Article
Polymer Science
Xiaohua Chang, Dengwen Hu, Liangren Chen, Yaping Wang, Yutian Zhu
Summary: Thermoresponsive block copolymer micelles have potential in biological applications, with studies showing that changes in hydrophobic/hydrophilic block ratio, micelle concentration and addition of salt can alter the cloud point. Increasing the amount of PLGA hydrophobic block significantly decreases the cloud point, while higher micelle concentration and salt addition also lower the cloud point.
Article
Polymer Science
Jidong Dai, Min Liang, Zhigang Zhang, Katrien Bernaerts, Tianzhu Zhang
Summary: By crosslinking nucleation to prepare crystalline 4arm-PLGA, the degradation rate of PLGA can be effectively controlled, promoting cell growth and potentially having ideal performance in tissue engineering.
Article
Polymer Science
M. Margarida Cardoso, Ines N. Peca, Telma Lopes, Rui Gardner, A. Bicho
Summary: DWNPs were produced with PLGA and PLLA containing doxorubicin as a model drug. Optical and fluorescence microscopy were used to examine the inner morphology and drug distribution of the double-walled microparticles. The study showed that the double-walled nanoparticles exhibited sustained drug release and the PLLA layer acted as a rate control barrier.
Article
Chemistry, Physical
Bong-Seop Lee
Summary: In a polymer-based drug delivery system, the polymer material entwines the drug and transports it to the desired target. Poly(lactide-co-glycolide) (PLGA) is a widely utilized controlled-release system for drugs with short half-lives, low stability, easy decomposition, and non-toxic side effects. Supercritical fluid (SCF) technology can be employed to prepare or micronize drug-loaded particles without the need for additional purification or cleaning procedures. The liquid-liquid phase transition behavior of PLGA in several supercritical fluids, including dimethyl ether (DME), CO2, chlorodifluoromethane (HCFC-22), and trifluoromethane (HFC-23), has been investigated. The phase behavior of PLGA is primarily controlled by the lactide-to-glycolide ratio in the copolymer backbone.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Biomedical
Yang Zhou, Yuecheng Cui, Li-Qun Wang
Summary: A dual-sensitive hydrogel was developed by introducing a photocrosslinkable group into triblock copolymers, allowing for excellent shear thinning properties and rapid elastic recovery properties. Through a two-step crosslinking strategy, tissue-like constructs with high shape fidelity can be printed using the dual-sensitive inks.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Materials Science, Multidisciplinary
Liuyun Jiang, Yingjun Ma, Shuo Tang, Yan Zhang, Shengpei Su
Summary: In this study, a functionalized hybrid nanohydroxyapatite (n-HA) was proposed to obtain a high-performance poly(lactide-co-glycolide) (PLGA)-based composite. By introducing carboxymethyl-beta-cyclodextrin (CMCD) and zoledronic acid (ZA), the mechanical and degradation properties of PLGA were improved, and the CMCD-ZA-n-HA also exhibited good biocompatibility and the ability to promote bone-like apatite deposition and cell proliferation in vitro.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Bukola A. Oseni, Chukwuemeka P. Azubuike, Omotunde O. Okubanjo, Cecilia I. Igwilo, Jayanth Panyam
Summary: Andrographolide, a potential chemopreventive and chemotherapeutic agent, was encapsulated in PLGA nanoparticles using emulsion solvent evaporation technique to improve its therapeutic efficacy. The optimal formulation, with a polymer ratio of 85:15 lactide to glycolide and ethyl acetate as the organic solvent, demonstrated sustained release of the drug and significantly enhanced in vitro anticancer efficacy compared to free drug in a metastatic breast cancer cell line. Further in-depth efficacy studies are warranted for the nanoparticle formulation of andrographolide.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lukasz Lamch, Kazimiera A. Wilk, Imre Dekany, Agota Deak, Viktoria Hornok, Laszlo Janovak
Summary: The encapsulation of hydrophilic and amphiphilic drugs in colloidal carrier systems for sustained release is a growing concern. The use of a core-shell approach with nanocarriers can provide a solution for hydrophilic/amphiphilic drugs. Amphiphilic polymers play a key role in stabilizing the system and enhancing the chemical stability and sustained release profiles.
Article
Engineering, Biomedical
Lucy Geddes, Efrosyni Themistou, James F. Burrows, Fraser J. Buchanan, Louise Carson
Summary: This study aimed to develop an in vitro protocol for assessing the long-term cytotoxicity of bioresorbable polymers. Results showed that PDLLGA samples exhibited increasing cytotoxicity at later degradation stages, while PLLGA samples demonstrated significantly less cytotoxic behavior. Additionally, a new dynamic flow culture methodology was developed and validated to test the cytotoxicity of these degradable materials, along with profiling of inflammatory cytokines released by cells in response to degraded PDLLGA and PLLGA.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Kinam Park, Andrew Otte, Farrokh Sharifi, John Garner, Sarah Skidmore, Haesun Park, Young Kuk Jhon, Bin Qin, Yan Wang
Summary: Injectable long-acting formulations, particularly those based on poly(lactide-co-glycolide) (PLGA), have been utilized for systemic drug delivery for up to 6 months, but the development of clinical products and generics has been slow. The limited understanding of PLGA polymers and the complex variables involved in composition and manufacturing processes hinder the control over formulation properties and drug efficacy. Factors such as formulation composition, manufacturing processes, and surface morphology play crucial roles in determining the pharmacokinetic profile of the formulations, highlighting the importance of proper characterization and control of these parameters for desired drug release kinetics and efficacy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Yihua Pei, Jianping Wang, Nisar Ul Khaliq, Fanfei Meng, Kaoutar A. Oucherif, Jie Xue, Sarena D. Horava, Amy L. Cox, Coralie A. Richard, Monica R. Swinney, Kinam Park, Yoon Yeo
Summary: Poly(lactide-co-glycolide) (PLGA) polymers are commonly used for drug delivery due to their biodegradability and biocompatibility. This study focused on achieving sustained drug release from PLGA microparticles (MPs) for two weeks using meloxicam. By encapsulating meloxicam as a solid and incorporating magnesium hydroxide (Mg(OH)2), the researchers were able to control the drug release kinetics of the MPs. The study demonstrated the feasibility of controlling drug release from PLGA MPs over weeks based on the physical state of the drug and the inclusion of Mg(OH)2 to neutralize the microenvironmental pH of the MPs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Maria Bialik, Joanna Proc, Anna Zgadzaj, Karolina Mulas, Marzena Kuras, Marcin Sobczak, Ewa Oledzka
Summary: This study developed thermosensitive liquid suppositories carrying the antihypertensive drug metoprolol tartrate. It was the first to use biodegradable nanoparticles to produce liquid metoprolol suppositories and optimized their rheological and mechanical properties for rectal administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Jaeik Song, Min-Suk Kook, Byung-Hoon Kim, Young-IL Jeong, Kyung-Jin Oh
Summary: ROS-sensitive nanoparticles were developed for CIP delivery to inhibit UTI, showing potential antibacterial activity in vitro without significant cytotoxicity to cells. Free CIP and CIP-incorporated nanoparticles demonstrated dose-dependent inhibitory effects against bacterial growth, with sustained release properties observed in the nanoparticles. Free CIP and CIP-incorporated nanoparticles showed superior antibacterial activity in a dialysis membrane model compared to free CIP.
Article
Biotechnology & Applied Microbiology
Anna Czapka, Christian Grune, Patrick Schaedel, Vivien Bachmann, Karl Scheuer, Michael Dirauf, Christine Weber, Alexios-Leandros Skaltsounis, Klaus D. Jandt, Ulrich S. Schubert, Dagmar Fischer, Oliver Werz
Summary: In this study, we encapsulated 6BIGOE into sustainable solvents-based PLGA nanoparticles, which resulted in efficient drug delivery systems with improved cellular uptake and the ability to mask cytotoxic effects. The anti-inflammatory properties of 6BIGOE were fully retained in these nanoparticles.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Monika Smiga-Matuszowicz, Jakub Wlodarczyk, Malgorzata Skorupa, Dominika Czerwinska-Glowka, Kaja Folta, Malgorzata Pastusiak, Malgorzata Adamiec-Organisciok, Magdalena Skonieczna, Roman Turczyn, Michal Sobota, Katarzyna Krukiewicz
Summary: This paper introduces a scaffold material made of PLGA/PISEB fibers and confirms its biocompatibility towards HUVEC. During a 12-week hydrolytic degradation process, the PLGA/PISEB fibers swell and disintegrate, resulting in the formation of highly developed structures resembling seaweeds. The change in the scaffold structure is expected to have a positive effect on blood vessel regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Tatiana Andreani, Joana F. Fangueiro, Sajan Jose, Antonello Santini, Amelia M. Silva, Eliana B. Souto
CURRENT PHARMACEUTICAL DESIGN
(2015)
Article
Chemistry, Multidisciplinary
Thomas A. Cinu, S. Kar Sidhartha, Bairy Indira, Bhat G. Varadaraj, P. Shenoy Vishnu, G. Gautham Shenoy
ARABIAN JOURNAL OF CHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Nila Mary Varghese, Venkatachalam Senthil, Sajan Jose, Cinu Thomas, Jyoti Harindran
CURRENT PHARMACEUTICAL ANALYSIS
(2020)
Article
Chemistry, Medicinal
Amol B. Khade, Sidhartha S. Kar, Cinu T. Alummoottil, Ashutosh Tiwari, Mradul Tiwari, Vandana K. Eshwara, Pritesh Bhat, Varadaraj B. Giliyar, Gurupur G. Shenoy
MEDICINAL CHEMISTRY
(2020)
Article
Education, Scientific Disciplines
Shan Mohanan, Sajan Jose
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2019)
Review
Medicine, General & Internal
Raquel Vieira, Selma B. Souto, Elena Sanchez-Lopez, Ana Lopez Machado, Patricia Severino, Sajan Jose, Antonello Santini, Amelia M. Silva, Ana Fortuna, Maria Luisa Garcia, Eliana B. Souto
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Polymer Science
Sajan Jose, Thomas A. Cinu, Rosmy Sebastian, M. H. Shoja, N. A. Aleykutty, Alessandra Durazzo, Massimo Lucarini, Antonello Santini, Eliana B. Souto
Review
Chemistry, Medicinal
Raquel Vieira, Selma B. Souto, Elena Sanchez-Lopez, Ana Lopez Machado, Patricia Severino, Sajan Jose, Antonello Santini, Ana Fortuna, Maria Luisa Garcia, Amelia M. Silva, Eliana B. Souto
Review
Pharmacology & Pharmacy
Sidhartha S. Kar, Cinu A. Thomas
CURRENT DRUG THERAPY
(2019)
Article
Pharmacology & Pharmacy
R. Vivek, Sajan Jose
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Bobby S. Prasad, K. K. Srinivasan, Jyoti Harindran
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
(2016)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)