4.6 Article

Body mass index trajectories and prostate cancer risk: Results from the EPICAP study

Journal

CANCER MEDICINE
Volume 9, Issue 17, Pages 6421-6429

Publisher

WILEY
DOI: 10.1002/cam4.3241

Keywords

body mass index; obesity; prostate cancer; trajectory; weight gain

Categories

Funding

  1. Ligue nationale contre le cancer
  2. Agence Nationale de Securite Sanitaire de l'Alimentation, de l'Environnement et du Travail
  3. Fondation de France
  4. Ligue departementale du Val de Marne

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Elevated body mass index (BMI) has been inconsistently associated with prostate cancer occurrence but it has been suggested that life course adulthood obesity may be associated with an increased risk of prostate cancer. However, few studies have investigated lifetime BMI and prostate cancer risk. We analyzed life course BMI trajectories on prostate cancer risk based on data from the Epidemiological study of Prostate Cancer (EPICAP). We included in our analyses 781 incident prostate cancer cases and 829 controls frequency matched by age. Participants were asked about their weight every decade from age 20 to two years before reference date. BMI trajectories were determined using group-based trajectory modeling to identify groups of men with similar patterns of BMI changes. We identified five BMI trajectories groups. Men with a normal BMI at age 20 developing overweight or obesity during adulthood were at increased risk of aggressive prostate cancer compared to men who maintained a normal BMI. Our results suggest that BMI trajectories resulting in overweight or obesity during adulthood are associated with an increased risk of aggressive prostate cancer, particularly in never smokers, emphasizing the importance of maintaining a healthy BMI throughout adulthood.

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