Hederagenin Attenuates Cerebral Ischaemia/Reperfusion Injury by Regulating MLK3 Signalling

The protective effect of Hederagenin on pulmonary fibrosis by regulating the Ras/JNK/NFAT4 axis in rats

(2020) Wenjing Ma et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation

(2020) Seiya Takada et al.   Journal of Neuroinflammation

Guanine nucleotide–binding protein G(i)α2 aggravates hepatic ischemia-reperfusion injury in mice by regulating MLK3 signaling

(2019) Qikai Sun et al.   FASEB JOURNAL

Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF-κB activation

(2019) Qian Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke

(2019) Xi Zhang et al.   Journal of Neuroinflammation

Sodium Benzoate Attenuates Secondary Brain Injury by Inhibiting Neuronal Apoptosis and Reducing Mitochondria-Mediated Oxidative Stress in a Rat Model of Intracerebral Hemorrhage: Possible Involvement of DJ-1/Akt/IKK/NFκB Pathway

(2019) Weilin Xu et al.   Frontiers in Molecular Neuroscience

Network pharmacology identification of mechanisms of cerebral ischemia injury amelioration by Baicalin and Geniposide

(2019) Jie Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Echinocystic acid, a natural plant extract, alleviates cerebral ischemia/reperfusion injury via inhibiting the JNK signaling pathway

(2019) Hailong Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats

(2019) Wen Zheng et al.   EXPERIMENTAL NEUROLOGY

The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke

(2019) Xiaoyan Yang et al.   NEUROPHARMACOLOGY

Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke

(2019) Can Yang Zhang et al.   Science Advances

Best practice in research – Overcoming common challenges in phytopharmacological research

(2019) Michael Heinrich et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cpg-ODN, a TLR9 Agonist, Aggravates Myocardial Ischemia/Reperfusion Injury by Activation of TLR9-P38 MAPK Signaling

(2018) Liang Xie et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mst1: function and mechanism in brain and myocardial ischemia reperfusion injury

(2018) Di Li et al.   Current Neuropharmacology

Neuregulin-1β Plays a Neuroprotective Role by Inhibiting the Cdk5 Signaling Pathway after Cerebral Ischemia-Reperfusion Injury in Rats

(2018) Rui Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Ferulic acid ameliorates cerebral infarction by activating Akt/mTOR/4E‑BP1/Bcl‑2 anti‑apoptotic signaling in the penumbral cortex following permanent cerebral ischemia in rats

(2018) Chin‑Yi Cheng et al.   Molecular Medicine Reports

Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential

(2018) Xiaojun Feng et al.   PHARMACOLOGICAL RESEARCH

Losartan protects against cerebral ischemia/reperfusion-induced apoptosis through β-arrestin1-mediated phosphorylation of Akt

(2017) Lin Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions

(2017) Revathy Guruswamy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

6-Gingerol protects intestinal barrier from ischemia/reperfusion-induced damage via inhibition of p38 MAPK to NF-κB signalling

(2017) Yanli Li et al.   PHARMACOLOGICAL RESEARCH

Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice

(2017) An-Guo Wu et al.   PHARMACOLOGICAL RESEARCH

Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats

(2017) Gyeong-Ji Kim et al.   Nutrients

Hi1a as a Novel Neuroprotective Agent for Ischemic Stroke by Inhibition of Acid-Sensing Ion Channel 1a

(2017) Yandong Ren et al.   Translational Stroke Research

Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats

(2015) Su-Hong Lu et al.   Evidence-based Complementary and Alternative Medicine

Hederagenin, a major component of Clematis mandshurica Ruprecht root, attenuates inflammatory responses in RAW 264.7 cells and in mice

(2015) Chul Won Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Involvement of norepinephrine and serotonin system in antidepressant-like effects of hederagenin in the rat model of unpredictable chronic mild stress-induced depression

(2014) Bao-Fang Liang et al.   PHARMACEUTICAL BIOLOGY

The exact science of stroke thrombolysis and the quiet art of patient selection

(2013) Joyce S. Balami et al.   BRAIN

Triterpene acids from euscaphis and assessment of their cytotoxic and anti-no activities

(2012) LJ Zhang et al.   PLANTA MEDICA

S-Nitrosylation of Mixed Lineage Kinase 3 Contributes to Its Activation after Cerebral Ischemia

(2011) Shu-Qun Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative determination of hederagenin in rat plasma and cerebrospinal fluid by ultra fast liquid chromatography–tandem mass spectrometry method

(2011) Xuemei Yang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Critical factors in the development of tumor-targeted anti-inflammatory nanomedicines

(2011) Maria Coimbra et al.   JOURNAL OF CONTROLLED RELEASE

Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-κB and p38 pathways

(2009) Ji-Yeon Kim et al.   FOOD AND CHEMICAL TOXICOLOGY