Blockade of HCN2 Channels Provides Neuroprotection Against Ischemic Injury via Accelerating Autophagic Degradation in Hippocampal Neurons

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Therapeutic hypothermia for ischemic stroke; pathophysiology and future promise

(2018) Kota Kurisu et al.   NEUROPHARMACOLOGY

bFGF plays a neuroprotective role by suppressing excessive autophagy and apoptosis after transient global cerebral ischemia in rats

(2018) Dawei Sun et al.   Cell Death & Disease

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia

(2018) Zhaofei Dong et al.   Neuroscience Bulletin

The Hyperpolarization-Activated Cyclic Nucleotide–Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels

(2017) Laura Sartiani et al.   PHARMACOLOGICAL REVIEWS

Autophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats

(2017) Lixuan Zhan et al.   Cell Death & Disease

HCN1 channels reduce the rate of exocytosis from a subset of cortical synaptic terminals

(2017) Zhuo Huang et al.   Scientific Reports

Neuroprotection of Ro25-6981 Against Ischemia/Reperfusion-Induced Brain Injury via Inhibition of Autophagy

(2016) Fuxing Dong et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Activation of GABA B2 subunits alleviates chronic cerebral hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels

(2016) Yun Lu et al.   NEUROPHARMACOLOGY

Analysis of the Efficacy and Safety of Recombinant Tissue Plasminogen Activator for Chinese Patients over 80 Years of Age with Acute Ischemic Stroke: A Pilot Study

(2016) Jiandao Yang et al.   Neuroscience Bulletin

Low-Dose Ethanol Preconditioning Protects Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Injury By Activating Large Conductance, Ca2+-Activated K+ Channels In Vitro

(2016) Fang Su et al.   Neuroscience Bulletin

Decreased HCN2 expression in STN contributes to abnormal high-voltage spindles in the cortex and globus pallidus of freely moving rats

(2015) Chen Yang et al.   BRAIN RESEARCH

Differential contribution of Ih to the integration of excitatory synaptic inputs in substantia nigra pars compacta and ventral tegmental area dopaminergic neurons

(2015) Alessio Masi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Distribution and Function of HCN Channels in the Apical Dendritic Tuft of Neocortical Pyramidal Neurons

(2015) M. T. Harnett et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent downregulation of M-Type (Kv7) K+ channels surface expression requires the activation of iGluRs/Ca2+/PKC signaling pathway in hippocampal neuron

(2015) Cai Li et al.   NEUROPHARMACOLOGY

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

(2014) Ya-Dan Wen et al.   Autophagy

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

(2014) Mayurbhai Himatbhai Sahani et al.   Autophagy

Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia

(2014) Pavel Honsa et al.   GLIA

Activation of GABAB Receptors Ameliorates Cognitive Impairment via Restoring the Balance of HCN1/HCN2 Surface Expression in the Hippocampal CA1 Area in Rats With Chronic Cerebral Hypoperfusion

(2014) Chang-jun Li et al.   MOLECULAR NEUROBIOLOGY

Autophagy Activation Contributes to the Neuroprotection of Remote Ischemic Perconditioning Against Focal Cerebral Ischemia in Rats

(2014) Jingyuan Su et al.   NEUROCHEMICAL RESEARCH

Neuronal autophagy in cerebral ischemia – a potential target for neuroprotective strategies?

(2014) Bożena Gabryel et al.   Pharmacological Reports

Recanalization and Reperfusion Therapies of Acute Ischemic Stroke: What have We Learned, What are the Major Research Questions, and Where are We Headed?

(2014) Meritxell Gomis et al.   Frontiers in Neurology

The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice

(2013) W.-L. Li et al.   NEUROSCIENCE

Neuronal Autophagy and Neurodevelopmental Disorders

(2013) Kyung-Min Lee et al.   Experimental Neurobiology

Toll-like receptor 3 agonist Poly I:C protects against simulated cerebral ischemia in vitro and in vivo

(2012) Lin-na Pan et al.   ACTA PHARMACOLOGICA SINICA

The end of autophagic cell death?

(2012) Shensi Shen et al.   Autophagy

Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

(2012) Xing Wu et al.   Channels

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

Use of siRNA in knocking down of dopamine receptors, a possible therapeutic option in neuropsychiatric disorders

(2011) Mohammad-Reza Noori-Daloii et al.   MOLECULAR BIOLOGY REPORTS

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Autophagy and protein aggregation after brain ischemia

(2010) Chunli Liu et al.   JOURNAL OF NEUROCHEMISTRY

Postischemic treatment of neonatal cerebral ischemia should target autophagy

(2009) Julien Puyal et al.   ANNALS OF NEUROLOGY

Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons

(2009) S. Steiger-Barraissoul et al.   APOPTOSIS

Associated changes in HCN2 and HCN4 transcripts and If pacemaker current in myocytes

(2009) Qi Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

(2009) Y. T. Zheng et al.   JOURNAL OF IMMUNOLOGY

Hyperpolarization-Activated Cation Channels: From Genes to Function

(2009) Martin Biel et al.   PHYSIOLOGICAL REVIEWS

HCN channels: Structure, cellular regulation and physiological function

(2008) C. Wahl-Schott et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats

(2008) Kim L. Powell et al.   EPILEPSIA

Autophagy–physiology and pathophysiology

(2008) Yasuo Uchiyama et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein

(2008) Narasimman Gurusamy et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells

(2008) J.L. Sánchez-Alonso et al.   NEUROSCIENCE LETTERS

The Itinerary of Autophagosomes: From Peripheral Formation to Kiss-and-Run Fusion with Lysosomes

(2008) Luca Jahreiss et al.   TRAFFIC

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

(2007) A. Rami et al.   NEUROBIOLOGY OF DISEASE