Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 147, Issue -, Pages 281-290Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2016.08.009
Keywords
Albumin nanoparticles; Supramolecular association; beta-cyclodextrin; Adamantane; Self-assembly; Tumor targeting
Funding
- Basic Science Research Program through National Research Foundation of Korea (NRF) - Ministry of Science, ICT, and Future Planning [NRF-2014R1A2A2A05002133]
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Albumin has been viewed as one of the most attractive biomacromolecules for making nanoparticulate systems due to its biocompatibility and chemical functionality. Thus far, albumin nanoparticles (NPs) are prepared by several limited methods, such as, desolvation, emulsification or high-pressure homogenization. In this article, we introduce a new albumin NPs prototype fabricated via a 'host' ((3-cyclodextrin)-'guest' (adamantane) supramolecular association. These NPs (GC-CD/HSA-ADA NPs) consisted of13-cyclodextrin-modified glycol chitosan (GC-CD) and adamantane-conjugated human serum albumin (HSA-ADA) (GC-CD/HSA-ADA NPs) that were facilely prepared by a consequent dropwise mixing and sonication method. Doxorubicin-loaded GC-CD/HSA-ADA NPs exhibited an appropriate particle size (similar to 260 nm), good physicochemical stability (similar to 48 h), significant HCT116 cell cytotoxicity (IC50: 0.32 mu g/ml) and cell internalization. Furthermore, GC-CD/HSA-ADA NPs showed excellent tumor targetability probably due to gp60-mediated transcytosis mechanism because it was markedly accumulated in the tumor site of a HCT 116 cell-xenograft mouse. Based on these results, these albumin NPs will be promising for a new NP platform that can be applied for cancer therapy or imaging. (C) 2016 Elsevier B.V. All rights reserved.
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