Article
Medicine, Research & Experimental
Fan Xue, Zheng He, De-Zheng Zhuang, Feng Lin
Summary: This study provides evidence for the causal effects of specific gut microbial taxa on circulating inflammatory cytokines and sheds light on their potential roles in the development and progression of various host diseases.
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Haijian Sun, Yunke Guo, Haidan Wang, Ailing Yin, Jing Hu, Tianjie Yuan, Shuxin Zhou, Weichen Xu, Peng Wei, Shusheng Yin, Panru Liu, Xi Guo, Yizhao Tang, Yujiao Yan, Zichen Luo, Majie Wang, Qingqing Liang, Peng Wu, Aifeng Zhang, Zhuxiu Zhou, Yueyue Chen, Yongming Li, Jing Li, Jinjun Shan, Wei Zhou
Summary: This study found that the food-derived Parabacteroides distasonis can ameliorate the development of rheumatoid arthritis (RA) and is negatively correlated with disease activity in RA patients. In addition, 3-oxoLCA and isoLCA can inhibit the development of RA by stimulating TGR5 and promoting macrophage polarization.
Article
Biochemistry & Molecular Biology
Shi-Le Wang, Man-Man Zhang, Han Zhou, Guo-Qiang Su, Yi Ding, Guang-Hui Xu, Xu Wang, Cheng-Fu Li, Wei-Feng Huang, Li-Tao Yi
Summary: This study suggests that inhibition of NLRP3 inflammasome regulates gut microbiota and attenuates IBD-like symptoms, providing a basis for the clinical application of NLRP3 as a target for the treatment of IBD.
BIOMEDICAL JOURNAL
(2023)
Article
Food Science & Technology
Lingyu Zhu, Yang Song, Huilin Liu, Min Wu, Haizhou Gong, Hainan Lan, Xin Zheng
Summary: Beta-carotene has significant effects on anti-inflammatory response and gut microbiota composition in a rat UC model, improving colitis severity and regulating inflammatory cytokine levels. Beta-carotene alleviates DSS-induced UC by modulating the gut microbiota, providing a potential target for UC treatment.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Immunology
Jiana Huang, Peigen Chen, Yuting Xiang, Qiqi Liang, Taibao Wu, Jiawen Liu, Yanyan Zeng, Haitao Zeng, Xiaoyan Liang, Chuanchuan Zhou
Summary: This study explores the role of gut microbiota-derived macrophage pyroptosis in polycystic ovary syndrome (PCOS). The results show that dysbiosis of gut microbiota leads to reduced Akkermansia and increased gram-negative bacteria, along with elevated lipopolysaccharide levels in PCOS mice. Pyroptosis disrupts estrogen production and promotes apoptosis of granulosa cells. Interferon-gamma, which is elevated in PCOS, enhances pyroptosis and its effect on estrogen receptor in granulosa cells. Disulfiram and metformin may be potential therapeutic strategies for PCOS by enhancing Akkermansia abundance and suppressing macrophage pyroptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Peng Qiu, Takatsugu Ishimoto, Lingfeng Fu, Jun Zhang, Zhenyong Zhang, Yang Liu
Summary: Crohn's disease and ulcerative colitis are two main forms of inflammatory bowel disease (IBD), and intestinal microorganisms play a key role in the development and maintenance of these diseases. However, the specific causes of IBD are still unclear, and it is unknown whether a single transmissible agent is involved. Changes in the bacterial communities in the gut may be due to inflammatory reactions and tissue destruction, rather than causing the disease itself. Antibiotic therapy has generally been ineffective in treating IBD, but recent studies suggest that manipulating the gut microbiota and interacting with the gut immune system through probiotics, prebiotics, and synbiotics may hold potential in controlling these diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Environmental Sciences
Lei Zhang, Jiaru Jing, Lin Han, Jingyu Wang, Wei Zhang, Ziyan Liu, Ai Gao
Summary: This study identified critical characteristics of gut microbiota, metabolism and cytokines involved in benzene-induced hematopoietic toxicity. The decline in hematopoietic stem cells occurred earlier than hematological changes in mice exposed to benzene, with disrupted homeostasis of gut microbiota, metabolism and cytokine. Additionally, specific bacteria, metabolites and cytokines were associated with benzene-induced hematopoietic damage, indicating potential mechanisms for further exploration.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biotechnology & Applied Microbiology
Stefano Bibbo, Gianluca Ianiro, Federica Giambo, Carlo Romano Settanni, Giovanni Cammarota, Antonio Gasbarrini
Summary: The gut microbiota plays a crucial role in cancer pathophysiology and therapy response. Studies have shown that modulation of the microbiota can help predict and improve the response to immunotherapy, with promising results particularly in melanoma research.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Zhi Liu, Xuhua Mao, Zhou Dan, Yang Pei, Rui Xu, Mengchen Guo, Kangjian Liu, Faming Zhang, Junyu Chen, Chuan Su, Yaoyao Zhuang, Junming Tang, Yankai Xia, Lianhong Qin, Zhibin Hu, Xingyin Liu
Summary: The study systematically explored the interplay between host genetic variation and gut microbiota in ASD children, finding that ASD SNVs were significantly enriched in specific genes and correlated with microbial composition and metabolism. The abundance of metabolites involved in the metabolic network of neurotransmitters was inferred to be causally related to specific SNVs and microbes, suggesting a crucial role of host genetics and gut microbes in immune and metabolism homeostasis in ASD.
Review
Nutrition & Dietetics
Helena R. Rocha, Marta C. Coelho, Ana M. Gomes, Manuela E. Pintado
Summary: Numerous epidemiologic studies have shown that the consumption of fruits and vegetables can decrease the risk of various chronic diseases. The positive health benefits are attributed to secondary plant metabolites, particularly carotenoids and their metabolites, which affect gene expression and protein translation. However, there is still a lack of research on the digestive processes, stability, functionality, and impact on gut microbiota of carotenoids, as well as their role in oxidative stress and inflammatory pathways. Future studies should focus on understanding the relationships between carotenoids, related metabolites, and their effects on transcription factors and metabolism.
Review
Cell Biology
Xiao-hang Qian, Xiao-xuan Song, Xiao-li Liu, Sheng-di Chen, Hui-dong Tang
Summary: Multiple studies in the past decade have shown the close relationship between gut microbiota and Alzheimer's disease (AD), but the specific mechanism is still unclear. Inflammation, both neuroinflammation and systemic inflammation, play a key role in accelerating the process of AD. Gut microbiota regulation of inflammation is crucial in the development of AD.
AGEING RESEARCH REVIEWS
(2021)
Review
Immunology
Man Wang, Yuan Zhang, Chunmei Li, Wenguang Chang, Lei Zhang
Summary: The global health crisis caused by COVID-19 highlights the importance of competent immune responses and the disastrous consequences of immune dysregulation. The gut microbiota plays a vital role in immune homeostasis and the gut-lung crosstalk, and its disruption, known as gut dysbiosis, can contribute to COVID-19 progression. This review provides an overview of alterations in gut microbiota in COVID-19 patients and summarizes the bidirectional regulation between intestinal microbes and host immunity in the pathology of SARS-CoV-2.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Yongjia Hu, Zhouzhou Chen, Chengchen Xu, Shidong Kan, Daijie Chen
Summary: Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disease whose pathogenesis is still unclear. Disturbances in the gut microbiota are associated with IBD, and probiotics may have beneficial effects on IBD but face challenges in application.
Review
Medicine, Research & Experimental
Min'an Zhao, Jiayi Chu, Shiyao Feng, Chuanhao Guo, Baigong Xue, Kan He, Lisha Li
Summary: The gut microbiota plays a crucial role in maintaining host health by enhancing digestion, protecting the intestinal barrier, and interacting with the immune system. Dysbiosis of the gut microbiota, caused by various factors, is a major contributor to inflammatory diseases. The mechanisms underlying these diseases resulting from gut microbiota dysbiosis are not well categorized.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Metallurgy & Metallurgical Engineering
Jin-Meng Wang, Xiang Sun, Liang Song, M. Bobby Kannan, Fen Zhang, Lan-Yue Cui, Yu-Hong Zou, Shuo-Qi Li, Rong-Chang Zeng
Summary: This study investigated the effects of intermetallic compounds on the formation mechanism of Mg-Al layered double hydroxide (LDH) steam coatings and the corrosion behavior. The results showed that citric acid pretreatment significantly influenced the activity of the alloy surface, promoting the growth of the coatings and improving the corrosion resistance of the coated alloy.
JOURNAL OF MAGNESIUM AND ALLOYS
(2023)
Article
Chemistry, Physical
Lei Cai, Xiang Song, Cheng-Bao Liu, Lan-Yue Cui, Shuo-Qi Li, Fen Zhang, M. Bobby Kannan, Dong-Chu Chen, Rong-Chang Zeng
Summary: This work presents the design and preparation of a novel organic-inorganic hybrid coating for corrosion protection of magnesium alloys. By incorporating polyvinyl alcohol (PVA) and neodymium nitrate (Nd(NO3)3) into the micro-arc oxidation (MAO) coating, the properties of the coating are improved and self-healing function is achieved.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Nutrition & Dietetics
Linxi Ma, Huaijun Tu, Tingtao Chen
Summary: In the 21st century, more and more people are advocating compressive health and functional foods to eliminate sub-health conditions. Probiotics and postbiotics have become the focus of scientific and nutrition communities. However, there are noteworthy safety concerns and disadvantages associated with the mature and wide application of probiotics, and postbiotics have both considerable potential and plentiful drawbacks that should be optimized.
Article
Biotechnology & Applied Microbiology
Xin-liang Wang, Wen-jie Chen, Rui Jin, Xuan Xu, Jing Wei, Hong Huang, Yan-hua Tang, Chang-wei Zou, Ting-tao Chen
Summary: In this study, the researchers constructed engineered probiotics CB-GLP-1 by transforming CB with recombinant plasmid pMTL007 encoded with hGLP gene. The results showed that CB-GLP-1 significantly reduced blood pressure and improved cardiac markers in SHR rat models. The high-throughput sequencing further demonstrated that CB-GLP-1 treatments improved gut microbiome dysbiosis. Therefore, CB-GLP-1 could be a potential treatment for hypertension.
MICROBIAL BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Lixin Long, Yang Song, Xiaoyi Tian, Lanyue Cui, Chengbao Liu, Shuoqi Li, Yu Wang, Rongchang Zeng
Summary: This study prepared a micro-arc oxidation/polymethyltrimethoxysilane (MAO/PMTMS)@hemin-induced calcium-bearing phosphate microsphere (Hemin-CaP) coating and applied it to magnesium bone implants, demonstrating rapid and effective bacteriostasis and broad-spectrum antibacterial activity.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Physical
Dan Jiang, Yun-Zhi Liu, Bo Li, Shuo Chen, Shuo-Qi Li, Wen-Jiu Yang, Lan-Yue Cui, Rong-Chang Zeng
Summary: In this study, polyelectrolytes such as PEI, PSS, PAA, and PPA were used to enhance the degradation resistance and mechanical properties of hydroxyapatite (HA) coatings on Mg alloys. The composition and microstructure of the samples were characterized using various techniques. Nanoindentation, electrochemical methods, and hydrogen evolution were employed to investigate the mechanical behavior and degradation of the coatings. Density functional theory calculations were performed to understand the role of the polyelectrolytes in the interlocking process. The results highlight the potential of polyelectrolytes in improving the performance of HA coatings on Mg alloys.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Physical
Kui Xue, Yan-Jin Li, Tian-Hao Ma, Lan-Yue Cui, Cheng-bao Liu, Yu-hong Zou, Shuo-Qi Li, Fen Zhang, Rong-Chang Zeng
Summary: In this research, a self-assembled amorphous calcium carbonate (ACC)@curcumin (Cur) loaded polymethyltrimethoxysilane (PMTMS) coating on micro-arc oxidation (MAO) coated magnesium (Mg) alloy was proposed to overcome the issues of rapid corrosion and bacterial infection in using biodegradable Mg alloy for biomedical materials. The coating exhibited favorable corrosion resistance, dual antibacterial ability, and good biocompatibility. Cur was employed as an antibacterial agent and photosensitizer for photothermal therapy. The core of ACC significantly improved the loading of Cur and the deposition of hydroxyapatite corrosion products during degradation, thus enhancing the long-term corrosion resistance and antibacterial activity of Mg alloys.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Food Science & Technology
Jian-zhao Zhang, Fang-yuan Zhu, En-xu Feng, Fei Wu, Xin Fang, Huai-jun Tu, Jin Wei, Ai-lan Wan, Ting-tao Chen
Summary: This study found that probiotics adjuvant therapy could enhance the efficacy of conventional medications in patients with depressive BD-I and reduce metabolic side effects.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Gastroenterology & Hepatology
Xinyue Hu, Xuan Xu, Xiangdi Zeng, Rui Jin, Shengnan Wang, Huifu Jiang, Yuwen Tang, Guanxiang Chen, Jing Wei, Tingtao Chen, Qi Chen
Summary: This study found that the gut microbiota (GM) of patients with epithelial ovarian cancer (EOC) differs from that of healthy women, showing GM dysbiosis. Furthermore, the GM from EOC patients promotes tumor progression and activates Hh signaling as well as inflammation. Therefore, the role of GM in EOC development should not be overlooked, and improving GM dysbiosis could be a novel therapeutic approach for delaying EOC development.
Article
Biotechnology & Applied Microbiology
Yun Wang, Wen-jie Chen, Yi-yang Han, Xuan Xu, Ai-xia Yang, Jing Wei, Dao-jun Hong, Xin Fang, Ting-tao Chen
Summary: In this study, an engineered strain of Clostridium butyricum-GLP-1 was constructed and its neuroprotective mechanism on Parkinson's disease (PD) mice models was investigated. The results showed that C. butyricum-GLP-1 improved PD by promoting PINK1/Parkin mediated mitophagy and attenuating oxidative stress.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Chengbao Liu, Li Cheng, Lan-Yue Cui, Peimin Hou, Bei Qian, Rong-Chang Zeng
Summary: This article validates a robust strategy based on damage-induced fluorescence enhancement effect to visualize dynamic damage-healing processes in anticorrosion coatings on magnesium alloy AZ31. Through embedding fluorescent poly-dopamine nanoparticles into thermo-responsive epoxy resin, immediate fluorescence was intensified at coating damages. The prepared coating possessed pronounced healing and corrosion protection capability with near-infrared irradiation, and the healing behavior can be traced and visualized based on the decrease in fluorescence intensity. This work opens a new avenue to monitor the failure and self-healing mechanism of anticorrosion coatings, providing guideline for engineering of next-generation smart protection materials.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Li-Xin Long, Fen-Fen Chen, Lan-Yue Cui, Ze-Song Wei, Hai-Tao Wang, Rong-Chang Zeng, Yu-Feng Zheng
Summary: The microstructure, mechanical properties, and degradation rates of LX11 and LX41 alloys were studied through optical microscopy, tensile tests, and electrochemical tests. The LX11 alloy exhibited finer grains, fewer twins, and smaller intermetallic phase volume fractions compared to the LX41 alloy. Increasing Li concentration resulted in a slight decrease in yield strength, a substantial increase in elongation, and a stable ultimate tensile strength for the Mg-Li-Ca alloys. LX11 alloy showed superior corrosion resistance compared to LX41 alloy. The release rate of metallic ions in Hank's solution cannot accurately reflect the corrosion rate of Mg-Li-Ca alloys due to the formation of corrosion products and their solubility difference.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Kaige Zhang, Hui Liu, Peng Liu, Qi Feng, Lihong Gan, Ling Yao, Gen Huang, Ziling Fang, Tingtao Chen, Nian Fang
Summary: This study shows that the administration of Lactiplantibacillus plantarum MH-301 can improve postoperative symptoms in patients with internal hemorrhoids. High-throughput sequencing analysis reveals that the group treated with L. plantarum MH-301 has a higher diversity of intestinal microbiota and a higher relative abundance of beneficial bacteria such as Bifidobacterium, Megamonas, and Lactobacillus. Therefore, L. plantarum MH-301 can enhance the efficacy of endoscopic sclerotherapy and improve bowel movements.
Article
Materials Science, Multidisciplinary
Yuanyuan Wang, Chengbao Liu, Zuojun Jiao, Lei Cai, Cong Sun, Deming Wang, Lanyue Cui, Cuie Wen, Rong-Chang Zeng
Summary: This study investigates the corrosion behavior and mechanical properties of an extruded Mg-4Li-1Ca alloy under different micro-compressive stresses. The results show that micro-compressive stress can induce grain growth and precipitation of second-phase particles, accelerating the corrosion rate. However, when the stress level reaches a certain point, the volume fraction of the second phase becomes the dominant factor controlling the corrosion rate, and residual stress is released, forming corrosion product films that weaken the microstructural effect on corrosion behavior.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2024)
Article
Entomology
Wei Hu, Rongkun Zheng, Xianglin Feng, Fan Kuang, Jiong Chun, Hanhong Xu, Tingtao Chen, Junhua Lu, Weimin Li, Ning Zhang
Summary: This study found that mineral oils demonstrate toxic and antifeedant effects on Diaphorina citri Kuwayama, a serious insect pest of citrus. The oils also inhibit the emergence of adults and reduce the spread of huanglongbing, highlighting their importance in pest control.
INTERNATIONAL JOURNAL OF PEST MANAGEMENT
(2023)