Journal
JOURNAL OF SAUDI CHEMICAL SOCIETY
Volume 24, Issue 9, Pages 683-692Publisher
ELSEVIER
DOI: 10.1016/j.jscs.2020.07.007
Keywords
Anti-allergic drug; Cationic surfactant; Anionic surfactant; Mixed micelle; Synergism
Categories
Funding
- Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Saudi Arabia [KEP-76-130-38]
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To search a new drug delivery excipient, this effort deals with the effects of cationic (hexadecyltrimethylammonium bromide, CTAB) and anionic (sodium dodecylbenzene sulfonate, SDBS) surfactants on the physicochemical properties of the anti-allergic drug (diphenhydramine hydrochloride, DPH). The tensiometric study has been done to find the nature of the interaction between drug and ionic surfactants. Numerous micellar, surface and conforming energetic parameters have been intended from this technique. Several physical models (Clint, Rubingh, Rosen, and Motomura) based on pseudo-phase approximation and regular solution theory, have been applied to compute these meaningful physical parameters. The DPH is a positively charged amphiphilic drug, while CTAB and SDBS are positively and negatively charged surfactants. It is experienced stronger attractive interaction of DPH with SDBS as compared to CTAB. (c) 2020 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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