Article
Multidisciplinary Sciences
Arianna Baggiolini, Scott J. Callahan, Emily Montal, Joshua M. Weiss, Tuan Trieu, Mohita M. Tagore, Sam E. Tischfield, Ryan M. Walsh, Shruthy Suresh, Yujie Fan, Nathaniel R. Campbell, Sarah C. Perlee, Nathalie Saurat, Miranda Hunter, Theresa Simon-Vermot, Ting-Hsiang Huang, Yilun Ma, Travis Hollmann, Satish K. Tickoo, Barry S. Taylor, Ekta Khurana, Richard P. Koche, Lorenz Studer, Richard M. White
Summary: The intrinsic transcriptional program present in the cell of origin plays a key role in the transforming ability of oncogenes like BRAF(V600E), with developmental chromatin factors mediating oncogenic competence and allowing for proper response to oncogenes.
Article
Cell & Tissue Engineering
Pihu Mehrotra, Izuagie Ikhapoh, Pedro Lei, Georgios Tseropoulos, Yali Zhang, Jianmin Wang, Song Liu, Marianne E. Bronner, Stelios T. Andreadis
Summary: Neural crest-like stem cells derived from adult human tissues can maintain their multipotency and enhance their differentiation potential by activating Wnt and BMP signaling and metabolic reprogramming, suggesting potential implications for regenerative medicine.
Article
Biochemistry & Molecular Biology
Maria Eleni Kastriti, Louis Faure, Dorothea Von Ahsen, Thibault Gerald Bouderlique, Johan Bostroem, Tatiana Solovieva, Cameron Jackson, Marianne Bronner, Dies Meijer, Saida Hadjab, Francois Lallemend, Alek Erickson, Marketa Kaucka, Viacheslav Dyachuk, Thomas Perlmann, Laura Lahti, Jan Krivanek, Jean-Francois Brunet, Kaj Fried, Igor Adameyko
Summary: The study reveals the similarities between Schwann cell precursors (SCPs) and neural crest cells in terms of transcriptional profiles and cell fate. SCPs diverge from neural crest cells during lineage differentiation. Defects in SCPs may affect neural crest cells along peripheral nerves and are associated with certain tumor development.
Review
Cell Biology
Peter Fabian, J. Gage Crump
Summary: Of all the cell types arising from the neural crest, ectomesenchyme is unique as it generates connective tissue and skeletal cell types in common with mesoderm. The origin and potential of this ectoderm-derived mesenchyme is still debated, and recent studies are exploring intrinsic and extrinsic cues in determining its potential and its influence on craniofacial repair.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Alek G. Erickson, Polina Kameneva, Igor Adameyko
Summary: Since its discovery by His in 1850, the neural crest has been extensively studied for its crucial role in vertebrate development. Understanding the function and regulation of neural crest cell differentiation has made it an important model system in stem cell biology. Recent advancements in single cell multi-omics, statistical modeling, and developmental biology have provided valuable insights into the intriguing questions surrounding neural crest cells.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marie A. Lefevre, Rodolphe Soret, Nicolas Pilon
Summary: This review provides an updated overview of the cellular diversity and functions of the enteric nervous system (ENS), focusing on the important role of enteric glial cells (EGCs) in regulating bowel functions. It highlights the current research gap in understanding EGCs and their potential in regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zachary T. Olmsted, Janet L. Paluh
Summary: Researchers have successfully studied the co-development of the central and peripheral nervous systems with trunk mesendoderm in elongating multi-lineage organized (EMLO) gastruloids. They identified NCCs that differentiate to form peripheral neurons integrated with an upstream spinal cord region after day 8.
NATURE COMMUNICATIONS
(2021)
Review
Cell & Tissue Engineering
Surangi N. Perera, Laura Kerosuo
Summary: The neural crest (NC) is a unique embryonic stem cell population in vertebrates, contributing to a wide range of derivatives. Recent discoveries have revealed the coexpression of pluripotency factors in NC cells, leading to the proposal of a new term pleistopotent. Studies on the maintenance of NC stemness are crucial for understanding its contribution to tissue formation.
Article
Biochemistry & Molecular Biology
Margot E. Bowen, Abigail S. Mulligan, Aryo Sorayya, Laura D. Attardi
Summary: Studies show that hyperactivation of p53 in embryonic neural crest cells leads to developmental defects, but deleting key components of the apoptotic pathway does not rescue these defects, suggesting p53 hyperactivation can trigger developmental phenotypes via alternative pathways.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell & Tissue Engineering
Prateeksha Prateeksha, Prathyusha Naidu, Manjusri Das, Derek Barthels, Hiranmoy Das
Summary: This study reveals the critical role of KLF2 in the neurogenesis of dental pulp-derived stem cells, by inducing autophagy and mitophagy. These findings provide new insights into the treatment of neurodegenerative disorders.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Fanny Boulet, Gaelle Odelin, Alenca Harrington, Thomas Moore-Morris
Summary: This study provides direct evidence for valve formation defects in Nipbl+/- mice and suggests specific developmental abnormalities as the origin of valve disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Hyun-Jee Kim, Sungho Shin, Seon-Yeong Jeong, Sun-Ung Lim, Dae-Won Lee, Yunhee-Kim Kwon, Jiyeon Kang, Sung-Won Kim, Chan-Kwon Jung, Cheolju Lee, Il-Hoan Oh
Summary: TB-MSCs derived from the turbinate exhibit unique characteristics compared to BM-MSCs, showing higher neural crest-like properties and a distinct secretome profile. While TB-MSCs have potential for neurogenic differentiation, they also display comparable immunosuppressive effects as BM-MSCs, but with a stronger stimulatory effect on breast cancer cell growth and metastasis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Ling Tao, Myrthala Moreno-Smith, Rodrigo Ibarra-Garcia-Padilla, Giorgio Milazzo, Nathan A. Drolet, Blanca E. Hernandez, Young S. Oh, Ivanshi Patel, Jean J. Kim, Barry Zorman, Tajhal Patel, Abu Hena Mostafa Kamal, Yanling Zhao, John Hicks, Sanjeev A. Vasudevan, Nagireddy Putluri, Cristian Coarfa, Pavel Sumazin, Giovanni Perini, Ronald J. Parchem, Rosa A. Uribe, Eveline Barbieri
Summary: This study shows that CHAF1A gain-of-function supports cell malignancy, blocks neuronal differentiation, and promotes NB oncogenesis. Mechanistically, CHAF1A upregulates polyamine metabolism, which blocks neuronal differentiation and promotes cell cycle progression.
Article
Cell Biology
Steven L. Klein, Andre L. P. Tavares, Meredith Peterson, Charles H. Sullivan, Sally A. Moody
Summary: The formation of the embryonic ectoderm domains involves a series of signaling factor gradients. Early cell autonomous repressive transcription factor interactions within individual cells are followed by non-cell autonomous signaling between cells contributing to the separation of the domains.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Adam Shellard, Roberto Mayor
Summary: The neural crest uses durotaxis to follow stiffness gradients in adjacent placodal tissue, contributing to efficient collective cell migration. Durotaxis synergizes with chemotaxis to polarize actomyosin machinery of the cell group, promoting efficient directional cell migration in vivo.
Article
Dermatology
Alessia Paganelli, Elisabetta Tarentini, Luisa Benassi, Daniel Scelfo, Alessandra Pisciotta, Elena Rossi, Cristina Magnoni
Summary: This study assessed the interactions between ADSCs and ADMs in vitro and analyzed extracellular matrix production. Results showed that collagen production was significantly higher when ADSCs were seeded on ADM compared to other control conditions. The findings suggest that combined therapies using MSCs and collagenic ADMs could be promising options for chronic wounds, with ADMs potentially enhancing the regenerative properties of ADSCs.
SKIN RESEARCH AND TECHNOLOGY
(2022)
Article
Immunology
Rebecca Borella, Sara De Biasi, Annamaria Paolini, Federica Boraldi, Domenico Lo Tartaro, Marco Mattioli, Lucia Fidanza, Anita Neroni, Alfredo Caro-Maldonado, Marianna Meschiari, Erica Franceschini, Daniela Quaglino, Giovanni Guaraldi, Carlo Bertoldi, Marco Sita, Stefano Busani, Massimo Girardis, Cristina Mussini, Andrea Cossarizza, Lara Gibellini
Summary: Patients with severe COVID-19 pneumonia exhibit dysfunctional neutrophil functions characterized by high levels of neutrophil extracellular traps (NET) markers. Metabolic remodelling plays a vital role in the formation of NET, and manipulating HIF-1α or PYGL could potentially lead to innovative therapeutic approaches. Significant increases in plasma levels of molecules involved in the regulation of neutrophil function were observed in these patients.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Hematology
Julian Swatler, Laura Turos-Korgul, Marta Brewinska-Olchowik, Sara De Biasi, Wioleta Dudka, Bac Viet Le, Agata Kominek, Salwador Cyranowski, Paulina Pilanc, Elyas Mohammadi, Dominik Cysewski, Ewa Kozlowska, Wioleta Grabowska-Pyrzewicz, Urszula Wojda, Grzegorz Basak, Jakub Mieczkowski, Tomasz Skorski, Andrea Cossarizza, Katarzyna Piwocka
Summary: Leukemic extracellular vesicles play a role in stimulating immunosuppressive Tregs and promoting leukemia growth. The study identifies Rab27a-dependent secretion of leukemic EVs as a potential therapeutic target in myeloid neoplasms.
Article
Nutrition & Dietetics
Milena Nasi, Anna De Gaetano, Gianluca Carnevale, Laura Bertoni, Valentina Selleri, Giada Zanini, Alessandra Pisciotta, Stefania Caramaschi, Luca Reggiani Bonetti, Alberto Farinetti, Andrea Cossarizza, Marcello Pinti, Antonio Manenti, Anna Vittoria Mattioli
Summary: Energy drinks may not cause acute damage to the gastrointestinal tract, but they can induce eosinophilic infiltration in the intestinal mucosa, likely due to the presence of caffeine.
Review
Biochemistry & Molecular Biology
Mariangela Di Vincenzo, Federico Diotallevi, Silvia Piccirillo, Gianluca Carnevale, Annamaria Offidani, Anna Campanati, Monia Orciani
Summary: Micro RNAs (miRNAs), a type of non-coding RNA, interact with specific target mRNAs through base pairing, affecting their translation and stability. MiRNAs play a crucial role in regulating the fate of mesenchymal stromal cells (MSCs) in various skin diseases, both inflammatory and neoplastic. However, the exact role of miRNAs in these diseases is still a matter of debate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Giulia Bertani, Rosanna Di Tinco, Laura Bertoni, Giulia Orlandi, Alessandra Pisciotta, Roberto Rosa, Luca Rigamonti, Michele Signore, Jessika Bertacchini, Paola Sena, Sara De Biasi, Erica Villa, Gianluca Carnevale
Summary: The effects of pulsatile unidirectional flow and an inflammatory microenvironment on the biological properties of human dental pulp stem cells were evaluated in this study. The results showed that both pulsatile unidirectional flow and an inflammatory microenvironment led to a decrease in the immunomodulatory and inflammatory properties of dental pulp stem cells.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Alessandra Pisciotta, Rosanna Di Tinco, Giulia Bertani, Giulia Orlandi, Laura Bertoni, Elisa Pignatti, Monia Orciani, Paola Sena, Jessika Bertacchini, Carlo Salvarani, Gianluca Carnevale
Summary: There is a strong correlation between chronic inflammation and fibrosis in autoimmune diseases. Human dental pulp stem cells (hDPSCs) have been found to play a crucial role in the fibrogenetic process, with different effects on fibrosis depending on the inflammatory conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Alessia Paganelli, Andrea Giovanni Naselli, Laura Bertoni, Elena Rossi, Paola Azzoni, Alessandra Pisciotta, Anna Maria Cesinaro, Luisa Benassi, Shaniko Kaleci, Federico Garbarino, Barbara Ferrari, Chiara Fiorentini, Camilla Reggiani, Cristina Magnoni
Summary: This study compared the clinical and histological results of MatriDerm and Integra, two widely used acellular dermal matrices (ADMs) in dermato-oncological surgery. The findings showed no significant differences in final clinical outcomes or extracellular matrix content of the neoformed dermis between the two ADMs. However, Matriderm was found to cause scar retraction more frequently, while Integra carried a higher infectious risk and was more slowly reabsorbed into the wound bed. Granulomatous reactions resembling foreign bodies were also observed in Integra samples. In conclusion, both ADMs demonstrated comparable global outcomes after dermato-oncological surgery.
Article
Biochemistry & Molecular Biology
Alessia Paganelli, Alessandra Pisciotta, Giulia Bertani, Rosanna Di Tinco, Nadia Tagliaferri, Giulia Orlandi, Paola Azzoni, Laura Bertoni
Summary: An increasing number of people are seeking treatment for aging-related conditions, and plant-derived nutraceuticals have attracted great interest in the prevention of photoaging in dermo-cosmetic studies. In this in vitro study, a commercially available product, Venerinase(®), comprised of a mixture of Rhodiola rosea, Tribulus terrestris, Moringa oleifera, Undaria pinnatifida, folic acid, and vitamin B12, was tested for its potential anti-aging effects on the skin. The results showed that Venerinase(®) could prevent UV-induced morphological changes in both keratinocytes and fibroblasts, as well as inhibit senescence-related and proinflammatory pathways triggered by UV exposure. These findings support the potential use of oral supplements for the treatment and prevention of cutaneous photodamage.
Review
Biochemistry & Molecular Biology
Giulia Orlandi, Luca Roncucci, Gianluca Carnevale, Paola Sena
Summary: Colorectal cancer remains a major threat to life, despite attempts at therapeutic and screening. Apoptosis and autophagy share signaling pathways and protein components. In cancer development, these processes can interact and inhibit each other. Understanding the regulation and molecular mechanisms behind this duality is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Lara Gibellini, Rebecca Borella, Elena Santacroce, Eugenia Serattini, Federica Boraldi, Daniela Quaglino, Beatrice Aramini, Sara De Biasi, Andrea Cossarizza
Summary: This review discusses the emerging concepts in the field of neutrophils in cancer, summarizing recent findings that highlight the role of both circulating neutrophils and tumor-associated neutrophils in tumor prognosis and resistance to immune checkpoint inhibitors. Neutrophils are the most abundant myeloid cells in the blood and significant components of the tumor microenvironment. However, their functional importance has been overlooked in the past due to the perception of them as a mono-dimensional population of terminally differentiated, short-lived cells. The use of cutting-edge single-cell technologies has revealed the phenotypic and functional heterogeneity of neutrophils, leading to a new understanding of their significance in cancer.
Article
Biochemistry & Molecular Biology
Annamaria Paolini, Rebecca Borella, Anita Neroni, Domenico Lo Tartaro, Marco Mattioli, Lucia Fidanza, Alessia Di Nella, Elena Santacroce, Licia Gozzi, Stefano Busani, Tommaso Trenti, Marianna Meschiari, Giovanni Guaraldi, Massimo Girardis, Cristina Mussini, Lara Gibellini, Sara De Biasi, Andrea Cossarizza
Summary: Specific T cells play a crucial role in controlling SARS-CoV-2 infection and providing protection after vaccination. Recovered patients from severe or moderate COVID-19 pneumonia show a high proportion of polyfunctional antigen-specific CD4+ T cells, while CD8+ T cells do not exhibit significant differences in polyfunctionality. Identifying these functional cell subsets can help in understanding the complexity of the immune response to SARS-CoV-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)