Article
Biochemistry & Molecular Biology
Abid A. Reza, Fatemeh Kohram, Hasan A. Reza, Timothy R. Kalin, Paranthaman S. Kannan, William J. Zacharias, Vladimir V. Kalinichenko
Summary: Mutations in the FOXF1 gene are associated with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), leading to abnormal lung development. The mutant FOXF1 stimulates WNT/beta-catenin signaling, resulting in increased proliferation and decreased differentiation of alveolar epithelial cells. The activation of Wnt5a gene transcription by FOXF1 is crucial for the abnormal epithelial cell expansion and differentiation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Pei-Li Yao, Vipul M. Parmar, Mayur Choudhary, Goldis Malek
Summary: The expression and activity of NURR1 play critical roles in the physiological and pathological functions of human RPE cells. Targeting NURR1 may have therapeutic potential for AMD by improving EMT, inflammation, and lipid homeostasis in RPE cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Michela Serresi, Sonia Kertalli, Lifei Li, Matthias Jurgen Schmitt, Yuliia Dramaretska, Jikke Wierikx, Danielle Hulsman, Gaetano Gargiulo
Summary: Research has shown that chromatin regulators have a broader impact on EMT interconversion in lung cancer cells than kinases, and the loss of ARID1A, DOT1L, BRD2, and ZMYND8 may have nondeterministic and sometimes opposite consequences. These findings reveal general principles underlying transcriptional control of cancer cell plasticity.
Article
Biology
Lauren E. Carter, David P. Cook, Curtis W. McCloskey, Melanie A. Grondin, David A. Landry, Tiffany Dang, Olga Collins, Lisa F. Gamwell, Holly A. Dempster, Barbara C. Vanderhyden
Summary: The authors used spheroids as a model to study the molecular signatures of ovarian surface epithelial cells exhibiting stemness phenotype in vitro, finding a high degree of heterogeneity in the transcriptional profiles of stem cells induced under different conditions. They suggest that maintenance of the ovarian surface epithelium may not require a single stem cell population but instead rely on heterogeneous stem cells induced transiently under diverse environmental cues, indicating a more complex and dynamic system in regulating the stem cell characteristics in this tissue.
COMMUNICATIONS BIOLOGY
(2021)
Article
Developmental Biology
Karol Kaiser, Ahram Jang, Petra Kompanikova, Melody P. Lun, Jan Prochazka, Ondrej Machon, Neil Dani, Michaela Prochazkova, Benoit Laurent, Daniel Gyllborg, Renee van Amerongen, Ryann M. Fame, Suhasini Gupta, Feizhen Wu, Roger A. Barker, Ivana Bukova, Radislav Sedlacek, Zbynek Kozmik, Ernest Arenas, Maria K. Lehtinen, Vitezslav Bryja
Summary: The study reveals the dual role of WNT5A in ChP development and identifies MEIS transcription factors as upstream regulators of Wnt5a in the 4V ChP epithelium.
Article
Multidisciplinary Sciences
Vajihe Azimian-Zavareh, Zeinab Dehghani-Ghobadi, Marzieh Ebrahimi, Kian Mirzazadeh, Irina Nazarenko, Ghamartaj Hossein
Summary: The study found that Wnt5A can regulate the expression of its receptors, affecting cell proliferation, migration, invasion, and multicellular aggregates formation. Moreover, Wnt5A can also modulate integrin expression levels, potentially associated with ovarian cancer cell proliferation, migration, and fibronectin attachment.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Anda Huna, Beatrice Nawrocki-Raby, Teresita Padilla-Benavides, Julie Gavard, Sylvie Coscoy, David Bernard, Mathieu Boissan
Summary: NME1, not NME2, acts specifically to inhibit EMT and prevent the earliest stages of metastasis. Loss of NME1 leads to a hybrid phenotype associated with higher metastatic potential, while overexpression of NME1 results in a more epithelial phenotype. Additionally, NME1 inhibits key intracellular signaling pathways involved in inducing EMT, such as AKT and MAPK pathways, and affects the distribution and cell-cell adhesion of E-cadherin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Emergency Medicine
Young In Lee, Jung Eun Shim, Jihee Kim, Won Jai Lee, Jae Woo Kim, Kee Hyun Nam, Ju Hee Lee
Summary: This study identified a partial mechanism of keloid pathogenesis, which involves intercellular communication via the WNT5A and STAT pathways leading to the occurrence of EMT-like phenomena. Improving our understanding of keloid development and the role of WNT5A in EMT could promote the development of targeted treatments for keloid scars.
Article
Chemistry, Multidisciplinary
William W. Du, Javeria Qadir, Kevin Y. Du, Yu Chen, Nan Wu, Burton B. Yang
Summary: Current studies have shown that nuclear actin plays a significant role in the regulation of epithelial-mesenchymal transition (EMT). Different binding partners for nuclear F-actin and G-actin have been discovered, which respectively modulate EMT-promoting and EMT-repressing transcriptional events. Mechanistically, nuclear F-actin enhances the expression and stability of proteins involved in EMT promotion, while nuclear G-actin increases the expression and stability of proteins involved in EMT repression. The association between nuclear actin and EMT suggests that targeting nuclear actin dynamics for dysregulated EMT is a promising area for further study.
Article
Biochemistry & Molecular Biology
Iason Psilopatis, Jule Ida Schaefer, Dimitrios Arsenakis, Dimitrios Bolovis, Georgia Levidou
Summary: This study provides preliminary evidence suggesting that overexpression of SOX11 might promote EMT in metastatic serous ovarian cancer, thereby enhancing tumor metastasis.
Article
Medicine, General & Internal
Eabha O'Driscoll, Emily Hughes, Mustapha Irnaten, Markus Kuehn, Deborah Wallace, Colm O'Brien
Summary: Optic nerve head cupping, a feature of glaucoma, is associated with extracellular matrix remodeling and lamina cribrosa fibrosis. Peripapillary atrophy is common in glaucoma and involves the loss of retinal pigment epithelium adjacent to the optic nerve head. Under pro-fibrotic conditions, epithelial cells can undergo epithelial-to-mesenchymal transition and contribute to extracellular matrix fibrosis. This study investigates the role of this process in glaucoma and peripapillary atrophy, demonstrating the presence of retinal pigment epithelium cells in glaucomatous optic nerve heads and the potential of these cells to differentiate into fibroblast-like cells.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Ningning Yang, Hongchun Chen, Yuchen Huang, Xuexue Song, Panpan Yang, Shan Zhang, Wentian Yan, Nan Li, Zhenzhong Feng
Summary: The study evaluated the expression and significance of Wnt5a in endometrioid adenocarcinoma and its relationship with epithelial-mesenchymal transition (EMT)-related proteins. Wnt5a was found to have a suppressive effect on endometrioid adenocarcinoma by inhibiting EMT. The findings provide insights into the Wnt5a signaling pathway and have implications for the pathological diagnosis and targeted therapy of endometrioid adenocarcinoma.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Reproductive Biology
Ping Cui, Hao Li, Can Wang, Yuan Liu, Mengjun Zhang, Yue Yin, Zhenxing Sun, Yiru Wang, Xiuwei Chen
Summary: This study demonstrates that UBE2T is highly expressed in ovarian cancer and is closely related to poor prognosis. It also reveals that UBE2T regulates EMT via the PI3K-AKT pathway and plays a carcinogenic role in ovarian cancer. Additionally, UBE2T may interact with BRCA to affect the occurrence and development of ovarian cancer. These findings suggest that UBE2T may serve as a valuable novel biomarker for the early diagnosis, prognosis, and treatment of ovarian cancer, and UBE2T inhibition may be effective for treating ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2022)
Review
Endocrinology & Metabolism
Sabrina J. Ritch, Carlos M. Telleria
Summary: Epithelial ovarian cancer is the deadliest gynecological disease, commonly diagnosed at late stages with metastasis. Understanding the unique microenvironments that promote EOC dissemination is crucial in improving patient outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Hee Yun, Gwan Hee Han, Julie Kim, Joon-Yong Chung, Jae-Hoon Kim, Hanbyoul Cho
Summary: NANOG and pAMPK alpha expression are associated with the prognosis of epithelial ovarian cancer (EOC). The combination of high NANOG and low pAMPK alpha expression is related to EOC progression and platinum resistance.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
