from a regional referral center. The results showed an increasing trend in the number of retrievals from 2016 to 2020, with 86% of the retrievals being for medical reasons. Missed opportunities and delays in patient back transfer were also identified. Therefore, increasing bed capacity, utilizing telehealth, and recruiting regional special care nursery staff could improve outcomes and reduce strain on tertiary neonatal resources.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Nutrition & Dietetics
Natalie Gray, Isobel G. Stoodley, Lisa E. Wood, Clare J. Collins, Leanne M. Brown, Kym G. Rae, Kirsty L. Pringle, Tracy Schumacher
Summary: Higher intakes of Omega-3 long-chain polyunsaturated fatty acids are associated with lower rates of preterm birth and preeclampsia. This study analyzed the dietary intake and fractions of LC-PUFAs in Indigenous Australian women during pregnancy. Results showed that a majority of the women met national recommendations for n-3 LC-PUFA intake, but had low levels of ALA in their RBC membranes. Further research is needed to understand the role of fatty acids in preterm birth and preeclampsia.
Review
Endocrinology & Metabolism
Kirsty G. Pringle, Lisa K. Philp
Summary: Angiotensin-converting enzyme 2 (ACE2) is a viral receptor for SARS-CoV-2 and also plays important physiological roles in different organs. Dysregulation of ACE2 abundance and activity has been implicated in various diseases. Emerging evidence highlights the role of ACE2 in COVID-19 susceptibility and severity.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Cell Biology
Lachlan G. Schofield, Richard G. S. Kahl, Samantha L. Rodrigues, Joshua J. Fisher, Saije K. Endacott, Sarah J. Delforce, Eugenie R. Lumbers, Jacinta H. Martin, Kirsty G. Pringle
Summary: The (P)RR is a multifunctional receptor involved in activating tissue renin-angiotensin system and regulating intracellular pathways. Our study demonstrated that (P)RR plays a crucial role in placental development and function, affecting trophoblast cell proliferation, migration, and invasion. Furthermore, altered (P)RR expression leads to changes in placental morphology and maternal blood space.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Lachlan George Schofield, Sarah A. Marshall, Sarah J. Delforce, Saije K. Morosin, Eugenie R. Lumbers, Kirsty G. Pringle
REPRODUCTIVE SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Sonia Tamanna, Sarah J. Delforce, Saije K. Morosin, Dirk F. Van Helden, Eugenie R. Lumbers, Kirsty G. Pringle
REPRODUCTIVE SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Alyssa J. Lochrin, Sarah J. Delforce, Eugenie R. Lumbers, Kirsty G. Pringle
REPRODUCTIVE SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Saije K. Morosin, India A. Brooker, Ava Tollard, Richard G. S. Kahl, Oyepeju M. Onifade, Eugenie R. Lumbers, Kym Rae, Kirsty G. Pringle
REPRODUCTIVE SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
Sarah J. Delforce, Fisher J. Joshua, Eugenie R. Lumbers, G. Pringle Pringle
REPRODUCTIVE SCIENCES
(2023)