Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 510, Issue -, Pages 33-42Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfa.2016.07.065
Keywords
Morpholinium surfactant; Gemini; Solubilization; Thymolphthalein; Indomethacin
Categories
Funding
- Russian Science Foundation [14-23-00073] Funding Source: Russian Science Foundation
Ask authors/readers for more resources
Herein, novel dicationic surfactants bearing morpholinium moieties in polar group, 14-s-14 Mor (s = 4, 6, 8, 10) are synthesized, and their aggregation behavior is studied and compared with reference surfactants, single-head morpholinium surfactant Mor-14, typical gemini with ammonium head group and dicationic surfactants with heterocyclic polar fragment. Geminis studied are found to exhibit superior solubilization capacity toward a pH indicator thymolphthalein and an inflammatory drug indomethacin, exceeding that of reference amphiphiles. The solubility of the probes is contributed by multifactor mechanism involving the solubilization in nonpolar core of micelles and periphery electrostatic interaction between micellar surface charge and ionic moieties of the drug. Mutual influence of the components occurs on their properties, including pK(a) shift of ionogenic groups of a guest molecule and decrease in critical micelle concentration of geminis. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available