Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy

Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1

(2019) Hatem Maamoun et al.   Frontiers in Physiology

Nicorandil Attenuates LPS-Induced Acute Lung Injury by Pulmonary Endothelial Cell Protection via NF-κB and MAPK Pathways

(2019) Mengyu He et al.   Oxidative Medicine and Cellular Longevity

Honokiol post-treatment ameliorates myocardial ischemia/reperfusion injury by enhancing autophagic flux and reducing intracellular ROS production

(2019) Zhipeng Tan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Genipin protects rats against lipopolysaccharide-induced acute lung injury by reinforcing autophagy

(2019) Zhijie Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Asatone Prevents Acute Lung Injury by Reducing Expressions of NF-κB, MAPK and Inflammatory Cytokines

(2018) Heng-Yuan Chang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Apigenin C-glycosides of Microcos paniculata protects lipopolysaccharide induced apoptosis and inflammation in acute lung injury through TLR4 signaling pathway

(2018) Kunping Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective Effects of Isoliquiritigenin on LPS-Induced Acute Lung Injury by Activating PPAR-γ

(2018) Wenbin Zhang et al.   INFLAMMATION

Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro

(2018) Junke Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways

(2018) Yu-Cheng Li et al.   Nutrients

Alpinumisoflavone attenuates lipopolysaccharide-induced acute lung injury by regulating the effects of anti-oxidation and anti-inflammation both in vitro and in vivo

(2018) Pei-Ying Li et al.   RSC Advances

Pterostilbene 4′-β-Glucoside Attenuates LPS-Induced Acute Lung Injury via Induction of Heme Oxygenase-1

(2018) Jeongmin Park et al.   Oxidative Medicine and Cellular Longevity

Sclareol ameliorate lipopolysaccharide-induced acute lung injury through inhibition of MAPK and induction of HO-1 signaling

(2017) Yung-Hung Hsieh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-Inflammatory Activity of Sanghuangporus sanghuang Mycelium

(2017) Wang-Ching Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tanshinone IIA increases protein expression levels of PERK, ATF6, IRE1α, CHOP, caspase-3 and caspase-12 in pancreatic cancer BxPC-3 cell-derived xenograft tumors

(2017) Tsung-Lang Chiu et al.   Molecular Medicine Reports

4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models

(2017) Meichun Zeng et al.   TOXICOLOGY LETTERS

Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells

(2017) Min-Chieh Hsin et al.   Cell Death & Disease

Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages

(2017) Weishan Fang et al.   Scientific Reports

Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies

(2016) Kim M. Keppler-Noreuil et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Calcium-Oxidant Signaling Network Regulates AMP-activated Protein Kinase (AMPK) Activation upon Matrix Deprivation

(2016) Ananthalakshmy Sundararaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2

(2016) S. Fogarty et al.   MOLECULAR CANCER RESEARCH

Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury

(2016) Ravirajsinh N. Jadeja et al.   Oxidative Medicine and Cellular Longevity

Lipopolysaccharide Induces Autophagic Cell Death through the PERK-Dependent Branch of the Unfolded Protein Response in Human Alveolar Epithelial A549 Cells

(2015) Shaoying Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway

(2015) Yao-Feng Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis

(2015) Genyuan Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hispolon from Phellinus linteus induces apoptosis and sensitizes human cancer cells to the tumor necrosis factor-related apoptosis-inducing ligand through upregulation of death receptors

(2015) JI-HUN KIM et al.   ONCOLOGY REPORTS

Hispolon inhibits TPA-induced invasion by reducing MMP-9 expression through the NF-κB signaling pathway in MDA-MB-231 human breast cancer cells

(2015) YI-SHENG SUN et al.   Oncology Letters

Hispolon Decreases Melanin Production and Induces Apoptosis in Melanoma Cells through the Downregulation of Tyrosinase and Microphthalmia-Associated Transcription Factor (MITF) Expressions and the Activation of Caspase-3, -8 and -9

(2014) Yi-Shyan Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hispolon from Phellinus linteus possesses mediate caspases activation and induces human nasopharyngeal carcinomas cells apoptosis through ERK1/2, JNK1/2 and p38 MAPK pathway

(2014) Ming-Ju Hsieh et al.   PHYTOMEDICINE

Activation of volume-sensitive outwardly rectifying chloride channel by ROS contributes to ER stress and cardiac contractile dysfunction: involvement of CHOP through Wnt

(2014) M Shen et al.   Cell Death & Disease

Hispolon from Phellinus linteus Induces G0/G1 Cell Cycle Arrest and Apoptosis in NB4 Human Leukaemia Cells

(2013) Yi-Chuan Chen et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

RETRACTED ARTICLE: Human leptin triggers proliferation of A549 cells via blocking endoplasmic reticulum stress-related apoptosis

(2013) Wei Wang et al.   BIOCHEMISTRY-MOSCOW

Non-apoptotic roles of Bcl-2 family: The calcium connection

(2013) Benjamin Bonneau et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nicorandil inhibits hypoxia-induced apoptosis in human pulmonary artery endothelial cells through activation of mitoKATP and regulation of eNOS and the NF-κB pathway

(2013) HUI WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hispolon Induces Apoptosis through JNK1/2-Mediated Activation of a Caspase-8, -9, and -3-Dependent Pathway in Acute Myeloid Leukemia (AML) Cells and Inhibits AML Xenograft Tumor Growth in Vivo

(2013) Pei-Ching Hsiao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation

(2013) Ugo Moens et al.   Genes

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9

(2011) Guan-Jhong Huang et al.   Evidence-based Complementary and Alternative Medicine

Hispolon Induces Apoptosis and Cell Cycle Arrest of Human Hepatocellular Carcinoma Hep3B Cells by Modulating ERK Phosphorylation

(2011) Guan-Jhong Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Hispolon Suppresses SK-Hep1 Human Hepatoma Cell Metastasis by Inhibiting Matrix Metalloproteinase-2/9 and Urokinase-Plasminogen Activator through the PI3K/Akt and ERK Signaling Pathways

(2010) Guan-Jhong Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers

(2009) Murali Shyamsundar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Analgesic Effects and the Mechanisms of Anti-Inflammation of Hispolon in Mice

(2009) Heng-Yuan Chang et al.   Evidence-based Complementary and Alternative Medicine

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Selenocystine Induces S-Phase Arrest and Apoptosis in Human Breast Adenocarcinoma MCF-7 Cells by Modulating ERK and Akt Phosphorylation

(2008) Tianfeng Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY