Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes

Discovery and Characterization of a PKS–NRPS Hybrid in Aspergillus terreus by Genome Mining

(2020) Shen Tang et al.   JOURNAL OF NATURAL PRODUCTS

Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii

(2019) Hang Li et al.   ORGANIC LETTERS

Enzyme-Catalyzed Inverse-Electron Demand Diels–Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H

(2019) Zhuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

(2019) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli

(2019) Sebastian Theobald et al.   BMC GENOMICS

Structural Revision and Absolute Configuration of Burnettramic Acid A

(2019) Jiao Li et al.   ORGANIC LETTERS

Identification of the pyranonigrin A biosynthetic gene cluster by genome mining in Penicillium thymicola IBT 5891

(2018) Man-Cheng Tang et al.   AICHE JOURNAL

Control of the Stereochemical Course of [4+2] Cycloaddition during trans -Decalin Formation by Fsa2-Family Enzymes

(2018) Naoki Kato et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of the Biosynthetic Gene Cluster for Himeic Acid A: A Ubiquitin-Activating Enzyme (E1) Inhibitor in Aspergillus japonicus MF275

(2018) Makoto Hashimoto et al.   CHEMBIOCHEM

Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids

(2018) Li Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The architectures of iterative type I PKS and FAS

(2018) Dominik A. Herbst et al.   NATURAL PRODUCT REPORTS

Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases

(2017) Michio Sato et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The biosynthesis of cytochalasans

(2017) Elizabeth Skellam   NATURAL PRODUCT REPORTS

SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis

(2017) Masao Ohashi et al.   NATURE

Biochemical Characterization of a Eukaryotic Decalin-Forming Diels–Alderase

(2016) Li Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genome mining approach for harnessing the cryptic gene cluster in Alternaria solani: production of PKS–NRPS hybrid metabolite, didymellamide B

(2016) Takahiro Ugai et al.   TETRAHEDRON LETTERS

A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis

(2015) Naoki Kato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition

(2015) Michio Sato et al.   CHEMBIOCHEM

An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS–NRPS is necessary for synthesis of the 2-pyridones, leporins

(2015) Jeffrey W. Cary et al.   FUNGAL GENETICS AND BIOLOGY

Biosynthesis of the Tetramic Acids Sch210971 and Sch210972

(2015) Thomas B. Kakule et al.   ORGANIC LETTERS

Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and exo-Methylene Formation

(2015) Tsuyoshi Yamamoto et al.   ORGANIC LETTERS

Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae

(2015) Zhongshu Song et al.   Chemical Science

Elucidation of Pseurotin Biosynthetic Pathway Points to Trans-ActingC-Methyltransferase: Generation of Chemical Diversity

(2014) Yuta Tsunematsu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Three Acyltetronic Acid Derivatives: Noncanonical Cryptic Polyketides fromAspergillus nigerIdentified by Genome Mining

(2014) Xiao-Long Yang et al.   CHEMBIOCHEM

Naturally occurring tetramic acid products: isolation, structure elucidation and biological activity

(2014) Xuhua Mo et al.   RSC Advances

Two Related Pyrrolidinedione Synthetase Loci in Fusarium heterosporum ATCC 74349 Produce Divergent Metabolites

(2013) Thomas B. Kakule et al.   ACS Chemical Biology

Genetic Manipulation of the Fusarium fujikuroi Fusarin Gene Cluster Yields Insight into the Complex Regulation and Fusarin Biosynthetic Pathway

(2013) Eva-Maria Niehaus et al.   CHEMISTRY & BIOLOGY

Combinatorial Generation of Complexity by Redox Enzymes in the Chaetoglobosin A Biosynthesis

(2013) Kan’ichiro Ishiuchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthetic assembly of cytochalasin backbone

(2013) Ryuya Fujii et al.   TETRAHEDRON LETTERS

One pathway, many compounds: heterologous expression of a fungal biosynthetic pathway reveals its intrinsic potential for diversity

(2013) Zahida Wasil et al.   Chemical Science

Biosynthesis of Xyrrolin, a New Cytotoxic Hybrid Polyketide/Non-ribosomal Peptide Pyrroline with Anticancer Potential, in Xylaria sp. BCC 1067

(2012) Suranat Phonghanpot et al.   CHEMBIOCHEM

Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules

(2012) Yit-Heng Chooi et al.   JOURNAL OF ORGANIC CHEMISTRY

Evolution of Secondary Metabolite Genes in Three Closely Related Marine Actinomycete Species

(2011) Kelle C. Freel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Multifactorial Induction of an Orphan PKS-NRPS Gene Cluster in Aspergillus terreus

(2011) Markus Gressler et al.   CHEMISTRY & BIOLOGY

Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite

(2011) Katja M. Fisch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1

(2011) Kangjian Qiao et al.   METABOLIC ENGINEERING

The programming role of trans-acting enoyl reductases during the biosynthesis of highly reduced fungal polyketides

(2011) Mary N. Heneghan et al.   Chemical Science

SMURF: Genomic mapping of fungal secondary metabolite clusters

(2010) Nora Khaldi et al.   FUNGAL GENETICS AND BIOLOGY

Analysis of Intact and Dissected Fungal Polyketide Synthase-Nonribosomal Peptide Synthetase in Vitro and inSaccharomyces cerevisiae

(2010) Wei Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The chemistry and biology of cytochalasans

(2010) Kirstin Scherlach et al.   NATURAL PRODUCT REPORTS

4-Hydroxy-2-pyridone alkaloids: Structures and synthetic approaches

(2010) Henning Jacob Jessen et al.   NATURAL PRODUCT REPORTS

Cyclopiazonic Acid Biosynthesis inAspergillussp.: Characterization of a Reductase-like R* Domain in Cyclopiazonate Synthetase That Forms and Releasescyclo-Acetoacetyl-l-tryptophan

(2009) Xinyu Liu et al.   BIOCHEMISTRY

Towards Prediction of Metabolic Products of Polyketide Synthases: An In Silico Analysis

(2009) Gitanjali Yadav et al.   PLoS Computational Biology

Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae

(2009) Perng-Kuang Chang et al.   Toxins

Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

(2008) Laura M. Halo et al.   CHEMBIOCHEM

Thioesterase-Like Role for Fungal PKS-NRPS Hybrid Reductive Domains

(2008) James W. Sims et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Late Stage Oxidations during the Biosynthesis of the 2-Pyridone Tenellin in the Entomopathogenic FungusBeauveria bassiana

(2008) Laura M. Halo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY