Article
Nutrition & Dietetics
Martyna Wiecek, Paulina Panufnik, Magdalena Kaniewska, Konrad Lewandowski, Grazyna Rydzewska
Summary: The study found that in patients in remission of IBD, a low-FODMAP diet intervention is effective in reducing IBS-like symptoms, regardless of the presence of bacterial overgrowth.
Article
Nutrition & Dietetics
Samira Rastgoo, Nasser Ebrahimi-Daryani, Shahram Agah, Sara Karimi, Mohammad Taher, Bahram Rashidkhani, Ehsan Hejazi, Fatemeh Mohseni, Mina Ahmadzadeh, Amir Sadeghi, Azita Hekmatdoost
Summary: The study demonstrated the superiority of adding glutamine supplementation to a low FODMAP diet in alleviating IBS symptoms, while also confirming the beneficial effects of a low FODMAP diet in IBS management through a randomized controlled trial.
FRONTIERS IN NUTRITION
(2021)
Review
Nutrition & Dietetics
Jongsung Hahn, Jeongwon Choi, Min Jung Chang
Summary: This meta-analysis revealed that a low fermentable oligo-, di-, monosaccharides, and polyols diet (LFD) has a moderate reduction effect on the symptom severity and a slight improvement effect on the quality of life of irritable bowel syndrome (IBS) patients, as well as a significant improvement in stool habits.
Review
Pharmacology & Pharmacy
Chao-Rong Xie, Bin Tang, Yun-Zhou Shi, Wen-Yan Peng, Kun Ye, Qing-Feng Tao, Shu-Guang Yu, Hui Zheng, Min Chen
Summary: This study evaluated the most effective approaches for managing irritable bowel syndrome (IBS) by analyzing different combinations and components of probiotics or a low FODMAP diet. The results showed that Lactobacillus was the most effective component for relieving IBS symptoms, while Bifidobacterium and Bacillus were potentially effective and require further verification.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Daniel So, Chu K. Yao, Zaid S. Ardalan, Phoebe A. Thwaites, Kourosh Kalantar-Zadeh, Peter R. Gibson, Jane G. Muir
Summary: Concomitant supplementation of fibers during a low FODMAP diet did not alter symptomatic response in patients with IBS but augmented stool bulk and normalized low stool water content and slow transit.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
William D. Chey, Jana G. Hashash, Laura Manning, Lin Chang
Summary: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that affects quality of life. The latest clinical practice update recommends dietary modifications, such as the low-FODMAP diet, as the primary treatment for IBS symptoms. Best practice advice includes involving patients who are insightful and motivated in dietary changes, avoiding restrictive diets for patients who are poor candidates, highlighting the benefits of soluble fiber and the low-FODMAP diet, and following a three-phase approach for the low-FODMAP diet. The efficacy of a gluten-free diet for IBS is uncertain and there is limited evidence to support the routine use of biomarkers in clinical practice.
Review
Nutrition & Dietetics
Ionela-Daniela Morariu, Liliana Avasilcai, Madalina Vieriu, Vasile Valeriu Lupu, Branco-Adrian Morariu, Ancuta Lupu, Paula-Cristina Morariu, Oana-Lelia Pop, Iuliana Magalena Starcea, Laura Trandafir
Summary: Irritable bowel syndrome is a common gastrointestinal disease that causes various symptoms such as bloating, abdominal pain, and diarrhea. A low-FODMAP diet has been shown to effectively reduce these symptoms and improve the quality of life for patients with irritable bowel syndrome.
Article
Nutrition & Dietetics
Ameen Eetemadi, Ilias Tagkopoulos
Summary: This study identified two types of IBS patients based on gut microbiome data - those who respond well to a low-FODMAP diet and those who would benefit from dietary supplementation. Microbiome data can predict patient response to the low-FODMAP diet.
CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Anne-Sophie van Lanen, Angelika de Bree, Arno Greyling
Summary: The low-FODMAP diet is effective in reducing symptoms severity and improving quality of life in patients with irritable bowel syndrome, regardless of age, intervention duration, and IBS subtype. Future research should focus on the long-term effects of such diets on nutritional adequacy and the gut microbiome.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Sanna Nybacka, Stine Storsrud, Helen M. Lindqvist, Hans Tornblom, Magnus Simren, Anna Winkvist
Summary: The study found subtle differences in FODMAP intake among IBS patients with different subtypes, with the association between IBS symptoms and FODMAP intake being most prominent in unsubtyped IBS patients. However, patients intolerant to certain FODMAPs may have already reduced their intake, requiring future cohort or experimental studies for further investigation.
Article
Nutrition & Dietetics
Cezary Chojnacki, Tomasz Poplawski, Aleksandra Blonska, Paulina Konrad, Jan Chojnacki, Janusz Blasiak
Summary: This study evaluated the efficacy of a low-FODMAP diet with a concomitant reduction in tryptophan intake for the treatment of IBS-D. The results showed that limiting tryptophan intake was more effective in improving symptoms in IBS-D patients compared to using only a low-FODMAP diet.
Article
Nutrition & Dietetics
Laura Prospero, Giuseppe Riezzo, Michele Linsalata, Antonella Orlando, Benedetta D'Attoma, Francesco Russo
Summary: The study shows that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (LFD) improves both gastrointestinal symptoms and the psychological profile of patients with irritable bowel syndrome with diarrhea (IBS-D). The LFD also enhances intestinal barrier function and reduces inflammation levels.
Review
Pediatrics
Elvira Ingrid Levy, Charlotte De Geyter, Abdelhalim Ouald Chaib, Berthold Albert Aman, Badriul Hegar, Yvan Vandenplas
Summary: There are limited randomized controlled trials on managing pediatric IBS, with most intervention trials targeting changes to the gastrointestinal microbiome. Heterogeneity in study designs and outcomes make it difficult to formulate recommendations. Insufficient evidence exists to recommend therapeutic interventions in pediatric IBS, despite the association with dysbiosis. More prospective trials are needed.
Article
Gastroenterology & Hepatology
Hanna Fjeldheim Dale, Sissi Christiane Stove Lorentzen, Tonje Mellin-Olsen, Jorgen Valeur
Summary: Diet plays a crucial role in modulating the gut microbiota and is decisive for gut-microbiota-related diseases like IBS. While the LFD is commonly used to treat IBS, its long-term effects on microbiota, symptoms, and QoL are unclear. Therefore, alternative dietary strategies that promote beneficial gut microbiota and improve symptoms and QoL are of interest.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Nutrition & Dietetics
Jinsheng Wang, Pengcheng Yang, Lei Zhang, Xiaohua Hou
Summary: Through a systematic review and meta-analysis of ten studies, it was found that a low-FODMAP diet is effective in reducing global symptoms and improving bowel habits, especially for IBS-D patients.
FRONTIERS IN NUTRITION
(2021)
Article
Medicine, General & Internal
Rosalinda Madonna, Silvia Fabiani, Riccardo Morganti, Arianna Forniti, Filippo Biondi, Lorenzo Ridolfi, Riccardo Iapoce, Francesco Menichetti, Raffaele De Caterina
Summary: This study found an association between exercise-induced pulmonary hypertension (ExPH) and a high cardiovascular (CV) risk score in patients with HIV. Assessment of ExPH may help in better stratifying CV risk in HIV patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Amedeo Nuzzo, Simona Manacorda, Enrico Sammarco, Andrea Sbrana, Serena Bazzurri, Federico Paolieri, Fiorella Manfredi, Chiara Mercinelli, Marco Ferrari, Giulia Massaro, Adele Bonato, Alessia Salfi, Luca Galli, Riccardo Morganti, Andrea Antonuzzo, Chiara Cremolini, Gianluca Masi
Summary: This study investigated the safety and tolerability of COVID-19 vaccines in patients being treated for solid tumors. The results showed that vaccine-related adverse events were mild and transient, with no severe or uncommon adverse events recorded.
Article
Medicine, General & Internal
Eleonora Russo, Maria Magdalena Montt Guevara, Koray Gorkem Sacinti, Giulia Misasi, Maria Falcone, Riccardo Morganti, Liliana Mereu, Francesca Dalpra, Saverio Tateo, Tommaso Simoncini
Summary: This study compares the outcomes of abdominal lateral suspension (ALS) and abdominal sacral colpopexy (ASC) for the treatment of multicompartmental prolapse. The results show that at 1-year follow-up, ALS and ASC have similar anatomical and symptomatic cure rates of 92% and 94% respectively, with recurrence rates of 8% and 6%. The study concludes that ALS is not inferior to ASC for the surgical treatment of apical prolapse.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Edoardo Benedetti, Claudia Barate, Fabrizio Mavilia, Emilia Bramanti, Riccardo Morganti, Valentina Guerri, Giulia Cervetti, Enrico Capochiani, Ilaria Bertaggia, Salvatore Massimo Stella, Ginevra Traverso, Benedetto Bruno, Sara Galimberti
Summary: Fixed duration VenR treatment showed significant improvements in PFS and uMRD compared to bendamustine-rituximab in relapsed/refractory CLL patients. Ultrasonography and palpation were suggested as possible techniques to evaluate visceral and superficial lymph node involvement outside of clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Giorgio Guglielmi, Stefania Crucitta, Lorenzo Bertani, Martina Ruglioni, Giovanni Baiano Svizzero, Linda Ceccarelli, Marzia Del Re, Romano Danesi, Francesco Costa, Stefano Fogli
Summary: This study suggests that the expression levels of circulating let-7e and miR-126 may serve as biomarkers for predicting clinical remission in Crohn's disease patients treated with anti-TNF-& alpha; biologics.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Marasco, Pierfrancesco Visaggi, Mariagiulia Vassallo, Miriam Fiocca, Cesare Cremon, Maria Raffaella Barbaro, Nicola De Bortoli, Massimo Bellini, Vincenzo Stanghellini, Edoardo Vincenzo Savarino, Giovanni Barbara
Summary: Eosinophilic gastrointestinal diseases (EGIDs) are a group of pathological conditions characterized by eosinophil infiltration in the gut. They can be classified into different types based on the specific tract involved. The epidemiology of EGIDs is evolving rapidly, and research on treatment options is ongoing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
M. Ghilli, M. D. Mariniello, F. Ferre, R. Morganti, E. Perre, R. Novaro, L. Colizzi, V. Camilleri, G. Baldetti, E. Rossetti, L. Coletti, C. Scatena, M. Ghilardi, M. C. Cossu, M. Roncella
Summary: This study aimed to evaluate the impact of oncoplastic surgery on patient satisfaction and quality of life, compared with traditional conservative surgery. The results showed significant improvement in psychosocial well-being and satisfaction with breasts 3 months after surgery, while physical well-being in the chest area worsened compared to the baseline. There was no significant change in sexual well-being. Only in terms of physical well-being, there was a significant difference between the post-operative outcomes of oncoplastic surgery and traditional surgery, with traditional surgery having better results.
Article
Medicine, General & Internal
Lorenzo Bertani, Claudia DAlessandro, Marco Fornili, Francesca Coppini, Federico Zanzi, Luca Carmisciano, Francesca Geri, Giovanni Baiano Svizzero, Emma Maria Rosi, Alice De Bernardi, Linda Ceccarelli, Maria Gloria Mumolo, Laura Baglietto, Massimo Bellini, Nicola De Bortoli, Francesco Costa
Summary: The study aimed to evaluate the impact of ustekinumab on body composition in patients with Crohn's disease. The results showed that ustekinumab treatment could modify body composition indicators in CD patients, with a significant improvement in nutritional status observed in responders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Alessandro Massano, Luisa Bertin, Fabiana Zingone, Andrea Buda, Pierfrancesco Visaggi, Lorenzo Bertani, Nicola de Bortoli, Matteo Fassan, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Cristina Bezzio, Valentina Casini, Davide Giuseppe Ribaldone, Edoardo Vincenzo Savarino, Brigida Barberio
Summary: This review summarizes the evidence on the association between inflammatory bowel disease (IBD) and extraintestinal cancers (EICs), as well as the safety and management of immunomodulators and biologics for IBD patients with prior or current EICs.
Review
Oncology
Claudio Spinelli, Marco Ghionzoli, Linda Idrissi Sahli, Carla Guglielmo, Silvia Frascella, Silvia Romano, Carlo Ferrari, Fabrizio Gennari, Giovanni Conzo, Riccardo Morganti, Luigi De Napoli, Lucia Quaglietta, Lucia De Martino, Stefania Picariello, Anna Grandone, Caterina Luongo, Antonella Gambale, Armando Patrizio, Poupak Fallahi, Alessandro Antonelli, Silvia Martina Ferrari
Summary: DICER1 syndrome is a rare genetic disorder that predisposes patients to the development of malignant and non-malignant diseases. The diagnosis of DICER1 syndrome still often occurs late, after surgical operations, adversely affecting patients' outcomes, particularly in relation to subsequent neoplasms associated with this syndrome. Thus, a multicenter report of DICER1 syndrome was presented here, with the aim of enhancing post-surgical surveillance. Additionally, a comprehensive literature review of DICER1 cases from 1996 to June 2022 was conducted and compared with data from a cohort of patients.
Review
Medicine, General & Internal
Emanuele Tumino, Pierfrancesco Visaggi, Valeria Bolognesi, Linda Ceccarelli, Christian Lambiase, Sergio Coda, Purushothaman Premchand, Massimo Bellini, Nicola de Bortoli, Emanuele Marciano
Summary: Lower gastrointestinal endoscopy is the gold standard for diagnosing and removing colonic polyps. However, some patients refuse conventional colonoscopy due to fear of risks and discomfort. Robotic colonoscopy offers a promising alternative, allowing for a painless examination of the colon. Barium enema, computed tomographic colonography, and colon capsule endoscopy are also possible alternatives.
Article
Medicine, General & Internal
Alessandra Michelucci, Valentina Dini, Giorgia Salvia, Giammarco Granieri, Flavia Manzo Margiotta, Salvatore Panduri, Riccardo Morganti, Marco Romanelli
Summary: This study used ultra-high-frequency ultrasound to monitor the changes in nail bed and matrix in patients with psoriatic onychopathy during monoclonal antibody treatment. The results showed a significant decrease in some parameters after treatment. Therefore, ultra-high-frequency ultrasound could be a valuable technique for evaluating and monitoring psoriatic onychopathy.
Article
Medicine, General & Internal
Martina Pappalardo, Laura Gori, Emioli Randazzo, Riccardo Morganti, Michelangelo Scaglione, Margherita Valiani, Alessandra Beni, Maria Di Cicco, Diego G. Peroni, Ferdinando Franzoni, Pasquale Comberiati
Summary: This study found an association between body weight and structural changes in the foot in children and adolescents, which may be related to weight gain rather than diabetes pathology. Ultrasound is a valuable tool for assessing early structural changes in the foot in young individuals.
Article
Rheumatology
Marco Di Battista, Andrea Delle Sedie, Chiara Romei, Laura Tavanti, Mattia Da Rio, Riccardo Morganti, Alessandra Della Rossa, Marta Mosca
Summary: This study assessed the changes in lung ultrasound (LUS) and high-resolution CT (HRCT) in SSc-ILD patients treated with NIN, and found that NIN treatment significantly reduced the number of B-lines and pleural line irregularities. Male gender, smoking habit, and baseline forced vital capacity <70% predicted were associated with worse LUS outcomes. A greater reduction in imaging abnormalities was observed in those who improved in functional and quality-of-life outcomes.
