Anti-cancer peptides: classification, mechanism of action, reconstruction and modification

Research Progress Evaluating the Function and Mechanism of Anti-Tumor Peptides

(2020) Xinxing Pan et al.   Cancer Management and Research

Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII

(2019) Yurong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Copy number variation of PR-39 cathelicidin, and identification of PR-35, a natural variant of PR-39 with reduced mammalian cytotoxicity

(2019) Hyoim Jeon et al.   GENE

Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease

(2019) Anwesha Sanyal et al.   JOURNAL OF MOLECULAR BIOLOGY

Natural products against cancer: Review on phytochemicals from marine sources in preventing cancer

(2019) Adil Farooq Wali et al.   SAUDI PHARMACEUTICAL JOURNAL

A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin

(2019) Ji-Yeong Sim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms and therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy

(2019) Wei-Di Yu et al.   CANCER LETTERS

Emerging strategies in cancer therapy combining chemotherapy with immunotherapy

(2019) Qiuhua Luo et al.   CANCER LETTERS

Monosaccharide Analogues of Anticancer Peptide R-Lycosin-I: Role of Monosaccharide Conjugation in Complexation and the Potential of Lung Cancer Targeting and Therapy

(2019) Peng Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

An international survey on the management of patients receiving CAR T-cell therapy for haematological malignancies on behalf of the Chronic Malignancies Working Party of EBMT

(2019) P.J. Hayden et al.   Current Research in Translational Medicine

Expression de PD-L1 et inhibiteurs de la voie PD-1/PD-L1 dans le cancer du sein

(2018) Audrey Monneur et al.   BULLETIN DU CANCER

MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells

(2018) Mengyun Ke et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Enhanced radiosensitization of human glioblastoma multiforme cells with phosphorylated peptides derived from Gli2

(2018) Lizhang Han et al.   NEUROPEPTIDES

Comparative effectiveness of preoperative, postoperative and perioperative treatments for resectable gastric cancer: A network meta-analysis of the literature from the past 20 years

(2018) Zhaolun Cai et al.   SURGICAL ONCOLOGY-OXFORD

Potential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells

(2018) Haobin Zhao et al.   AMB Express

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CRISPR/Cas9 and CAR-T cell, collaboration of two revolutionary technologies in cancer immunotherapy, an instruction for successful cancer treatment

(2018) Hasan Mollanoori et al.   HUMAN IMMUNOLOGY

The Roles of Fatty-Acid Modification in the Activity of the Anticancer Peptide R-Lycosin-I

(2018) Cui Jian et al.   MOLECULAR PHARMACEUTICS

Antibacterial and Antibiofilm Activity and Mode of Action of Magainin 2 against Drug-Resistant Acinetobacter baumannii

(2018) Min Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression and significance of CD47, PD1 and PDL1 in T-cell acute lymphoblastic lymphoma/leukemia

(2018) Kun Yang et al.   PATHOLOGY RESEARCH AND PRACTICE

The expression profile of p14, p53 and p21 in tumour cells is associated with disease-specific survival and the outcome of postoperative chemotherapy treatment in muscle-invasive bladder cancer

(2018) Firas Aljabery et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

CAR T-cell therapy for pancreatic cancer

(2017) Carl J. DeSelm et al.   JOURNAL OF SURGICAL ONCOLOGY

Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications

(2017) Yeji Lee et al.   PEPTIDES

Cholesterol-directed nanoparticle assemblies based on single amino acid peptide mutations activate cellular uptake and decrease tumor volume

(2017) Shang Li et al.   Chemical Science

Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities

(2017) Jun-Pil Jang et al.   PLoS One

Cell surface binding, uptaking and anticancer activity of L-K6, a lysine/leucine-rich peptide, on human breast cancer MCF-7 cells

(2017) Che Wang et al.   Scientific Reports

Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C α amino acids

(2016) Rickey P. Hicks   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting cancer cells via tumor-homing peptide CREKA functional PEG nanoparticles

(2016) Aysu Ceren Okur et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Plant protein glycosylation

(2016) Richard Strasser   GLYCOBIOLOGY

Methionine enkephalin, its role in immunoregulation and cancer therapy

(2016) Dingliang Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ultrashort cationic lipopeptides and lipopeptoids: Evaluation and mechanistic insights against epithelial cancer cells

(2016) Ronald Domalaon et al.   PEPTIDES

Bovine lactoferricin P13 triggers ROS-mediated caspase-dependent apoptosis in SMMC7721 cells

(2016) Lixiang Meng et al.   Oncology Letters

Cyclic depsipeptides as potential cancer therapeutics

(2015) Jirouta Kitagaki et al.   ANTI-CANCER DRUGS

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

(2015) Diana Gaspar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Methionine Enkephalin (MENK) Inhibits tumor growth through regulating CD4+Foxp3+ Regulatory T cells (Tregs) in mice

(2015) Xuan Li et al.   CANCER BIOLOGY & THERAPY

Design, Synthesis, and Biological Evaluation of Novel Cholesteryl Peptides with Anticancer and Multidrug Resistance-Reversing Activities

(2015) Xin Deng et al.   Chemical Biology & Drug Design

Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells

(2015) Yoshihiro Kuroda et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melanoma cell surface-expressed phosphatidylserine as a therapeutic target for cationic anticancer peptide, temporin-1CEa

(2015) Che Wang et al.   JOURNAL OF DRUG TARGETING

APD3: the antimicrobial peptide database as a tool for research and education

(2015) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

TAT Modification of Alpha-Helical Anticancer Peptides to Improve Specificity and Efficacy

(2015) Xueyu Hao et al.   PLoS One

PEGylation and its impact on the design of new protein-based medicines

(2014) Claire Ginn et al.   Future Medicinal Chemistry

Ion channel regulation by protein S-acylation

(2014) Michael J. Shipston   JOURNAL OF GENERAL PHYSIOLOGY

Effects of Single Amino Acid Substitution on the Biophysical Properties and Biological Activities of an Amphipathic α-Helical Antibacterial Peptide Against Gram-Negative Bacteria

(2014) Juanjuan Tan et al.   MOLECULES

Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment

(2014) Rima Beesoo et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Bovine Lactoferrin Induces Cell Cycle Arrest and Inhibits Mtor Signaling in Breast Cancer Cells

(2014) Yunlei Zhang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Antimicrobial and Immunomodulatory Activities of PR-39 Derived Peptides

(2014) Edwin J. A. Veldhuizen et al.   PLoS One

A novel cyclic pentapeptide, H-10, inhibits B16 cancer cell growth and induces cell apoptosis

(2014) GENG ZHANG et al.   Oncology Letters

Site-Specific N-Glycosylation of Caprine Lysostaphin Restricts its Bacteriolytic Activity TowardStaphylococcus Aureus

(2013) Ching-Ying Huang et al.   ANIMAL BIOTECHNOLOGY

Role of glycosylation in the anticancer activity of antibacterial peptides against breast cancer cells

(2013) Yang-Yang Han et al.   BIOCHEMICAL PHARMACOLOGY

A Brief Overview of Antimicrobial Peptides Containing Unnatural Amino Acids and Ligand-Based Approaches for Peptide Ligands

(2013) Jayendra Bhonsle et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Generation of a hematologic malignancy-selective membranolytic peptide from the antimicrobial core (RRWQWR) of bovine lactoferricin

(2013) Ashley L. Hilchie et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The effect of alloferon on the enhancement of NK cell cytotoxicity against cancer via the up-regulation of perforin/granzyme B secretion

(2013) Seyeon Bae et al.   IMMUNOBIOLOGY

Marine natural products: Bryostatins in preclinical and clinical studies

(2013) Peter Kollár et al.   PHARMACEUTICAL BIOLOGY

FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells

(2013) Shun X. Ren et al.   PLoS One

The Use of Therapeutic Peptides to Target and to Kill Cancer Cells

(2012) R. J. Boohaker et al.   CURRENT MEDICINAL CHEMISTRY

Designed synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin αvβ3 homing domain

(2012) Yuwen Diao et al.   JOURNAL OF PEPTIDE SCIENCE

Overview on the recent study of antimicrobial peptides: Origins, functions, relative mechanisms and application

(2012) Yanmei Li et al.   PEPTIDES

Protein palmitoylation and subcellular trafficking

(2011) Clara Aicart-Ramos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Determining the effect of the incorporation of unnatural amino acids into antimicrobial peptides on the interactions with zwitterionic and anionic membrane model systems

(2011) Amanda L. Russell et al.   CHEMISTRY AND PHYSICS OF LIPIDS

PEGylation of Proteins and Liposomes: a Powerful and Flexible Strategy to Improve the Drug Delivery

(2011) Paola Milla et al.   CURRENT DRUG METABOLISM

Peptides in cancer nanomedicine: Drug carriers, targeting ligands and protease substrates

(2011) Xiao-Xiang Zhang et al.   JOURNAL OF CONTROLLED RELEASE

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

(2011) Pipsa Saharinen et al.   TRENDS IN MOLECULAR MEDICINE

Novel antimicrobial peptides that exhibit activity against select agents and other drug resistant bacteria

(2010) Divakaramenon Venugopal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting apoptotic and autophagic pathways for cancer therapeutics

(2010) Jun-jie Liu et al.   CANCER LETTERS

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Advances in PEGylation of important biotech molecules: delivery aspects

(2008) Sinéad M Ryan et al.   Expert Opinion on Drug Delivery

A novel peptide from human apolipoprotein(a) inhibits angiogenesis and tumor growth by targeting c-Src phosphorylation in VEGF-induced human umbilical endothelial cells

(2008) Zheng-Fang Yi et al.   INTERNATIONAL JOURNAL OF CANCER

Activation of NF-κB by alloferon through down-regulation of antioxidant proteins and IκBα

(2008) Myung-Jeom Ryu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY