Article
Reproductive Biology
Naiara Z. Saraiva, Clara S. Oliveira, Nathalia N. C. Almeida, Marivaldo R. Figueiro, Carolina C. R. Quintao, Joaquim M. Garcia
Summary: This study investigated the epigenetic changes resulting from the use of histone deacetylase inhibitors in the maturation of bovine oocytes and subsequent embryo development. The results showed that the treatment with histone deacetylase inhibitors promoted the development of bovine oocytes and had a positive impact on embryo development.
Article
Horticulture
Chao Gong, Huihui Su, Zhenxing Li, Peiting Mai, Baojuan Sun, Zhiliang Li, Zhou Heng, Xiaowan Xu, Songguang Yang, Tao Li
Summary: Our study revealed that histone acetylation mediated by histone deacetylases (HDACs) plays a critical role in the resistance of tomato to bacterial wilt (BW). Most defense-related genes were up-regulated in resistant cultivar, while down-regulated in susceptible cultivar, and silencing of HDACs genes led to a decrease in disease incidence in susceptible cultivar. Under R. solanacearum infection, histone H3 and H4 acetylation levels of defense-related genes were increased, especially in the resistant cultivar.
SCIENTIA HORTICULTURAE
(2021)
Article
Multidisciplinary Sciences
Agnieszka Pierzynska-Mach, Alberto Diaspro, Francesca Cella Zanacchi
Summary: This study used single-molecule localization microscopy (SMLM) to analyze the nanoscale organization of DEK protein. It found differences in cluster features of DEK protein in different breast cell types and showed that the nanoscale organization of DEK clusters remains stable regardless of protein overexpression or chromatin compaction changes.
Article
Cell Biology
Joanna Moronczyk, Agnieszka Braszewska, Barbara Wojcikowska, Karolina Chwialkowska, Katarzyna Nowak, Anna M. Wojcik, Miroslaw Kwasniewski, Malgorzata D. Gaj
Summary: Somatic embryogenesis (SE) is a complex process involving the reprogramming of plant somatic cells, and histone acetylation plays a crucial role in regulating the expression of key transcription factor genes during SE. This study investigated the global and gene-specific changes in histone acetylation in Arabidopsis explants undergoing SE and identified H3 and H4 acetylation as potential regulators of critical TF genes. The findings also revealed that HDA19 negatively affects SE by regulating LEC1, LEC2, and BBM, and provided evidence of HDA19's involvement in histone acetylation-mediated regulation of LEC2 during SE.
Article
Multidisciplinary Sciences
Sean M. Callahan, Trevor J. Hancock, Ryan S. Doster, Caroline B. Parker, Mary E. Wakim, Jennifer A. Gaddy, Jeremiah G. Johnson
Summary: Histone modifications are involved in many processes in eukaryotes, including inflammation. Some bacterial pathogens use sirtuins to alter host histones and induce responses that promote infection. In this study, a Campylobacter jejuni deacetylase with sirtuin activities was found to contribute to activation of human neutrophils. This bacterial sirtuin is secreted into neutrophils, deacetylates host histones, and promotes neutrophil activation and extracellular trap production. The study also showed that this bacterial sirtuin is responsible for the inflammation and pathology observed during campylobacteriosis.
Article
Engineering, Environmental
Huanliang Liu, Lijie Tian, Man Qu, Dayong Wang
Summary: Using Caenorhabditis elegans as a model, the study demonstrates that CBP-1 mediates protective response to polystyrene nanoparticles (PS-NPs) toxicity by regulating various signaling pathways in intestinal, neuronal, and germline cells.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Zehao Zhou, Jian Zhao, Zhenghan Di, Bei Liu, Zhaohui Li, Xuemin Wu, Lele Li
Summary: A mesoporous MOF shell was synthesized on the surface of gold nanorods to capture single AuNRs for combinational phototherapy against solid tumors. The core-shell heterostructures combine a mesoporous structure and photoinduced singlet oxygen generation behavior with plasmonic photothermal conversion characteristic of AuNRs, enabling an efficient tumor treatment strategy. Applications beyond cancer therapy, such as plasmonic harvesting of light energy for catalytic reactions within MOFs and multifunctional nanocarriers for agricultural formulations, are also highlighted.
Article
Chemistry, Multidisciplinary
Xin Chai, Deyu Yi, Chuangui Sheng, Jian Zhao, Lele Li
Summary: This article presents a near-infrared light-controlled nanosystem that enables spatiotemporally controlled regulation of gene expression and combinational tumor therapy. The nanosystem is composed of enzyme-activatable antisense oligonucleotide, upconversion nanoparticle-based photodynamic system, and a mitochondria localization signal. The system utilizes photodynamic effect-induced translocation of a DNA repair enzyme to mitochondria for spatially selective gene regulation via enzymatic reactions. The study demonstrates that NIR light-induced mitochondrial photodamage and gene regulation enhance the antitumor effect.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Seung Hee Choi, Woo Seok Ahn, Myoung Hui Lee, Da Mon Jin, Areum Lee, Eun Yee Jie, Su Ji Ju, Sung Ju Ahn, Suk Weon Kim
Summary: Whole-plant regeneration through plant tissue culture is a complex process regulated by genetic and environmental factors. Epigenetic regulation has been found to play a crucial role in plant cell differentiation and pluripotency. In this study, the effects of epigenetic regulators on lettuce and tobacco protoplasts were tested, and it was found that these chemicals promoted cell division and callus formation. These findings suggest that these chemicals can be used to enhance plant regeneration and crop improvement.
Article
Pharmacology & Pharmacy
Yujie Fang, Jing Zhao, Xu Guo, Yunfeng Dai, Hao Zhang, Fanxin Yin, Xiaoxu Zhang, Chenxi Sun, Zequan Han, Hecheng Wang, Yanshuo Han
Summary: In this study, a prognostic model of ovarian cancer associated with histone acetylation modulator genes was established using TCGA database and validated externally. The accuracy of the model was verified through immunological bioinformatics analysis, and the tumor microenvironment and treatment response were evaluated. Ten histone acetylation modulators were identified as independent prognostic factors for ovarian cancer, and potential targeted drugs were screened.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seung Hee Choi, Myoung Hui Lee, Da Mon Jin, Su Ji Ju, Woo Seok Ahn, Eun Yee Jie, Ji Min Lee, Jiyoung Lee, Cha Young Kim, Suk Weon Kim
Summary: TSA treatment increases the efficiency of CRISPR/Cas9-mediated genome editing in plant cells by regulating chromatin de-condensation, especially in lettuce and tobacco protoplasts, showing a concentration-dependent increase in indel frequency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Fanyun Kong, Lihong Ma, Xing Wang, Hongjuan You, Kuiyang Zheng, Renxian Tang
Summary: Research has found that lysine acetylation plays a role in modulating molecules involved in EMT, including marker proteins, transcription factors, and signal transduction molecules. Histone acetylation functions through epigenetic regulation, while non-histone acetylation is a post-translational modification, both contributing to the control of EMT. Inhibitors targeting KATs and KDACs have potential therapeutic value in cancer treatment by suppressing EMT and tumor development.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Kwon Young Chou, Jun-Yeong Lee, Kee-Beom Kim, Eunjeong Kim, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: The budding yeast Saccharomyces cerevisiae is a widely used model system for studying histone modifications and chromatin states. Recent advances in biotechnology have allowed for the detection and quantification of protein post-translational modifications, leading to the identification of new modification sites in histones. Understanding the cellular functions of these new histone markers is crucial for unraveling epigenetic mechanisms and their impact on biological processes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Farzaneh Afkhami, Parisa Forghan, James L. Gutmann, Anil Kishen
Summary: The limitations of conventional root canal disinfection strategies and antimicrobials have affected the efficient elimination of microorganisms and their byproducts from infected root canals. Silver nanoparticles (AgNPs) have wide-spectrum anti-microbial activity, making them advantageous for root canal disinfection. Compared to other nanoparticulate antibacterials, AgNPs have acceptable antibacterial properties and relatively low cytotoxicity. They penetrate deeper into the complexities of the root canal systems and dentinal tubules, enhancing the antibacterial properties of endodontic irrigants and sealers.
Review
Cell Biology
Kenya Bonitto, Kirthana Sarathy, Kaiser Atai, Mithun Mitra, Hilary A. Coller
Summary: This article discusses the epigenetic changes during cell entry into and exit from quiescence, examines the role of different histone marks during quiescence, and explores the possibility of a quiescence histone code.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Physical
Timea Benko, Shaohua Shen, Miklos Nemeth, Jinzhan Su, Akos Szamosvolgyi, Zoltan Kovacs, Gyorgy Safran, Sahir M. Al-Zuraiji, Endre Zsolt Horvath, Andras Sapi, Zoltan Konya, Jozsef Sandor Pap
Summary: Photoelectrochemical water splitting can be more efficient by grafting co-catalysts on semiconductors. We used a non-noble metal pre-catalyst, [FeII(PBI)(3)](2+), on a nanopyramidal BiVO4 semiconductor to improve its performance and charge transfer efficiency.
APPLIED CATALYSIS A-GENERAL
(2023)
Article
Chemistry, Physical
Mohit Yadav, Imre Szenti, Marietta Abel, Akos Szamosvolgyi, Korneli B. Abrahamne, Janos Kiss, Pap Zsolt, Andras Sapi, Akos Kukovecz, Zoltan Konya
Summary: This study successfully synthesized platinum-gallium nanoalloy catalyst via ultrasound-assisted impregnation method, which exhibited excellent catalytic activity and H-2 formation rate in the steam reforming of ethanol reaction. This is attributed to the high interaction between gallium and platinum, resulting in enhanced dehydrogenation and acidic properties, thus increasing the yield of H-2.
Article
Chemistry, Physical
Gabor Vari, Csaba Vass, Gyula Halasi, Laszlo Szabo, Krisztian Palotas, Peter Dombi, Andras Berko, Laszlo Ovari, Zoltan Konya
Summary: In this study, the thermal properties of Au and Rh deposits on hexagonal boron nitride (h-BN) nanomesh prepared on Rh(1 1 1) were compared using various techniques. Both metals showed Volmer-Weber growth at room temperature, and agglomeration, intercalation, and desorption were observed upon annealing. For Rh, an additional encapsulation mechanism was suggested. The agglomeration of gold nanoparticles was found to be faster than that of rhodium, and gold atoms diffused below h-BN at higher temperatures. Intercalation of individual adatoms was observed during deposition, and it required higher temperatures for rhodium due to its slower diffusion and higher probability of nucleation.
APPLIED SURFACE SCIENCE
(2023)
Correction
Chemistry, Physical
Owais Al-Aqtash, Ferenc Farkas, Andras Sapi, Imre Szenti, Tamas Boldizsar, Kornelia B. Abrahamne, Akos Kukovecz, Zoltan Konya
REACTION KINETICS MECHANISMS AND CATALYSIS
(2023)
Article
Multidisciplinary Sciences
Hadid Sukmana, Gergo Ballai, Tamas Gyulavari, Erzsebet Illes, Gabor Kozma, Zoltan Konya, Cecilia Hodur
Summary: The study investigated the removal of methylene blue (MB) and basic red 9 (BR9) dyes using Hungarian rice husk (HRH) and Indonesian rice husk (IRH) as bioadsorbents. Various factors influencing the biosorption were evaluated using different techniques. The results showed that both HRH and IRH were effective in removing MB and BR9 through binary biosorption.
Article
Environmental Sciences
Zsuzsanna Kolbert, Arpad Molnar, Kamilla Kovacs, Sara Liptak-Lukacsik, Peter Benko, Reka Szollosi, Katalin Gemes, Laszlo Erdei, Andrea Ronavari, Zoltan Konya
Summary: This study compared the effects of different doses of multi-walled carbon nanotubes (MWCNTs) on Brassica napus and Solanum lycopersicum seedlings. It was found that higher concentrations of MWCNTs negatively affected root viability and cell proliferation, leading to oxidative stress and increased toxicity. The toxicity was more severe in Solanum lycopersicum compared to Brassica napus.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Green & Sustainable Science & Technology
Loghman Rezaei, Samrand Saeidi, Andras Sapi, M. R. Abdollahi Senoukesh, Gyula Grof, Wei-Hsin Chen, Zoltan Konya, Jiri Jaromir Klemes
Summary: The solar chimney power plant is a simple and clean technology to generate electricity from solar radiation. This study developed a novel collector design with hanging metallic tubes to improve efficiency. Experimental and computational fluid dynamics analysis validated the new design and found that the metallic tubes significantly affected temperature and velocity distribution. The efficiency of the collector increased with the hanging metallic tubes and was also influenced by the geometry variation.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Materials Science, Ceramics
Tamas Boldizsar, Henrik Bali, Imre Szenti, Imre Sebok-Papp, Zsolt Ban, Sara Herczeg, Gabor Barna, Andras Sapi, Akos Kukovecz, Zoltan Konya
Summary: In this study, lightweight cordierite-mullite ceramics with high strength and high thermal-shock resistance were successfully synthesized using hollow ceramic microspheres. The resulting cordierite material had a low bulk density of 1.40 g/cm3, apparent porosity of 44.78%, flexural strength of 20.17 MPa, and coefficient of thermal expansion of 2.26 x 10-6 oC-1, compared to the bulk counterpart with a bulk density of 2.00 g/cm3, apparent porosity of 25.75%, flexural strength of 23.69 MPa, and coefficient of thermal expansion of 2.47 x 10-6 oC-1. As a catalyst support, the economical cordierite showed the same stability and activity in CO2 hydrogenation towards C5+ fuels as the bulk cordierite-based catalyst counterparts.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Green & Sustainable Science & Technology
Samrand Saeidi, Andras Sapt, Asif Hussain Khoja, Sara Najari, Mariam Ayesha, Zoltan Konya, Bernard Baffour Asare-Bediako, Adam Tatarczuk, Volker Hessel, Frerich J. Keil, Alirio E. Rodrigues
Summary: Fossil fuel depletion, global warming, climate change, and rising fuel prices have prompted scientists to explore hydrogen as a commercial and environmentally friendly energy carrier. Steam methane reforming (SMR) is currently the most effective method for hydrogen production, but it faces challenges such as catalyst deactivation, coking, and CO2 generation. This article comprehensively reviews the influence of catalyst types, kinetic models, and operating conditions on high-yield H-2 production through conventional SMR, discusses intensified techniques for SMR to blue H-2, and proposes a novel and sustainable path for the SMR process to produce turquoise H-2 using new materials and emerging technologies. Additionally, the article discusses the critical points of steam reforming process technology to enhance environmental, social, and governance (ESG) profiling.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Nanoscience & Nanotechnology
Gergo Ballai, Tomaz Kotnik, Matjaz Finsgar, Albin Pintar, Zoltan Konya, Andras Sapi, Sebastijan Kovacic
Summary: Highly porous metal oxide-polymer nanocomposites with unique structural and functional features were prepared by coating metal oxide nanolayers onto polyHIPE beads using the ALD technique. It was found that the number of ALD cycles affected the thickness and crystallinity of the nanolayers. Furthermore, the ALD-derived TiO2-polyHIPE beads exhibited superior activity in photocatalytic oxidation.
ACS APPLIED NANO MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
Hadid Sukmana, Etelka Tombacz, Gergo Ballai, Gabor Kozma, Zoltan Konya, Cecilia Hodur
Summary: This study compares Indonesian and Hungarian rice husks as bio-adsorbents for removing dyes from aqueous solutions and finds that they are potential adsorbents.
Article
Materials Science, Multidisciplinary
Livia Vasarhelyi, Daniel Sebok, Imre Szenti, Adam Toth, Sara Levay, Robert Vajtai, Zoltan Konya, Akos Kukovecz
Summary: Mixing is a fundamental process in practically every industry, but there is a lack of literature on its 3D analysis. High-resolution computed tomography (micro-CT) is an ideal X-ray imaging tool for investigating the mixing of granular materials. In addition to qualitative analysis, 3D micro-CT images provide an opportunity for quantitative analysis, which is crucial for the efficiency and environmental impact of the mixing process. This study proposes lacunarity as a measure of mixing, which allows for a temporal description of mixing in three dimensions. The lacunarity curve provides additional information about the spatial distribution of grains compared to traditional mixing indices. Discrete element method simulations showed similar results to the experiments.
OXFORD OPEN MATERIALS SCIENCE
(2023)
Article
Biochemical Research Methods
Sanja Mutic, Dalibor Stankovic, Zoltan Konya, Jasmina Anojcic
Summary: A cholesterol biosensor (Naf/ChOx/Pt,Ru-C/IL-CPE) was developed by immobilizing cholesterol oxidase (ChOx) on Pt,Ru-C nanocomposite and an ionic liquid (IL)-modified carbon paste electrode (CPE) using Nafion (R) (Naf). The biosensor showed excellent analytical performance for cholesterol amperometric determination in phosphate buffer solution pH 7.50. Under optimized conditions, the biosensor exhibited a linear relationship between oxidation current and cholesterol concentration, with a detection limit of 0.13 mu M and low relative standard deviation (RSD). The biosensor also demonstrated good repeatability and high selectivity for cholesterol biosensing in human blood serum samples, making it a promising alternative to existing commercial cholesterol tests used in medical practice.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Krisztina Karadi, Thanh-Truc Nguyen, Adel Anna Adam, Kornelia Baan, Andras Sapi, Akos Kukovecz, Zoltan Konya, Pal Sipos, Istvan Palinko, Gabor Varga
Summary: Glucose-to-fructose isomerization is a key process in biomass conversion to fine chemicals. Catalyzing glucose isomerization in ethanol using hydrotalcite has shown promising results. The study reveals the relationship between the structural and textural parameters of hydrotalcites and their catalytic performance, indicating that hydrophilicity and LDH surface factors are the determining factors. A comparable catalytic performance with lower reaction temperature can be achieved using easily recyclable LDH with suitable surface features.
Article
Chemistry, Physical
Marianna Kocsis, Kornelia Baan, Sandor B. Otvos, Akos Kukovecz, Zoltan Konya, Pal Sipos, Istvan Palinko, Gabor Varga
Summary: Oxidative dehydrogenative coupling (ODC) is a versatile and sustainable tool for forming new C-C, C-O, and N=N bonds. However, it is less explored for N-heterocycle synthesis. In this study, we developed an environmentally friendly synthesis strategy to selectively produce azobenzenes, quinolines, and quinoxalines through the ODC of anilines and 2-aminoanilies with vicinal diols. The reactions were catalyzed by bifunctional catalysts based on transition metal oxides/Bi(iii), enabling solvent-, additive-, oxidant-, and base-free cyclizations/couplings. The catalysts showed high robustness and reusability.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)