Article
Cell Biology
You Chi Tang, Khoren Ponsin, Adda-Lee Graham-Paquin, Carole Luthold, Kevin Homsy, Magdalena Schindler, Viviane Tran, Jean-Francois Cote, Francois Bordeleau, Anmar Khadra, Maxime Bouchard
Summary: During urinary tract development, the common nephric duct (CND) undergoes shortening through non-professional efferocytosis, where apoptotic bodies are engulfed by epithelial cells. This process, coupled with actomyosin contractility, ensures CND shortening without compromising the structural connection between the ureter and bladder. Disruption of apoptosis, non-professional efferocytosis, or actomyosin activity leads to deficient CND shortening. These findings highlight the importance of non-professional efferocytosis and actomyosin contractility in controlling CND morphogenesis.
Article
Oncology
Luzie Helene Unseld, Laura S. Hildebrand, Florian Putz, Maike Buettner-Herold, Christoph Daniel, Rainer Fietkau, Luitpold Valentin Distel
Summary: Non-professional phagocytosis, specifically cell-in-cell structures, are increasingly studied in malignant melanoma metastasis. This study examined primary melanoma cell lines and tissue samples and found that all primary melanoma cell lines were capable of phagocytosis, with higher rates observed during suspension co-incubation. The presence of cell-in-cell structures was also detected in most tissue samples, indicating that non-professional phagocytosis mechanism is ubiquitous in malignant melanoma.
Article
Oncology
Youg R. Thaker, Ianne Rivera, Christophe Pedros, Alok R. Singh, Laura Rivero-Nava, Heyue Zhou, Barbara A. Swanson, Lisa Kerwin, Yanliang Zhang, J. Dixon Gray, Gunnar F. Kaufmann, Henry Ji, Robert D. Allen, Damien Bresson
Summary: STI-6643 is an affinity-engineered fully human anti-CD47 IgG(4) antibody that does not bind to normal cells, and has the potential to be an effective treatment for tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Mechanical
Tieding Guo, Giuseppe Rega, Houjun Kang
Summary: This article proposes a physics-based interpretation of error sources and a perturbation correction method to address the errors in discretized perturbation analysis. It provides an explanation for the incomplete characterization of low-order non-secular effects and presents a correction procedure for finite mode truncation commonly used in perturbation analysis, which is validated through numerical examples.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2022)
Review
Immunology
Darya Malko, Tarek Elmzzahi, Marc Beyer
Summary: Treg cells play a crucial role in controlling autoimmunity, immune responses during infections and tumor development, and tissue homeostasis. This review highlights the recent findings on the differentiation and function of tissue Treg cells, emphasizing their importance in tissue maintenance, regeneration, and repair in various organs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Mohammad Hossein Behzad Moghadam, Hamed Shoorei, Zahra Bahroudi, Mohammad Taheri, Afshin Taheriazam
Summary: Self-renewal and differentiation are main characteristics of stem cells, regulated by miRNAs and lncRNAs. Various miRNAs and lncRNAs play important roles in the differentiation of stem cells, impacting tissue regeneration and homeostasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Astronomy & Astrophysics
Kota Numajiri, Taishi Katsuragawa, Shin'ichi Nojiri
Summary: In this study, a compact star in general F(R) gravity is investigated. It is confirmed that an arbitrary relation between mass and radius of the compact star can be achieved by adjusting the functional form of F(R). It is also found that the functional form of F(R) is constrained by the solution of a differential equation for the polytropic equation of state.
Review
Biochemistry & Molecular Biology
Tom J. Harryvan, Sabine de Lange, Lukas J. A. C. Hawinkels, Els M. E. Verdegaal
Summary: In addition to professional antigen-presenting cells (APCs), nonprofessional APCs also play a role in presenting antigens to T cells, and their function has significant implications for immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Kieran D. James, William E. Jenkinson, Graham Anderson
Summary: The thymus supports T-cell development through specialized microenvironments consisting of stromal cells, including thymic epithelial cells and non-epithelial stromal cells. While the roles of thymic epithelial cells in T-cell development have been extensively studied, the developmental origins and functional properties of non-epithelial stromal cells remain poorly understood. Experimental evidence suggests that these non-epithelial stromal cells play important roles in thymus function by influencing T-cell development directly or regulating thymic epithelial cell development and function indirectly.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Geosciences, Multidisciplinary
Di Wang, Sanyi Yuan, Tao Liu, Shengjun Li, Shangxu Wang
Summary: The study presents a non-stationary NMO correction method and prestack high-resolution processing to address both attenuation and wavelet stretch by adopting spatiotemporal variant wavelets via an inversion scheme. The structural sparsity constraint restricts the optimal solution to the most structurally sparse reflectivity, contributing to construct the flattened corrected gather with invariant wavelets.
JOURNAL OF APPLIED GEOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Lucio Diaz-Flores, Ricardo Gutierrez, Miriam Gonzalez-Gomez, Maria del Pino Garcia, Jose Luis Carrasco, Juan Francisco Madrid, Lucio Diaz-Flores Jr
Summary: Telocytes/CD34+ stromal cells (TCs/CD34+ SCs) are important cellular components in the human parathyroid stroma, except around vessels within parenchymal nests. They exhibit typical characteristics and play a role in development, as well as various pathological conditions such as hyperplastic and adenomatous parathyroids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Xian Xu, Jingming Gao, Shuyun Liu, Liang Chen, Min Chen, Xiaoye Yu, Ning Ma, Jun Zhang, Xiaobin Chen, Lisen Zhong, Lin Yu, Liming Xu, Quanyi Guo, Jiandong Ding
Summary: With the advancement of tissue engineering and regenerative medicine, utilizing MRI techniques to monitor the regeneration of knee cartilage after implantation of a biomaterial scaffold seeded with chondrocytes has shown promising results. The study found a significant difference between the regeneration site and normal neighboring site, with this difference gradually decreasing over a year of regeneration, as indicated by both quantitative T1 and T2 MRI methods. The correlation between MRI evaluation and clinical Lysholm scores was established for the first time, confirming MRI as a feasible semi-quantitative and non-invasive method for assessing in vivo knee articular cartilage regeneration.
REGENERATIVE BIOMATERIALS
(2021)
Article
Computer Science, Interdisciplinary Applications
Huisi Wu, Canfeng Lin, Jiasheng Liu, Youyi Song, Zhenkun Wen, Jing Qin
Summary: Detecting cells in blood smear images is challenging due to dense cells and overlapping boundaries. To address this, this paper proposes a detection framework that utilizes non-overlapping regions (NOR) to compensate for the intensity deficiency. The framework includes a feature masking approach to guide the network in extracting NOR features and predicting NOR bounding boxes (NOR BBoxes). Non-overlapping regions NMS (NOR-NMS) is introduced to suppress redundant BBoxes using NOR BBoxes, improving detection performance.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Cell Biology
Niclas C. Blessin, Raed Abu-Hashem, Tim Mandelkow, Wenchao Li, Ronald Simon, Claudia Hube-Magg, Christina Moeller-Koop, Melanie Witt, Alice Schmidt, Franziska Buescheck, Christoph Fraune, Andreas M. Luebke, Katharina Moeller, Frank Jacobsen, Florian Lutz, Maximilian Lennartz, Stefan Steurer, Guido Sauter, Doris Hoeflmayer, Maria Christina Tsourlakis, Andrea Hinsch, Eike Burandt, Waldemar Wilczak, Sarah Minner, Till S. Clauditz
Summary: This study found that the percentage of Ki67(+)CD8(+) cells in healthy lymphoid tissues is usually below 3%, but significantly higher in inflammatory and neoplastic diseases. In colorectal cancer, the density of Ki67(+)CD8(+) cells and the percentage of proliferating CD8+ cytotoxic T-cells are associated with tumor features, suggesting a potential clinical utility for predicting patient outcomes.
Article
Multidisciplinary Sciences
Humna Hasan, Ikjot Singh Sohal, Zulaida Soto-Vargas, Anjali M. Byappanhalli, Sean E. Humphrey, Hana Kubo, Sarunya Kitdumrongthum, Sarah Copeland, Feng Tian, Arthit Chairoungdua, Andrea L. Kasinski
Summary: Extracellular vesicles (EVs) released from non-small cell lung cancer (NSCLC) cells play a crucial role in promoting cancer progression. There are differences in the secretion profile and the ability to induce phenotypic changes in non-tumorigenic cells among EVs derived from different NSCLC cell lines. EV-encapsulated RNA (EV-RNA) is identified as a key factor in mediating these phenotypes. The aggressiveness of NSCLC subtypes may be correlated with the ability of their respective EVs to induce cancerous phenotypes.
SCIENTIFIC REPORTS
(2022)
