Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)
Article
Chemistry, Multidisciplinary
Jing-Jie Ye, Wuyang Yu, Bo-Ru Xie, Ke Li, Miao-Deng Liu, Xue Dong, Zhao-Xia Chen, Jun Feng, Xian-Zheng Zhang
Summary: Conventional cancer targeting methods have low efficiency and need reform. This study introduces the concept of self-reinforced cancer targeting (SRCT), which enhances targeting efficiency by correlating targeting with therapy. Experimental results demonstrate that a specific targeted nanovehicle can effectively target cancer cells and induce upregulation of target molecules.
Article
Engineering, Chemical
Yangjian Wang, Junshui Zheng, Jian Lin, Kai Ye, Peng Wei
Summary: In this study, a red light-triggered nanocarrier was synthesized to deliver photosensitizers to mitochondria and achieve light-activated release, resulting in significantly enhanced efficacy of photodynamic therapy.
ADVANCES IN POLYMER TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Maegen Kincanon, Catherine J. Murphy
Summary: The self-assembly of colloidal nanocrystals is of great interest for creating hierarchical nanomaterials with advanced function. Gold nanocrystals can enhance local electric fields and provide plasmonic fields for surface-enhanced spectroscopies. A selective biotinylation method was developed for gold nanorods, allowing for self-assembly upon addition of streptavidin. The self-assembly was analyzed for different sized nanorods, showing high yield for larger nanorods and low yield for smaller nanorods.
Article
Materials Science, Multidisciplinary
Wenyuan Xie, Chenguang Jiang, Xing Yu, Xinyu Shi, Shubin Wang, Yu Sun, Ming Yin, Defeng Wu
Summary: Biodegradable polymersomes were fabricated by blending amphiphilic block copolymers in an aqueous solution, resulting in various nanostructures depending on the hydrophobic chain length and incubation temperature. In equimolar mixtures, self-assembled morphologies were greatly affected by the formation of stereocomplexes. The SC-induced self-assembly can be controlled by changing the incubation temperature, making these polymersomes potentially useful in various applications.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Zhuangzhuang Zhang, Lijun Cheng, Qiongsi Zhang, Yifan Kong, Daheng He, Kunyu Li, Matthew Rea, Jianling Wang, Ruixin Wang, Jinghui Liu, Zhiguo Li, Chongli Yuan, Enze Liu, Yvonne N. Fondufe-Mittendorf, Lang Li, Chi Wang, Xiaoqi Liu, Tao Han
Summary: The study introduces a novel network-based systems biology approach, XDeath, to identify crosstalk of signaling pathways associated with PCa progression, and reveals the important roles of Plk1 and DNMT3a-related signaling pathways in PCa advancement, with a negative feedback mechanism between the two proteins.
Article
Biochemistry & Molecular Biology
Zulal Ozdemir, Uladzimir Bildziukevich, Martina Capkova, Petra Lovecka, Lucie Rarova, David Saman, Michala Zgarbova, Barbora Lapunikova, Jan Weber, Oxana Kazakova, Zdenek Wimmer
Summary: Several triterpenoid molecular ribbons showed better pharmacological profiles than their parent compounds, with good antimicrobial and antiviral activities. Some compounds displayed specific activity against HIV-1 and malignant melanoma cell lines.
Article
Biochemistry & Molecular Biology
Qijun Liu, Lin Zhou, Runxin Lu, Chunyan Yang, Siqi Wang, Li Hai, Yong Wu
Summary: In this study, multi-targeting liposomes based on glucose and biotin were constructed for the first time, showing promising efficacy in targeting glioma. The results indicated that the multi-targeting liposomes had satisfactory glioma-targeting ability in vitro and could be a potential formulation for glioma treatment, consistent with the in vivo imaging results.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Editorial Material
Cell Biology
Anna Mukha, Ugur Kahya, Anna Dubrovska
Summary: Prostate cancer's resistance to radiotherapy is a major hurdle in treatment efficacy, with mechanisms driving tumor cell survival and molecular prognostic markers lacking comprehensive understanding.
Article
Chemistry, Multidisciplinary
Panyong Zhu, Pin Lv, Yazhou Zhang, Rongqiang Liao, Jing Liu, Rong Guo, Xuan Chen, Xiali Liao, Chuanzhu Gao, Kun Zhang, Ming Yang, Bo Yang
Summary: CBD is a specific kind of cannabinoid in Cannabis sativa L with a wide range of pharmacological activities. In this study, a targeted carrier named BIO-CD was prepared by grafting biotin onto ethylenediamine-beta-Cyclodextrin, and an amantadine-conjugated cannabinoids (AD-CBD) was self-assembled with BIO-CD to form a host-guest inclusion complex. The inclusion complex demonstrated excellent targeted and anticancer activity against human cancer cell lines and could release drugs under weakly acidic conditions, showing potential for new therapeutic approaches in clinical applications.
FRONTIERS IN CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Sheng Li, Leilei Zhang, Guoan Zhang, Guoqiang Shangguan, Xitan Hou, Wanglin Duan, Yan Xi, Nan Xu, Bowen Zhang, Junli Dong, Yequan Wang, Wen Cui, Su Chen
Summary: Autophagy is a crucial biological process for maintaining cell homeostasis, with levels usually lower under normal conditions but still with important regulatory factors present. A study revealed that the autophagy-related protein ATG5 regulates c-Myc protein degradation through the ubiquitin-proteasome pathway in normal conditions, limiting cell growth and playing a key role in embryonic stem cell differentiation.
Article
Chemistry, Multidisciplinary
Jan Pille, Antonio Aloi, Duc H. T. Le, Ilia Vialshin, Nathalie van de Laar, Kirsten Kevenaar, Maarten Merkx, Ilja K. Voets, Jan C. M. van Hest
Summary: This study introduces a novel pathway-dependent assembly method based on stimulus-responsive polymers, which can form monodisperse and stable polymeric particles under specific heating conditions. This method shows high efficiency in encapsulating cargo, such as fluorescent proteins and bioluminescent enzymes, and maintaining their function within cells.
Article
Engineering, Environmental
Lihuan Shang, Ting Yang, Conglian Yang, Zhen Li, Li Kong, Zhiping Zhang
Summary: Carrier-free drug delivery systems based on drug self-assembly can improve the safety and efficacy of drug therapy. The developed ferrous ions-mediated self-assembly nanomedicine (p-QDF@M) showed high drug loading capacities in the combinational treatment of triple-negative breast cancer (TNBC), demonstrating enhanced antitumor efficacy.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Pin-Wei Lee, Adrian Saura-Sanmartin, Christoph A. Schalley
Summary: This study presents a supramolecular assembly method for superhydrophobic coatings using a low molecular weight gelator and acrylate polymers, resulting in scratch-resistant and transparent coatings. The incorporation of covalent polymers improves the mechanical resistance and optical transparency of the coatings while maintaining their water and oil repellency.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Audrey Lequeux, Muhammad Zaeem Noman, Malina Xiao, Kris Van Moer, Meriem Hasmim, Alice Benoit, Manon Bosseler, Elodie Viry, Tsolere Arakelian, Guy Berchem, Salem Chouaib, Bassam Janji
Summary: Inhibition of HIF-1 alpha transcriptional activity can increase levels of NK and CD8(+) T cells in the tumor microenvironment, enhancing the efficacy of cancer immunotherapy. Combining acriflavine can significantly improve the benefits of cancer immunotherapy based on TRP-2 peptide vaccination and anti-PD-1 blocking antibody, while melanoma patients with high CCL5 levels have a higher survival rate.
Review
Chemistry, Analytical
Sera Hong, Annie Agnes Suganya Samson, Joon Myong Song
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2020)
Article
Materials Science, Multidisciplinary
Annie Agnes Suganya Samson, Sera Hong, Baskaran Purushothaman, Jeongmin Lee, Joon Myong Song
APPLIED MATERIALS TODAY
(2020)
Article
Engineering, Biomedical
Sera Hong, Joon Myong Song
Summary: Drug-resistant cancer spheroids were fabricated using 3D bioprinting to evaluate the drug resistance of cancer cells. The study successfully created drug-resistant breast cancer spheroids using a gelatin-alginate hydrogel and demonstrated that these spheroids maintained their drug-resistant characteristics. The research also showed that the drug-resistant spheroids had higher expression levels of drug resistance markers compared to bulk cancer spheroids. Additionally, the study developed a method to determine the efficacy of anticancer drugs using the EC50 values based on in situ fluorescence imaging of the spheroids. This research provides a new approach for drug screening and evaluation in cancer treatment.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Sera Hong, Won Seok Choi, Baskaran Purushothaman, Jaemoon Koh, Hyo-Cheol Kim, Jin Wook Chung, Joon Myong Song, Jin Woo Choi
Summary: Through the technique of transparent tissue imaging, this study provides the first elucidation of the role of anti-cancer drugs in transarterial chemoembolization (TACE). The results indicate that the drugs have limited penetration distance and induce extensive tumor necrosis. Drug loading does not significantly affect immune responses. These findings are significant for a better understanding of drug delivery mechanisms in TACE and reevaluation of drug use in this procedure.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Analytical
Ayman A. Abdelrahim, Sera Hong, Joon Myong Song
Summary: A three-dimensional bioprinted cancer spheroid-embedded hydrogel model was proposed to evaluate the efficacy of anticancer drugs. The model successfully measured the fluorescence intensities of tumor spheroids in situ, without the need for separate measurements. Compared to two-dimensional cultures, the hydrogel model showed higher drug resistance and heterogeneous response, mimicking the tumor microenvironment.
ANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Sera Hong, Joon Myong Song
Summary: A 3D printing-based HepG2 liver spheroid culture model was developed for in situ quantitative evaluation and high-content monitoring of drug-induced hepatotoxicity, allowing for potential screening and characterization of drug-induced liver toxicity.
BIOMATERIALS SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Sera Hong, Baskaran Purushothaman, Joon Myong Song
Article
Materials Science, Biomaterials
Baskaran Purushothaman, Jinhyeok Choi, Solji Park, Jeongmin Lee, Annie Agnes Suganya Samson, Sera Hong, Joon Myong Song
JOURNAL OF MATERIALS CHEMISTRY B
(2019)