Article
Medicine, General & Internal
Cajsa Aranaes, Christian E. Edvardsson, Olesya T. Shevchouk, Qian Zhang, Sarah Witley, Sebastian Blid Skoeldheden, Lindsay Zentveld, Daniel Valloef, Maximilian Tufvesson-Alm, Elisabet Jerlhag
Summary: This study found that glucagon-like peptide1 receptor (GLP-1R) agonists can reduce alcohol intake and prevent relapse in rodents. The results also showed that semaglutide has a suppressive effect on alcohol-induced behavior and its impact on the brain. These findings suggest that semaglutide may be effective in reducing alcohol consumption and body weight by reducing the rewarding effects of alcohol and its impact on neurons.
Article
Neurosciences
Jidong Fang, Patti Miller, Patricia S. Grigson
Summary: The study found that liraglutide dose-dependently decreased wakefulness and increased non-rapid eye movement (NREM) sleep, primarily during the dark period. The decrease in body weight after liraglutide treatments suggests its therapeutic effect on obesity.
BRAIN RESEARCH BULLETIN
(2023)
Article
Behavioral Sciences
Kayla J. Colvin, Henry S. Killen, Maxwell J. Kanter, Maximilian C. Halperin, Liv Engel, Matthew B. Dickinson, Anna Fimmel, James G. Holland, Paul J. Currie
Summary: This study investigated the effects of ghrelin and glucagon-like peptide-1 (GLP-1) on ethanol intake and their interaction with d-amphetamine and cocaine in rats. The results showed that ghrelin increased ethanol intake and potentiated the effects of d-amphetamine and cocaine, while GLP-1 inhibited ethanol intake and antagonized the effects of d-amphetamine and cocaine.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Adrianne M. DiBrog, Katherine A. Kern, Ashmita Mukherjee, Johnathan T. Przybysz, Elizabeth G. Mietlicki-Baase
Summary: Obesity is a prevalent disease with limited treatment options. This study investigated the effects of the alpha-7 nicotinic acetylcholine receptor (alpha 7nAChR) agonist GTS-21 on food intake and body weight in rats. The results showed that GTS-21 did not decrease food intake or body weight in rats, and it also did not induce GLP-1 secretion in rats. These findings suggest important differences between rats and mice in the response to GTS-21/alpha 7nAChR activation.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Chemistry, Medicinal
Yongliang Yuan, Zhiming Yan, Qifang Lao, Neng Jiang, Shuangmin Wu, Qinpei Lu, Jing Han, Songfeng Zhao
Summary: The development of a unimolecular triple agonist peptide targeting GLP-1, glucagon, and Y2 receptors shows great potential as a novel anti-obesity and anti-diabetic agent. This peptide, 3b, demonstrated potent activity in reducing food intake without causing nausea and had better effects on lipid metabolism, body weight, and glycemic control compared to other agonist counterparts. Targeting GLP-1R, GCGR, and Y2R with a unimolecular triple agonist peptide offers a promising route for developing new treatments for obesity and T2DM.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yasmine Al-Sabagh, Hayley Thorpe, Bryan Jenkins, Shahnaza Hamidullah, Malik Talhat, Cara Suggett, Cristine Reitz, Mina Rasouli, Tami Martino, Jibran Khokhar
Summary: Alcohol misuse contributes to approximately 3 million premature deaths annually. Disruption of circadian rhythms is a risk factor for alcohol misuse, but this relationship is poorly understood. This study suggests that genetic variation in REV-ERB alpha may be involved in differences in alcohol drinking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chao-Shun Chan, Fong-Jhih Lin, Yao-Chang Chen, Yung-Kuo Lin, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen
Summary: GLP-1 receptor agonists reduce the risk of atrial fibrillation by regulating the activity of protein kinase A, calmodulin-dependent protein kinase II, and the Na+/Ca2+ exchanger, and by modulating intracellular calcium homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xian-kun Tu, Quan Chen, Song Chen, Bin Huang, Bao-gang Ren, Song-sheng Shi
Summary: Liraglutide can reduce brain injury, inhibit inflammatory response and neuronal apoptosis, showing neuroprotection in a rat model of subarachnoid hemorrhage.
Article
Cardiac & Cardiovascular Systems
Xuefei Liu, Kaushik P. Patel, Hong Zheng
Summary: The study reveals that activation of renal sympathetic nerves contributes to the blunted diuretic and natriuretic effects of GLP-1 in HFD obese rats. The renal nerve-neprilysin-GLP-1 pathway is involved in renal dysfunction during obesity that leads to hypertension.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Maria Elena Quilaqueo, Sofia Adasme, Fresia Solis-Egana, Maria Elena Quintanilla, David Vasquez, Paola Morales, Mario Herrera-Marschitz, Mario Rivera-Meza
Summary: The aim of this study was to assess the effect of Alda-1 on relapse-like ethanol intake in alcohol-preferring UChB rats and investigate the possible mechanisms associated with its effects. The results showed that Alda-1 significantly blocked relapse-like ethanol intake and increased Iba-1 reactivity in the nucleus accumbens of ethanol deprived rats. Alda-1 did not influence the levels of GLT-1, oxidative stress markers (MDA, GSH) or GFAP reactivity in the mesocorticolimbic system.
Article
Pharmacology & Pharmacy
Songfeng Zhao, Zhiming Yan, Yue Du, Zeyun Li, Chunli Tang, Lin Jing, Lidan Sun, Qimeng Yang, Xueling Tang, Yongliang Yuan, Jing Han, Neng Jiang
Summary: This study demonstrates the therapeutic potential of dual agonists targeting GLP-1/glucagon and GLP-1/CCK2 receptors in the treatment of obesity and diabetes. The newly developed peptide, xGLP-1/GCG/gastrin, showed significant anti-diabetes and anti-obesity effects in both in vitro and in vivo experiments.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Ira S. S. Rostevanov, Batya Betesh-Abay, Ahmad Nassar, Elina Rubin, Sarit Uzzan, Jacob Kaplanski, Linoy Biton, Abed N. N. Azab
Summary: This study aimed to examine the behavioral effects and inflammatory mediator levels of chronic MTK treatment in male and female rats. The results suggest that MTK may be associated with select beneficial behavioral outcomes and differentially affects male vs. female rats in respect to brain inflammatory mediators.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Jade L. Thornton, Nicholas A. Everett, Paige Webb, Anita J. Turner, Jennifer L. Cornish, Sarah J. Baracz
Summary: The study found that adolescent oxytocin treatment can prevent the expression of depressive-like behaviors following early life stress in both male and female rats. Early life stress resulted in weight loss, while oxytocin treatment had no impact on body weight but prevented the increase in adrenal gland weight caused by early life stress.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Wen-Hsuan Tsai, Fung-Chang Sung, Lu-Ting Chiu, Ying-Hsiu Shih, Ming-Chieh Tsai, Shu- Wu
Summary: Patients with diabetes mellitus receiving GLP1-RA therapy have a greater reduction in the risk of anxiety than that of depression. The treatment effectiveness is significant for women and patients taking GLP1-RA for longer than 180 days. Dulaglutide could significantly decrease risks of both anxiety and depression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Tina Zimmermann, Leo Thomas, Tamara Baader-Pagler, Peter Haebel, Eric Simon, Wolfgang Reindl, Besnik Bajrami, Wolfgang Rist, Ingo Uphues, Daniel J. Drucker, Holger Klein, Rakesh Santhanam, Dieter Hamprecht, Heike Neubauer, Robert Augustin
Summary: Obesity and its associated comorbidities require effective pharmaceutical interventions. BI 456906 is a dual agonist that reduces bodyweight by increasing energy expenditure and decreasing food intake.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Daniel Vallof, Aimilia Lydia Kalafateli, Elisabet Jerlhag
Article
Neurosciences
Jesper Vestlund, Aimilia Lydia Kalafateli, Erik Studer, Lars Westberg, Elisabet Jerlhag
Article
Biochemistry & Molecular Biology
Aimilia Lydia Kalafateli, Jesper Vestlund, Kirsten Raun, Emil Egecioglu, Elisabet Jerlhag
Summary: Studies on the use of salmon calcitonin to activate amylin receptors have shown effective reduction in alcohol behaviors in male rodents, but further research on selective AMYR agonists in both male and female rodents is needed.
Article
Biochemistry & Molecular Biology
Jesper Vestlund, Filip Bergquist, Valentina Licheri, Louise Adermark, Elisabet Jerlhag
Summary: GLP-1 receptor agonists, such as Ex4, liraglutide, and dulaglutide, have varying effects on motivation and learning in complex motor tasks, depending on the context. While Ex4 and liraglutide decreased motivation in skilled reach foraging tasks, dulaglutide enhanced learning in rats without prior experience. Additionally, Ex4 and liraglutide suppressed evoked field potentials in the NAc shell, highlighting the diverse behavioral outcomes of different GLP-1R agonists.
Article
Neurosciences
Aimilia Lydia Kalafateli, Cajsa Aranas, Elisabet Jerlhag
PSYCHOPHARMACOLOGY
(2020)
Article
Behavioral Sciences
Aimilia Lydia Kalafateli, Cajsa Aranas, Elisabet Jerlhag
Summary: Research has shown that activation of the amylin pathway can reduce cocaine-induced locomotor stimulation and dopamine release, without altering cocaine's rewarding properties or reward-dependent memory. The findings suggest a potential role for the amylinergic pathway in regulating the mesolimbic dopamine system activation caused by cocaine, and open the door for further exploration of amylin signaling in the modulation of other drugs of abuse.
HORMONES AND BEHAVIOR
(2021)
Review
Neurosciences
Aimilia Lydia Kalafateli, Tugce Munise Satir, Daniel Vallof, Henrik Zetterberg, Elisabet Jerlhag
Summary: Alcohol activates reward-processing brain areas causing stimulatory behavioral responses, while sCT attenuates alcohol-mediated behaviors when infused into the laterodorsal, ventral tegmental, and nucleus accumbens regions, indicating an inhibitory effect on alcohol-induced behaviors.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Cajsa Aranas, Jesper Vestlund, Sarah Witley, Christian E. Edvardsson, Aimilia Lydia Kalafateli, Elisabet Jerlhag
Summary: The study shows that the amylinergic pathway regulates certain nicotine-induced behaviors but does not affect nicotine-induced reward acquisition and expression. Additionally, the results demonstrate that sCT blocks nicotine's stimulatory effects and dopamine release, while preventing its impact on locomotor sensitization.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Substance Abuse
Kusum K. Kharbanda, Mehdi Farokhnia, Sara L. Deschaine, Raghav Bhargava, Marcela Rodriguez-Flores, Carol A. Casey, Anthony P. Goldstone, Elisabet Jerlhag, Lorenzo Leggio, Karuna Rasineni
Summary: Unhealthy alcohol consumption is a global health issue that has adverse consequences on individuals, public health, and society. Alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) are the most common pathologies among alcohol-related diseases. The liver is particularly vulnerable to alcohol-induced damage due to its role in alcohol metabolism. Currently, the only effective approaches to treating ALD are alcohol abstinence or liver transplantation. Ghrelin, a hormone primarily produced by the stomach, has dual effects on addictive behaviors and metabolic pathways, making it a potential therapeutic target for AUD and ALD. This review discusses recent advancements in understanding the peripheral and central functions of the ghrelin system and its involvement in AUD and ALD pathogenesis. The correlation between blood ghrelin levels and alcohol use or abstinence is examined, as well as the role of ghrelin in alcohol-seeking behaviors and the development of fatty liver. A better understanding of the ghrelin system could lead to improved treatments for AUD and its medical consequences, including ALD.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Psychiatry
Jesper Vestlund, Qian Zhang, Olesya T. Shevchouk, Daniel Hovey, Lundstrom Sebastian, Lars Westberg, Elisabet Jerlhag
Summary: Aggression is a complex social behavior that is regulated by the gut-brain hormone GLP-1. Preclinical and human genetic association studies have shown that GLP-1 can suppress aggressive behaviors through central neurotransmission.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Stina Borchers, Jil Carl, Katharina Schormair, Jean-Philippe Krieger, Mohammed Asker, Christian E. Edvardsson, Elisabeth Jerlhag, Karolina P. Skibicka
Summary: Studies show that contrary to the common notion that female rats are not aggressive, female rats also exhibit aggressive behavior outside of maternal context and find winning in aggressive interactions rewarding. This reward is similar to that experienced by male rats and is dopamine-dependent.
TRANSLATIONAL PSYCHIATRY
(2023)