Review
Immunology
Consolato M. Sergi, Elka Miller, Dina El Demellawy, Fan Shen, Mingyong Zhang
Summary: Chronic recurrent and multifocal osteomyelitis (CRMO) is a continuous autoinflammatory disorder commonly found in children and adolescents. Whole-body MRI plays a crucial role in diagnosing and monitoring the progression of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Bridget A. Rafferty, Pooja Thakrar
Summary: CNO/CRMO is an underrecognized autoinflammatory disorder of the skeletal system resulting from immune dysregulation. Diagnosis is often delayed due to vague symptoms and the lack of accepted diagnostic criteria or specific biomarkers. Untreated CRMO can lead to chronic skeletal deformities, arthritis, and chronic pain. Diagnosis requires MRI and WB-MRI. Treatment primarily involves antiinflammatory medications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Andressa Guariento, Parth Sharma, Savvas Andronikou
Summary: This study characterized the MR imaging features and patterns of pediatric spinal CRMO/CNO. The results showed that CRMO/CNO typically involves the thoracic spine, vertebral body edema is often focal at the superior vertebral body, and kyphosis and scoliosis occur in about a quarter of children at spinal disease recognition, with vertebral height loss in about a third.
PEDIATRIC RADIOLOGY
(2023)
Article
Rheumatology
Marie Robert, Anna Giolito, Heloise Reumaux, Linda Rossi-Semerano, Claire Guillemin, Louis Biarrotte, Damia Leguevaques, Alexandre Belot, Agnes Duquesne, Cecile Frachette, Audrey Laurent, Marine Desjonqueres, Jean-Paul Larbre, Caroline Galeotti, Isabelle Kone-Paut, Perrine Dusser
Summary: This study aimed to investigate the frequency, characteristics and treatment of extra-osseous (EO) manifestations in chronic recurrent multifocal osteomyelitis (CRMO) and whether different phenotypes can benefit from special management. The study included 133 CRMO patients and found that 67.7% of them had EO manifestations, primarily skin lesions, sacroiliitis, enthesitis, arthritis, and gastrointestinal manifestations. Patients with EO manifestations were more likely to be treated with biologics, and a significant number of them achieved complete remission under this treatment.
Article
Biochemistry & Molecular Biology
Ryo Yoshikawa, Koichiro Abe
Summary: The study demonstrates that dasatinib kinase inhibitor effectively suppresses autoinflammation and related-bone phenotypes in CRMO model animals, suggesting its potential for clinical treatments. Dasatinib has the ability to restore bone density and reduce inflammation in affected areas, making it a strong candidate for CRMO therapy when combined with molecular diagnosis.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Review
Pediatrics
Fernando Moreno-Mateo, Sofia Hidalgo Perea, Karen Brandt Onel
Summary: Recent advancements in MRI imaging and understanding of pathophysiology have improved the diagnosis and treatment of CRMO, with TNF-alpha inhibitors and bisphosphonates showing promising results for symptomatic relief and normalization of bone morphology. Better knowledge of genetic and molecular factors may lead to early diagnosis and development of more effective individualized treatments in the future.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Akshay Waghmode, Nikhith Soman, Aryan Gupta
Summary: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoimmune inflammatory condition that mainly affects children and young adults. Its typical features include recurrent severe bone pain and imaging findings suggestive of osteomyelitis or malignancy. Diagnosis of CRMO requires excluding other possibilities and considering various diagnostic criteria.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Rheumatology
Philipp Rausch, Meike Hartmann, John F. Baines, Philipp von Bismarck
Summary: This study investigates the differences in oral and fecal microbial communities between children with and without chronic recurrent multifocal osteomyelitis (CRMO) using bacterial 16S rRNA gene profiling. The results suggest that the absence of potential probiotic bacteria in fecal communities and the presence of known pathobionts in oral microbial communities may serve as indicators of underlying susceptibility to CRMO. Furthermore, the gut bacterial communities appear to reflect altered host physiology more strongly than the oral community, indicating an oral disease origin followed by systemic propagation or responses.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Mohamad Ali Tahririan, Seyed Mohamad Hossein Tabatabaei Nodushan, Mehrdad Farrokhi
Summary: This is a rare case of multifocal bone disorder, where the patient was ultimately diagnosed with chronic recurrent multifocal osteomyelitis (CRMO) and showed significant improvement after a 5-month treatment with nonsteroidal anti-inflammatory drugs.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sarah J. Menashe, Hassan Aboughalia, Yongdong Zhao, Anh-Vu Ngo, Jeffrey P. Otjen, Mahesh M. Thapa, Ramesh S. Iyer
Summary: CRMO is an autoinflammatory bone disease of childhood and adolescence characterized by episodic bone pain. Diagnosis relies heavily on whole-body MRI and differentiates the disease by excluding other disorders with overlapping imaging features.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Rheumatology
Shima Yasin, T. Shawn Sato, Polly Ferguson
Summary: Advances in understanding the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO) in children have influenced therapeutic strategies. The use of whole-body MRI (WBMRI) and increased awareness of CRMO have led to higher rates and timeliness of CRMO diagnoses. This review highlights recent findings from CRMO cohorts and discusses the course, complications, and long-term sequelae of the disease. It is important for clinicians to be aware of the potential for long-term sequelae in order to optimize therapy and prevent complications.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Immunology
Martina Sundqvist, Karin Christenson, Per Wekell, Halla Bjornsdottir, Agnes Dahlstrand Rudin, Felix P. Sanchez Klose, Tilmann Kallinich, Amanda Welin, Lena Bjorkman, Johan Bylund, Anna Karlsson-Bengtsson, Stefan Berg
Summary: This article describes a female patient with severe chronic non-bacterial osteomyelitis (CNO) and complete deficiency of myeloperoxidase (MPO). The patient showed a good response to TNF-alpha blockade (adalimumab), suggesting a possible link between the MPO deficiency and abnormal neutrophil function.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Amman Yousaf, Shoaib Muhammad, Sohaib Bassam Mahmoud Zoghoul, Syed Intekhab Alam, Ahmed Mounir Elsyaed
Summary: CRMO is a childhood inflammatory disorder of bones characterized by pain and swelling. Diagnosis relies on clinical findings, elevated inflammatory markers, X-ray, and MRI results. Treatment mainly involves NSAIDs and corticosteroids.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Rheumatology
Ivana Stojkic, Eric Rubin, Jay Lee, Ashley Sang Eun Lee, Ekemini Akan Ogbu
Summary: Chronic recurrent multifocal osteomyelitis is a rare inflammatory disease that affects children and adolescents. This case report describes an atypical presentation of the disease in an African-American adolescent male with recurrent swelling in the temporal region and skull involvement. The patient showed clinical and laboratory improvement after treatment with indomethacin and pamidronate.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Isabelle Kone-Paut, Ines Mannes, Perrine Dusser
Summary: The article "Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Juvenile Spondyloarthritis (SpA)" discusses the differences and similarities between CRMO and juvenile SpA in terms of clinical, radiological, and pathophysiological aspects. It suggests that both conditions may share similar pathophysiological mechanisms, with intestinal dysbiosis potentially playing a role. The article also highlights the importance of considering interindividual factors in disease development.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Rheumatology
C. Zimmer, M. Moll, N. Rieber, R. Goldbach-Mansky, I. Aksentijevich, J. Kuemmerle-Deschner
ANNALS OF THE RHEUMATIC DISEASES
(2013)
Article
Pediatrics
Christiane Reiser, Nina A. Zeltner, Beatrix Rettenbacher, Petra Baumgaertner, Martina Huemer, Christian Huemer
Summary: The study focused on creating easy-to-understand illustrations and texts for children and adolescents with JIA to improve disease knowledge and treatment adherence. Results showed significant knowledge gain in both patients and controls, with a higher enhancement in disease knowledge in the control group. The newly developed materials also led to an improvement in self-efficacy in patients, without any impact on their health-related quality of life.
PEDIATRIC RHEUMATOLOGY
(2021)
Article
Rheumatology
Christiane Reiser, Jens Klotsche, Anton Hospach, Rainer Berendes, Anja Schnabel, Annette F. Jansson, Markus Hufnagel, Nadine Groesch, Martina Niewerth, Kirsten Minden, Hermann Girschick
Summary: The study assessed the first-year features of patients with chronic nonbacterial osteomyelitis. Most patients were most affected at the tibia, pelvis, and femur during the initial visit, and treatment primarily involved nonsteroidal anti-inflammatory drugs.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Rheumatology
Hermann J. Girschick, Christiane Zimmer, Guenter Klaus, Kassa Darge, Anke Dick, Henner Morbach
NATURE CLINICAL PRACTICE RHEUMATOLOGY
(2007)