Article
Hematology
Ming-Lu Lin, Tieh-Cheng Fu, Chih-Chin Hsu, Shu-Chun Huang, Yu-Ting Lin, Jong-Shyan Wang
Summary: In this study, cycling exercise training significantly improved systemic aerobic capacity, platelet mitochondrial bioenergetics, and exercise capacity in patients with PAD. These improvements also led to an enhancement in health-related quality of life.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, General & Internal
Franziska Koppe-Schmeisser, Melanie Schwaderlapp, Julian Schmeisser, Joern F. Dopheide, Thomas Muenzel, Andreas Daiber, Christine Espinola-Klein
Summary: In patients with intermittent claudication, a combination of endovascular therapy and exercise training reduces inflammation by decreasing oxidative stress, leading to improved ankle-brachial index (ABI), absolute and initial claudication distances (ACD, ICD). This combination approach also results in lower leukocyte activation state and reduced ROS production, indicating its effectiveness in managing intermittent claudication.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Tsutomu Shimura
Summary: Under physiological and stress conditions, mitochondria function as a signaling platform for biological events, transmitting information from the mitochondria to the rest of the cell. Mitochondrial molecules such as ATP, reactive oxygen species, cytochrome C, and damage-associated molecular patterns act as messengers in metabolism, stress response, apoptosis, senescence, and inflammation. This review paper summarizes the mitochondrial signaling in response to DNA damage, as well as the regulation of mitochondrial quality control and the role of mitochondrial dysfunction in radiation-induced carcinogenesis. The analysis of the mitochondrial radiation effect is crucial in assessing radiation risks to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Ndivhuwo Muvhulawa, Sithandiwe E. Mazibuko-Mbeje, Duduzile Ndwandwe, Sonia Silvestri, Khanyisani Ziqubu, Marakiya T. Moetlediwa, Sinenhlanhla X. H. Mthembu, Jeanine L. Marnewick, Francois H. Van der Westhuizen, Bongani B. Nkambule, Albertus K. Basson, Luca Tiano, Phiwayinkosi V. Dludla
Summary: Sarcopenia, the loss of muscle mass and function, is a major pathological feature of type 2 diabetes (T2D). Dysregulated mitochondrial dynamics and impaired NADPH oxidase system contribute to oxidative stress and skeletal muscle damage in T2D. Inflammatory markers in the serum are also associated with muscle deterioration in T2D. Strengthening intracellular antioxidant systems is crucial for preserving muscle health in individuals with T2D.
Article
Cell Biology
Luiz Alexandre Medrado de Barcellos, William Antonio Goncalves, Marcos Paulo Esteves de Oliveira, Juliana Bohnen Guimaraes, Celso Martins Queiroz-Junior, Carolina Braga de Resende, Remo Castro Russo, Candido Celso Coimbra, Albena Nunes Silva, Mauro Martins Teixeira, Barbara Maximino Rezende, Vanessa Pinho
Summary: Acute high intensity exercise induces inflammation, but physical training can attenuate exercise-induced inflammation. Training enhances immune adaptations and decreases inflammatory response post-exercise.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Hematology
Laurent A. Messonnier
Summary: Although sickle cell disease (SCD) is related to a single point mutation, there is extreme variability in the clinical presentation among patients. Genetic variants may contribute to this variability. In this study, Dosunmu-Ogunbi et al. highlighted the importance of a genetic variant affecting mitochondrial function in the cardiovascular pathophysiology of SCD. Their findings provide important insights and perspectives for patient management.
Review
Physiology
Hamed Alizadeh Pahlavani, Ismail Laher, Beat Knechtle, Hassane Zouhal
Summary: Sarcopenia is a severe condition of muscle loss and functional decline during aging, leading to reduced quality of life, limited independence, and increased risk of falls. The causes of sarcopenia include inactivity, oxidative stress, and mitochondrial dysfunction. Exercise can be used as a non-invasive treatment for sarcopenia by regulating pathways that control the mitochondrial network.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Heikki V. Sarin, Eija Pirinen, Kirsi H. Pietilainen, Ville Isola, Keijo Hakkinen, Markus Perola, Juha J. Hulmi
Summary: This study on 42 healthy athletic females revealed that prolonged energy deficit can lead to metabolic adaptations, including suppression of mitochondrial and ribosome biogenesis gene expression. These findings suggest that adaptation to energy deficit in humans is broader than previously believed.
Review
Biochemistry & Molecular Biology
Ai Yin Lim, Yi-Ching Chen, Chih-Chin Hsu, Tieh-Cheng Fu, Jong-Shyan Wang
Summary: This systematic review investigated the effect of exercise training on mitochondrial function in cardiovascular disease (CVD) patients. The results showed that exercise can improve mitochondrial morphology, biogenesis, and significantly enhance oxidative capacity in CVD patients. However, the effects on mitochondrial dynamics, antioxidant capacity, and quality were inconclusive or inadequate. Further research, including randomized controlled trials, is needed to explore the pathways through which exercise modifies mitochondrial quantity and quality in CVD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Chih-Chin Hsu, Yu-Ting Lin, Tieh-Cheng Fu, Shu-Chun Huang, Cheng-Hsien Lin, Jong-Shyan Wang
Summary: Supervised cycling training (SCT) improves aerobic capacity and quality of life by enhancing erythrocyte deformability in patients with peripheral arterial disease (PAD).
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Saul Penin-Grandes, Juan Martin-Hernandez, Pedro L. Valenzuela, Susana Lopez-Ortiz, Jose Pinto-Fraga, Lourdes del Rio Sola, Enzo Emanuele, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano
Summary: Peripheral arterial disease is a cardiovascular disease characterized by atherosclerosis and myopathy in the lower limbs. Physical exercise can positively impact the clinical manifestation of PAD, improving functional capacity and quality of life.
Review
Medicine, Research & Experimental
Pamela Carvalho Da Rosa, Judit Borras Bertomeu, Luis Fernando Freire Royes, Raul Osiecki
Summary: Peripheral blood mononuclear cells (PBMCs) are specialized immune cells produced in the bone marrow that protect the body from pathogens and can serve as a sentinel tissue source for monitoring physiological changes. Physical exercise has been shown to influence the metabolic state and immune system through its interactions with PBMCs. However, the specific metabolic processes and biomarkers related to exercise-induced changes in PBMCs are not fully understood. This review aims to summarize the current literature on the inflammatory and oxidative stress responses of PBMCs to physical exercise and highlights their potential for assessing exercise-induced metabolic adaptations.
Article
Geriatrics & Gerontology
Zhen Fan, Jing-yu Yang, Yi Guo, Yao-xia Liu, Xiao-yi Zhong
Summary: This study aims to investigate the role of mitochondrial DNA (MtDNA) in sarcopenia. The study found that circulating MtDNA levels were higher in sarcopenia patients and were positively correlated with the level of the inflammatory cytokine, interleukin (IL)-6. Further analysis showed abnormal mitochondrial function in sarcopenia patients. These findings suggest that circulating MtDNA may be an important inflammatory stimulus in sarcopenia.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Nutrition & Dietetics
Suk-Ling Ma, Junyi Wu, Liuying Zhu, Ruth Suk-Mei Chan, Xingyan Wang, Dan Huang, Nelson Leung-Sang Tang, Jean Woo
Summary: By examining T cell gene expression responses to a 12-week intervention with exercise and nutrition supplementation in older adults with sarcopenia, it was found that combined exercise and HMB supplementation resulted in significant changes in T cell-specific inflammatory gene expression, which correlated with lower limb muscle strength performance.
Article
Engineering, Biomedical
Jingyan Huang, Ruoqi Li, Jinghong Yang, Min Cai, Yichen Lee, Anxun Wang, Bin Cheng, Yan Wang
Summary: This study found that titanium implants coated with TiO2 nanotubes (TNT) exhibit superior antioxidative and osteoimmune regeneration effects on bone mesenchymal stem cells and macrophages under oxidative stress (OS) conditions, leading to improved osseointegration capacity.
BIOACTIVE MATERIALS
(2021)
Article
Surgery
Megane Pizzimenti, Anne L. Charles, Marianne Riou, Fabien Thaveau, Nabil Chakfe, Bernard Geny, Anne Lejay
Summary: The study found that sarcopenia is one of the factors associated with poor prognosis in patients with critical limb threatening ischemia (CLTI). Preoperative platelet-to-lymphocyte ratio (PLR) may serve as an auxiliary diagnostic marker, with a PLR value >=292.5 identified as a diagnostic marker for sarcopenia, but it has low sensitivity.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Taiga Wakabayashi, Manuel Barberio, Takeshi Urade, Raoul Pop, Emilie Seyller, Margherita Pizzicannella, Pietro Mascagni, Anne-Laure Charles, Yuta Abe, Bernard Geny, Andrea Baiocchini, Yuko Kitagawa, Jacques Marescaux, Eric Felli, Michele Diana
Summary: Pancreatic perfusion quantification using fluorescence imaging and hyperspectral imaging has shown promising results with statistically correlated metrics. These imaging modalities have potential for real-time assessment of pancreatic perfusion and are currently being translated for clinical use in human pancreatic surgery.
Article
Neurosciences
Valerie Biancalana, John Rendu, Annabelle Chaussenot, Helen Mecili, Eric Bieth, Melanie Fradin, Sandra Mercier, Maud Michaud, Marie-Christine Nougues, Laurent Pasquier, Sabrina Sacconi, Norma B. Romero, Pascale Marcorelles, Francois Jerome Authier, Antoinette Gelot Bernabe, Emmanuelle Uro-Coste, Claude Cances, Bertrand Isidor, Armelle Magot, Marie-Christine Minot-Myhie, Yann Pereon, Julie Perrier-Boeswillwald, Gilles Bretaudeau, Nicolas Dondaine, Alison Bouzenard, Megane Pizzimenti, Bruno Eymard, Ana Ferreiro, Jocelyn Laporte, Julien Faure, Johann Bohm
Summary: The recurrent RYR1 mutation previously classified as VUS was found in thirteen patients from nine unrelated congenital myopathy families with consistent clinical presentation, providing evidence of its pathogenicity. This mutation causes an atypical congenital myopathy with slowly improving motor function over the first decades of life, indicating a potential for directing molecular diagnosis for patients with similar clinical presentation.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Cell Biology
Roberto Silva-Rojas, Anne-Laure Charles, Sarah Djeddi, Bernard Geny, Jocelyn Laporte, Johann Boehm
Summary: Store-operated Ca2+ entry (SOCE) is a crucial mechanism for regulating various signaling pathways and cellular processes, with dysfunctions of key factors STIM1 and ORAI1 leading to human pathologies. Overactive SOCE can cause muscle function and structural anomalies, affecting muscle contraction and relaxation kinetics, causing reticular stress, abnormal mitochondrial activity, and muscle degeneration.
Article
Rheumatology
Anna Lia, Tiziana Annese, Marco Fornaro, Margherita Giannini, Dario D'Abbicco, Mariella Errede, Loredana Lorusso, Angela Amati, Marilina Tampoia, Maria Trojano, Daniela Virgintino, Domenico Ribatti, Luigi Serlenga, Florenzo Iannone, Francesco Girolamo
Summary: In different idiopathic inflammatory myopathies (IIMs), infiltrating macrophages and interactions with microvascular cells play a significant role in myofiber and blood vessel formation. Anti-HMGCR associated IMNM showed higher vascular density and expression of angiogenic molecules.
Article
Nutrition & Dietetics
Dan Levy, Margherita Giannini, Walid Oulehri, Marianne Riou, Christophe Marcot, Megane Pizzimenti, Lea Debrut, Anne Charloux, Bernard Geny, Alain Meyer
Summary: Post-COVID-19 condition, which refers to the signs and symptoms lasting at least 2 months and persisting more than 3 months after COVID-19 infection, is found to affect malnutrition and sarcopenia in patients. The study shows that sarcopenia is more common in patients with longer ICU stays. However, these nutrition and muscle issues can be reversed within 6 months after discharge.
Review
Medicine, General & Internal
Francois Sauer, Marianne Riou, Anne-Laure Charles, Alain Meyer, Emmanuel Andres, Bernard Geny, Samy Talha
Summary: Heart failure is a leading cause of hospitalization in patients aged over 65 and is associated with high mortality rates. Recent studies have focused on the mitochondrial respiration of peripheral blood circulating cells (PBMCs) in order to better understand the physiopathology of HF. These studies suggest that cardiovascular metabolic risk factors and cellular switch may contribute to decreased PBMC mitochondrial respiration, which is associated with HF severity. Further research is needed to investigate the potential diagnostic, prognostic, and therapeutic utility of monitoring PBMC mitochondrial function and mitoDAMPs in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Walid Oulehri, Olivier Collange, Charles Tacquard, Abdelouahab Bellou, Julien Graff, Anne-Laure Charles, Bernard Geny, Paul-Michel Mertes
Summary: The aim of this study was to evaluate the involvement of mitochondria in early-stage cardiac dysfunction associated with anaphylactic shock (AS). The results showed that AS was associated with a rapid decrease in arterial blood pressure, blood flow, and lactate levels. The mitochondrial respiration and oxidative stress were significantly impaired in the AS group, with increased superoxide dismutase activity and oxidative damage. However, no changes were observed in the mitochondrial ultrastructure at the early stage of AS.
Article
Nutrition & Dietetics
Anouk Charlot, Lucas Morel, Anthony Bringolf, Isabelle Georg, Anne-Laure Charles, Fabienne Goupilleau, Bernard Geny, Joffrey Zoll
Summary: This study found that consuming a diet rich in octanoic acid (C8) can enhance spontaneous activity and endurance capacity in mice. The C8-rich diet also affects the metabolic phenotype of skeletal muscle, increasing the number of oxidative fibers rich in mitochondria. At the molecular level, the C8 diet activates AMPK and increases the expression of PGC1a and CS genes and proteins. These findings suggest that C8-enrichment improves endurance capacity and activates mitochondrial biogenesis pathways, leading to higher oxidative capacities in skeletal muscle.
Review
Biochemistry & Molecular Biology
Cindy Barnig, Gaetan Lutzweiler, Margherita Giannini, Anne Lejay, Anne-Laure Charles, Alain Meyer, Bernard Geny
Summary: This article discusses the inflammatory response and recent discoveries in resolution pathways during skeletal muscle ischemia reperfusion. Lipid mediators play an important role in regulating the inflammatory response, reducing damage caused by ischemia reperfusion, and have potential therapeutic applications.
Article
Medicine, General & Internal
Erika Van Wambeke, Cecile Bezler, Anne-Marie Kasprowicz, Anne-Laure Charles, Emmanuel Andres, Bernard Geny
Summary: COVID-19 patients with long-lasting symptoms benefited from a coordination team, but the efficacy of the therapeutic strategy still needs to be determined. Phone consultations and personalized support showed some improvement in symptoms and ability to return to work after 15 and 22 months of COVID infection. Common symptoms such as fatigue and neurocognitive disorders did not resolve, but dyspnea, anxiety, and chest pain were significantly reduced.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Abrar Alfatni, Anne-Laure Charles, Francois Sauer, Marianne Riou, Fabienne Goupilleau, Samy Talha, Alain Meyer, Emmanuel Andres, Michel Kindo, Jean-Philippe Mazzucotelli, Eric Epailly, Bernard Geny
Summary: The mitochondrial function of circulating peripheral blood mononuclear cells in heart-transplanted patients appears to be modified, potentially linked to cellular shift, mild diastolic dysfunction, and/or acute rejection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Marianne Riou, Irina Enache, Francois Sauer, Anne-Laure Charles, Bernard Geny
Summary: Pulmonary arterial hypertension (PAH) is a rare disease characterized by pulmonary vascular remodeling and right heart failure. Despite current therapeutic approaches, there is still a need for new targets and therapies to improve outcomes for PAH patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Lea Debrut, Margherita Giannini, Delphine Klein, Lionel Spielmann, Philippe Mertz, Thierry Martin, Aleksandra Nadaj-Pakleza, Sandrine Hirschi, Benoit Nespola, Beatrice Lannes, Joelle Terzic, Olivier Hinschberger, Benjamin Dervieux, Dan Lipsker, Laurent Arnaud, Jacques-Eric Gottenberg, Jean Francois Kleinmann, Bernard Geny, Francois Severac, Michel Velten, Jean Sibilia, Alain Meyer
Summary: This study aimed to refine the incidence of inflammatory myopathies (IM) and found that the incidence rate of IM was 8.22 new cases per million inhabitants per year (95% confidence interval 6.76-9.69) in Alsace, France.
ARTHRITIS & RHEUMATOLOGY
(2023)
Letter
Rheumatology
Margherita Giannini, Alain Meyer