Article
Chemistry, Multidisciplinary
Chenglei Li, Zhaohuan Li, Xue Gong, Jianhao Liu, Tingyue Zheng, Fangqing Wang, Jingliang Wu, Bo Zhang
Summary: Cancer-associated fibroblasts (CAFs) are crucial in tumor invasion and metastasis within the tumor microenvironment (TME). A novel TME acid-responsive liposome co-delivering IRI and 398 was developed, showing decreased CAF activation, increased cytotoxicity, enhanced drug accumulation, superior anti-tumor activity in mice, and anti-metastatic efficiency. This combinational approach offers promising prospects for cancer therapy.
Article
Plant Sciences
Ruixiao Li, Jing Zhou, Xinnan Wu, Haoze Li, Yunzhou Pu, Ningning Liu, Zhifen Han, Lihong Zhou, Yan Wang, Huirong Zhu, Liu Yang, Qi Li, Qing Ji
Summary: JPJDR reduces the levels of ITGBL1 in CRC-derived EVs and inhibits the migration and growth of CRC cells by regulating ITGBL1-rich EVs mediated fibroblasts activity. Mechanistically, JPJDR decreases fibroblasts activation by regulating ITGBL1-rich EVs mediated TNFAIP3-NF-Kappa B signaling. Further in vivo experiments demonstrate that JPJDR reduces CRC liver metastasis by regulating ITGBL1-rich EVs secretion from CRC and blocking the fibroblasts activation by regulating ITGBL1-TNFAIP3-NF-Kappa B signaling. Our research confirms the preventive effects of JPJDR on CRC liver metastasis by down-regulating CRC derived ITGBL1-loaded EVs mediated activation of CAFs, highlighting the potential clinical application of JPJDR in the prevention and treatment of CRC metastasis. Therapeutic targeting of EVs-mediated metastasis shows promising benefits and warrants further clinical validation.
Article
Medicine, Research & Experimental
Ambre Giguelay, Evgenia Turtoi, Lakhdar Khelaf, Guillaume Tosato, Ikrame Dadi, Tommy Chastel, Marie-Alix Poul, Marine Pratlong, Stefan Nicolescu, Dany Severac, Antoine Adenis, Olivia Sgarbura-Popescu, Sebastien Carrere, Philippe Rouanet, Marc Ychou, Francois Quenet, Didier Pourqier, Pierre-Emmanuel Colombo, Andrei Turtoi, Jacques Colinge
Summary: This study confirms the heterogeneity of CRC-LM CAFs through single-cell transcriptomic analysis and proposes a model for recruiting different origins of CAFs to the liver in different liver malignancies. Additionally, the study finds that targeting LTBP2 with antibodies may help deplete ECM-remodeling CAFs in CRC-LMs.
Article
Oncology
Kai M. Brown, Aiqun Xue, Ross C. Smith, Jaswinder S. Samra, Anthony J. Gill, Thomas J. Hugh
Summary: This study validated the prognostic significance of stromal protein biomarkers in primary CRC and CRLM, and identified key differences in stromal gene expression between paired primary CRC and CRLM, as well as several targetable biomarkers and transcriptomic pathways.
Article
Pharmacology & Pharmacy
Jinbing Sun, Zhihua Lu, Wei Fu, Kuangyi Lu, Xiuwen Gu, Feng Xu, Jiamin Dai, Yang Yang, Jianlong Jiang
Summary: Exosomes derived from cancer cells, particularly those containing elevated levels of ADAM17, play a role in promoting the migratory ability of colorectal cancer cells by cleaving E-cadherin junctions. This finding suggests that exosomal ADAM17 may serve as a blood-based biomarker for colorectal cancer metastasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Wenhu Zhao, Shipeng Dai, Lei Yue, Fan Xu, Jian Gu, Xinzheng Dai, Xiaofeng Qian
Summary: Colorectal cancer is a common malignant tumor with the liver being the most common site of metastasis. Metastasis to the liver from colorectal cancer is a complex process involving various stages. This review discusses the characteristics of CRC cells and their interactions with liver cells and immune cells. It also explores current immunotherapy approaches and challenges, as well as potential therapeutic targets based on novel sequencing technologies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kathleen M. McAndrews, Karina Vazquez-Arreguin, Changsoo Kwak, Hikaru Sugimoto, Xiaofeng Zheng, Bingrui Li, Michelle L. Kirtley, Valerie S. LeBleu, Raghu Kalluri
Summary: The study demonstrates that alpha SMA(+) CAFs in CRC exert tumor-restraining functions via BMP4/TGF beta 1 paracrine signaling that serves to suppress Lgr5(+) CSCs and promote anti-tumor immunity, ultimately limiting CRC progression.
Article
Oncology
Hao Wang, Xuemin Li, Ran Peng, Yuxia Wang, Junjie Wang
Summary: SABR plays a crucial role in the multidisciplinary treatment of CRLM by causing an immunological change in the tumor microenvironment and potentially increasing the abscopal response rate of out-field lesions. The synergy of SABR and immunotherapy targets different steps of the immune-mediated response and may lead to a higher response rate by inducing cell death within and beyond the tumor sites.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Kai-Li Zhang, Wen-Wei Zhu, Sheng-Hao Wang, Chao Gao, Jun-Jie Pan, Zun-Guo Du, Lu Lu, Hu-Liang Jia, Qiong-Zhu Dong, Jin-Hong Chen, Ming Lu, Lun-Xiu Qin
Summary: This study identified a specific cholesterol metabolic pathway in colorectal cancer liver metastasis involving the activation of SREBP2-dependent cholesterol biosynthesis, which is essential for the growth and colonization of metastatic CRC cells in the liver. Targeting this pathway could be a promising treatment for CRC liver metastasis.
Article
Oncology
Maria Gonzalez-Gonzalez, Maria Laura Gutierrez, Jose Maria Sayagues, Luis Munoz-Bellvis, Alberto Orfao
Summary: Sporadic colorectal cancer (sCRC) is the third leading cause of cancer death in the Western world, with approximately a quarter of patients presenting metastatic dissemination at the time of diagnosis. Patients with sCRC generally have a worse prognosis compared to those with primary colorectal tumors, and there are still many genetic alterations involved in the metastatic process that need to be further identified and studied.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Tingyan Ruan, Shourong Lu, Junying Xu, Ju-Ying Zhou
Summary: This study revealed that LINC00460 is upregulated in colorectal cancer tissues and promotes cancer metastasis by binding with miR-149-5p and affecting the expression of biglycan, an oncogenic driver in colorectal cancer.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Review
Oncology
Carolina de la Pinta, Maria E. Castillo, Manuel Collado, Cristina Galindo-Pumarino, Cristina Pena
Summary: Colorectal cancer is the third leading cause of cancer globally, with the liver being the most common site of metastasis in CRC patients. Radiomics and radiogenomics are important tools for diagnosing, predicting, and managing cancer patients through analyzing imaging data. Studies on liver metastatic colorectal cancer patients have shown the potential for improved diagnosis, treatment decisions, and prognostic biomarkers through advanced radiomics and radiogenomics techniques.
Article
Chemistry, Multidisciplinary
Xiaobo Li, Qi Qi, Yong Li, Qun Miao, Wenqian Yin, Jinghua Pan, Zhan Zhao, Xiaoying Chen, Fan Yang, Xiaofeng Zhou, Maohua Huang, Chenran Wang, Lijuan Deng, Dandan Huang, Ming Qi, Shuran Fan, Yiran Zhang, Shenghui Qiu, Weiqing Deng, Tongzheng Liu, Minfeng Chen, Wencai Ye, Dongmei Zhang
Summary: This study identified the overexpression of TRP channel-associated factor 2 (TCAF2) in tumor initiating cells (TPCs) from colorectal cancer liver metastasis (CRCLM) patients, and demonstrated its role in promoting tumor cell motility, epithelial-mesenchymal transition (EMT), and CRCLM. Mechanistically, TCAF2 inhibits the expression and activity of TRPM8, leading to Wnt5a secretion in TPCs, which facilitates EMT via the activation of the STAT3 signaling pathway. This study provides a potential diagnostic biomarker and therapeutic target for CRCLM.
Review
Oncology
Yun Wang, Lu-Yao Ma, Xiao-Ping Yin, Bu-Lang Gao
Summary: This paper reviews the application of radiomics and radiogenomics in the diagnosis, treatment, monitoring of disease progression, and prognosis of patients with colorectal cancer liver metastases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Colin S. Wood, Kathryn A. F. Pennel, Holly Leslie, Assya Legrini, Andrew J. Cameron, Lydia Melissourgou-Syka, Jean A. Quinn, Hester C. van Wyk, Jennifer Hay, Antonia K. Roseweir, Colin Nixon, Campbell S. D. Roxburgh, Donald C. McMillan, Andrew V. Biankin, Owen J. Sansom, Paul G. Horgan, Joanne Edwards, Colin W. Steele, Nigel B. Jamieson
Summary: Strong immune responses in primary colorectal cancer are associated with better patient survival. However, identifying patients with good prognosis after surgery for colorectal cancer liver metastases remains challenging. This study aims to determine the practical application of immune cell infiltration and stromal content in predicting outcome and investigate the underlying functional biology.
