Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features

(2020) Jeroen Geurts et al.   Scientific Reports

CRELD2 is a novel LRP1 chaperone that regulates non‐canonical WNT signalling in skeletal development.

(2020) Ella P. Dennis et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Energy metabolism in osteoclast formation and activity

(2016) Silvia Lemma et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength

(2016) Lingli Zhang et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Age- and Sex-Related Changes in Bone Microarchitecture and Estimated Strength: A Three-Year Prospective Study Using HRpQCT

(2016) Vikram V Shanbhogue et al.   JOURNAL OF BONE AND MINERAL RESEARCH

GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation

(2016) Weiqing Liu et al.   Nature Communications

Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA−/− mice

(2016) Philip F. Dobson et al.   Scientific Reports

A look behind the scenes: the risk and pathogenesis of primary osteoporosis

(2015) Gretl Hendrickx et al.   Nature Reviews Rheumatology

Age-related differences in volumetric bone mineral density, microarchitecture, and bone strength of distal radius and tibia in Chinese women: a high-resolution pQCT reference database study

(2015) V. W. Y. Hung et al.   OSTEOPOROSIS INTERNATIONAL

Mitochondrial superoxide in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis

(2015) Keiji Kobayashi et al.   Scientific Reports

Optimisation of the differing conditions required for bone formation in vitro by primary osteoblasts from mice and rats

(2014) ISABEL R. ORRISS et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

(2013) Holly L. Baines et al.   AGING CELL

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

(2013) Jaime M. Ross et al.   NATURE

miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6

(2013) J Wang et al.   Cell Death & Disease

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

Intracellular and Extracellular ATP Coordinately Regulate the Inverse Correlation between Osteoclast Survival and Bone Resorption

(2012) Tsuyoshi Miyazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

(2011) Gudmundur L. Norddahl et al.   Cell Stem Cell

MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo

(2011) T. Eskildsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Enhanced mitochondrial biogenesis contributes to Wnt induced osteoblastic differentiation of C3H10T1/2 cells

(2010) Jee Hyun An et al.   BONE

Differential effects of swimming versus weight-bearing activity on bone mineral status of eumenorrheic athletes

(2010) Dennis R. Taaffe et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Age-related changes in osteogenic stem cells in mice

(2010) R.J. Bergman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transcription factor C/EBPβ isoform ratio regulates osteoclastogenesis through MafB

(2009) Jeske J Smink et al.   EMBO JOURNAL

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

Mitochondrial Function Determines the Viability and Osteogenic Potency of Human Mesenchymal Stem Cells

(2009) Mika Pietilä et al.   TISSUE ENGINEERING PART C-METHODS

Locating the stem cell niche and tracing hepatocyte lineages in human liver

(2008) Tariq G. Fellous et al.   HEPATOLOGY

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS

Coordinated Changes of Mitochondrial Biogenesis and Antioxidant Enzymes During Osteogenic Differentiation of Human Mesenchymal Stem Cells

(2008) Chien-Tsun Chen et al.   STEM CELLS