Article
Psychiatry
Shaojia Lu, Congchong Wu, Lili Jia, Zhe Fang, Jing Lu, Tingting Mou, Shaohua Hu, Hongjian He, Manli Huang, Yi Xu
Summary: The study aimed to investigate the inflammatory factors and brain structural alterations in patients with major depressive disorder (MDD) and anhedonia, and evaluate the relationship between these factors. The results showed that anhedonia was associated with increased plasma levels of IL-6 and decreased GMV in the left striatal structures.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Chia-Min Chen, Chia-Yu Kuo, Meng-Ni Wu, Jen-Yu Hung, Chung-Yao Hsu, Ming-Ju Tsai
Summary: The study found that patients with sleep apnea have an increased risk of developing major depressive disorder. Physicians should pay attention to the psychosocial health status of sleep apnea patients.
SCIENTIFIC REPORTS
(2021)
Article
Neuroimaging
Yingrui Guo, Xiaowei Jiang, Linna Jia, Yue Zhu, Xinyu Han, Yifan Wu, Wen Liu, Wenhui Zhao, Huaqian Zhu, Dahai Wang, Zhaoyuan Tu, Yifang Zhou, Qikun Sun, Lingtao Kong, Feng Wu, Yanqing Tang
Summary: This study aims to investigate the pathophysiological mechanisms of Major Depressive Disorder with Suicidal Ideation (MDD + S) by examining the gray matter volumes (GMVs) and plasma IL-6 levels. It was found that MDD + S patients had decreased GMVs in the left cerebellum Crus I/II and increased plasma IL-6 levels. Compared to healthy controls, both MDD + S and MDD - S patients had decreased GMVs in the right precentral and postcentral gyri.
NEUROIMAGE-CLINICAL
(2023)
Article
Psychiatry
Takaki Tanifuji, Satoshi Okazaki, Ikuo Otsuka, Kentaro Mouri, Tadasu Horai, Ryota Shindo, Toshiyuki Shirai, Akitoyo Hishimoto
Summary: Depression is associated with epigenetic changes that regulate gene expression. This study assessed the biological aging in patients with MDD using genome-wide DNA methylation data. The results showed no significant difference in epigenetic age, but significantly higher levels of plasma cystatin C in patients with MDD.
PSYCHIATRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yue Wang, Yan Li, Zhonghao Wu, Zhi Chen, Heming Yu, Yong He, Yu Tian, Tianlan Lan, Mengge Bai, Xiangyu Chen, Ke Cheng, Peng Xie
Summary: This study aimed to explore the relationship between ferritin and major depressive disorder (MDD). Findings revealed decreased FTL levels in MDD patients and significantly reduced FTH expression in the hippocampus of depressed mice. These results provide new insight into the pathogenesis of MDD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Psychiatry
Xianmei Luo, Zeman Fang, Lingyun Lin, Haiyun Xu, Qingjun Huang, Handi Zhang
Summary: This study found that medication-free MDD patients have significantly higher levels of complement C3 and C3a in their peripheral plasma compared to healthy controls, while the levels of C1q and CRP are comparable. However, these inflammatory factors are not associated with childhood trauma experiences in MDD patients.
Article
Psychiatry
Cai-Fang Ji, Guan-Hui Wu, Xiang Dong Du, Gui-Xian Wang, Li-Li Liu, Mei-E. Niu, Robert Logan, Fan-Zhen Kong
Summary: Mindfulness training is effective in reducing symptoms, preventing relapse, and improving prognosis among patients with major depressive disorder (MDD), especially for those with high trait mindfulness. In a study of 126 hospitalized MDD patients, trait mindfulness level was found to be associated with MDD severity, age, marital status, and quality of life. The findings suggest that characterizing trait mindfulness levels can help predict treatment efficiency, establish a prognosis, and identify therapeutic targets for mindfulness-related interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Haimei Li, Jing Lu, Shangda Li, Bochao Huang, Gongde Shi, Tingting Mou, Yi Xu
Summary: This study revealed significant increases in plasma hypocretin-1 levels in patients with major depressive disorder (MDD) and bipolar disorder (BD) compared to controls. Additionally, MDD patients with higher suicidal ideation had higher hypocretin-1 levels. These findings suggest that changes in hypocretin-1 levels may be useful in diagnosing depression and distinguishing between MDD and BD.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Yuan Cai, Zhen Hua Zhu, Rong Hua Li, Xu Yuan Yin, Ru Feng Chen, Li Juan Man, Wen Long Hou, Hong Liang Zhu, Jing Wang, Huiping Zhang, Qiu Fang Jia, Li Hui
Summary: This study examined the effects of neuroinflammatory cytokines and selective serotonin reuptake inhibitors (SSRIs) on cognitive deficits in patients with major depressive disorder (MDD). The results showed that MDD patients treated with SSRIs had lower cognitive performance and higher levels of IL-8 compared to healthy controls. The positive correlation between IL-8 levels and delayed memory and visuospatial/constructional function was only observed in MDD patients with SSRIs.
Article
Clinical Neurology
Wen Liu, Xiaowei Jiang, Yide Xin, Zijing Deng, Yu Xie, Yifang Zhou, Yifan Wu, Qikun Sun, Lingtao Kong, Feng Wu, Yanqing Tang
Summary: This study identified differences in dynamic amplitude low-frequency fluctuations (dALFF) between patients with major depressive disorder (MDD) and those who converted to bipolar disorder (BD), and described the role of sex effects in differentiating the two disorders. A positive correlation was found between dALFF values and WCST scores in MDD patients, and this correlation was observed only in female MDD patients in the occipital gyrus.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Frederikke Hordam Gronemann, Janne Petersen, Sarah Alulis, Kristoffer Jarlov Jensen, Jesper Riise, Mikkel Zollner Ankarfeldt, Espen Jimenez Solem, Nikolaj Bodker, Merete Osler
Summary: This study found that the majority of MDD patients in Denmark initially received treatment with antidepressants or ECT, and often changed medications during the course of treatment. TRD patients were more likely to use SNRIs, and a significant proportion initiated new treatments in the following year.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Zhonghao Wu, Heming Yu, Yu Tian, Yue Wang, Yong He, Tianlan Lan, Yan Li, Mengge Bai, Xiangyu Chen, Zhi Chen, Ping Ji, Hongmei Zhang, Xin Jin, Jinlin Song, Ke Cheng, Peng Xie
Summary: This study identified 6 differential metabolites in patients with major depressive disorder (MDD) compared to healthy controls, suggesting that some of these metabolites may serve as promising biomarkers for MDD diagnosis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
Annamari Sorri, Kaija Jarventausta, Olli Kampman, Kai Lehtimaki, Minna Bjorkqvist, Kati Tuohimaa, Mari Hamalainen, Eeva Moilanen, Esa Leinonen
Summary: In this study, Vascular Endothelial Growth Factor (VEGF) levels were found to increase between the 2-hour and 4-hour measurements during the first and fifth ECT sessions in patients with Major Depressive Disorder (MDD). However, these increases were not associated with clinical outcomes. This suggests that VEGF may play a role in the mechanism of action of ECT.
BRAIN AND BEHAVIOR
(2021)
Article
Psychology, Clinical
Hua Yu, Peiyan Ni, Yang Tian, Liansheng Zhao, Mingli Li, Xiaojing Li, Wei Wei, Jinxue Wei, Xiangdong Du, Qiang Wang, Wanjun Guo, Wei Deng, Xiaohong Ma, Jeremy Coid, Tao Li
Summary: This study found that major depressive disorder (MDD) and bipolar disorder (BD) are associated with dysregulation of complement components and structural impairment in the brain. The elevated levels of certain complement factors are related to structural defects in the medial orbital frontal cortex (mOFC), providing insight into the shared neuro-inflammatory pathogenesis of mood disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Caitlin C. Clements, Robert Karlsson, Yi Lu, Anders Jureus, Christian Ruck, Evelyn Andersson, Julia Boberg, Nancy L. Pedersen, Cynthia M. Bulik, Axel Nordenskjold, Erik Palsson, Patrick F. Sullivan, Mikael Landen
Summary: Analysis of severe cases of major depressive disorder (MDD) using genome-wide SNP genotyping revealed a higher burden of genetic risk loci, stronger genetic correlations with other psychiatric disorders, and weaker correlations with personality and stress-related traits, suggesting a different genetic architecture at the severe end of the MDD spectrum.
MOLECULAR PSYCHIATRY
(2021)
