Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization

Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction

(2020) Adam R. Wende et al.   DIABETES

Diabetic Cardiomyopathy

(2018) Guanghong Jia et al.   CIRCULATION RESEARCH

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia

(2018) Maria Rohm et al.   DIABETES

Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance

(2018) Mark E. Pepin et al.   Molecular Metabolism

Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure

(2018) Mark E. Pepin et al.   LABORATORY INVESTIGATION

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism

(2018) Sungmi Park et al.   Diabetes & Metabolism Journal

O-GlcNAc homeostasis contributes to cell fate decisions during hematopoiesis

(2018) Zhen Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk

(2017) Sanket Kumar Shukla et al.   Scientific Reports

Ketone Body Infusion With 3‐Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study

(2017) Lars C. Gormsen et al.   Journal of the American Heart Association

My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy

(2017) Manoja K. Brahma et al.   Diabetes & Metabolism Journal

Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients

(2017) Francesco Spallotta et al.   CIRCULATION RESEARCH

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

(2016) Kenneth C. Bedi et al.   CIRCULATION

The Failing Heart Relies on Ketone Bodies as a Fuel

(2016) Gregory Aubert et al.   CIRCULATION

CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis

(2016) Ele Ferrannini et al.   DIABETES CARE

Successful metabolic adaptations leading to the prevention of high fat diet-induced murine cardiac remodeling

(2015) Nathan W. Roberts et al.   Cardiovascular Diabetology

Removal of Abnormal MyofilamentO-GlcNAcylation Restores Ca2+Sensitivity in Diabetic Cardiac Muscle

(2015) Genaro A. Ramirez-Correa et al.   DIABETES

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diabetes-associated dysregulation ofO-GlcNAcylation in rat cardiac mitochondria

(2015) Partha S. Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational modifications of the cardiac proteome in diabetes and heart failure

(2015) Adam R. Wende   Proteomics Clinical Applications

High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats

(2014) Jian Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Exploring the Potential of the SGLT2 Inhibitor Dapagliflozin in Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

(2014) Robert R. Henry et al.   DIABETES CARE

Cardiomyocyte-Specific BMAL1 Plays Critical Roles in Metabolism, Signaling, and Maintenance of Contractile Function of the Heart

(2014) Martin E. Young et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Enhanced Cardiac Akt/Protein Kinase B Signaling Contributes to Pathological Cardiac Hypertrophy in Part by Impairing Mitochondrial Function via Transcriptional Repression of Mitochondrion-Targeted Nuclear Genes

(2014) Adam R. Wende et al.   MOLECULAR AND CELLULAR BIOLOGY

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling

(2014) Rebecca C. Schugar et al.   Molecular Metabolism

Inducible Overexpression of GLUT1 Prevents Mitochondrial Dysfunction and Attenuates Structural Remodeling in Pressure Overload but Does Not Prevent Left Ventricular Dysfunction

(2013) Renata O. Pereira et al.   Journal of the American Heart Association

Taking Diabetes to Heart—Deregulation of Myocardial Lipid Metabolism in Diabetic Cardiomyopathy

(2013) Marina Bayeva et al.   Journal of the American Heart Association

Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation

(2012) David G. Cotter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genetic loss of insulin receptors worsens cardiac efficiency in diabetes

(2012) Heiko Bugger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac PI3K-Akt Impairs Insulin-Stimulated Glucose Uptake Independent of mTORC1 and GLUT4 Translocation

(2012) Yi Zhu et al.   MOLECULAR ENDOCRINOLOGY

The monocarboxylate transporter family-Role and regulation

(2011) Andrew P. Halestrap et al.   IUBMB LIFE

O-GlcNAcylation, Novel Post-Translational Modification Linking Myocardial Metabolism and Cardiomyocyte Circadian Clock

(2011) David J. Durgan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Successful Treatment of Severe Cardiomyopathy in Glycogen Storage Disease Type III With D,L-3-Hydroxybutyrate, Ketogenic and High-Protein Diet

(2011) Vassili Valayannopoulos et al.   PEDIATRIC RESEARCH

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

(2011) P. Krebs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscle-specific overexpression of NCOATGK, splice variant of O-GlcNAcase, induces skeletal muscle atrophy

(2010) Ping Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Adaptation of Myocardial Substrate Metabolism to a Ketogenic Nutrient Environment

(2010) Anna E. Wentz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Glucose Uptake and Oxidation in Mouse Hearts Prevent High Fatty Acid Oxidation but Cause Cardiac Dysfunction in Diet-Induced Obesity

(2009) Jie Yan et al.   CIRCULATION