Review
Nutrition & Dietetics
Luigi Barrea, Ludovica Verde, Luigi Schiavo, Gerardo Sarno, Elisabetta Camajani, Antonio Iannelli, Massimiliano Caprio, Vincenzo Pilone, Annamaria Colao, Giovanna Muscogiuri
Summary: Bariatric surgery is the most effective method for long-term weight loss in severe obesity patients. The pre-operative diet plays a crucial role in determining patients' suitability for surgery and their post-operative outcomes. Nutritional management of bariatric patients requires specialized expertise.
Review
Endocrinology & Metabolism
Mariangela Rondanelli, Clara Gasparri, Gabriella Peroni, Milena Anna Faliva, Maurizio Naso, Simone Perna, Philip Bazire, Ignacio Sajuox, Roberto Maugeri, Chiara Rigon
Summary: Studies have shown that very low calorie diets and very low carbohydrate diets can affect the gut microbiota composition of obese patients, while very low calorie ketogenic diets alter the composition of fecal microbial populations and impact the plasma metabolome and fecal bile acid composition.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Food Science & Technology
Luigi Barrea, Matteo Megna, Sara Cacciapuoti, Evelyn Frias-Toral, Gabriella Fabbrocini, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: Psoriasis is a chronic immune-mediated skin disease influenced by genetic and lifestyle factors. Nutrition and obesity are significant contributors to its pathogenesis and severity. Certain diets with anti-inflammatory properties, such as the very-low-calorie ketogenic diet (VLCKD), may improve clinical severity by reducing weight and systemic inflammation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Valeria Calcaterra, Hellas Cena, Francesca Sottotetti, Chiara Hruby, Nagaia Madini, Noemi Zelaschi, Gianvincenzo Zuccotti
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and is mainly driven by hyperandrogenism, hyperinsulinism, and insulin resistance. Lifestyle and dietary interventions, particularly the quality and quantity of carbohydrates consumed, play a crucial role in the management of PCOS, and the ketogenic diet (KD) has shown promise in improving insulin resistance and carbohydrate metabolism. Further studies are needed to determine the specific effects of the very low-calorie ketogenic diet (LCKD) in adolescents with PCOS and excessive body weight. Rating: 8/10
Article
Medicine, Research & Experimental
Luigi Barrea, Ludovica Verde, Cherubino Di Lorenzo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: The study aimed to investigate the short-term effect of a very low calorie ketogenic diet (VLCKD) on sleep quality in overweight/obese women. The results showed that VLCKD significantly improved sleep quality, and this improvement was mainly due to the reduction in fat mass.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Ana Karina Zambrano, Santiago Cadena-Ullauri, Patricia Guevara-Ramirez, Evelyn Frias-Toral, Viviana A. Ruiz-Pozo, Elius Paz-Cruz, Rafael Tamayo-Trujillo, Sebastian Chapela, Martha Montalvan, Gerardo Sarno, Claudia V. Guerra, Daniel Simancas-Racines
Summary: The very-low-calorie KD (VLCKD) is a diet with a caloric intake of under 800 kcal/day, less than 50 g/day of carbohydrate, and a balance of protein and fat. VLCKD has been proven to have beneficial effects on diseases like heart failure, schizophrenia, multiple sclerosis, Parkinson's, and obesity. The gut microbiota plays a role in metabolism, appetite, and energy regulation, and there is evidence of an association between gut microbiota dysbiosis and obesity. More research is needed to understand the mechanisms and potential benefits of VLCKD on gut microbiota composition in individuals with obesity.
Article
Medicine, Research & Experimental
Luigi Barrea, Ludovica Verde, Pasquale Santangeli, Stefania Luca, Annamaria Docimo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: Very low-calorie ketogenic diet (VLCKD) significantly reduces blood pressure and improves body weight and composition in women with obesity and hypertension.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Angela D. Clontz
Summary: English summary: Glioblastoma Multiforme is an aggressive brain cancer with limited treatment options. Researchers have explored the use of the ketogenic diet as a potential therapy due to the inability of gliomas to utilize ketones. This review examines the current research on the effectiveness and manageability of the ketogenic diet in glioblastoma patients, revealing limitations and the need for further reproducible studies in human subjects.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Ludovica Verde, Maria Dalamaga, Xavier Capo, Giuseppe Annunziata, Maria Hassapidou, Annamaria Docimo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Luigi Barrea
Summary: High adherence to the Mediterranean diet (MD) leads to better results in the very low-calorie ketogenic diet (VLCKD), possibly due to the antioxidant and anti-inflammatory properties of the MD, which create a metabolic state favorable for more effective ketosis.
Article
Nutrition & Dietetics
Dina Hafez Griauzde, Kathleen Standafer Lopez, Laura R. Saslow, Caroline R. Richardson
Summary: Individuals show varied responses to different eating patterns, leading to a call for personalized nutrition counseling strategies. Challenges remain in translating evidence-based eating patterns into clinical practice, as certain dietary approaches are perceived as less healthy despite potential benefits.
FRONTIERS IN NUTRITION
(2021)
Review
Nutrition & Dietetics
Mohamed Rafiullah, Mohthash Musambil, Satish Kumar David
Summary: This meta-analysis examines the efficacy of very low-carbohydrate ketogenic (VLCK) diets in managing type 2 diabetes. The results show that VLCK diets can improve glycemic control and promote weight loss after 3 and 6 months. They also improve lipid profile and reduce the use of antidiabetic medications. However, the quality of the currently available evidence is insufficient to recommend VLCK diets.
Article
Surgery
Livia Lugarinho Correa, Adriana Moretti, Priscila Alves Medeiros de Sousa, Leticia Dinis, Mariana Fuganti de Souza, Isabel Tostes, Maitane Nunez-Garcia, Ignacio Sajoux
Summary: This study evaluated the response to a very low-calorie ketogenic diet (VLCKD) in patients who did not achieve desired weight loss or experienced weight regain after bariatric surgery. The results showed significant reductions in weight, BMI, abdominal circumference, and glycated hemoglobin levels post-ketogenic diet, with no differences in certain biochemical markers. The ketogenic diet was recommended as an effective and safe treatment option for these patients.
Article
Biochemical Research Methods
Giuseppe Castaldo, Imma Pagano, Manuela Grimaldi, Carmen Marino, Paola Molettieri, Angelo Santoro, Ilaria Stillitano, Rocco Romano, Paola Montoro, Anna Maria D'Ursi, Luca Rastrelli
Summary: Psoriasis is an inflammatory disease associated with immunological mechanisms and obesity. Using a low-calorie ketogenic diet can effectively improve metabolic and inflammatory status in psoriasis patients.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Darrell H. G. Crawford, Diana G. F. Ross, Lesley-Anne Jaskowski, Leslie J. Burke, Laurence J. Britton, Nick Musgrave, David Briskey, Gautam Rishi, Kim R. Bridle, Nathan Subramaniam
Summary: Results from experiments on Hfe(-/-) mice indicate that reducing iron intake can alleviate the development of steatosis caused by a high-calorie diet, suggesting that modulation of iron balance could be a potential approach for treating NAFLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Endocrinology & Metabolism
Vincenzo Garofalo, Federica Barbagallo, Rossella Cannarella, Aldo Eugenio Calogero, Sandro La Vignera, Rosita Angela Condorelli
Summary: This systematic review found no significant effect of different types of ketogenic diet on bone health, including bone mass density, bone formation, and overall bone turnover. Only in female subjects after a 10% weight loss, an increase in bone resorption and a decrease in new bone synthesis were observed, without increasing the risk of osteoporosis. Additionally, ketogenic diet was associated with weight loss, increased vitamin D levels, and reduced parathyroid hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Sanja Medenica, Maria Elena Spoltore, Paulina Ormazabal, Ljiljana V. Marina, Antoan Stefan Sojat, Antongiulio Faggiano, Lucio Gnessi, Rossella Mazzilli, Mikiko Watanabe
Summary: Obesity is linked to reduced fertility, with mechanisms such as insulin resistance, hyperglycemia, and polycystic ovary syndrome playing a role. Other factors like gut microbiome alterations, low-grade chronic inflammation, and oxidative stress also contribute. Women with obesity take longer to conceive and have lower success rates with in vitro fertilization (IVF).
CLINICAL ENDOCRINOLOGY
(2023)
Review
Food Science & Technology
Luigi Barrea, Massimiliano Caprio, Elisabetta Camajani, Ludovica Verde, Ausilia Elce, Evelyn Frias-Toral, Florencia Ceriani, Gabriela Cucalon, Eloisa Garcia-Velasquez, Marwan El Ghoch, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri
Summary: Psoriasis is an immune-mediated inflammatory skin disease associated with multiple comorbidities. Obesity is a risk factor for the onset and severity of psoriasis. The very-low-calorie ketogenic diet (VLCKD) has shown significant effects in reducing inflammatory processes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Luigi Barrea, Massimiliano Caprio, Mikiko Watanabe, Giuseppe Cammarata, Alessandra Feraco, Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao, Silvia Savastano
Summary: Obesity is an emerging non-communicable disease associated with chronic low-grade inflammation and oxidative stress. The ketogenic diet (KD), characterized by high fat intake, moderate to low protein consumption, and very low carbohydrate intake, has proven to be effective in weight loss and improving the inflammatory state and oxidative stress in individuals with obesity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Elisabetta Camajani, Agnese Persichetti, Mikiko Watanabe, Savina Contini, Michaela Vari, Settimia Di Bernardo, Maria Faro, Carla Lubrano, Lucio Gnessi, Massimiliano Caprio, Sabrina Basciani
Summary: This study evaluated the effectiveness of a short-term low-calorie diet combined with supplementation with whey protein and leucine on weight loss, lean mass, and muscle strength in sarcopenic, obese, hyperinsulinemic, and post-menopausal women. The results showed that this approach can effectively reduce body weight and waist circumference while improving muscle strength and function.
Review
Andrology
Giuseppe Defeudis, Rossella Mazzilli, Alfonso Maria Di Tommaso, Virginia Zamponi, Francesco Carlomagno, Dario Tuccinardi, Mikiko Watanabe, Antongiulio Faggiano, Daniele Gianfrilli
Summary: This study systematically reviewed the effects of diet and antihyperglycemic drugs on erectile function in diabetic patients. The results showed that the Mediterranean diet was effective in protecting erectile function, and antihyperglycemic drugs had an overall protective role. However, further research is needed on specific drugs.
Article
Endocrinology & Metabolism
Luigi Barrea, Claudia Vetrani, Massimiliano Caprio, Mauro Cataldi, Marwan El Ghoch, Ausilia Elce, Elisabetta Camajani, Ludovica Verde, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This review examines the evidence on diet and physical exercise approaches for post-CoVID, proposing an ideal approach for patients with obesity to reduce clinical conditions. The CoVID-19 pandemic has caused millions of deaths and is associated with medical complications, especially in obese patients, with little known about the best nutritional approach for post-CoVID syndrome.
CURRENT OBESITY REPORTS
(2022)
Review
Nutrition & Dietetics
Mauro Lombardo, Alessandra Feraco, Morena Ottaviani, Gianluca Rizzo, Elisabetta Camajani, Massimiliano Caprio, Andrea Armani
Summary: This study, through a systematic literature review, confirms the correlation between vitamin D deficiency and fibromyalgia syndrome (FMS) and chronic widespread musculoskeletal pain (CMP), and suggests that vitamin D supplementation may alleviate pain symptoms.
Review
Endocrinology & Metabolism
R. Mazzilli, S. Medenica, A. M. Di Tommaso, G. Fabozzi, V. Zamponi, D. Cimadomo, L. Rienzi, F. M. Ubaldi, M. Watanabe, A. Faggiano, S. La Vignera, G. Defeudis
Summary: This article provides an overview of the impact of impaired thyroid function on male and female fertility. In females, thyroid dysfunction is detrimental to pregnancy and fetal outcomes, and the reference range of TSH has recently become a topic of debate. The impact of thyroid function on the male reproductive system is still unclear, but it may play a role in modulating Sertoli and Leydig cells function and spermatogenesis.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Editorial Material
Endocrinology & Metabolism
Renata Risi, Catherine Postic, Mikiko Watanabe
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Ilaria Ernesti, Francesco Baratta, Mikiko Watanabe, Renata Risi, Elisabetta Camajani, Agnese Persichetti, Dario Tuccinardi, Stefania Mariani, Carla Lubrano, Alfredo Genco, Giovanni Spera, Lucio Gnessi, Sabrina Basciani
Summary: The Very Low-Calorie Ketogenic Diet (VLCKD) is a safe and effective intervention for metabolic diseases and obesity. This study examined the predictors of weight loss during VLCKD treatment, including the role of Fibroblast Growth Factor 21 (FGF21). Results revealed that VLCKD led to improvements in body weight, composition, and metabolic parameters. Lower baseline FGF21, male sex, and central obesity were associated with greater weight loss. This suggests that individuals with these characteristics may benefit more from VLCKD in terms of weight loss. More research is needed to determine if these findings are specific to VLCKD or apply to other calorie restriction diets.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Giuseppe Defeudis, Rossella Mazzilli, Domenico Benvenuto, Massimo Ciccozzi, Alfonso Maria Di Tommaso, Antongiulio Faggiano, Dario Tuccinardi, Mikiko Watanabe, Silvia Manfrini, Yeganeh Manon Khazrai
Summary: The study aimed to evaluate glucose control and insulin regimen modifications during pregnancy in women with T1D, comparing them to non-diabetic, normal-weight pregnant women. The findings showed that women with T1D need to modify their insulin regimen and dietary habits to control weight gain and promote optimal birth outcomes. However, due to the increase in insulin regimen, women with T1D gave birth to babies with higher birth weights than non-diabetic pregnant women.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Editorial Material
Nutrition & Dietetics
Mikiko Watanabe, Silvia Savastano, Carla Lubrano, Giovanni Spera
Article
Biochemistry & Molecular Biology
Filippo Biagi, Francesco Carlomagno, Martina Carbone, Roberta Veralli, Umberto Vespasiani-Gentilucci, Elisabetta Riva, Silvia Manfrini, Dario Tuccinardi, Adriano De Santis, Lucio Gnessi, Mikiko Watanabe, Amedeo Lonardo
Summary: This study investigated the relationship between fibroblast growth factor 21 (FGF-21) levels and liver health in patients with hepatitis C virus (HCV) undergoing direct-acting antiviral (DAA) treatment. The results showed that after DAA therapy, the increase in FGF-21 levels was negatively correlated with liver stiffness but not associated with hepatic steatosis.
Review
Nutrition & Dietetics
Luigi Barrea, Ludovica Verde, Luigi Schiavo, Gerardo Sarno, Elisabetta Camajani, Antonio Iannelli, Massimiliano Caprio, Vincenzo Pilone, Annamaria Colao, Giovanna Muscogiuri
Summary: Bariatric surgery is the most effective method for long-term weight loss in severe obesity patients. The pre-operative diet plays a crucial role in determining patients' suitability for surgery and their post-operative outcomes. Nutritional management of bariatric patients requires specialized expertise.
Meeting Abstract
Endocrinology & Metabolism
R. Tozzi, R. Rossetti, S. Basciani, D. Masi, R. Risi, A. Balena, M. Spoltore, M. Watanabe, S. Mariani, L. Gnessi, C. Lubrano
