Article
Polymer Science
Patrik Stenlund, Linnea Enstedt, Karin Margaretha Gilljam, Simon Standoft, Astrid Ahlinder, Maria Lundin Johnson, Henrik Lund, Anna Millqvist Fureby, Mattias Berglin
Summary: Current standard wound care lacks dressings that actively promote healing and is costly. In this study, we developed an environmentally friendly 3D printed bioactive hydrogel-based wound dressing suitable for hard-to-heal wounds. The dressing, composed of renewable marine components including heat-treated salmon roe extract, alginate, and nanocellulose, showed enhanced wound healing properties. The dressing was successfully tested on burn wounds and demonstrated accelerated wound closure and reduced inflammation.
Article
Dermatology
Dimitri Beeckman, Matthew Cooper, Emily Greenstein, Patricia Idensohn, Robert J. Klein, Norbert Kolbig, Kimberly Leblanc, Catherine Milne, Terry Treadwell, Dot Weir, Wendy White
Summary: Many community-based healthcare providers without specialized training in wound care are responsible for managing various types of wounds. Failure to recognize and address issues that cause delayed wound healing can lead to increased costs and suffering. To encourage early intervention, a panel of wound care experts developed evidence-based recommendations for community-based healthcare providers to identify and treat hard-to-heal wounds.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, Research & Experimental
Rahimeh B. Atashgah, Amir Ghasemi, Mohammad Raoufi, Mohammad-Amin Abdollahifar, Steven Zanganeh, Hossein Nejadnik, Alieh Abdollahi, Shahriar Sharifi, Baltazar Lea, Miguel Cuerva, Mehdi Akbarzadeh, Carmen Alvarez-Lorenzo, Seyed Nasser Ostad, Andrea S. Theus, Doris L. LaRock, Christopher N. LaRock, Vahid Serpooshan, Rouzbeh Sarrafi, Ki-Bum Lee, Hojatollah Vali, Holger Schoenherr, Lisa Gould, Pablo Taboada, Morteza Mahmoudi
Summary: A multifunctional wound dressing has been developed by the research team to target multiple challenges in wound healing, accelerating the healing process and representing a promising alternative to current products.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Lei Xu, Liqiang Ding, Yuehua Sun, Tong Zhang, Youfu Zhu, Bingyu Yan, Min Yang, Seeram Ramakrishna, Jun Zhang, Yun-Ze Long
Summary: In this study, a stretchable, flexible, and breathable bandage is developed for use on wounds in joints. It consists of three layers: Mxene coating on top, a Kirigami structure made of PLA/PVP in the middle, and an f-sensor at the bottom. This smart bandage features a monitoring-treatment closed-loop working mode, allowing real-time sensing of microenvironmental changes and anti-infection treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Bahram Mirani, Zhina Hadisi, Erik Pagan, Seyed Mohammad Hossein Dabiri, Antonia van Rijt, Lama Almutairi, Iman Noshadi, David G. Armstrong, Mohsen Akbari
Summary: Managing slow-healing wounds and associated complications is challenging. Systematic collection, analysis, and dissemination of correct wound status data are critical for enhancing healing outcomes and reducing complications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Dermatology
Jan Stryja, Katerina Tepla, Miroslav Routek, Vojtech Pavlik, Darja Perutkova
Summary: This study compared the clinical efficacy and safety of a novel hard-to-heal wound dressing (Sorelex) with a silver-based dressing. The results showed that Sorelex achieved better infection management, reduced wound slough, decreased wound size, promoted wound healing, and improved pain management. Compared to the standard-of-care dressing, Sorelex significantly improved the condition of surrounding skin after three weeks of treatment.
JOURNAL OF WOUND CARE
(2023)
Article
Chemistry, Multidisciplinary
Ziqi Liu, Junqing Liu, Tiancheng Sun, Deke Zeng, Chengduan Yang, Hao Wang, Cheng Yang, Jun Guo, Qianni Wu, Hui-Jiuan Chen, Xi Xie
Summary: Infection is the most common complication of chronic wounds, and tracking wound markers for accurate diagnosis holds great potential. A multiplex sensing bandage system has been developed for real-time monitoring of various indicators, showing promising applications in wound management and other diseases.
Article
Immunology
Thomas E. Serena, Robert J. Snyder, Philip G. Bowler
Summary: Fluorescence imaging provides accurate and relevant microbiological information, guiding tissue sampling and enabling earlier bacterial detection and intervention, particularly in large and complex wounds. This can help guide early and appropriate wound hygiene, potentially reducing the need for antibiotics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Eun Jo Jang, Rajkumar Patel, Madhumita Patel
Summary: Globally, diabetic mellitus (DM) is a common metabolic disease that inhibits insulin production, destroys pancreatic beta cells, and promotes hyperglycemia. This disease causes complications such as slow wound healing, increased risk of infection, and development of chronic wounds, which can be fatal. The current methods of wound healing are insufficient for diabetic patients due to a lack of antibacterial ability and sustained delivery of necessary factors. To address this, a new method of creating wound dressings using electrospinning has been developed, which mimics the extracellular matrix and effectively stores and delivers active substances for diabetic wound healing. This review discusses different polymers used in creating nanofiber membranes and their effectiveness in treating diabetic wounds.
Review
Medicine, General & Internal
Michael Burnet, Daniel G. Metcalf, Scarlet Milo, Clemens Gamerith, Andrea Heinzle, Eva Sigl, Kornelia Eitel, Marieke Haalboom, Philip G. Bowler
Summary: Traditionally, wound infection is defined by clinical signs and microbiological analysis. However, these approaches have limitations, especially in early or complex wounds. Patient-derived biomarkers of immune activation may indicate wound infection earlier and more reliably. Detection of innate immune cell enzymes offers a new, simple, and effective approach to determine wound infection status, enhancing infection resolution and wound healing.
Article
Engineering, Biomedical
Zhengyang Yang, Huanhuan Chen, Peizheng Yang, Xiaofei Shen, Yiqiao Hu, Yuhao Cheng, Hongwei Yao, Zhongtao Zhang
Summary: This study reports a technique to deliver dissolved oxygen locally into wound surface by adding lyophilized oxygen encapsulated nanoparticles to traditional gel-based wound dressings. The results show that this technique has therapeutic effects on hypoxic cells in vitro and on open wounds and diabetic mice models. With its biocompatibility, effectiveness and practicality, this hydrogel has significant transformation value in caring for and accelerating the healing of various clinical wounds, especially chronic wounds.
Article
Chemistry, Multidisciplinary
Zhan Xu, Jialiang Fan, Weiguo Tian, Xin Ji, Yuqian Cui, Qinying Nan, Feifei Sun, Jun Zhang
Summary: This study proposes a multifunctional dressing for the management of diabetic wounds. The dressing has rapid moisture-drained and non-adhesive properties, as well as pH-responsive and antibacterial capabilities. Wound monitoring can be easily conducted using a smartphone integrated with Python-RGB programs. Experimental results show that the dressing has a superior pro-healing rate, collagen deposition, and angiogenesis compared to commercial gauze.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Kelly McElvain, Joshua Klister, Alessandra Ebben, Sandeep Gopalakrishnan, Mahsa Dabagh
Summary: Chronic wounds have a significant impact on individuals' health-related quality of life and healthcare systems worldwide. This study investigates the influence of mechanotransduction on the healing process in chronic wounds through the development of three-dimensional tissue models. The results demonstrate that wound dressings with lower stiffness promote force transmission within the wound tissue, with larger dressings exerting higher stresses. These findings highlight the importance of dressing characteristics in promoting healing and provide insights for the design of precision dressings.
Article
Nanoscience & Nanotechnology
Wei Zhu, Ya-Qin Liu, Pei Liu, Jun Cao, Ai-Guo Shen, Paul K. Chu
Summary: A smart hydrogel dressing capable of consuming blood glucose and generating antibacterial agents is designed to promote wound healing. The hydrogel degrades glucose to produce hydrogen peroxide and gluconic acid, supporting a chemodynamic reaction that kills bacteria. Additionally, it can convert near infrared light into heat for photothermal therapy. This multifunctional hydrogel has great potential in the treatment of diabetic wounds.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Dermatology
Deborah Baines, Marissa Carter, Brenda Pimlott, Mkyla Reilly
Summary: This study aimed to evaluate the use of a point-of-care test for bacterial protease activity (BPA) in guiding antimicrobial dressing use for hard-to-heal wounds. The results showed that using the BPA test led to a reduction in nursing resource utilization, improved patient outcomes, and a decrease in antibiotic prescribing for wound-related infections. These findings highlight the importance of the BPA test in guiding wound treatment.
JOURNAL OF WOUND CARE
(2022)
Review
Materials Science, Multidisciplinary
Paul Galvin, Narayanasamy Padmanathan, Kafil M. Razeeb, James F. Rohan, Lorraine C. Nagle, Amelie Wahl, Eric Moore, Walter Messina, Karen Twomey, Vladimir Ogurtsov
JOURNAL OF MATERIALS RESEARCH
(2017)
Article
Education, Scientific Disciplines
Usama Saleh, Tom O'Connor, Tareq Afaneh, Zena Moore, Declan Patton, Rosemarie Derwin
NURSE EDUCATION TODAY
(2017)
Article
Chemistry, Analytical
Des Brennan, Helena Coughlan, Eoin Clancy, Nikolay Dimov, Thomas Barry, David Kinahan, Jens Ducree, Terry J. Smith, Paul Galvin
SENSORS AND ACTUATORS B-CHEMICAL
(2017)
Article
Chemistry, Analytical
Des Brennan, Barry Glynn, Gemma Keegan, Colette McDonagh, Thomas Barry, Paul Galvin
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Materials Science, Multidisciplinary
Desmond Brennan, Paul Galvin
MRS COMMUNICATIONS
(2018)
Review
Chemistry, Analytical
Mohammed Taj-Eldin, Christian Ryan, Brendan O'Flynn, Paul Galvin
Article
Chemistry, Analytical
Desmond Brennan, Louise O'Connor, Martin Cormican, James Kileen, Eoin Clancy, Terry J. Smith, Paul Galvin
Summary: A PCR assay was developed to screen Chlamydia trachomatis directly from urine with high sensitivity and specificity, suitable for implementation on a disposable cartridge system. The assay protocol involved heating urine samples to 85°C for ten minutes and performing a duplex realtime PCR on resulting urine lysate.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Dermatology
Rosemarie Derwin, Declan Patton, Pinar Avsar, Helen Strapp, Zena Moore
Summary: This systematic review assessed the impact of topical agents and dressings on wound pH, temperature, and healing outcomes. Different dressings and topical agents were found to reduce wound pH and improve outcomes, but due to the low certainty of evidence, specific recommendations could not be made. Further research is needed to better understand this topic.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Chemistry, Analytical
Julia Madden, Eoghan Vaughan, Michael Thompson, Alan O' Riordan, Paul Galvin, Daniela Iacopino, Sofia Rodrigues Teixeira
Summary: We developed a flexible laser scribed graphitic carbon based lactate biosensor with good working and storage stability for lactate detection.
Review
Geriatrics & Gerontology
Preethy Manoj, Rosemarie Derwin, Sherly George
Summary: Daily oral supplementation of 800 IU vitamin D3 plus 1200 mg calcium can effectively reduce hip fracture and non-vertebral fracture incidence in people over 65 years old; no significant impact on femoral neck bone mineral density.
INTERNATIONAL JOURNAL OF OLDER PEOPLE NURSING
(2023)
Article
Dermatology
Rosemarie Derwin, Declan Patton, Helen Strapp, Zena Moore
Summary: This study investigates the impact of inflammation management on wound pH, temperature, bacterial burden, and wound size, and demonstrates that it has a positive effect on these factors. It highlights the feasibility of using a structured approach to inflammation management to enhance wound outcomes.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Chemistry, Analytical
Julia Madden, Conor O'Mahony, Michael Thompson, Alan O'Riordan, Paul Galvin
SENSING AND BIO-SENSING RESEARCH
(2020)
Proceedings Paper
Engineering, Electrical & Electronic
Conor O'Mahony, Andrea Bocchino, Michael J. Haslinger, Daniel Fechtig, Klaudia Schossleitner, Paul Galvin, Stefan Brandstaetter
2019 IEEE 32ND INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS)
(2019)
