Article
Medicine, General & Internal
Yuning Lin, Zhongying Zhang, Ying Li, Yongquan Chen, Meiying Su, Wenzhen Zhao
Summary: This study found that increased expression of DIRC1 in stomach adenocarcinoma (STAD) was associated with clinical-pathologic features such as T stage, race, histologic grade, and anatomic neoplasm subdivision, and high DIRC1 expression predicted poorer overall survival. Genes associated with DIRC1 were found to be related to functions such as epidermis, collagen-containing extracellular matrix, receptor-ligand activity, and protein digestion and absorption. Immune infiltration analysis revealed a strong correlation between DIRC1 and immune cells like macrophages.
Article
Oncology
Dandan Zhu, Sifan Wu, Yafang Li, Yu Zhang, Jierong Chen, Jianhong Ma, Lixue Cao, Zejian Lyu, Tieying Hou
Summary: In this study, a ceRNA network was constructed to explore the relationship between ferroptosis-related genes and immune infiltration in stomach adenocarcinoma (STAD). It was found that the ferroptosis-related gene SLC1A5 was associated with tumor-infiltrating immune cells and immune checkpoints, suggesting its potential as a prognostic marker and therapeutic target for STAD immunotherapy.
CANCER CELL INTERNATIONAL
(2022)
Article
Immunology
Miaosen Zheng, Jian Liu, Tingting Bian, Lei Liu, Hui Sun, Haomiao Zhou, Cui Zhao, Zheng Yang, Jiahai Shi, Yifei Liu
Summary: The study showed that AHNAK2 gene is significantly overexpressed in LUAD tumor tissues and serves as an independent prognostic indicator for LUAD patients. AHNAK2 expression is associated with disease stage, differentiation, tumor size, and lymph node metastasis. Furthermore, AHNAK2 expression is related to specific immune cell infiltrates in the tumor microenvironment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Kai Shen, Tong Liu
Summary: The study found that the expression of most immune checkpoints is upregulated in STAD and is associated with drug sensitivity, drug resistance, and patient prognosis. Factors such as CD70 and ICOSLG were identified as independent factors affecting the prognosis of STAD patients. Furthermore, the expression of ICOSLG and CD70 is correlated with immune cells, indicating that they may serve as prognostic biomarkers for STAD.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Genetics & Heredity
Xiaoping Xu, Zhenglan Zhong, Yongxiang Shao, Yong Yi
Summary: Accumulating evidence has shown that dysregulated lncRNA expression plays a role in cancer progression. This study focused on evaluating the significance of MEG3 in glioma prognosis and its immune-related roles. The results indicated that MEG3 expression was correlated with patient survival and prognosis, as well as with tumor-infiltrating immune cells in gliomas.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Chao Li, Jun Meng, Tongtong Zhang
Summary: This study found that NCAPH is overexpressed in lung adenocarcinoma (LUAD) and is associated with prognosis and immune infiltrates. High expression of NCAPH is associated with shorter overall survival and decreased progression-free interval and disease-specific survival. In addition, NCAPH is associated with several gene sets and immune cell levels. Knocking down NCAPH can inhibit the malignant phenotype of LUAD cells in vitro.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Xiao-Fei Wang, Wei Lei, Chuan-Mei Liu, Jie Yang, Ye-Han Zhu
Summary: This study found that high expression of BOLA3 in lung adenocarcinoma (LUAD) is associated with poor prognosis and immune infiltrates, suggesting that BOLA3 may serve as a potential immunotherapy target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Jiahui Han, Xinzhou Deng, Renhuang Sun, Ming Luo, Meng Liang, Bing Gu, Te Zhang, Zhen Peng, Ying Lu, Chao Tian, Yutao Yan, Zhiguo Luo
Summary: The study indicates that GPI is overexpressed in LUAD and can serve as a reference for diagnosis and prognostic estimation. Knockdown of GPI affects cell proliferation and the cell cycle, and is correlated with immune cell infiltration levels.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Yu Jing, Ziming Mao, Jing Zhu, Xirui Ma, Huifang Liu, Fengling Chen
Summary: In this study, TRAIP was found to be significantly overexpressed in lung adenocarcinoma (LUAD) tissues and associated with poor prognosis. TRAIP was involved in DNA replication, cell cycle, and immune cell infiltration. Knockdown of TRAIP inhibited cell migration, invasion, and M2-like macrophage recruitment. CMap analysis identified potential small molecule compounds targeting TRAIP as therapeutic options for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Long Chen, Chong Zeng, Limei Yan, Wanyu Liao, Chen Zhen, Jie Yao
Summary: This study found that high expression of Holliday junction-recognizing protein (HJURP) is associated with poor prognosis in lung adenocarcinoma (LUAD), and investigated the biological pathways related to HJURP in LUAD pathogenesis. Further experiments are needed to demonstrate the biological effects of HJURP.
Article
Oncology
Feng Xu, Na Xiong, Yuhong Yuan, Jun Liu
Summary: This study found that ubiquitin-conjugating enzyme E2T (UBE2T) is highly expressed in non-small cell lung cancer (LUAD) and is associated with gender, age, advanced clinical stage, and decreased overall survival. Multivariable analysis showed that UBE2T expression is a significant independent diagnostic factor for patients with LUAD. Additionally, UBE2T expression is correlated with immune infiltration in LUAD.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Haining Li, Liping Guo, Zhigang Cai
Summary: TCN1, highly expressed in lung adenocarcinomas (LUAD), is found to be associated with poor prognosis and can serve as a diagnostic biomarker. This study suggests that TCN1 may serve as a potential therapeutic target and prognostic marker for LUAD development.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Medical Laboratory Technology
Shan Wang, Zhaoxin Chen, Hongwei Lv, Cong Wang, Huamin Wei, Jing Yu
Summary: This study found that the expression of endothelial lipase gene (LIPG) is higher in lung adenocarcinoma (LUAD) and is associated with prognosis, lipid metabolism, and immune infiltration.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Medicine, Research & Experimental
Lili Guo, Dingsheng Liu
Summary: This study found that the expression of RFX family genes, particularly RFX5, was significantly elevated in stomach adenocarcinoma (STAD). High expression of RFX5 was associated with better prognosis and immune cell infiltration. Furthermore, RFX5 was involved in T cell activation and antigen receptor-mediated signaling pathway.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xin Jin, Liwei Chen, Ning Zhou, Hong Ni, Lingling Zu, Jinling He, Lingqi Yang, Yifan Zhu, Xiaoyue Sun, Xiaojiang Li, Song Xu
Summary: LRMP is significantly downregulated in LUAD tissues and cell lines, with high expression correlating with better patient prognosis. Overexpression of LRMP in A549 cells inhibits proliferation, migration, and invasion, and downregulates oncogenic signaling pathways. GSEA analysis reveals enrichment of immune-related pathways in samples with high LRMP expression, and LRMP is positively correlated with tumor-infiltrating immune cells and their markers.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Ya Guo, Xiao-Dong Zhu, Song Qu, Ling Li, Fang Su, Ye Li, Shi-Ting Huang, Dan-Rong Li
INTERNATIONAL JOURNAL OF ONCOLOGY
(2012)
Article
Genetics & Heredity
Ya Guo, Yang Zhang, Shu Juan Zhang, Yi Nan Ma, Yun He
BMC MEDICAL GENOMICS
(2019)
Article
Genetics & Heredity
Ya Guo, Ya Li Wang, Wang Hui Su, Peng Tao Yang, Jing Chen, Heng Luo
FRONTIERS IN GENETICS
(2020)
