Article
Clinical Neurology
Amtul S. Farheen, Ilena C. George, Divya Singhal, Regina M. Troxell, Jyoti Pillai, Logan Schneider, Catherine Lomen-Hoerth, Jennifer S. Graves, Stefano Sandrone, Christa O'Hana S. Nobleza
Summary: The article summarizes the literature on mentoring women, outlines ideal components of programs aimed at closing gender gaps, and presents a mentoring program for AAN members. Developing effective mentorship and sponsorship programs are crucial for ensuring a diverse pool of academic and private practitioners and establishing equal representation in leadership roles in the field.
Article
Hospitality, Leisure, Sport & Tourism
Gozde Ozdemir Ucgun, Salih Zeki Sahin
Summary: This study examines the potential effects of the Metaverse on tourism through exploratory research. The participants' opinions and evaluations on the interaction between the Metaverse and tourism were presented, covering various aspects such as the definition and characteristics of tourism, tourism businesses and employment, tourism experiences and satisfaction. The study found that the Metaverse has the potential to change the traditional concepts and characteristics of tourism, create its own tourism literature and sector, and positively affect tourism through various means such as sales and marketing, participation of disadvantaged groups, job creation, and realistic virtual experiences. Concerns about legal and personal issues, sustainability, and structural problems in tourism were also highlighted.
CURRENT ISSUES IN TOURISM
(2023)
Article
Oncology
Rachel Stewart, Michelle White, Jennifer Tan, Shankar Siva, Lama Karroum, Steven David
Summary: Oligometastatic breast cancer is a heterogeneous disease with intrinsic biological diversity. The review discusses treatment options, classifications, and potential future directions, emphasizing the role of local ablative treatments and systemic therapies. It also suggests the use of biological or genomic classifiers for predicting treatment benefits in the future.
Review
Genetics & Heredity
Tahir Zaib, Hibba Rashid, Hanif Khan, Xiaoling Zhou, Pingnan Sun
Summary: This review article provides a comprehensive summary of recent knowledge in syndactyly, including genetic etiology, phenotypic and genetic heterogeneity, gene mutations, the role of HOXD13, and modern surgical techniques. It also proposes a procedure for genetic analysis to improve genotype-phenotype correlation in the future.
Review
Oncology
Imke Boekestijn, Matthias N. van Oosterom, Paolo Dell'Oglio, Floris H. P. van Velden, Martin Pool, Tobias Maurer, Daphne D. D. Rietbergen, Tessa Buckle, Fijs W. B. van Leeuwen
Summary: Molecular imaging technologies are increasingly important in the diagnosis, monitoring, and treatment of cancer. The relevance and accessibility of surgical targets, as well as the selection of the correct combination of imaging agents for visualizing disease sites with high affinity and specificity are crucial. Developments within engineering/imaging physics continue to drive image-guided surgery, enhancing sensitivity and spatial resolution to ensure cancer sites are not overlooked during surgery.
Review
Surgery
Alaa El-Hussuna, Musliu Adetola Tolani
Summary: Surgical research has seen various patterns of collaboration, including global, specialist, trainee-/student-led, and patient-led collaboratives. Implementation of information technologies in surgical collaboration is limited, with early attempts to involve researchers from low-and middle-income countries.
Article
Urology & Nephrology
Athina Pirpiris, Garson Chan, Helen E. O'Connell, Johan Gani
Summary: This study aimed to objectively determine the interest of female trainees and consultants in pursuing a career in female urology (FU). Results showed that a significant portion of respondents selected a career in FU due to their gender, but many were also interested in the field independently. However, concerns were raised regarding the lack of awareness of FU in both the medical community and the public. Despite this, most trainees were optimistic about their future work opportunities in FU and expressed intentions to pursue further training in this sub-specialty.
Review
Immunology
Johnny Duerinck, Sandra Tuyaerts, Kiavash Movahedi, Bart Neyns
Summary: Despite efforts to improve outcomes, glioblastoma prognosis remains poor. Immunotherapy, including immune checkpoint inhibition, has limited efficacy in glioblastoma due to its low immunogenicity and strong immunosuppressive tumor microenvironment. This review discusses strategies to overcome immune suppression in glioblastoma, highlighting the potential advantages of incorporating surgical resection in immunotherapy clinical trials and the use of combination strategies for an effective immunological response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alberto A. Robles-Loaiza, Edgar A. Pinos-Tamayo, Bruno Mendes, Catia Teixeira, Claudia Alves, Paula Gomes, Jose R. Almeida
Summary: Peptide-based drugs are recognized by the pharmaceutical industry for their potential in developing innovative therapies, including for conditions like leishmaniasis. This review details over one hundred peptides and their biochemical and structural characteristics, as well as their potential use in designing antileishmanial drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Rahul Dev Mukhopadhyay, Ayyappanpillai Ajayaghosh
Summary: Metallo-supramolecular polymers have gained attention and development in the field of soft materials due to their well-defined topologies and dynamic metallosupramolecular interactions. These stimuli-responsive supramolecular structures have potential applications in optoelectronic device fabrication, but challenges remain in developing systems with offbeat applications and achieving precise control. Controlling the morphology of these soft materials also presents challenges. This review discusses recent developments and future directions, including synthetic methodologies and programmed synthesis techniques, for constructing stimuli-responsive metallosupramolecular systems.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Medicine, General & Internal
Donal P. McLornan, Janet E. Pope, Jason Gotlib, Claire N. Harrison
Summary: The understanding of the importance of JAK and STAT signalling in various disease states has led to the increasing use of therapeutic intervention with JAK inhibitors. These agents have revolutionised treatments for different disorders and shown rapid translation from bench to bedside. Future developments in the field of JAK inhibitors are promising.
Article
Computer Science, Information Systems
Jagadeesha R. Bhat, Salman A. Alqahtani
Summary: The next-generation cellular network, 6G, aims to overcome the limitations of current networks and become a game-changer in the telecom industry. Experts predict a sharp increase in performance requirements from various sectors in the next decade, with 6G being influenced by key requirements such as UN sustainability goals, business models, edge intelligence, digital divide, and machine learning trends.
Review
Biochemistry & Molecular Biology
Hanley N. Abramson
Summary: The landscape of therapeutic measures to treat multiple myeloma has changed significantly in recent years, primarily due to the introduction of new classes of small molecules and immunotherapeutic agents. These advancements have led to improved survival rates, but challenges such as drug resistance and relapse remain. This review discusses the currently available and emerging immunotherapeutic agents for multiple myeloma, highlighting their benefits and the challenges that need to be addressed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Ioannis M. Koukourakis, Vassilis Kouloulias, Dina Tiniakos, Ioannis Georgakopoulos, Anna Zygogianni
Summary: Rectal cancer treatment has advanced over the years, with surgery initially being the primary method. The addition of radiation and chemotherapy has improved postoperative treatments. Trials have shown the efficacy of neoadjuvant radiation or chemoradiotherapy, making them the standard choice for advanced cases. Total neoadjuvant therapy, delivering the entire course of treatment before surgery, has also shown promise. While targeted therapies have not shown benefit, immunotherapy may be effective in rectal carcinomas with mismatch-repair deficiency. This review provides a critical overview of significant randomized trials and discusses future trends in treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Leila T. Tchelebi, Cathy Eng, Craig A. Messick, Theodore S. Hong, Ethan B. Ludmir, Lisa A. Kachnic, Nicholas G. Zaorsky
Summary: The treatment of squamous cell carcinoma of the anus has shifted from radical surgery to sphincter-preserving chemoradiation, with chemotherapy using mitomycin-C and 5-fluorouracil found to be essential for cure. Advanced radiation techniques are now considered standard of care, and further studies are exploring the addition of immune checkpoint inhibitors in locally advanced cancers.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)