Article
Geriatrics & Gerontology
T. Sun, Z. Ma, L. Gao, Y. Wang, Hui Xie
Summary: The study of 2511 elderly subjects found a positive correlation between sarcopenia and arteriosclerosis, with a higher prevalence of sarcopenia in subjects with high baPWV. Additionally, HGS was negatively correlated with baPWV. These findings suggest potential shared pathophysiological mechanisms between arteriosclerosis and sarcopenia, with implications for future interventions.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Chemistry, Analytical
Kenshi Saho, Masahiro Fujimoto, Yoshiyuki Kobayashi, Michito Matsumoto
Summary: In this study, the effectiveness of a model using micro-Doppler radar for fall risk detection was verified by collecting actual MDR data from community-dwelling elderly people. The classification accuracy achieved for the actual MDR data was 78.8%. The validity of the experimental results was confirmed based on a comparison with the results of a previous simulation study.
Review
Public, Environmental & Occupational Health
Cathrine Axfors, John P. A. Ioannidis
Summary: This mixed design synthesis estimated the infection fatality rate (IFR) of COVID-19 in community-dwelling elderly populations and other age groups through seroprevalence studies. The results showed that the IFR in community-dwelling elderly was lower than previously reported.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Mathuramat Seesen, Wachiranun Sirikul, Jetsada Ruangsuriya, Jiranan Griffiths, Penprapa Siviroj
Summary: The study found a correlation between malnutrition and cognitive frailty among Thai elderly, with MNA-SF category and score being independently associated factors, while serum prealbumin level and anthropometric measurements showed no correlation with cognitive frailty. Advanced age and low educational level were also identified as risk factors for cognitive frailty.
Review
Public, Environmental & Occupational Health
Xiaoyu Ren, Xianliang Zhang, Qiang He, Litao Du, Ke Chen, Si Chen, Yang Pan
Summary: This systematic review aims to estimate the prevalence of sarcopenia among community-dwelling Chinese populations aged 65 years and older and to characterize its epidemiology. The overall prevalence of sarcopenia in community-dwelling older adults aged over 65 years in the Chinese population was 17.4%.
Article
Neurosciences
Erin L. Richard, Linda K. McEvoy, Eyal Oren, John E. Alcaraz, Gail A. Laughlin, Andrea Z. LaCroix, Rany M. Salem
Summary: In older men, albuminuria and hyperuricemia are associated with cognitive decline. However, no such associations were detected in women. eGFR showed no significant association with cognitive performance in either sex.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Psychology, Clinical
Jingjing Fu, Zhen Cheng, Siqi Liu, Zongping Hu, Zhu Zhong, Yu Luo
Summary: This study aimed to develop and test the psychometric properties of peer relationship scales for Chinese community-dwelling elderly. The results supported a two-factor model for PRS-Quantity and a three-factor model for PRS-Quality, showing good reliability and validity. These scales can be useful tools for assessing social health and service effectiveness among elderly individuals.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2021)
Article
Medicine, General & Internal
Yuesong Pan, Jing Jing, Xueli Cai, Zening Jin, Suying Wang, Yilong Wang, Chunlai Zeng, Xia Meng, Jiansong Ji, Long Li, Lingchun Lyu, Zhe Zhang, Lerong Mei, Hao Li, Shan Li, Tiemin Wei, Yongjun Wang
Summary: This study investigated the prevalence and vascular distribution of multiterritorial atherosclerotic plaque and stenosis in older community-dwelling populations in China. The study found that atherosclerotic plaque was highly prevalent and a substantial proportion of individuals had stenosis of 50% or greater.
Article
Environmental Sciences
Yanru Sang, Jingjing Zhang, Kaiyong Liu, Qunan Wang, Sufang Wang, Jie Sheng, Li Wang, Dongmei Zhang, Xiude Li, Hongjuan Cao, Annuo Liu, Fangbiao Tao
Summary: The study found that elderly individuals exposed to specific types of antibiotics, potentially from the food chain, may contribute to obesity. Specifically, norfloxacin concentrations were associated with body mass index, waist circumference, and body fat percentage. Women were found to have a higher risk of obesity compared to men.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Geriatrics & Gerontology
Ottavia Eleonora Ferraro, Antonio Guaita, Simona Villani
Summary: This study evaluated 993 elders and identified three different aging trajectories, finding that individuals with the worst performance had the highest incidence of dementia. Factors such as female gender, obesity, and low education were more represented in the severe trajectory group.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yongkang Su, Shuxia Wang, Jin Sun, Yan Zhang, Shouyuan Ma, Man Li, Anhang Zhang, Bokai Cheng, Shuang Cai, Qiligeer Bao, Ping Zhu
Summary: This study in Chinese older adults found a significant association between the TyG index and arterial stiffness assessed by baPWV. For each SD increase in the TyG index, the baPWV increased by 49 cm/s.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
E. Karoopongse, V Srinonprasert, C. Chalermsri, W. Aekplakorn
Summary: Anemia is a significant public health issue among the elderly population in Thailand, being associated with an increased risk of mortality. Individuals with anemia and low MCV levels have a higher risk of mortality, highlighting the importance of systematic screening for at-risk patients. Further research focusing on the causes of anemia and factors contributing to mortality in individuals with normal to high MCV levels is warranted for improving mortality risk identification and management among older individuals.
SCIENTIFIC REPORTS
(2022)
Article
Peripheral Vascular Disease
Yan Zhang, Akira Fujiyoshi, Aya Higashiyama, Miyoko Utsumi, Tatsuya Takeshita, Nobuyuki Miyai, Mikio Arita
Summary: Among healthy elderly individuals, there is a negative association between muscle mass and atherosclerosis, and this association is stronger than the relationship between body mass index (BMI) and atherosclerosis in the elderly population. This study suggests that muscle mass provides more important information on atherosclerosis in the elderly than BMI does.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Medicine, General & Internal
Sriprapa Loonlawong, Weerawat Limroongreungrat, Thanapoom Rattananupong, Kamonrat Kittipimpanon, Wanvisa Saisanan Na Ayudhaya, Wiroj Jiamjarasrangsi
Summary: The study aimed to determine the predictive validity of the fall-risk screening algorithm based on the STEADI program for Thai elderly in the community. The results showed that the screening based on the clinician's 3 key questions had a high AUC, sensitivity, and specificity. However, there were slight differences in risk categorization compared to the original STEADI program.
Review
Biochemistry & Molecular Biology
Michael Poledniczek, Christoph Neumayer, Christoph W. Kopp, Oliver Schlager, Thomas Gremmel, Alicja Jozkowicz, Michael E. Gschwandtner, Renate Koppensteiner, Patricia P. Wadowski
Summary: Inflammation plays a crucial role in the development and progression of atherosclerosis. It negatively affects endothelial barrier properties, glycocalyx, and extracellular matrix composition, leading to vascular remodeling, aneurysm formation, and reduced tissue perfusion. This review discusses the molecular and clinical effects of inflammatory processes on micro- and macrovasculature, with a focus on peripheral artery disease.
Article
Cardiac & Cardiovascular Systems
Erifili Venieri, Constantina Aggeli, Aris Anastasakis, Helen Sambatakou, Christodoulos Stefanadis, Dimitrios Tousoulis
Summary: This study assessed the mitral valve in HCM patients and found that patients with and without obstruction share some common anatomic features, but those with obstruction have unique characteristics that may contribute to LVOT obstruction.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Review
Pharmacology & Pharmacy
Hassan Yousefi, Ladan Mashouri, Samuel C. Okpechi, Nikhilesh Alahari, Suresh K. Alahari
Summary: The outbreak of the novel coronavirus has caused a major global public health concern, with over 31 million cases confirmed and efforts being made to repurpose existing cancer drugs to treat COVID-19. These drugs target the viral replication cycle and immune response, offering a potential novel approach to combat the virus.
BIOCHEMICAL PHARMACOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Georgios Zakynthinos, Gerasimos Siasos, Evangelos Oikonomou, Maria Gazouli, Konstantinos Mourouzis, Marina Zaromitidou, Vasiliki Tsigkou, Evanthia Bletsa, Panagiota Stampouloglou, Stamatis Tsouroulas, Georgios Marinos, Konstantinos Vlasis, Manolis Vavuranakis, Christodoulos Stefanadis, Dimitris Tousoulis
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Eirini Pagkalidou, Athanasios Kordalis, Spyridon Deftereos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: Our network meta-analysis identified the most effective antiarrhythmics for pharmacologic cardioversion over different time settings, with intravenous vernakalant and flecainide showing the highest conversion rate within 4 hours. Flecainide, especially when compared to propafenone, demonstrated superiority for conversion rates within 12 hours, while amiodarone exhibited efficacy within 24 hours, particularly if ranolazine was added.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Gastroenterology & Hepatology
Corey J. Ketchem, Craig C. Reed, Zoe Stefanadis, Evan S. Dellon
Summary: The study evaluated the efficacy of a compounded fluticasone suspension for treating eosinophilic esophagitis, showing significant improvements in symptoms and endoscopic findings, with over a third of patients achieving histologic response.
DISEASES OF THE ESOPHAGUS
(2021)
Letter
Cardiac & Cardiovascular Systems
Dimitrios A. Vrachatis, George V. Giannopoulos, Sotiria G. Giotaki, Konstantinos Raisakis, Charalampos Kossyvakis, Konstantinos E. Iliodromitis, Bernhard Reimers, Dimitrios Tousoulis, Michael Cleman, Christodoulos Stefanadis, Alexandra Lansky, Spyridon G. Deftereos
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)