Article
Nanoscience & Nanotechnology
Dongying Li, Jiarun Li, Siwei Wang, Wei Teng, Qinmei Wang
Summary: Efficient introduction of iRGD onto nanopolymersomes was achieved using a physical method, allowing for precise control of the amount incorporated. The iRGD-decorated nanopolymersomes exhibited excellent tumor-targeting and penetration capabilities, facilitating effective delivery of siRNA to inhibit tumor growth.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ilaria Arduino, Zehua Liu, Rosa Maria Iacobazzi, Angela Assunta Lopedota, Antonio Lopalco, Annalisa Cutrignelli, Valentino Laquintana, Letizia Porcelli, Amalia Azzariti, Massimo Franco, Helder A. Santos, Nunzio Denora
Summary: Solid lipid nanoparticles (SLNs) can effectively deliver drugs, and their production through microfluidics enables continuous and replicable manufacturing. Surface functionalized SLNs with iRGD peptide show enhanced cellular uptake and cytotoxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Anna Egorova, Mariya Petrosyan, Marianna Maretina, Elena Bazian, Iuliia Krylova, Vladislav Baranov, Anton Kiselev
Summary: In this study, the potential of RGD1-R6 peptide carrier as a non-viral vehicle for targeted siRNA delivery to endothelial cells was evaluated. The results showed that the modified siRNA complexes had higher gene silencing efficiency and lower endothelial cell migration compared to unmodified complexes. In a rat endometriosis model, the combination therapy of the carrier with anti-VEGF siRNA complexes significantly inhibited implant growth and VEGFA gene expression, comparable to Dienogest.
Article
Nanoscience & Nanotechnology
Akhil K. Mohan, M. Minsa, T. R. Santhosh Kumar, G. S. Vinod Kumar
Summary: This study developed a targeted delivery system using multi-layered PLGA-PEI nanoparticles functionalized with a targeting peptide to selectively deliver the antitumor peptide, Pep5, to breast tumor cells. The results showed that the TKD conjugation enhanced the antitumor activity of Pep5 in breast cancer cells. The nanoparticles induced cytoskeletal damage and apoptosis in the cells, and actively targeted Pep5 suppressed tumor growth in an ex vivo model.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Mohd Aslam Saifi, Gauri Sathish, Mohd Rabi Bazaz, Chandraiah Godugu
Summary: Cancer therapy remains challenging due to adverse effects and poor distribution. Nanotechnology offers advantages, but tumor penetration is still an issue. iRGD has shown promise in improving delivery of cancer nanomedicine. While clinical translation is at an early stage, preclinical observations are encouraging.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Nanoscience & Nanotechnology
Mengting Liu, Wenjuan Ma, Dan Zhao, Jiajie Li, Qirong Li, Yuhao Liu, Liying Hao, Yunfeng Lin
Summary: A DNA-based drug delivery system with iRGD decoration was developed to overcome the poor penetrability and nonselective distribution of chemotherapeutic drugs for TNBC, showing superior drug penetration and targeting properties.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Gye Lim Kim, Byeongmin Park, Eun Hyang Jang, Jaeun Gu, Seo Ra Seo, Hyein Cheung, Hyo Jung Lee, Sangmin Lee, Jong-Ho Kim
Summary: Nanotechnology, specifically self-aggregated nanoparticles, has proven to be highly effective in treating solid tumors. To enhance therapeutic efficacy and overcome the limitations of conventional cancer therapies, the combination of photodynamic therapy (PDT) and chemotherapy is considered an effective strategy. This study focuses on the development of tumor-targeting polysialic acid (PSA) nanoparticles for chemo-PDT, which increase cellular uptake and cytotoxic effects in cancer cells.
Article
Chemistry, Multidisciplinary
Haoran Jing, Marcell Palmai, Badeia Saed, Anne George, Preston T. Snee, Ying S. Hu
Summary: This study focused on the single-particle characterization of membrane-penetrating semiconductor quantum dots in T cell lymphocytes, demonstrating that peptide-functionalized QDs exhibited different internalization behaviors compared to control QDs. A significant finding was the alternative cell-entry mechanism observed in DSS-QDs when endocytosis was inhibited, suggesting potential implications for gene therapy and drug delivery optimization.
Article
Nanoscience & Nanotechnology
Jingbin Huang, Wenjing Lai, Qing Wang, Qin Tang, Changpeng Hu, Min Zhou, Fengling Wang, Dandan Xie, Qian Zhang, Wuyi Liu, Zhe Zhang, Rong Zhang
Summary: This study successfully developed biomimetic iRGD-RM-(DOX/MSNs) that effectively targeted tumors, providing a promising strategy for the treatment of TNBC.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Linda Waldherr, Maria Seitanidou, Marie Jakesova, Verena Handl, Sophie Honeder, Marta Nowakowska, Tamara Tomin, Meysam Karami Rad, Tony Schmidt, Joachim Distl, Ruth Birner-Gruenberger, Gord Campe, Ute Schafer, Magnus Berggren, Beate Rinner, Martin Asslaber, Nassim Ghaffari-Tabrizi-Wizsy, Silke Patz, Daniel T. Simon, Rainer Schindl
Summary: The study confirms Gem's significantly greater potency in killing GBM cells compared to temozolomide, and demonstrates the potential of the electronically-driven organic ion pump GemIP for targeted delivery to GBM cells.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Review
Biotechnology & Applied Microbiology
Mingpeng Liu, Xiaocui Fang, Yanlian Yang, Chen Wang
Summary: Receptor-targeting peptides are extensively pursued for improving drug binding specificity and accumulation at the site of interest, and are widely recognized as candidates of novel therapeutics due to their high specificity and biocompatibility.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Krister J. Barkovich, Zhongchao Zhao, Nicole F. Steinmetz
Summary: Nanomedicine shows promise for molecular treatment. Targeted delivery of nanoparticles to specific tissues, especially cancerous ones, remains a challenge. In this study, iRGD peptides were conjugated to Physalis mottle virus-like nanoparticles, resulting in targeted uptake by tumor cells and homing in tumors in vivo. Furthermore, these targeted nanoparticles loaded with the chemotherapeutic doxorubicin demonstrated increased potency in a mouse model of cancer. These findings validate the potential of iRGD-PhMV as a platform for targeted delivery of molecular cargo to tumors.
Article
Nanoscience & Nanotechnology
Silvia Cirillo, Mhd Anas Tomeh, Robert N. Wilkinson, Chris Hill, Stephen Brown, Xiubo Zhao
Summary: The amphiphilic alpha-helical peptide G3 shows high specificity and affinity for cancer cells, making it a promising therapeutic agent for cancer treatment. The peptide enters cancer cells through an energy-dependent endocytic pathway and can protect and selectively deliver siRNAs to modulate gene expression. In vivo toxicity studies on zebrafish embryos show that G3's toxicity is concentration-dependent but can be attenuated when complexed with siRNA, making it a potential effective gene delivery agent with low toxicity.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Cell Biology
Panhui Yang, Lei Wu, Guoyuan Zhang, Yuqing Ge, Ting Liu, Hongju Mao, Jianlong Zhao
Summary: Cancer cell spheroids are used for in vitro drug screening as they can imitate the tumour microenvironment in vivo. Microfluidic technology offers convenience for spheroid assays, such as high-throughput capabilities and simplified manual operation. This study introduces a concentration gradient generator based on microfluidic technology for cell spheroid culture and assay, offering a promising approach for high-throughput and standardized anti-cancer drug screening.
CELL PROLIFERATION
(2023)
Article
Materials Science, Biomaterials
Hyeonjeong Han, Jik-Han Jung, Hyoungjin Lee, Junsung Lee, Seong-Hoon Jang, Unbyeol Goh, Jooeun Yoon, Ji-Ho Park
Summary: This study presents a targeted fusogenic liposome (TFL) that selectively delivers lipophilic drugs to tumor cell membranes and distributes them throughout the tumor tissue via extracellular vesicles. Systemically administered TFL accumulates in the perivascular region of tumors and enables the autonomous transfer of lipophilic drugs among tumor cells. When loaded with a lipophilic pro-apoptotic drug, TFL effectively inhibits tumor growth in a mouse colorectal cancer model.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Martyna Michalska, Alessandro Rossi, Gasper Kokot, Callum M. M. Macdonald, Silvia Cipiccia, Peter R. T. Munro, Alessandro Olivo, Ioannis Papakonstantinou
Summary: This paper presents a method for fabricating high-aspect ratio nanogratings, which have important applications in X-ray imaging. By combining laser interference and nanoimprint lithography, physical vapor deposition, metal assisted chemical etching, and electroplating, the fabrication challenges are overcome. The results show that the fabricated nanogratings have aspect ratios exceeding 40, and they exhibit excellent diffractive abilities when exposed to a hard X-ray beam, suggesting potential applicability in phase-based X-ray imaging.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Environmental Sciences
Shoomaila Latif, Amna Liaqat, Muhammad Imran, Ayesha Javaid, Nazim Hussain, Teofil Jesionowski, Muhammad Bilal
Summary: A comparative study was conducted on the degradation of diclofenac sodium using ZnO and ZnFe2O4 as photocatalysts. The results showed that ZnFe2O4 exhibited higher degradation efficiency, degrading 61.4% of the drug in 120 minutes, compared to 48.9% by ZnO. Zinc ferrite also showed good recyclability and stability, making it a promising catalyst for wastewater remediation.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Zhongbiao Tan, Hairong Cheng, Gang Chen, Fang Ju, Jesus Fernandez-Lucas, Jakub Zdarta, Teofil Jesionowski, Muhammad Bilal
Summary: In recent years, enzyme-based biocatalytic systems have gained increasing attention in industrial and applied research. These systems have been applied in sustainable and environmentally friendly production processes in various industries. However, the low stability of enzymes and difficulties in separation, recovery, and reusability have limited their industrial-scale manufacturing. Immobilization and co-immobilization on robust support materials have emerged as valuable strategies to overcome these challenges. By using environmentally friendly bio-polymers and nanostructured materials, multi-enzyme co-immobilization offers improved process efficiency and cost-effectiveness in biotechnological and chemical industries.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Longxiang Liu, Liqun Kang, Arunabhiram Chutia, Jianrui Feng, Martyna Michalska, Pilar Ferrer, David C. Grinter, Georg Held, Yeshu Tan, Fangjia Zhao, Fei Guo, David G. Hopkinson, Christopher S. Allen, Yanbei Hou, Junwen Gu, Ioannis Papakonstantinou, Paul R. Shearing, Dan J. L. Brett, Ivan P. Parkin, Guanjie He
Summary: The electrochemical synthesis of hydrogen peroxide via a two-electron oxygen reduction reaction provides a promising alternative to the energy-intensive anthraquinone process. In this study, a highly active quinone-rich porous carbon catalyst was synthesized using a facile template-protected strategy. The optimized PCC900 material exhibited remarkable activity and selectivity for H2O2 production.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Muhammad Bilal, Ehsan Ullah Rashid, Junaid Munawar, Hafiz M. N. Iqbal, Jiandong Cui, Jakub Zdarta, Syed Salman Ashraf, Teofil Jesionowski
Summary: Nanobiocatalysts are an emerging field of nanobiocatalysis that integrates enzyme molecules into multifunctional materials like metal-organic frameworks (MOFs). Among these materials, functionalized magnetic MOFs have gained significant interest as versatile nano-biocatalytic systems for various organic transformations. These systems offer controllable enzyme microenvironments and show promise in enzyme engineering and biocatalytic transformations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Muhammad Bilal, Jakub Zdarta, Teofil Jesionowski, Hafiz M. N. Iqbal
Summary: Manganese peroxidases (MnPs) are enzymes with robust catalytic features that have gained attention in biotechnological applications, particularly in environmental remediation. They can degrade various organic pollutants and immobilized MnP fractions perform well in hostile environments. The article covers the microbial sources, structural attributes, immobilization strategies, and various biotechnological applications of MnP.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Sadia Anjum, Shakira Aslam, Nazim Hussain, Muhammad Bilal, Grzegorz Boczkaj, Wojciech Smulek, Teofil Jesionowski, Hafiz M. N. Iqbal
Summary: Given the current issues with global warming and rising greenhouse gas emissions, bio-hydrogen is a viable alternative fuel option. This study examines the different technologies and processes involved in bio-hydrogen production, as well as the limitations and challenges. Organic waste, particularly biodegradable waste, is the preferred feedstock for bio-hydrogen generation. The review also explores alternative options for improving process efficiency and discusses the hindrances to fuel-cell commercialization.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Review
Environmental Sciences
Karolina Bachosz, Jakub Zdarta, Muhammad Bilal, Anne S. Meyer, Teofil Jesionowski
Summary: Enzymatic processes are becoming increasingly important, and the role of enzymatic cofactors is crucial for efficient biocatalytic activities. Therefore, the development of cofactor regeneration systems is essential. This review summarizes current knowledge on enzymatic regeneration methods and highlights potential directions for further development.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Physical
Joanna Kuzminska, Paulina Kobylka, Marcin Wierzchowski, Dawid Lazewski, Lukasz Popenda, Paulina Szubska, Weronika Jankowska, Stefan Jurga, Tomasz Goslinski, Izabela Muszalska-Kolos, Marek Murias, Malgorzata Kucinska, Agnieszka Sobczak, Anna Jelinska
Summary: In this study, a library of 14 fluorinated curcumin (F-CUR) derivatives and their F-CUR-BF2 adducts were designed and synthesized. The cytotoxic effect of the curcumin derivatives on bladder cancer cells was determined, and the structure-activity relationship was established. The results showed that the presence of the BF2 moiety in the curcumin derivative structure determined its cytotoxic effect, with the F-CUR-BF2 adducts exhibiting higher activity than curcumin.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Polymer Science
Krzysztof Jerczynski, Julita Muszynska, Gokhan Demirci, Onur Cetinkaya, Paulina Filipczak, Grzegorz Nowaczyk, Jaroslaw Grobelny, Krzysztof Matyjaszewski, Marcin Kozanecki, Joanna Pietrasik
Summary: This work reports on the efficient performance of hybrid particles with silver nanoparticles distributed within single polymer molecules as Surface Enhanced Raman Scattering (SERS) supports. Through controlled synthesis methods and structure parameters of polymer templates, the researchers successfully synthesized hybrid particles with star-like topology and achieved stable detection of analytes at nanomolar level.
Article
Chemistry, Analytical
Maria Kuznowicz, Tomasz Rebis, Artur Jedrzak, Grzegorz Nowaczyk, Teofil Jesionowski
Summary: A novel catechol-based PCA@MWCNT-Ni(OH)(2) hybrid material was developed and used for non-enzymatic glucose biosensing. The hybrid material showed enhanced redox properties and electrocatalytic activity for glucose detection. The nonenzymatic glucose biosensor exhibited a low detection limit, high selectivity, wide linear range, good stability, and reproducibility.
Article
Engineering, Environmental
Jakub Zdarta, Filip Ciesielczyk, Muhammad Bilal, Katarzyna Jankowska, Karolina Bachosz, Oliwia Degorska, Agnieszka Rybarczyk, Teofil Jesionowski, Anne S. Meyer
Summary: Synthetic hormones are dangerous pollutants that pose risks to the reproductive health of both ecosystems and humans through water, including drinking water. Traditional wastewater treatment methods are not efficient enough. In this study, a new biosystem made of CaSiO3 and laccase was designed and fabricated, and its application for the removal of the synthetic estrogen 17 alpha-ethynylestradiol (EE2) from aqueous systems was demonstrated. The biosystem achieved 100% removal efficiency and showed synergistic degradation through simultaneous adsorption and biocatalytic conversion, with enzymatic conversion dominating.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Environmental Sciences
Shahid Nawaz, Andleeb Tabassum, Sara Muslim, Tayyaba Nasreen, Ausra Baradoke, Tak H. Kim, Grzegorz Boczkaj, Teofil Jesionowski, Muhammad Bilal
Summary: Persistent contaminants in wastewater effluent are a significant threat to aquatic life and a major environmental concern. The traditional methods of wastewater treatment are not cost-effective in removing toxic pollutants from the water environment. Therefore, the development of new technologies and more sustainable alternatives, such as biopolymers, is necessary for wastewater treatment.
Article
Biochemistry & Molecular Biology
Oliwia Degorska, Daria Szada, Teofil Jesionowski, Jakub Zdarta
Summary: Due to the importance of synthesizing APIs in enantiomerically pure form, new methods of asymmetric synthesis are being sought. Biocatalysis is a promising technique that can lead to enantiomerically pure products. In this study, lipase immobilized on modified silica nanoparticles was used to achieve kinetic resolution of a racemic mixture of 3H3P, with the most suitable IL being [BMIM]Cl.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Environmental Sciences
Yonghong Han, Juan Tao, Adnan Khan, Afrasiab Khan, Nisar Ali, Sumeet Malik, Chunhao Yu, Yong Yang, Teofil Jesionowski, Muhammad Bilal
Summary: Mercury emissions from the industrial sector are a significant concern due to their toxic health effects. Researchers have developed a method using sorption process to remove mercury from wastewater. Nickel-sulfide nanoparticles incorporated in chitosan microspheres have shown promising results for the removal of toxic mercury ions in wastewater.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
