Article
Neurosciences
Zahra Alizadeh, Amin Azimi, Maryam Ghorbani
Summary: This study analyzed the impact of thalamic spindles on hippocampal dynamics and found that the coupling between the hippocampus and thalamocortical networks was enhanced during slower and longer spindles. Additionally, spindles occurring closer to slow oscillation troughs were more strongly coupled to hippocampal ripples. The study also revealed that the temporal association between CA1 spiking/ripples and thalamic spindles was stronger after spatial exploration.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Ivan Skelin, Haoxin Zhang, Jie Zheng, Shiting Ma, Bryce A. Mander, Olivia Kim McManus, Sumeet Vadera, Robert T. Knight, Bruce L. McNaughton, Jack J. Lin
Summary: Studies suggest that during sleep, hippocampal sharp-wave ripples and other neural activities can modulate widespread high-frequency activity, predicting coordinated activity between different brain regions. These findings imply a mechanism where hippocampal and cortical slow-wave synchronization supports memory consolidation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Behavioral Sciences
Renan Augusto Viana Mendes, Leonardo Rakauskas Zacharias, Rafael Naime Ruggiero, Joao Pereira Leite, Marcio Flavio Dutra Moraes, Cleiton Lopes-Aguiar
Summary: Memory impairment is a common cognitive deficit in patients with temporal lobe epilepsy, which has been increasingly associated with network dysfunctions during sleep, specifically involving hippocampal-cortical coupling. Studies suggest that coordination between brain waves during sleep is crucial for spatial memory consolidation, with REM sleep playing a critical role in synaptic plasticity and memory formation. However, the extent to which REM sleep is affected in TLE remains unclear, with preliminary results indicating exacerbated hippocampal theta-gamma phase-amplitude coupling.
EPILEPSY & BEHAVIOR
(2021)
Article
Neurosciences
Maya Geva-Sagiv, Emily A. Mankin, Dawn Eliashiv, Shdema Epstein, Natalie Cherry, Guldamla Kalender, Natalia Tchemodanov, Yuval Nir, Itzhak Fried
Summary: The study found that delivering brief prefrontal pulses synchronized with MTL slow-wave active periods during human sleep can enhance sleep oscillation coupling and memory accuracy. This demonstrates the crucial role of hippocampal-thalamocortical synchronization in memory consolidation during sleep.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Jaekyung Kim, Abhilasha Joshi, Loren Frank, Karunesh Ganguly
Summary: This study investigates the dynamics of cross-area coupling between the hippocampus, prefrontal cortex, and primary motor cortex during sleep. The results reveal two distinct stages of processing, characterized by different patterns of interaction between these brain areas. The first stage is associated with rapid learning and variability of motor cortex activity, while the second stage is characterized by increased coupling between the prefrontal cortex and motor cortex and decreased coupling between the hippocampus and motor cortex. Additionally, manipulation of task parameters can re-engage the interaction between the hippocampus and motor cortex.
Article
Neurosciences
Flavie Kersante, Ross J. Purple, Matthew W. Jones
Summary: Benzodiazepines and 'Z-drugs' are commonly prescribed as hypnotics, but their effects on network and cellular activity during sleep and memory consolidation are not well understood. This study investigated the effects of zolpidem and other drugs on neural population activity and found that zolpidem enhanced coordinated activity between the hippocampus and neocortex during non-REM sleep. These findings suggest that zolpidem may have the potential to modulate offline memory processing.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Adrian Aleman-Zapata, Richard G. M. Morris, Lisa Genzel
Summary: This study reveals that memory reactivation during non-rapid-eye-movement ripples plays a crucial role in communicating new information to the cognitive system, contributing to the positive effect of sleep on memory consolidation. Disrupting sleep or hippocampal ripples impairs long-term memory. Additionally, high-frequency oscillations in the cortex are found to be involved in memory consolidation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Clinical Neurology
Hong-Viet V. Ngo, James W. Antony, Bjoern Rasch
Summary: Real-time brain stimulation is a powerful technique gaining importance in sleep and cognition. This special issue collects 14 articles, including a review, 12 research articles, and a letter covering human and rodent research. The aim is to inspire interest and new ideas in real-time stimulation among sleep researchers and clinicians.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Neurosciences
Lisa Bastian, Anumita Samanta, Demetrius Ribeiro de Paula, Frederik D. Weber, Robby Schoenfeld, Martin Dresler, Lisa Genzel
Summary: This study investigates the role of fast and slow spindle-slow oscillation coupling in the consolidation of spatial memory in humans and analyzes the evolution of resting-state functional connectivity across learning, consolidation, and retrieval of a virtual watermaze task.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Rafael Pedrosa, Mojtaba Nazari, Majid H. Mohajerani, Thomas Knopfel, Federico Stella, Francesco P. Battaglia
Summary: Hippocampus-neocortex interactions play a critical role in memory processes during sleep. Activation transients in the neocortex are associated with communication across remote brain areas and consolidation processes rely on bidirectional signaling between hippocampus and neocortex, with slow gamma rhythms being particularly important.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Hannah Twarkowski, Victor Steininger, Min Jae Kim, Amar Sahay
Summary: Memories encoded in the DG-CA3 circuit of the hippocampus play a crucial role in memory consolidation. By enhancing the neural circuitry between the CA1 and DG regions, the formation and maintenance of context-associated neuronal ensembles are facilitated, leading to improved long-term contextual fear memory. These findings provide important insights into the neural mechanisms of memory consolidation.
Review
Neurosciences
W. Xu, F. De Carvalho, A. K. Clarke, A. Jackson
Summary: Through long-term wireless recording, researchers characterized dynamic cerebro-thalamo-cerebellar interactions during natural sleep in monkeys. The observations suggest a contribution of the cerebellum to neocortical sleep spindles, potentially involving communication via cerebello-thalamo-neocortical pathways. The study highlights the complexity of neural activity in the sleeping cerebellum and its interaction with other brain regions during sleep.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Simone Sarasso, Frederic Zubler, Andrea Pigorini, Ivana Sartori, Laura Castana, Lino Nobili
Summary: Studies have focused on the relationship between EEG spindles and slow waves during sleep, revealing different temporal dynamics at the cortical and thalamic levels. These findings contribute to understanding the neurophysiological determinants of sleep spindles and slow waves.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Neurosciences
Line Folvik, Markus H. Sneve, Hedda T. Ness, Didac Vidal-Pineiro, Liisa Raud, Oliver M. Geier, Kristine B. Walhovd, Anders M. Fjell
Summary: Systems consolidation of new experiences into lasting episodic memories involves interactions between the hippocampus and neocortex. This process can be observed during early post-encoding rest periods, where there is increased connectivity between the hippocampus and neocortical regions involved in memory encoding. The similarity in hippocampal functional coupling between online memory encoding and offline post-encoding rest suggests a spectrum of cognitive processes involved in memory reactivation.
Article
Clinical Neurology
Tomomi Tsunematsu, Sumire Matsumoto, Mirna Merkler, Shuzo Sakata
Summary: P-waves, known as an electrophysiological signature of rapid eye movement (REM) sleep, are also observed during non-REM (NREM) sleep. Recent studies have discovered that P-waves in NREM sleep are functionally coupled with hippocampal sharp wave ripples (SWRs). The waveform shapes and local neural ensemble dynamics of P-waves in NREM sleep are similar to those in REM sleep in a short timescale. However, the dynamics of mesopontine cholinergic neurons and the coupling of P-waves with SWRs differ between NREM and REM sleep.
Article
Behavioral Sciences
Marit Petzka, Ian Charest, George M. Balanos, Bernhard P. Staresina
Summary: Sleep plays a crucial role in stabilizing newly acquired memories through a process known as memory consolidation. Recent studies have shown that weaker memories may benefit more from post-learning sleep, while stronger memories may not show as significant consolidation effects. However, under certain testing conditions, the true effects of sleep-dependent consolidation may be masked.
Article
Behavioral Sciences
Benjamin J. Griffiths, Maria Carmen Martin-Buro, Bernhard P. Staresina, Simon Hanslmayr, Tobias Staudigl
Summary: Research suggests that alpha/beta power decreases during episodic memory retrieval are linked to decreases in alpha/beta power during encoding. This indicates a relationship between alpha/beta power decreases in retrieval and encoding phases.
Article
Neurosciences
Marlene Derner, Leila Chaieb, Gert Dehnen, Thomas P. Reber, Valeri Borger, Rainer Surges, Bernhard P. Staresina, Florian Mormann, Juergen Fell
Summary: The study found that binaural and monaural beat stimulation has different effects on neural activity and memory performance, with specific neurons showing negative correlations between firing rate differences induced by binaural versus monaural beats and memory-related differences. This suggests that beat stimulation may influence memory performance by altering baseline firing levels in neurons, in line with concepts of homeostatic plasticity.
Article
Neurosciences
Federica Meconi, Juan Linde-Domingo, Catarina S. Ferreira, Sebastian Michelmann, Bernhard Staresina, Ian Apperly, Simon Hanslmayr
Summary: Through two experiments, the study found that memories play a significant role in empathy, as participants' experiences in empathetic tasks can trigger the reactivation of their autobiographical memories, leading to heightened emotional responses.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Lukas Kunz, Armin Brandt, Peter C. Reinacher, Bernhard P. Staresina, Eric T. Reifenstein, Christoph T. Weidemann, Nora A. Herweg, Ansh Patel, Melina Tsitsiklis, Richard Kempter, Michael J. Kahana, Andreas Schulze-Bonhage, Joshua Jacobs
Summary: The study identified neurons in the human brain that provide a neural code for egocentric spatial maps, which play a key role in navigation and memory recall.
Article
Multidisciplinary Sciences
Thomas Schreiner, Marit Petzka, Tobias Staudigl, Bernhard P. Staresina
Summary: The study shows that reactivating learning material during sleep, specifically during slow oscillations and sleep spindles, predicts the strength of memory consolidation, illustrating the role of these sleep rhythms in endogenous consolidation processes.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Marit Petzka, Alex Chatburn, Ian Charest, George M. Balanos, Bernhard P. Staresina
Summary: This study explores the role of sleep spindles in memory consolidation by using high-density scalp electroencephalography (EEG) and polysomnography (PSG). The results show that sleep spindles are most pronounced over learning-related cortical areas and the extent to which spindles track learning patterns predicts memory consolidation.
Article
Biochemistry & Molecular Biology
Oliver Ratcliffe, Kimron Shapiro, Bernhard P. Staresina
Summary: This study reports on the role of frontal-midline theta oscillations (FMT) in working memory (WM) content. The findings suggest that FMT plays a crucial role in coordinating the maintenance of memory content in posterior regions and that the observed frequency slowing supports phase coding in WM.
Article
Multidisciplinary Sciences
Jennifer Ashton, Bernhard Staresina, Scott Cairney
Summary: Sleep following learning improves memory recall, but factors such as rehearsal and schematic congruency also affect consolidation.
Article
Biology
Jacqueline Katharina Meier, Bernhard P. Staresina, Lars Schwabe
Summary: This study used EEG-based multivariate pattern analysis to decode neural representations of outcome and response in individuals under stress. The findings suggest that stress can lead to habitual behavior due to enhanced stimulus-response processing and diminished outcome processing.
Article
Neurosciences
Xiongbo Wu, Xavier Vinals, Aya Ben-Yakov, Bernhard P. Staresina, Lluis Fuentemilla
Summary: Prior research has shown that post-encoding reinstatement plays a crucial role in organizing the temporal sequence of unfolding episodes in memory. This study aimed to investigate whether post-encoding reinstatement promotes the encoding of one-shot episodic learning beyond temporal structure in humans. The findings suggest that post-encoding memory reinstatement is analogous to the rapid formation of unique and meaningful episodes that unfold over time.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Hong-Viet V. Ngo, Bernhard P. Staresina
Summary: Sleep is a privileged state for memory reactivation and consolidation. This research combines the use of reminder cues and brain stimulation to control the timing of memory reactivation. The results show that providing cues during specific sleep stages can significantly reduce overnight forgetting and enhance memory recall.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Multidisciplinary Sciences
Anli A. Liu, Simon Henin, Saman Abbaspoor, Anatol Bragin, Elizabeth A. Buffalo, Jordan S. Farrell, David J. Foster, Loren M. Frank, Tamara Gedankien, Jean Gotman, Jennifer A. Guidera, Kari L. Hoffman, Joshua Jacobs, Michael J. Kahana, Lin Li, Zhenrui Liao, Jack J. Lin, Attila Losonczy, Rafael Malach, Matthijs A. van der Meer, Kathryn McClain, Bruce L. McNaughton, Yitzhak Norman, Andrea Navas-Olive, Liset M. de la Prida, Jon W. Rueckemann, John J. Sakon, Ivan Skelin, Ivan Soltesz, Bernhard P. Staresina, Shennan A. Weiss, Matthew A. Wilson, Kareem A. Zaghloul, Michael Zugaro, Gyorgy Buzsaki
Summary: This article discusses the methodological challenges in detecting, analyzing, and reporting Sharp Wave Ripples, and suggests practical solutions to distinguish them from other high-frequency events. It emphasizes the importance of establishing shared experimental, detection, and reporting standards.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Frederic Roux, George Parish, Ramesh Chelvarajah, David T. Rollings, Vijay Sawlani, Hajo Hamer, Stephanie Gollwitzer, Gernot Kreiselmeyer, Marije J. ter Wal, Luca Kolibius, Bernhard P. Staresina, Maria Wimber, Matthew W. Self, Simon Hanslmayr
Summary: This study investigates the relationship between oscillations and neural firing patterns during memory formation in the medial temporal lobe, and finds that phase-coupling of neurons to theta and gamma oscillations is correlated with successful encoding of episodic memories.
Article
Neurosciences
Bernhard P. Staresina, Johannes Niediek, Valeri Borger, Rainer Surges, Florian Mormann
Summary: Using direct recordings from human MTL neurons during sleep, the study reveals that neuronal firing and communication are controlled by coupled slow oscillations, spindles, and ripples. These dynamics establish optimal conditions for synaptic plasticity and systems consolidation during sleep. The results shed light on how specific sleep rhythms orchestrate neuronal processing and communication in the sleeping brain.
NATURE NEUROSCIENCE
(2023)
