Article
Spectroscopy
Zhengbing Zhou, Xiao Yuan, Da Long, Manhua Liu, Kun Li, Yongmei Xie
Summary: A lysosomal-targeted near infrared fluorescent probe with high sensitivity towards reactive oxygen species (ROS) was developed, showing different response activity towards H2O2, · OH, and HClO. It has been successfully used for ROS detection and imaging in cells and in vivo.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Chemistry, Inorganic & Nuclear
Ya-Lin Qi, Yun-Zhan Li, Ming-Jun Tan, Fang-Fang Yuan, Niren Murthy, Yong-Tao Duan, Hai-Liang Zhu, Sheng-Yu Yang
Summary: In recent years, there has been great interest in the development of organic near-infrared (NIR) ratiometric fluorescent probes. Traditional intensity-based probes lack an internal standard method, resulting in unreliable and inaccurate detection signals as well as an inability to achieve quantitative determination of analytes. Smart dual emission probes with built-in correction ability have overcome the limitations of single channel fluorescent probes and enable reliable quantitative image analysis. Moreover, fluorescent chemosensors in the NIR window offer advantages such as high signal-to-noise ratio, low tissue damage, and deep tissue penetration. The combination of the advantages of ratiometric fluorescent probes and single-intensity-based NIR probes in NIR ratiometric fluorescent probes has led to their widespread application in biomedical research and clinical practice. This review provides a systematic summary of the recent advances (2020-2022) in this field, discussing the design strategies, sensing mechanisms, and bioapplications of these intelligent fluorescent probes. The challenges and prospects in this promising field are also addressed, with the anticipation that this work will inspire the development of organic NIR ratiometric fluorescent probes.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Inorganic & Nuclear
Caiping Ding, Tianbing Ren
Summary: Near infrared (NIR) fluorescent probes have advantageous features including low background interference, strong tissue penetration, and minimal tissue damage. This paper provides a summary and discussion on the various types and properties of fluorophores used in the design of NIR fluorescent probes. It also discusses the latest research achievements in detecting and imaging reactive oxygen species, reactive nitrogen, and active sulfur in cells or in vivo. Additionally, a concise overview of the future development of NIR molecular fluorescence probes is proposed based on existing research, offering a reference for current research directions.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Jiaguo Huang, Kanyi Pu
Summary: Near-infrared (NIR) fluorescence imaging shows great potential in both basic biomedical research and clinical practice, especially in the diagnosis of nephron-urological diseases. The development of molecular probes has improved detection specificity and contrast enhancement in imaging.
Review
Chemistry, Multidisciplinary
Shahi Imam Reja, Masafumi Minoshima, Yuichiro Hori, Kazuya Kikuchi
Summary: The development of near-infrared fluorescent probes has revolutionized biomolecular imaging and is now used as an important tool in understanding intracellular activities. The coupling of self-labeling protein tags with synthetic fluorescent probes is becoming a significant research area in chemical biology.
Article
Spectroscopy
Yibin Zhang, Hongjing Ge, Lin Sun, Yueting Cheng, Zihan Xu, Wei Gao, Boling Wang, Xiaoqian Rong, Xianyu Qiu, Jingjing Li, Mingxi Fang, Jinting Shang
Summary: In this study, two novel near-infrared fluorescent probes, CyHg-Cl, were designed and synthesized based on the merocyanine scaffold for the detection of Hg2+. These probes exhibited rapid fluorescence enhancement upon introduction of Hg2+ due to the release of the chloro-substituted merocyanine structure. Additionally, the CyHg-Cl probe showed NIR emission and a low detection limit.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Chemistry, Applied
Weijie Chen, Yihan Guan, Qiong Chen, Jun Ren, Yuan Xie, Jun Yin
Summary: Heavy metal pollution, especially mercury(II) contamination, is a severe threat to human health and environmental security. This study developed a new near-infrared fluorescent probe that can specifically detect and measure mercury(II) ions and be used for in vivo imaging in biological systems.
Article
Chemistry, Analytical
Jizhen Shang, Wen Shi, Xiaohua Li, Huimin Ma
Summary: The development of two new NIR fluorescent probes, Rma-1 and Rma-2, shows great potential for specific analysis of MAO-A in living biosystems. Among them, probe Rma-1, with a self-immolative linker, demonstrates superior analytical performance and successful imaging of MAO-A activity in cancer.
ANALYTICAL CHEMISTRY
(2021)
Article
Spectroscopy
Bin Liu, Conghui Zeng, Danna Zheng, Xiongfei Zhao, Chao Song, Tianyi Qin, Zhongyong Xu
Summary: This study focuses on the development of a fluorescent probe, DCO2, for the discrimination of human serum albumin (HSA) from bovine serum albumin (BSA). The results demonstrate that DCO2 selectively binds with HSA, exhibiting significant fluorescence enhancement. The study also reveals the sensing mechanism and the potential application of DCO2 in biological fluids.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Kun Huang, Yuting Liu, Piao Zhao, Lijuan Liang, Qing Wang, Dabin Qin
Summary: This study reports a new pyridyl-functionalized rhodamine dye, PR, which has stable fluorescence signal in water. Based on PR, a fluorescent probe, PRHg, has been developed for sensing Hg2+. PRHg shows high selectivity and sensitivity towards Hg2+ and can respond to Hg2+ within 40 minutes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Serkan Erdemir, Sait Malkondu
Summary: A novel probe RHI was designed and synthesized for sensitive and specific sensing of metal ions, showing potential for biological and environmental applications.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Engineering, Environmental
Miantai Ye, Yunhui Xiang, Jiankang Gong, Xiaoyu Wang, Zhiqiang Mao, Zhihong Liu
Summary: Noninvasively imaging mercury poisoning in living organisms is critical to understanding its toxicity and treatments. Especially, simultaneous fluorescence imaging of Hg2+ and MeHg+ in vivo is helpful to disclose the mysteries of mercury poisoning. A new near-infrared II (NIR II) emissive probe, NIR-Rh-MS, has been designed to visualize mercury toxicity in mice. The probe produces a marked fluorescence signal and displays good sensitivity to Hg2+ and MeHg+. It can penetrate deep into simulated tissues and has successfully monitored the toxicity of Hg2+ in mouse livers and the accumulation of MeHg+ in mouse brains via intravital NIR-II imaging.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Organic
Jiaxin He, Boyu Yan, Jiangtao Meng, Maogang Ran, Yutong Zhou, Jinfei Deng, Chao-Jun Li, Qiuli Yao
Summary: Rhodamine-based amide derivatives were synthesized for detecting radical intermediates in organic reactions and used as fluorescent probes in various solvents. Mechanistic studies verified the reversible opening and closing of the spirolactam ring. Compound 21 can be employed to support the radical mechanism or for real-time monitoring of radical intermediates.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Guannan Liu, Guishan Peng, Jianan Dai, Ri Zhou, Chenguang Wang, Xu Yan, Xiaoteng Jia, Xiaomin Liu, Yuan Gao, Lijun Wang, Geyu Lu
Summary: The newly developed Lipi-BDTO molecule fluorescent probe achieves a high resolution of 65 nm in STED imaging with high photostability. This probe not only allows monitoring of LDs dynamics but also visualizes the 3D spatial distribution of LDs through 3D STED imaging.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Wan-Qing Du, Wen-Qi Song, Tian-Yu Liang, Xiao-Fei Sun, Li-Jun Tang, Ke-Li Zhong
Summary: A novel fluorescence probe SAM-S with near infrared emission was synthesized and used for detection of Hg2+. The probe showed weak fluorescence in buffer solution and significant enhancement in the presence of Hg2+. The method exhibited good selectivity, strong anti-interference ability, and low detection limit.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Ling Li, Chunyan Wang, Jianjian Wu, Yu Chung Tse, Yue-Peng Cai, Keith Man-Chung Wong
INORGANIC CHEMISTRY
(2016)
Article
Chemistry, Multidisciplinary
Ling Li, Shu Wang, Hongxia Lan, Guiyi Gong, Yifan Zhu, Yu Chung Tse, Keith Man-Chung Wong
Article
Chemistry, Inorganic & Nuclear
Yukun Cheng, Ling Li, Fangfang Wei, Keith Man-Chung Wong
INORGANIC CHEMISTRY
(2018)
Article
Chemistry, Analytical
Jing-Hui Zhu, Keith Man-Chung Wong
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Nanoscience & Nanotechnology
Chuangjun Liu, Lihua Zhou, Fangfang Wei, Ling Li, Shunan Zhao, Ping Gong, Lintao Cai, Keith Man-Chung Wong
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Chemistry, Multidisciplinary
Fangfang Wei, Shiu-Lun Lai, Shunan Zhao, Maggie Ng, Mei-Yee Chan, Vivian Wing-Wah Yam, Keith Man-Chung Wong
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Energy & Fuels
Fangfang Wei, Zhiyuan Qian, Shiu-Lun Lai, Shunan Zhao, Mei-Yee Chan, Keith Man-Chung Wong
Summary: A series of orange-red-emitting cyclometalating rhodium(III) complexes have been successfully synthesized and applied in OLED fabrication, with fluorine substituents showing improved device lifetime and electroluminescence performance, demonstrating their potential for OLED applications.
Correction
Nanoscience & Nanotechnology
Chuangjun Liu, Lihua Zhou, Fangfang Wei, Ling Li, Shunan Zhao, Ping Gong, Lintao Cai, Keith Man-Chung Wong
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Fangrui Zheng, Yuhong Yang, Siye Wu, Shunan Zhao, Yifan Zhu, Huimin Su, Jun-Feng Dai, Zeyin Yan, Lung Wa Chung, Keith Man-Chung Wong
Summary: In contrast to the well-studied dirhodium(II) complexes and iridium(III) complexes, neutral or dicationic dinuclear iridium(II) complexes with unsupported ligands are relatively unexplored. In this study, a series of tetracationic dinuclear iridium(II) complexes with long bond distances and photoluminescent properties were synthesized and characterized. It was found that these complexes exhibit high stability due to London dispersion interactions, despite the long Ir(II)-Ir(II) bond lengths, and show potential for further photoreactivity studies involving the generation of iridium(II) radical monomers.
COMMUNICATIONS CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Jingyi Lu, Shunan Zhao, Fangfang Wei, Keith Man-Chung Wong
Summary: A series of NIR-emitting rhodium(III) complexes with extended pi-conjugation structure and electron-donating substituents have been synthesized. The luminescence can be further shifted to the red through the introduction of thienyl groups on the benzo[g]quinoxaline moiety. These complexes exhibit luminescence maxima ranging from 763 nm to 792 nm with a quantum yield of 0.41% to 0.66% in dichloromethane solution. This work presents the first examples of NIR-phosphorescent rhodium(III) complexes and offers a new strategy for the development of NIR materials.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shunan Zhao, Yifan Zhu, Ling Li, Veronique Guerchais, Julien Boixel, Keith Man-Chung Wong
Summary: A new Rhodyne ligand with chemo-induced ON-OFF switching capabilities was designed to coordinate a cyclometallated platinum(ii) system. The long-lived (IL)-I-3 excited state of Rhodyne in its ON state as an optically active opened form was revealed via steady-state and time-resolved spectroscopy studies, showing exceptional near-infrared (NIR) phosphorescence and delayed fluorescence based on a rhodamine-like structure at room temperature. The position of the alkyne communication bridge attached to the platinum(ii) unit was found to vary the lead(ii)-ion binding mode and also the possible resonance structure for metal-mediated allenylidene formation, suggesting the formation of a proposed allenylidene resonance structure to rationalize these phenomena.
Article
Chemistry, Multidisciplinary
Lihua Zhou, Fangfang Wei, Jingjing Xiang, Hongfeng Li, Chunbin Li, Pengfei Zhang, Chuangjun Liu, Ping Gong, Lintao Cai, Keith Man-Chung Wong
Article
Chemistry, Multidisciplinary
Jie Yang, Yifan Zhu, Anfernee Kai-Wing Tse, Xinghua Zhou, Yang Chen, Yu Chung Tse, Keith Man-Chung Wong, Chun-Yu Ho
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Man-Chung Tang, Daniel Ping-Kuen Tsang, Mei-Yee Chan, Keith Man-Chung Wong, Vivian Wing-Wah Yam
MATERIALS CHEMISTRY FRONTIERS
(2017)