Journal
ELIFE
Volume 9, Issue -, Pages -Publisher
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.56694
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Funding
- National Eye Institute [R01-EY022411]
- Joshua I Gold Long Ding
- Hearst Foundations Graduate Student Fellowship Yunshu Fan
- University of Pennsylvania University Research Foundation
- NATIONAL EYE INSTITUTE [P30EY001583] Funding Source: NIH RePORTER
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Our decisions often balance what we observe and what we desire. A prime candidate for implementing this complex balancing act is the basal ganglia pathway, but its roles have not yet been examined experimentally in detail. Here, we show that a major input station of the basal ganglia, the caudate nucleus, plays a causal role in integrating uncertain visual evidence and reward context to guide adaptive decision-making. In monkeys making saccadic decisions based on motion cues and asymmetric reward-choice associations, single caudate neurons encoded both sources of information. Electrical microstimulation at caudate sites during motion viewing affected the monkeys' decisions. These microstimulation effects included coordinated changes in multiple computational components of the decision process that mimicked the monkeys' similarly coordinated voluntary strategies for balancing visual and reward information. These results imply that the caudate nucleus plays causal roles in coordinating decision processes that balance external evidence and internal preferences.
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